Motif ID: TFAP2{A,C}.p2

Z-value: 2.761


Transcription factors associated with TFAP2{A,C}.p2:

Gene SymbolEntrez IDGene Name
Tcfap2a 21418 transcription factor AP-2, alpha
Tcfap2c 21420 transcription factor AP-2, gamma

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tcfap2achr13_-_408257890.206.0e-03Click!
Tcfap2cchr2_+_1723764900.129.5e-02Click!


Activity profile for motif TFAP2{A,C}.p2.

activity profile for motif TFAP2{A,C}.p2


Sorted Z-values histogram for motif TFAP2{A,C}.p2

Sorted Z-values for motif TFAP2{A,C}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TFAP2{A,C}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr13_-_78337844 48.911 Nr2f1
nuclear receptor subfamily 2, group F, member 1
chr4_-_57156022 41.147 NM_019427
Epb4.1l4b
erythrocyte protein band 4.1-like 4b
chr8_-_87323958 39.942 Nfix
nuclear factor I/X
chr4_-_151235861 39.890 NM_001081557
NM_001195565
Camta1

calmodulin binding transcription activator 1

chr4_-_57155985 38.955 Epb4.1l4b
erythrocyte protein band 4.1-like 4b
chr15_+_89330287 32.222 NM_021423
Shank3
SH3/ankyrin domain gene 3
chrX_+_20265522 31.903 Cdk16
cyclin-dependent kinase 16
chr8_-_87323896 31.111 Nfix
nuclear factor I/X
chrX_+_20265590 30.470 NM_011049
Cdk16
cyclin-dependent kinase 16
chr8_-_94325138 30.302 NM_008393
Irx3
Iroquois related homeobox 3 (Drosophila)
chr4_+_43644806 28.223 NM_173788
Npr2
natriuretic peptide receptor 2
chr5_+_109123455 28.215 Fgfrl1
fibroblast growth factor receptor-like 1
chr9_-_58160063 28.061 Loxl1
lysyl oxidase-like 1
chr5_-_21850490 27.189 NM_011261
Reln
reelin
chr2_-_168567422 26.214 Atp9a
ATPase, class II, type 9A
chrX_+_20265584 25.967 Cdk16
cyclin-dependent kinase 16
chr1_-_74170987 25.881 NM_027884
Tns1
tensin 1
chr9_-_58884114 25.775 NM_001042752
NM_008684
Neo1

neogenin

chr11_+_50415579 25.156 NM_175643
Adamts2
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 2
chr3_+_68298129 25.154 Schip1
schwannomin interacting protein 1
chr1_-_82287990 24.995 NM_010570
Irs1
insulin receptor substrate 1
chr4_+_136833403 24.918 NM_009523
Wnt4
wingless-related MMTV integration site 4
chr5_+_109123159 24.813 NM_001164259
NM_054071
Fgfrl1

fibroblast growth factor receptor-like 1

chr9_-_58160769 24.227 Loxl1
lysyl oxidase-like 1
chr16_+_35154935 23.832 Adcy5
adenylate cyclase 5
chr3_-_57651409 23.679 Pfn2
profilin 2
chr9_-_110645089 22.206 NM_001083936
Pth1r
parathyroid hormone 1 receptor
chr9_-_110644984 22.037 Pth1r
parathyroid hormone 1 receptor
chr3_+_108086993 22.002 Sort1
sortilin 1
chr15_-_77137015 21.843 Rbfox2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr1_+_94728217 21.615 NM_016696
Gpc1
glypican 1
chr8_-_11312729 21.491 NM_009931
Col4a1
collagen, type IV, alpha 1
chr16_-_46496886 21.248 NM_021495
NM_021496
NM_021497
Pvrl3


poliovirus receptor-related 3


chr13_-_60278558 21.009 Gas1
growth arrest specific 1
chr9_-_31019234 20.826 Aplp2
amyloid beta (A4) precursor-like protein 2
chr4_-_57156490 20.610 Epb4.1l4b
erythrocyte protein band 4.1-like 4b
chr13_-_34437042 20.558 NM_001033167
Slc22a23
solute carrier family 22, member 23
chr2_-_80421054 20.509 NM_016965
Nckap1
NCK-associated protein 1
chr6_-_101327849 20.506 NM_018884
Pdzrn3
PDZ domain containing RING finger 3
chr4_-_137882142 20.385 NM_026880
Pink1
PTEN induced putative kinase 1
chr3_-_57651621 20.294 NM_019410
Pfn2
profilin 2
chr17_+_83614611 19.928 NM_134117
Pkdcc
protein kinase domain containing, cytoplasmic
chr2_+_169459145 19.778 NM_080455
Tshz2
teashirt zinc finger family member 2
chr4_+_53453302 19.533 Slc44a1
solute carrier family 44, member 1
chr4_-_104782444 19.433 NM_178143
Prkaa2
protein kinase, AMP-activated, alpha 2 catalytic subunit
chr6_+_88674821 19.229 Mgll
monoglyceride lipase
chr16_+_65815758 18.970 NM_028572
Vgll3
vestigial like 3 (Drosophila)
chr4_-_133053867 18.948 Trnp1
TMF1-regulated nuclear protein 1
chr4_-_109149274 18.825 Rnf11
ring finger protein 11
chr2_-_165980462 18.796 Sulf2
sulfatase 2
chr4_-_109149038 18.692 NM_013876
Rnf11
ring finger protein 11
chrX_+_70918446 18.658 NM_001142809
NM_001142810
NM_133987
Slc6a8


solute carrier family 6 (neurotransmitter transporter, creatine), member 8


chr13_-_60278447 18.514 Gas1
growth arrest specific 1
chr7_+_120909625 18.509 Spon1
spondin 1, (f-spondin) extracellular matrix protein
chr8_-_124175827 18.363 NM_080855
Zcchc14
zinc finger, CCHC domain containing 14
chr7_-_74904546 18.158 NM_183312
NM_201639
NM_207663
Synm


synemin, intermediate filament protein


chr7_-_150646883 18.135 NM_001161624
NM_009876
Cdkn1c

cyclin-dependent kinase inhibitor 1C (P57)

chr15_-_77136972 17.842 Rbfox2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr3_+_108087046 17.810 NM_019972
Sort1
sortilin 1
chr19_+_5741862 17.674 Ltbp3
latent transforming growth factor beta binding protein 3
chr7_+_108469591 17.449 Stard10
START domain containing 10
chr10_+_115738429 17.433 NM_029928
Ptprb
protein tyrosine phosphatase, receptor type, B
chr5_-_122951791 17.392 Atp2a2
ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
chr13_-_69138164 17.288 Adcy2
adenylate cyclase 2
chr7_+_137836116 17.228 Tacc2
transforming, acidic coiled-coil containing protein 2
chr4_+_53453277 17.127 NM_001159633
NM_133891
Slc44a1

solute carrier family 44, member 1

chr10_+_18564876 17.068 NM_022032
Perp
PERP, TP53 apoptosis effector
chr7_+_137836057 17.002 NM_021314
Tacc2
transforming, acidic coiled-coil containing protein 2
chr5_-_53604673 16.977 NM_172710
Sel1l3
sel-1 suppressor of lin-12-like 3 (C. elegans)
chr9_-_31019412 16.963 Aplp2
amyloid beta (A4) precursor-like protein 2
chr13_+_48356795 16.803 NM_031166
Id4
inhibitor of DNA binding 4
chr13_-_78338131 16.716 NM_010151
Nr2f1
nuclear receptor subfamily 2, group F, member 1
chr2_+_27741864 16.711 NM_015734
Col5a1
collagen, type V, alpha 1
chr7_-_31911754 16.272 Scn1b
sodium channel, voltage-gated, type I, beta
chr4_-_41586992 16.218 Enho
energy homeostasis associated
chr2_+_27532692 16.001 NM_011305
Rxra
retinoid X receptor alpha
chr11_-_64976408 15.909 NM_001099288
NM_175003
Arhgap44

Rho GTPase activating protein 44

chr2_-_168567436 15.879 Atp9a
ATPase, class II, type 9A
chr8_-_67171481 15.809 Cpe
carboxypeptidase E
chr6_+_88674398 15.775 NM_001166249
NM_011844
Mgll

monoglyceride lipase

chr2_+_155207542 15.768 Trp53inp2
transformation related protein 53 inducible nuclear protein 2
chr7_+_108469819 15.694 NM_019990
Stard10
START domain containing 10
chr4_+_104830022 15.637 Ppap2b
phosphatidic acid phosphatase type 2B
chr8_-_11312686 15.577 Col4a1
collagen, type IV, alpha 1
chr5_+_104888468 15.568 NM_008861
Pkd2
polycystic kidney disease 2
chr4_+_151648348 15.551 NM_178406
Gpr153
G protein-coupled receptor 153
chr4_+_148960536 15.531 Clstn1
calsyntenin 1
chr12_+_88488691 15.526 Gstz1
glutathione transferase zeta 1 (maleylacetoacetate isomerase)
chr4_-_137882005 15.486 Pink1
PTEN induced putative kinase 1
chr5_-_53604536 15.442 Sel1l3
sel-1 suppressor of lin-12-like 3 (C. elegans)
chr7_-_31911884 15.430 NM_011322
Scn1b
sodium channel, voltage-gated, type I, beta
chr18_+_58038278 15.399 NM_009194
Slc12a2
solute carrier family 12, member 2
chr4_-_41587115 15.314 Enho
energy homeostasis associated
chr1_+_94728419 15.256 Gpc1
glypican 1
chr12_+_88488104 15.128 Gstz1
glutathione transferase zeta 1 (maleylacetoacetate isomerase)
chr9_+_43893029 14.975 Usp2
ubiquitin specific peptidase 2
chr7_+_19868009 14.896 NM_013648
Rtn2
reticulon 2 (Z-band associated protein)
chr13_-_69138229 14.826 Adcy2
adenylate cyclase 2
chr14_-_52533114 14.649 NM_001145959
NM_013864
Ndrg2

N-myc downstream regulated gene 2

chr14_-_52533039 14.649 Ndrg2
N-myc downstream regulated gene 2
chr8_-_92872139 14.644 NM_172913
Tox3
TOX high mobility group box family member 3
chr4_-_133054355 14.585 NM_001081156
Trnp1
TMF1-regulated nuclear protein 1
chr11_-_7113899 14.540 NM_008343
Igfbp3
insulin-like growth factor binding protein 3
chr7_-_28118628 14.414 NM_001113549
Ltbp4
latent transforming growth factor beta binding protein 4
chr8_-_48373564 14.307 Stox2
storkhead box 2
chr5_-_50450152 14.243 NM_133911
Gpr125
G protein-coupled receptor 125
chr14_-_22806631 14.174 Zfp503
zinc finger protein 503
chr6_+_55286292 14.124 NM_007472
Aqp1
aquaporin 1
chr17_+_87362612 14.083 Rhoq
ras homolog gene family, member Q
chr14_+_76815627 14.070 NM_207652
Tsc22d1
TSC22 domain family, member 1
chr14_-_22806999 13.981 Zfp503
zinc finger protein 503
chr2_-_168567602 13.881 Atp9a
ATPase, class II, type 9A
chr8_-_105308910 13.849 NM_009866
Cdh11
cadherin 11
chr16_+_35155621 13.780 NM_001012765
Adcy5
adenylate cyclase 5
chr6_+_71657791 13.685 NM_178608
Reep1
receptor accessory protein 1
chr11_-_7113386 13.647 Igfbp3
insulin-like growth factor binding protein 3
chr9_-_31019392 13.588 NM_001102455
NM_001102456
NM_009691
Aplp2


amyloid beta (A4) precursor-like protein 2


chr7_+_35904347 13.573 Cebpa
CCAAT/enhancer binding protein (C/EBP), alpha
chr11_-_7113547 13.405 Igfbp3
insulin-like growth factor binding protein 3
chr4_+_148960604 13.360 NM_023051
Clstn1
calsyntenin 1
chr4_-_41587334 13.186 NM_027147
Enho
energy homeostasis associated
chr7_-_96666035 13.177 Prss23
protease, serine, 23
chrX_-_49967090 13.136 Gpc3
glypican 3
chr14_+_58143613 13.102 NM_145837
Il17d
interleukin 17D
chr16_+_18777032 13.066 Cldn5
claudin 5
chr2_+_3035692 13.064 Fam171a1
family with sequence similarity 171, member A1
chr10_-_70622370 13.053 NM_031397
Bicc1
bicaudal C homolog 1 (Drosophila)
chr12_+_88488644 13.013 NM_010363
Gstz1
glutathione transferase zeta 1 (maleylacetoacetate isomerase)
chr2_+_74536030 13.004 Hoxd9
homeobox D9
chr5_-_107125559 12.882 Zfp644
zinc finger protein 644
chr9_+_118835589 12.854 NM_133710
Ctdspl
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
chr7_-_20281956 12.790


chr11_-_32122236 12.730 Rhbdf1
rhomboid family 1 (Drosophila)
chr7_+_108470264 12.684 Stard10
START domain containing 10
chr8_-_75876420 12.598 NM_010687
Large
like-glycosyltransferase
chr10_+_18564932 12.576 Perp
PERP, TP53 apoptosis effector
chr9_-_108166059 12.570 NM_010017
Dag1
dystroglycan 1
chr5_-_77836974 12.561 Igfbp7
insulin-like growth factor binding protein 7
chr10_-_94878845 12.560 NM_001168655
Socs2
suppressor of cytokine signaling 2
chr5_-_77837037 12.543 NM_001159518
NM_008048
Igfbp7

insulin-like growth factor binding protein 7

chr19_-_7061867 12.512 Vegfb
vascular endothelial growth factor B
chr19_+_7492081 12.430 NM_175381
2700081O15Rik
RIKEN cDNA 2700081O15 gene
chr1_-_159342068 12.416 Rasal2
RAS protein activator like 2
chr4_-_151235758 12.357 Camta1
calmodulin binding transcription activator 1
chr8_+_129587894 12.272 NM_001122850
NM_033620
Pard3

par-3 (partitioning defective 3) homolog (C. elegans)

chr7_-_139346304 12.226 Cpxm2
carboxypeptidase X 2 (M14 family)
chr9_-_91259829 12.214 Zic1
zinc finger protein of the cerebellum 1
chr5_+_74591290 12.180 Rasl11b
RAS-like, family 11, member B
chr5_+_74591336 12.050 NM_026878
Rasl11b
RAS-like, family 11, member B
chr19_+_53751795 12.001 NM_001170847
Rbm20
RNA binding motif protein 20
chr6_+_4853319 11.981 NM_181595
Ppp1r9a
protein phosphatase 1, regulatory (inhibitor) subunit 9A
chr2_+_74543545 11.968 NM_008276
Hoxd8
homeobox D8
chrX_-_49967112 11.963 NM_016697
Gpc3
glypican 3
chr17_+_78599556 11.935 NM_015800
Crim1
cysteine rich transmembrane BMP regulator 1 (chordin like)
chr7_-_35437859 11.929 NM_146188
Kctd15
potassium channel tetramerisation domain containing 15
chr2_-_165981085 11.924 Sulf2
sulfatase 2
chr11_-_116515361 11.807 Cygb
cytoglobin
chr6_+_72305440 11.726 NM_144916
Tmem150a
transmembrane protein 150A
chr7_-_31911733 11.716 Scn1b
sodium channel, voltage-gated, type I, beta
chr1_-_159342351 11.690 Rasal2
RAS protein activator like 2
chr2_-_25978328 11.610 NM_026495
Nacc2
nucleus accumbens associated 2, BEN and BTB (POZ) domain containing
chr15_-_3533122 11.608 NM_001048178
NM_010284
Ghr

growth hormone receptor

chr1_+_95132413 11.593 NM_172463
Sned1
sushi, nidogen and EGF-like domains 1
chr5_-_122952179 11.506 Atp2a2
ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
chr6_+_56782042 11.425 NM_012056
Fkbp9
FK506 binding protein 9
chr8_-_67171805 11.406 NM_013494
Cpe
carboxypeptidase E
chr5_-_107125618 11.297 Zfp644
zinc finger protein 644
chr2_+_59450080 11.115 NM_198294
Tanc1
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
chr1_+_75233028 11.113 Dnajb2
DnaJ (Hsp40) homolog, subfamily B, member 2
chr7_+_35904310 11.098 NM_007678
Cebpa
CCAAT/enhancer binding protein (C/EBP), alpha
chr11_-_11937330 11.054 NM_010345
Grb10
growth factor receptor bound protein 10
chr4_-_116136779 10.985 NM_001042743
NM_008641
Mast2

microtubule associated serine/threonine kinase 2

chr13_+_48356487 10.935 Id4
inhibitor of DNA binding 4
chr5_-_24107718 10.916 NM_025891
Smarcd3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
chr14_+_21526757 10.915 NM_027996
2310021P13Rik
RIKEN cDNA 2310021P13 gene
chr7_+_19661548 10.911 NM_010058
Dmwd
dystrophia myotonica-containing WD repeat motif
chr8_+_94881868 10.830 Irx5
Iroquois related homeobox 5 (Drosophila)
chr17_-_15963372 10.788 NM_178615
Rgmb
RGM domain family, member B
chr2_+_35516774 10.739 Dab2ip
disabled homolog 2 (Drosophila) interacting protein
chr10_-_8605668 10.709 NM_175155
Sash1
SAM and SH3 domain containing 1
chr11_+_69749297 10.653 NM_016875
Ybx2
Y box protein 2
chr17_-_33918382 10.642 Angptl4
angiopoietin-like 4
chr5_-_139470895 10.614 NM_008808
Pdgfa
platelet derived growth factor, alpha
chr18_-_43597640 10.553 Dpysl3
dihydropyrimidinase-like 3
chr11_-_5965555 10.461 Camk2b
calcium/calmodulin-dependent protein kinase II, beta
chr9_-_107569654 10.456 NM_023805
Slc38a3
solute carrier family 38, member 3
chr13_+_64263131 10.407 NM_019986
Habp4
hyaluronic acid binding protein 4
chr4_-_138648762 10.388 NM_008675
Nbl1
neuroblastoma, suppression of tumorigenicity 1
chr8_-_75877407 10.335 Large
like-glycosyltransferase
chr9_+_102737229 10.311 NM_001042607
NM_013649
Ryk

receptor-like tyrosine kinase

chr11_-_72303447 10.224 Spns2
spinster homolog 2 (Drosophila)
chr7_+_19661811 10.205 Dmwd
dystrophia myotonica-containing WD repeat motif
chr8_-_127187268 10.188 NM_175149
2310022B05Rik
RIKEN cDNA 2310022B05 gene
chr7_-_6683113 10.157 NM_008817
Peg3
paternally expressed 3
chr17_-_32303796 10.143 NM_008716
Notch3
Notch gene homolog 3 (Drosophila)
chr8_+_94881694 10.110 NM_018826
Irx5
Iroquois related homeobox 5 (Drosophila)
chr16_+_18776955 10.078 Cldn5
claudin 5
chrX_+_162676870 10.059 NM_001177961
NM_001177962
NM_023122
Gpm6b


glycoprotein m6b


chr7_-_106501642 10.021 NM_001111043
NM_001111044
NM_009825
Serpinh1


serine (or cysteine) peptidase inhibitor, clade H, member 1


chr8_-_67171692 10.012 Cpe
carboxypeptidase E

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
1.26 4.57e-44 GO:0044237 cellular metabolic process
1.31 4.09e-42 GO:0044260 cellular macromolecule metabolic process
1.24 3.35e-40 GO:0044238 primary metabolic process
1.27 4.02e-37 GO:0043170 macromolecule metabolic process
1.32 4.31e-37 GO:0019222 regulation of metabolic process
1.43 4.48e-36 GO:0048731 system development
1.21 1.94e-35 GO:0008152 metabolic process
1.40 4.65e-35 GO:0048856 anatomical structure development
1.38 7.48e-35 GO:0007275 multicellular organismal development
1.36 2.03e-34 GO:0032502 developmental process
1.33 4.76e-34 GO:0031323 regulation of cellular metabolic process
1.32 7.54e-31 GO:0080090 regulation of primary metabolic process
1.34 4.17e-29 GO:0071840 cellular component organization or biogenesis
1.35 5.56e-29 GO:0016043 cellular component organization
1.53 5.16e-28 GO:0009653 anatomical structure morphogenesis
1.37 8.09e-28 GO:0048522 positive regulation of cellular process
1.31 1.01e-27 GO:0060255 regulation of macromolecule metabolic process
1.34 5.45e-26 GO:0048518 positive regulation of biological process
1.34 6.34e-25 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.33 8.37e-25 GO:0051171 regulation of nitrogen compound metabolic process
1.38 1.00e-24 GO:0048523 negative regulation of cellular process
1.53 1.68e-24 GO:0009966 regulation of signal transduction
1.33 2.94e-23 GO:0010468 regulation of gene expression
1.52 7.86e-23 GO:0007399 nervous system development
1.29 1.01e-22 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.35 1.23e-22 GO:0048519 negative regulation of biological process
1.27 2.92e-22 GO:0006807 nitrogen compound metabolic process
1.27 3.84e-22 GO:0034641 cellular nitrogen compound metabolic process
1.35 1.04e-21 GO:0071841 cellular component organization or biogenesis at cellular level
1.37 1.25e-21 GO:0048869 cellular developmental process
1.36 1.45e-21 GO:0071842 cellular component organization at cellular level
1.38 1.98e-21 GO:0030154 cell differentiation
1.33 2.33e-21 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.10 1.14e-20 GO:0009987 cellular process
1.33 2.77e-20 GO:0051252 regulation of RNA metabolic process
1.40 3.00e-20 GO:0043412 macromolecule modification
1.30 4.44e-20 GO:0031326 regulation of cellular biosynthetic process
1.44 6.39e-20 GO:0023051 regulation of signaling
1.31 2.47e-19 GO:0010556 regulation of macromolecule biosynthetic process
1.34 2.90e-19 GO:0044267 cellular protein metabolic process
1.30 3.09e-19 GO:0009889 regulation of biosynthetic process
1.40 3.55e-19 GO:0006464 protein modification process
1.27 9.20e-19 GO:0051179 localization
1.32 3.30e-18 GO:0006355 regulation of transcription, DNA-dependent
1.27 3.62e-18 GO:0044249 cellular biosynthetic process
1.26 2.57e-17 GO:0009058 biosynthetic process
1.38 3.18e-17 GO:0048583 regulation of response to stimulus
1.28 4.57e-17 GO:0090304 nucleic acid metabolic process
1.30 6.14e-16 GO:0016070 RNA metabolic process
1.29 8.72e-16 GO:0009059 macromolecule biosynthetic process
1.27 8.73e-16 GO:0019538 protein metabolic process
1.29 1.37e-15 GO:0034645 cellular macromolecule biosynthetic process
1.34 2.32e-15 GO:0048513 organ development
1.27 6.27e-15 GO:0010467 gene expression
1.66 7.64e-15 GO:0072358 cardiovascular system development
1.66 7.64e-15 GO:0072359 circulatory system development
1.34 9.13e-15 GO:0032774 RNA biosynthetic process
1.34 9.31e-15 GO:0006351 transcription, DNA-dependent
1.46 2.90e-14 GO:0031324 negative regulation of cellular metabolic process
1.52 3.05e-14 GO:0048699 generation of neurons
1.50 3.30e-14 GO:0048468 cell development
1.44 4.69e-14 GO:0050793 regulation of developmental process
1.44 5.84e-14 GO:0009892 negative regulation of metabolic process
1.36 8.72e-14 GO:0065009 regulation of molecular function
1.64 1.60e-13 GO:0009792 embryo development ending in birth or egg hatching
1.45 2.17e-13 GO:0010605 negative regulation of macromolecule metabolic process
1.49 3.82e-13 GO:0022008 neurogenesis
1.40 4.79e-13 GO:0033036 macromolecule localization
1.25 5.02e-13 GO:0051234 establishment of localization
1.63 5.20e-13 GO:0043009 chordate embryonic development
1.49 5.72e-13 GO:0009790 embryo development
1.43 5.86e-13 GO:0006793 phosphorus metabolic process
1.43 7.11e-13 GO:0006796 phosphate metabolic process
1.25 1.11e-12 GO:0006810 transport
1.43 1.26e-12 GO:0051641 cellular localization
1.46 2.01e-12 GO:0009888 tissue development
1.43 2.24e-12 GO:0008104 protein localization
1.41 3.82e-12 GO:0035556 intracellular signal transduction
1.47 3.90e-12 GO:0051128 regulation of cellular component organization
1.48 4.01e-12 GO:0045595 regulation of cell differentiation
1.43 4.82e-12 GO:0032268 regulation of cellular protein metabolic process
1.76 5.39e-12 GO:0001944 vasculature development
1.49 8.10e-12 GO:0031327 negative regulation of cellular biosynthetic process
1.54 1.04e-11 GO:0009887 organ morphogenesis
1.48 1.34e-11 GO:0009890 negative regulation of biosynthetic process
1.50 1.42e-11 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.34 1.49e-11 GO:0006996 organelle organization
1.49 3.18e-11 GO:0010558 negative regulation of macromolecule biosynthetic process
1.39 4.63e-11 GO:0010646 regulation of cell communication
1.50 4.84e-11 GO:0010629 negative regulation of gene expression
1.35 7.69e-11 GO:0010604 positive regulation of macromolecule metabolic process
1.29 7.90e-11 GO:0065008 regulation of biological quality
1.49 8.05e-11 GO:0051172 negative regulation of nitrogen compound metabolic process
1.37 8.88e-11 GO:0050790 regulation of catalytic activity
1.52 9.06e-11 GO:0045892 negative regulation of transcription, DNA-dependent
1.49 1.17e-10 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.56 1.19e-10 GO:0048646 anatomical structure formation involved in morphogenesis
1.71 1.29e-10 GO:0035295 tube development
1.51 1.90e-10 GO:0051253 negative regulation of RNA metabolic process
1.33 2.38e-10 GO:0009893 positive regulation of metabolic process
1.42 5.47e-10 GO:2000026 regulation of multicellular organismal development
1.33 6.16e-10 GO:0031325 positive regulation of cellular metabolic process
1.38 6.49e-10 GO:0051246 regulation of protein metabolic process
1.48 6.79e-10 GO:0019220 regulation of phosphate metabolic process
1.48 6.79e-10 GO:0051174 regulation of phosphorus metabolic process
1.57 1.11e-09 GO:0071310 cellular response to organic substance
1.44 1.65e-09 GO:0031399 regulation of protein modification process
1.38 1.71e-09 GO:0010941 regulation of cell death
1.74 2.55e-09 GO:0001501 skeletal system development
1.70 3.83e-09 GO:0001568 blood vessel development
1.60 3.97e-09 GO:0060429 epithelium development
1.52 4.13e-09 GO:0010647 positive regulation of cell communication
1.52 4.24e-09 GO:0023056 positive regulation of signaling
1.83 4.24e-09 GO:0071495 cellular response to endogenous stimulus
1.55 4.83e-09 GO:0032989 cellular component morphogenesis
1.41 6.18e-09 GO:0010628 positive regulation of gene expression
1.52 6.56e-09 GO:0030182 neuron differentiation
1.63 7.69e-09 GO:0007167 enzyme linked receptor protein signaling pathway
1.47 9.09e-09 GO:0042325 regulation of phosphorylation
1.57 9.82e-09 GO:0000902 cell morphogenesis
1.40 1.03e-08 GO:0051649 establishment of localization in cell
1.61 1.05e-08 GO:0048729 tissue morphogenesis
1.41 1.08e-08 GO:0016310 phosphorylation
1.54 1.32e-08 GO:0009967 positive regulation of signal transduction
1.56 1.57e-08 GO:0048598 embryonic morphogenesis
1.57 1.64e-08 GO:0048666 neuron development
1.53 2.19e-08 GO:0030030 cell projection organization
1.64 2.56e-08 GO:0031175 neuron projection development
1.41 3.36e-08 GO:0051254 positive regulation of RNA metabolic process
1.36 5.18e-08 GO:0043067 regulation of programmed cell death
1.45 5.58e-08 GO:0012501 programmed cell death
1.36 5.60e-08 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.57 5.63e-08 GO:0060284 regulation of cell development
1.49 5.70e-08 GO:0051094 positive regulation of developmental process
1.36 6.39e-08 GO:0042981 regulation of apoptosis
1.67 1.28e-07 GO:0002009 morphogenesis of an epithelium
1.55 1.34e-07 GO:0009719 response to endogenous stimulus
1.54 1.44e-07 GO:0040008 regulation of growth
1.57 1.78e-07 GO:0090066 regulation of anatomical structure size
1.74 1.90e-07 GO:0035239 tube morphogenesis
1.40 2.05e-07 GO:0045893 positive regulation of transcription, DNA-dependent
1.45 2.09e-07 GO:0046907 intracellular transport
1.44 2.14e-07 GO:0006915 apoptosis
1.42 2.21e-07 GO:0006468 protein phosphorylation
1.39 2.27e-07 GO:0045184 establishment of protein localization
1.71 2.35e-07 GO:0048514 blood vessel morphogenesis
1.46 2.37e-07 GO:0001932 regulation of protein phosphorylation
1.63 2.49e-07 GO:0000904 cell morphogenesis involved in differentiation
1.39 2.81e-07 GO:0015031 protein transport
1.56 2.95e-07 GO:0009968 negative regulation of signal transduction
1.79 3.48e-07 GO:0032870 cellular response to hormone stimulus
1.41 3.80e-07 GO:0016265 death
1.48 4.20e-07 GO:0010942 positive regulation of cell death
1.44 4.54e-07 GO:0016192 vesicle-mediated transport
1.36 4.89e-07 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.35 4.97e-07 GO:0042127 regulation of cell proliferation
1.53 5.51e-07 GO:0023057 negative regulation of signaling
1.72 5.90e-07 GO:0051129 negative regulation of cellular component organization
1.56 6.35e-07 GO:0009725 response to hormone stimulus
1.52 6.96e-07 GO:0010648 negative regulation of cell communication
1.33 7.23e-07 GO:0032879 regulation of localization
1.53 9.08e-07 GO:0045597 positive regulation of cell differentiation
1.40 9.41e-07 GO:0008219 cell death
1.67 1.01e-06 GO:0048812 neuron projection morphogenesis
1.68 1.06e-06 GO:0051056 regulation of small GTPase mediated signal transduction
1.35 1.17e-06 GO:0051173 positive regulation of nitrogen compound metabolic process
1.35 1.22e-06 GO:0010557 positive regulation of macromolecule biosynthetic process
1.56 1.25e-06 GO:0008285 negative regulation of cell proliferation
1.26 2.03e-06 GO:0051239 regulation of multicellular organismal process
1.49 2.14e-06 GO:0034613 cellular protein localization
1.49 2.18e-06 GO:0070727 cellular macromolecule localization
1.78 2.71e-06 GO:0001525 angiogenesis
1.40 2.89e-06 GO:0070887 cellular response to chemical stimulus
1.46 3.11e-06 GO:0043068 positive regulation of programmed cell death
1.57 3.48e-06 GO:0050767 regulation of neurogenesis
1.33 3.52e-06 GO:0031328 positive regulation of cellular biosynthetic process
1.59 3.85e-06 GO:0001701 in utero embryonic development
1.61 4.53e-06 GO:0048568 embryonic organ development
1.56 5.31e-06 GO:0032535 regulation of cellular component size
1.89 5.53e-06 GO:0061138 morphogenesis of a branching epithelium
1.32 7.66e-06 GO:0009891 positive regulation of biosynthetic process
1.45 8.33e-06 GO:0043065 positive regulation of apoptosis
1.54 8.50e-06 GO:0022603 regulation of anatomical structure morphogenesis
1.61 1.02e-05 GO:0045664 regulation of neuron differentiation
1.69 1.05e-05 GO:0046578 regulation of Ras protein signal transduction
1.31 1.21e-05 GO:0044085 cellular component biogenesis
1.77 1.22e-05 GO:0016055 Wnt receptor signaling pathway
1.08 1.61e-05 GO:0065007 biological regulation
1.98 1.64e-05 GO:0071375 cellular response to peptide hormone stimulus
1.51 1.66e-05 GO:0051960 regulation of nervous system development
1.78 2.65e-05 GO:0001763 morphogenesis of a branching structure
1.48 3.03e-05 GO:0043549 regulation of kinase activity
1.78 3.32e-05 GO:0048705 skeletal system morphogenesis
1.34 3.40e-05 GO:0048584 positive regulation of response to stimulus
1.54 3.41e-05 GO:0009894 regulation of catabolic process
1.55 3.54e-05 GO:0048858 cell projection morphogenesis
1.65 3.56e-05 GO:0007409 axonogenesis
1.69 3.67e-05 GO:0031344 regulation of cell projection organization
1.81 4.93e-05 GO:0060541 respiratory system development
1.60 5.77e-05 GO:0061061 muscle structure development
1.85 5.98e-05 GO:0030323 respiratory tube development
1.32 6.15e-05 GO:0022607 cellular component assembly
1.23 6.64e-05 GO:0044281 small molecule metabolic process
1.74 6.95e-05 GO:0043434 response to peptide hormone stimulus
1.85 7.50e-05 GO:0030324 lung development
1.53 7.56e-05 GO:0032990 cell part morphogenesis
1.49 7.65e-05 GO:0045859 regulation of protein kinase activity
1.66 8.01e-05 GO:0044087 regulation of cellular component biogenesis
1.44 8.07e-05 GO:0051726 regulation of cell cycle
1.46 9.02e-05 GO:0051338 regulation of transferase activity
1.45 9.18e-05 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.93 1.04e-04 GO:0031346 positive regulation of cell projection organization
1.61 1.10e-04 GO:0030029 actin filament-based process
2.16 1.13e-04 GO:0045667 regulation of osteoblast differentiation
1.68 1.41e-04 GO:0009952 anterior/posterior pattern formation
1.71 1.52e-04 GO:0010975 regulation of neuron projection development
1.08 1.92e-04 GO:0050789 regulation of biological process
1.82 2.09e-04 GO:0048754 branching morphogenesis of a tube
1.50 2.10e-04 GO:0006886 intracellular protein transport
1.32 2.33e-04 GO:0044093 positive regulation of molecular function
1.88 2.44e-04 GO:0030278 regulation of ossification
1.54 2.58e-04 GO:0007507 heart development
1.37 3.56e-04 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.42 4.34e-04 GO:0007010 cytoskeleton organization
1.59 4.49e-04 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.69 4.53e-04 GO:0006605 protein targeting
1.08 4.90e-04 GO:0050794 regulation of cellular process
1.67 5.40e-04 GO:0060562 epithelial tube morphogenesis
1.57 5.41e-04 GO:0048667 cell morphogenesis involved in neuron differentiation
1.38 6.68e-04 GO:0055086 nucleobase, nucleoside and nucleotide metabolic process
1.49 6.73e-04 GO:0045596 negative regulation of cell differentiation
1.52 6.86e-04 GO:0018193 peptidyl-amino acid modification
1.49 6.99e-04 GO:0051270 regulation of cellular component movement
1.47 9.57e-04 GO:0051130 positive regulation of cellular component organization
1.55 9.66e-04 GO:0008361 regulation of cell size
1.83 1.03e-03 GO:0010639 negative regulation of organelle organization
1.58 1.06e-03 GO:0048732 gland development
1.44 1.06e-03 GO:0010627 regulation of intracellular protein kinase cascade
1.44 1.06e-03 GO:0051093 negative regulation of developmental process
2.25 1.07e-03 GO:0060021 palate development
1.68 1.11e-03 GO:0048545 response to steroid hormone stimulus
1.94 1.22e-03 GO:0010563 negative regulation of phosphorus metabolic process
1.94 1.22e-03 GO:0045936 negative regulation of phosphate metabolic process
1.34 1.27e-03 GO:0007155 cell adhesion
1.94 1.53e-03 GO:0060485 mesenchyme development
1.42 1.57e-03 GO:0032583 regulation of gene-specific transcription
1.71 1.65e-03 GO:0010769 regulation of cell morphogenesis involved in differentiation
1.71 1.65e-03 GO:0022604 regulation of cell morphogenesis
1.61 1.73e-03 GO:0030155 regulation of cell adhesion
1.69 2.00e-03 GO:0042692 muscle cell differentiation
1.56 2.20e-03 GO:0030036 actin cytoskeleton organization
1.40 2.24e-03 GO:0016044 cellular membrane organization
1.43 2.25e-03 GO:0016477 cell migration
1.87 2.29e-03 GO:0048706 embryonic skeletal system development
1.74 2.36e-03 GO:0043254 regulation of protein complex assembly
1.33 2.63e-03 GO:0022610 biological adhesion
1.32 2.67e-03 GO:0007154 cell communication
1.33 2.68e-03 GO:0046483 heterocycle metabolic process
2.24 2.90e-03 GO:0031333 negative regulation of protein complex assembly
1.46 3.02e-03 GO:0008283 cell proliferation
1.40 3.19e-03 GO:0061024 membrane organization
1.48 3.20e-03 GO:0030334 regulation of cell migration
1.37 3.21e-03 GO:0048585 negative regulation of response to stimulus
1.51 3.25e-03 GO:0010740 positive regulation of intracellular protein kinase cascade
1.48 3.30e-03 GO:0033043 regulation of organelle organization
2.04 3.35e-03 GO:0051494 negative regulation of cytoskeleton organization
1.32 3.41e-03 GO:0033554 cellular response to stress
1.60 3.72e-03 GO:0048562 embryonic organ morphogenesis
1.93 3.76e-03 GO:0042326 negative regulation of phosphorylation
1.37 3.92e-03 GO:0060548 negative regulation of cell death
1.49 4.43e-03 GO:0031329 regulation of cellular catabolic process
1.49 4.52e-03 GO:0007264 small GTPase mediated signal transduction
1.33 4.75e-03 GO:0040011 locomotion
1.44 5.57e-03 GO:0007420 brain development
1.24 5.68e-03 GO:0010033 response to organic substance
1.97 5.82e-03 GO:0010810 regulation of cell-substrate adhesion
1.38 6.20e-03 GO:0006928 cellular component movement
2.36 6.35e-03 GO:0010464 regulation of mesenchymal cell proliferation
2.39 7.24e-03 GO:0048286 lung alveolus development
1.53 7.26e-03 GO:0001558 regulation of cell growth
1.46 7.41e-03 GO:2000145 regulation of cell motility
1.27 7.83e-03 GO:0007049 cell cycle
1.49 7.92e-03 GO:0003002 regionalization
1.98 9.06e-03 GO:0034330 cell junction organization
1.48 9.99e-03 GO:0033674 positive regulation of kinase activity
1.31 1.04e-02 GO:0043085 positive regulation of catalytic activity
2.69 1.11e-02 GO:0046626 regulation of insulin receptor signaling pathway
1.47 1.25e-02 GO:0040007 growth
1.70 1.27e-02 GO:0043087 regulation of GTPase activity
1.38 1.27e-02 GO:0048870 cell motility
1.38 1.27e-02 GO:0051674 localization of cell
1.59 1.29e-02 GO:0043062 extracellular structure organization
1.49 1.41e-02 GO:0045860 positive regulation of protein kinase activity
1.35 1.44e-02 GO:0006753 nucleoside phosphate metabolic process
1.35 1.44e-02 GO:0009117 nucleotide metabolic process
1.76 1.45e-02 GO:0016331 morphogenesis of embryonic epithelium
1.59 1.52e-02 GO:0051493 regulation of cytoskeleton organization
1.35 1.53e-02 GO:0043069 negative regulation of programmed cell death
1.36 1.57e-02 GO:0043066 negative regulation of apoptosis
1.84 1.62e-02 GO:0035148 tube formation
1.39 1.66e-02 GO:0007389 pattern specification process
1.86 1.72e-02 GO:0001838 embryonic epithelial tube formation
1.86 1.72e-02 GO:0072175 epithelial tube formation
1.68 1.74e-02 GO:0033124 regulation of GTP catabolic process
2.36 1.75e-02 GO:0002053 positive regulation of mesenchymal cell proliferation
2.11 1.79e-02 GO:0002064 epithelial cell development
1.76 1.83e-02 GO:0030326 embryonic limb morphogenesis
1.76 1.83e-02 GO:0035113 embryonic appendage morphogenesis
1.62 1.88e-02 GO:0001655 urogenital system development
1.81 1.91e-02 GO:0032868 response to insulin stimulus
1.36 1.96e-02 GO:0007417 central nervous system development
1.63 2.06e-02 GO:0030811 regulation of nucleotide catabolic process
1.63 2.06e-02 GO:0033121 regulation of purine nucleotide catabolic process
1.74 2.07e-02 GO:0032318 regulation of Ras GTPase activity
1.86 2.16e-02 GO:0048638 regulation of developmental growth
1.96 2.27e-02 GO:0032869 cellular response to insulin stimulus
1.70 2.27e-02 GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
1.36 2.30e-02 GO:0070271 protein complex biogenesis
1.45 2.34e-02 GO:0051347 positive regulation of transferase activity
1.39 2.37e-02 GO:0044262 cellular carbohydrate metabolic process
1.67 2.38e-02 GO:0030111 regulation of Wnt receptor signaling pathway
1.47 2.60e-02 GO:0010608 posttranscriptional regulation of gene expression
1.60 2.63e-02 GO:0045786 negative regulation of cell cycle
1.35 2.72e-02 GO:0006461 protein complex assembly
1.41 2.96e-02 GO:0040012 regulation of locomotion
2.27 3.03e-02 GO:0045216 cell-cell junction organization
1.37 3.09e-02 GO:0072521 purine-containing compound metabolic process
2.15 3.26e-02 GO:0010811 positive regulation of cell-substrate adhesion
1.30 3.31e-02 GO:0065003 macromolecular complex assembly
2.02 3.40e-02 GO:0001843 neural tube closure
1.34 3.46e-02 GO:0071822 protein complex subunit organization
1.40 3.51e-02 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
1.27 3.70e-02 GO:0051049 regulation of transport
1.67 3.73e-02 GO:0048736 appendage development
1.67 3.73e-02 GO:0060173 limb development
2.17 3.96e-02 GO:0048546 digestive tract morphogenesis
1.46 3.98e-02 GO:0051259 protein oligomerization
1.17 4.05e-02 GO:0042221 response to chemical stimulus
1.97 4.45e-02 GO:0014020 primary neural tube formation
1.57 4.70e-02 GO:0030855 epithelial cell differentiation

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
1.25 2.06e-117 GO:0005622 intracellular
1.25 5.10e-113 GO:0044424 intracellular part
1.29 7.06e-85 GO:0005737 cytoplasm
1.25 5.50e-79 GO:0043226 organelle
1.25 5.70e-78 GO:0043229 intracellular organelle
1.26 6.48e-71 GO:0043227 membrane-bounded organelle
1.26 1.41e-69 GO:0043231 intracellular membrane-bounded organelle
1.10 7.02e-44 GO:0005623 cell
1.10 7.02e-44 GO:0044464 cell part
1.28 7.80e-43 GO:0044444 cytoplasmic part
1.29 3.90e-40 GO:0005634 nucleus
1.25 9.42e-25 GO:0044422 organelle part
1.25 3.70e-23 GO:0044446 intracellular organelle part
1.30 1.24e-21 GO:0043234 protein complex
1.27 9.13e-21 GO:0032991 macromolecular complex
1.42 5.86e-20 GO:0005829 cytosol
1.42 1.18e-14 GO:0042995 cell projection
1.58 4.98e-14 GO:0043005 neuron projection
1.29 8.77e-12 GO:0044428 nuclear part
1.24 3.35e-11 GO:0043228 non-membrane-bounded organelle
1.24 3.35e-11 GO:0043232 intracellular non-membrane-bounded organelle
1.39 1.36e-10 GO:0005794 Golgi apparatus
1.71 4.36e-10 GO:0030425 dendrite
1.37 4.60e-10 GO:0005654 nucleoplasm
1.34 7.31e-10 GO:0000267 cell fraction
1.28 8.56e-10 GO:0043233 organelle lumen
1.28 8.78e-10 GO:0070013 intracellular organelle lumen
1.27 9.71e-10 GO:0031974 membrane-enclosed lumen
1.30 1.01e-09 GO:0031981 nuclear lumen
1.36 1.24e-09 GO:0005783 endoplasmic reticulum
1.88 5.53e-09 GO:0031252 cell leading edge
1.29 5.64e-09 GO:0005856 cytoskeleton
1.44 1.41e-08 GO:0030054 cell junction
1.38 7.26e-08 GO:0012505 endomembrane system
1.41 1.10e-07 GO:0044451 nucleoplasm part
1.16 1.11e-07 GO:0071944 cell periphery
1.34 2.44e-07 GO:0005626 insoluble fraction
1.14 3.49e-06 GO:0005886 plasma membrane
1.46 7.03e-06 GO:0044463 cell projection part
1.31 9.20e-06 GO:0005624 membrane fraction
1.26 1.04e-05 GO:0031090 organelle membrane
1.61 1.44e-05 GO:0005911 cell-cell junction
1.50 1.70e-05 GO:0044297 cell body
1.53 1.90e-05 GO:0048471 perinuclear region of cytoplasm
1.51 2.34e-05 GO:0043025 neuronal cell body
1.41 2.87e-05 GO:0045202 synapse
1.59 7.37e-05 GO:0016323 basolateral plasma membrane
1.73 1.48e-04 GO:0070161 anchoring junction
1.19 1.75e-04 GO:0044459 plasma membrane part
1.75 2.32e-04 GO:0005912 adherens junction
1.52 2.45e-04 GO:0030424 axon
1.48 4.59e-04 GO:0044431 Golgi apparatus part
1.90 6.50e-04 GO:0030027 lamellipodium
1.26 7.84e-04 GO:0044430 cytoskeletal part
1.47 1.01e-03 GO:0015629 actin cytoskeleton
1.41 1.37e-03 GO:0005625 soluble fraction
1.18 4.22e-03 GO:0005739 mitochondrion
2.08 5.33e-03 GO:0030176 integral to endoplasmic reticulum membrane
1.76 6.39e-03 GO:0016327 apicolateral plasma membrane
1.60 6.65e-03 GO:0005938 cell cortex
2.11 8.08e-03 GO:0042641 actomyosin
3.26 1.64e-02 GO:0032154 cleavage furrow
1.72 2.02e-02 GO:0043296 apical junction complex
1.73 2.28e-02 GO:0030055 cell-substrate junction
2.10 2.63e-02 GO:0001725 stress fiber
1.77 2.84e-02 GO:0005925 focal adhesion
2.04 3.64e-02 GO:0032432 actin filament bundle
1.73 4.55e-02 GO:0005924 cell-substrate adherens junction
1.31 4.57e-02 GO:0044427 chromosomal part

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
1.21 4.36e-78 GO:0005488 binding
1.36 2.33e-76 GO:0005515 protein binding
1.34 7.31e-20 GO:0000166 nucleotide binding
1.50 3.37e-15 GO:0019899 enzyme binding
1.33 1.17e-14 GO:0035639 purine ribonucleoside triphosphate binding
1.32 1.91e-14 GO:0017076 purine nucleotide binding
1.32 1.99e-14 GO:0032553 ribonucleotide binding
1.32 2.72e-14 GO:0032555 purine ribonucleotide binding
1.62 4.02e-14 GO:0008092 cytoskeletal protein binding
1.17 5.47e-14 GO:0003824 catalytic activity
1.47 1.53e-12 GO:0016301 kinase activity
1.43 1.88e-12 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.58 2.65e-12 GO:0019904 protein domain specific binding
1.30 5.54e-12 GO:0016740 transferase activity
1.33 6.18e-12 GO:0005524 ATP binding
1.24 6.87e-12 GO:0003676 nucleic acid binding
1.33 6.90e-12 GO:0030554 adenyl nucleotide binding
1.33 9.81e-12 GO:0032559 adenyl ribonucleotide binding
1.20 1.56e-11 GO:0046872 metal ion binding
1.20 6.36e-11 GO:0043169 cation binding
1.19 1.05e-10 GO:0043167 ion binding
1.69 1.35e-09 GO:0003779 actin binding
1.45 2.32e-09 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.61 5.07e-09 GO:0032403 protein complex binding
1.71 2.24e-08 GO:0005083 small GTPase regulator activity
1.56 3.08e-08 GO:0030695 GTPase regulator activity
1.55 3.58e-08 GO:0060589 nucleoside-triphosphatase regulator activity
1.29 3.64e-08 GO:0008270 zinc ion binding
1.46 6.32e-08 GO:0004672 protein kinase activity
1.38 3.01e-07 GO:0001071 nucleic acid binding transcription factor activity
1.38 3.01e-07 GO:0003700 sequence-specific DNA binding transcription factor activity
1.51 4.44e-07 GO:0004674 protein serine/threonine kinase activity
1.39 4.72e-07 GO:0046983 protein dimerization activity
1.34 5.87e-07 GO:0030528 transcription regulator activity
1.40 6.32e-07 GO:0043565 sequence-specific DNA binding
1.24 7.04e-07 GO:0046914 transition metal ion binding
1.59 8.28e-07 GO:0019900 kinase binding
1.23 1.74e-06 GO:0003677 DNA binding
1.34 4.18e-06 GO:0042802 identical protein binding
1.33 5.16e-06 GO:0030234 enzyme regulator activity
1.60 1.17e-05 GO:0019901 protein kinase binding
1.47 5.30e-04 GO:0016564 transcription repressor activity
2.91 8.71e-04 GO:0043236 laminin binding
1.57 1.02e-03 GO:0005096 GTPase activator activity
1.74 1.25e-03 GO:0051020 GTPase binding
1.45 1.42e-03 GO:0008134 transcription factor binding
1.76 2.45e-03 GO:0031267 small GTPase binding
1.16 2.54e-03 GO:0016787 hydrolase activity
1.44 2.55e-03 GO:0008047 enzyme activator activity
1.23 4.01e-03 GO:0005102 receptor binding
1.99 4.69e-03 GO:0005178 integrin binding
1.29 6.96e-03 GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
1.29 7.11e-03 GO:0016462 pyrophosphatase activity
1.34 7.11e-03 GO:0042803 protein homodimerization activity
1.29 7.89e-03 GO:0016817 hydrolase activity, acting on acid anhydrides
1.41 9.47e-03 GO:0042578 phosphoric ester hydrolase activity
1.74 1.10e-02 GO:0017016 Ras GTPase binding
1.93 1.20e-02 GO:0019902 phosphatase binding
1.66 1.24e-02 GO:0005516 calmodulin binding
2.09 1.26e-02 GO:0051219 phosphoprotein binding
2.03 1.40e-02 GO:0046332 SMAD binding
1.46 1.86e-02 GO:0016791 phosphatase activity
1.38 2.23e-02 GO:0016563 transcription activator activity
1.27 2.83e-02 GO:0017111 nucleoside-triphosphatase activity