Motif ID: TLX2.p2

Z-value: 1.566


Transcription factors associated with TLX2.p2:

Gene SymbolEntrez IDGene Name
Tlx2 21909 T-cell leukemia, homeobox 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tlx2chr6_-_83020092-0.163.4e-02Click!


Activity profile for motif TLX2.p2.

activity profile for motif TLX2.p2


Sorted Z-values histogram for motif TLX2.p2

Sorted Z-values for motif TLX2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TLX2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_45401303 20.578 Col3a1
collagen, type III, alpha 1
chr1_+_45401659 18.753 Col3a1
collagen, type III, alpha 1
chr1_-_45559866 12.765 Col5a2
collagen, type V, alpha 2
chr1_-_45559904 12.359 Col5a2
collagen, type V, alpha 2
chr7_+_134355216 12.239 Mylpf
myosin light chain, phosphorylatable, fast skeletal muscle
chr7_+_134355120 12.132 NM_016754
 Mylpf
myosin light chain, phosphorylatable, fast skeletal muscle
chr16_-_56886260 11.869 NM_019631
 Tmem45a
transmembrane protein 45a
chr1_-_45559700 11.389 Col5a2
collagen, type V, alpha 2
chr10_+_79451332 11.341 NM_007725
 Cnn2
calponin 2
chr10_+_97028456 11.041 Lum
lumican
chr10_+_79451369 10.508 Cnn2
calponin 2
chr11_-_78798332 10.477 NM_001159301
NM_010708
 Lgals9

lectin, galactose binding, soluble 9

chr3_-_92819586 10.322 NM_028798
 Crct1
cysteine-rich C-terminal 1
chr1_-_92740348 10.264 Col6a3
collagen, type VI, alpha 3
chr9_-_45743950 10.151 Tagln
transgelin
chr3_+_54165028 10.012 NM_001198765
NM_001198766
NM_015784
 Postn


periostin, osteoblast specific factor


chr3_+_90472990 9.688 NM_013650
 S100a8
S100 calcium binding protein A8 (calgranulin A)
chr9_-_66880619 9.335 Tpm1
tropomyosin 1, alpha
chr8_+_95351212 9.185 NM_008610
 Mmp2
matrix metallopeptidase 2
chr9_-_45744036 9.028 NM_011526
 Tagln
transgelin

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 77 entries
Enrichment   P-value GO Accession GO Term
4.99 5.39e-03 GO:0048002 antigen processing and presentation of peptide antigen
4.60 1.44e-02 GO:0010464 regulation of mesenchymal cell proliferation
4.58 9.98e-09 GO:0006414 translational elongation
4.58 3.75e-02 GO:0002053 positive regulation of mesenchymal cell proliferation
3.92 1.97e-02 GO:0019882 antigen processing and presentation
2.94 4.83e-02 GO:0034504 protein localization to nucleus
2.50 1.63e-02 GO:0007517 muscle organ development
2.48 4.21e-02 GO:0042060 wound healing
2.15 4.33e-03 GO:0001568 blood vessel development
2.14 2.62e-02 GO:0061061 muscle structure development
2.12 8.81e-03 GO:0033043 regulation of organelle organization
2.11 1.60e-02 GO:0006412 translation
2.08 6.43e-04 GO:0009611 response to wounding
2.07 7.57e-03 GO:0001944 vasculature development
2.06 6.39e-03 GO:0048534 hemopoietic or lymphoid organ development
2.03 8.84e-11 GO:0002376 immune system process
2.03 3.52e-05 GO:0072358 cardiovascular system development
2.03 3.52e-05 GO:0072359 circulatory system development
2.02 3.15e-06 GO:0002682 regulation of immune system process
2.02 4.48e-02 GO:0030097 hemopoiesis

Gene overrepresentation in compartment category:

Showing 1 to 20 of 50 entries
Enrichment   P-value GO Accession GO Term
5.96 2.99e-03 GO:0042611 MHC protein complex
5.04 1.46e-02 GO:0005581 collagen
4.03 4.56e-03 GO:0022626 cytosolic ribosome
3.91 2.93e-02 GO:0001725 stress fiber
3.71 1.19e-02 GO:0015935 small ribosomal subunit
3.01 3.88e-04 GO:0044445 cytosolic part
2.93 4.80e-06 GO:0005840 ribosome
2.85 1.90e-02 GO:0030017 sarcomere
2.77 1.11e-02 GO:0044449 contractile fiber part
2.70 4.49e-03 GO:0043292 contractile fiber
2.32 2.81e-02 GO:0000139 Golgi membrane
2.25 4.20e-03 GO:0009897 external side of plasma membrane
2.18 6.38e-04 GO:0015629 actin cytoskeleton
2.10 2.05e-03 GO:0005578 proteinaceous extracellular matrix
2.03 1.90e-03 GO:0031012 extracellular matrix
1.96 1.23e-04 GO:0009986 cell surface
1.86 1.34e-08 GO:0044421 extracellular region part
1.82 1.70e-05 GO:0005615 extracellular space
1.80 5.01e-03 GO:0030529 ribonucleoprotein complex
1.66 2.27e-08 GO:0005829 cytosol

Gene overrepresentation in function category:

Showing 1 to 7 of 7 entries
Enrichment   P-value GO Accession GO Term
3.24 4.68e-05 GO:0003735 structural constituent of ribosome
2.14 9.28e-04 GO:0003779 actin binding
2.11 5.24e-05 GO:0005198 structural molecule activity
1.90 2.40e-04 GO:0008092 cytoskeletal protein binding
1.66 4.34e-05 GO:0005102 receptor binding
1.44 1.45e-20 GO:0005515 protein binding
1.24 8.50e-19 GO:0005488 binding