1.52
|
3.18e-154
|
GO:0044237
|
cellular metabolic process
|
1.61
|
1.55e-133
|
GO:0044260
|
cellular macromolecule metabolic process
|
1.42
|
1.45e-125
|
GO:0008152
|
metabolic process
|
1.46
|
5.75e-123
|
GO:0044238
|
primary metabolic process
|
1.53
|
1.84e-117
|
GO:0043170
|
macromolecule metabolic process
|
1.76
|
3.93e-97
|
GO:0010467
|
gene expression
|
1.62
|
1.19e-84
|
GO:0006139
|
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
|
1.58
|
3.34e-84
|
GO:0034641
|
cellular nitrogen compound metabolic process
|
1.56
|
9.69e-83
|
GO:0006807
|
nitrogen compound metabolic process
|
1.66
|
1.74e-78
|
GO:0090304
|
nucleic acid metabolic process
|
1.60
|
3.79e-76
|
GO:0044249
|
cellular biosynthetic process
|
1.68
|
1.52e-73
|
GO:0034645
|
cellular macromolecule biosynthetic process
|
1.68
|
3.35e-73
|
GO:0009059
|
macromolecule biosynthetic process
|
1.58
|
5.06e-73
|
GO:0009058
|
biosynthetic process
|
1.69
|
2.79e-72
|
GO:0016070
|
RNA metabolic process
|
1.18
|
5.69e-61
|
GO:0009987
|
cellular process
|
1.65
|
7.30e-60
|
GO:0044267
|
cellular protein metabolic process
|
1.46
|
1.87e-53
|
GO:0031323
|
regulation of cellular metabolic process
|
1.46
|
4.92e-52
|
GO:0060255
|
regulation of macromolecule metabolic process
|
1.45
|
2.06e-51
|
GO:0080090
|
regulation of primary metabolic process
|
1.41
|
5.09e-51
|
GO:0019222
|
regulation of metabolic process
|
1.51
|
8.11e-47
|
GO:0019538
|
protein metabolic process
|
1.51
|
1.70e-46
|
GO:0010468
|
regulation of gene expression
|
1.51
|
2.47e-44
|
GO:2000112
|
regulation of cellular macromolecule biosynthetic process
|
1.50
|
2.15e-42
|
GO:0010556
|
regulation of macromolecule biosynthetic process
|
1.51
|
6.91e-41
|
GO:0051252
|
regulation of RNA metabolic process
|
1.47
|
7.67e-40
|
GO:0019219
|
regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
|
1.60
|
7.67e-39
|
GO:0032774
|
RNA biosynthetic process
|
1.60
|
8.18e-39
|
GO:0006351
|
transcription, DNA-dependent
|
1.46
|
1.57e-38
|
GO:0051171
|
regulation of nitrogen compound metabolic process
|
1.50
|
2.28e-37
|
GO:0006355
|
regulation of transcription, DNA-dependent
|
1.45
|
3.81e-37
|
GO:0031326
|
regulation of cellular biosynthetic process
|
2.55
|
5.14e-37
|
GO:0006412
|
translation
|
1.44
|
1.72e-36
|
GO:0009889
|
regulation of biosynthetic process
|
2.06
|
1.68e-33
|
GO:0006396
|
RNA processing
|
1.40
|
5.89e-32
|
GO:0071840
|
cellular component organization or biogenesis
|
1.44
|
1.75e-28
|
GO:0071841
|
cellular component organization or biogenesis at cellular level
|
1.57
|
3.24e-28
|
GO:0006996
|
organelle organization
|
1.37
|
2.07e-25
|
GO:0016043
|
cellular component organization
|
3.28
|
1.81e-24
|
GO:0006414
|
translational elongation
|
2.24
|
1.04e-22
|
GO:0008380
|
RNA splicing
|
2.05
|
3.72e-21
|
GO:0016071
|
mRNA metabolic process
|
1.40
|
4.66e-21
|
GO:0071842
|
cellular component organization at cellular level
|
1.67
|
1.20e-20
|
GO:0007049
|
cell cycle
|
1.51
|
2.97e-20
|
GO:0010604
|
positive regulation of macromolecule metabolic process
|
1.99
|
3.32e-20
|
GO:0006325
|
chromatin organization
|
1.44
|
3.66e-20
|
GO:0043412
|
macromolecule modification
|
1.60
|
3.89e-20
|
GO:0010605
|
negative regulation of macromolecule metabolic process
|
1.45
|
4.59e-20
|
GO:0006464
|
protein modification process
|
1.36
|
4.91e-20
|
GO:0048519
|
negative regulation of biological process
|
1.38
|
7.69e-20
|
GO:0048523
|
negative regulation of cellular process
|
1.35
|
3.16e-19
|
GO:0048522
|
positive regulation of cellular process
|
1.83
|
3.42e-19
|
GO:0051276
|
chromosome organization
|
2.04
|
4.04e-19
|
GO:0016568
|
chromatin modification
|
1.32
|
4.35e-19
|
GO:0048518
|
positive regulation of biological process
|
1.56
|
4.72e-19
|
GO:0009892
|
negative regulation of metabolic process
|
1.52
|
5.73e-19
|
GO:0033036
|
macromolecule localization
|
1.95
|
9.52e-19
|
GO:0000278
|
mitotic cell cycle
|
1.64
|
2.46e-18
|
GO:0045184
|
establishment of protein localization
|
1.64
|
4.09e-18
|
GO:0015031
|
protein transport
|
1.57
|
4.65e-18
|
GO:0031324
|
negative regulation of cellular metabolic process
|
1.48
|
7.35e-18
|
GO:0031325
|
positive regulation of cellular metabolic process
|
1.46
|
1.18e-17
|
GO:0009893
|
positive regulation of metabolic process
|
1.55
|
2.74e-17
|
GO:0008104
|
protein localization
|
1.55
|
3.49e-17
|
GO:0044085
|
cellular component biogenesis
|
2.06
|
3.71e-17
|
GO:0006397
|
mRNA processing
|
2.06
|
6.36e-17
|
GO:0043632
|
modification-dependent macromolecule catabolic process
|
2.06
|
8.76e-17
|
GO:0019941
|
modification-dependent protein catabolic process
|
2.05
|
7.30e-16
|
GO:0006511
|
ubiquitin-dependent protein catabolic process
|
1.83
|
1.04e-15
|
GO:0044265
|
cellular macromolecule catabolic process
|
2.01
|
1.14e-15
|
GO:0051603
|
proteolysis involved in cellular protein catabolic process
|
1.53
|
1.47e-15
|
GO:0006357
|
regulation of transcription from RNA polymerase II promoter
|
1.68
|
2.20e-15
|
GO:0046907
|
intracellular transport
|
1.99
|
2.70e-15
|
GO:0044257
|
cellular protein catabolic process
|
1.94
|
6.00e-15
|
GO:0030163
|
protein catabolic process
|
2.21
|
6.19e-15
|
GO:0071843
|
cellular component biogenesis at cellular level
|
2.24
|
7.92e-15
|
GO:0022613
|
ribonucleoprotein complex biogenesis
|
1.67
|
4.03e-14
|
GO:0022402
|
cell cycle process
|
1.72
|
7.28e-14
|
GO:0009057
|
macromolecule catabolic process
|
1.48
|
1.29e-13
|
GO:0044248
|
cellular catabolic process
|
1.54
|
1.55e-13
|
GO:0010628
|
positive regulation of gene expression
|
1.56
|
3.50e-13
|
GO:0045893
|
positive regulation of transcription, DNA-dependent
|
1.50
|
3.62e-13
|
GO:0032268
|
regulation of cellular protein metabolic process
|
1.56
|
4.45e-13
|
GO:0051254
|
positive regulation of RNA metabolic process
|
1.51
|
5.54e-13
|
GO:0010557
|
positive regulation of macromolecule biosynthetic process
|
2.41
|
5.61e-13
|
GO:0042254
|
ribosome biogenesis
|
1.42
|
1.22e-12
|
GO:0009056
|
catabolic process
|
1.51
|
1.34e-12
|
GO:0045935
|
positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
|
1.70
|
4.41e-12
|
GO:0051726
|
regulation of cell cycle
|
1.49
|
5.44e-12
|
GO:0051173
|
positive regulation of nitrogen compound metabolic process
|
1.89
|
1.07e-11
|
GO:0018193
|
peptidyl-amino acid modification
|
1.45
|
1.81e-11
|
GO:0051641
|
cellular localization
|
1.46
|
5.62e-11
|
GO:0031328
|
positive regulation of cellular biosynthetic process
|
2.23
|
5.72e-11
|
GO:0010498
|
proteasomal protein catabolic process
|
2.23
|
5.72e-11
|
GO:0043161
|
proteasomal ubiquitin-dependent protein catabolic process
|
1.43
|
6.20e-11
|
GO:0051246
|
regulation of protein metabolic process
|
2.05
|
1.85e-10
|
GO:0016570
|
histone modification
|
2.04
|
2.03e-10
|
GO:0016569
|
covalent chromatin modification
|
1.44
|
3.51e-10
|
GO:0009891
|
positive regulation of biosynthetic process
|
1.25
|
5.07e-10
|
GO:0051234
|
establishment of localization
|
1.22
|
5.56e-10
|
GO:0051179
|
localization
|
2.70
|
1.22e-09
|
GO:0031145
|
anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
|
2.02
|
1.50e-09
|
GO:0034470
|
ncRNA processing
|
1.42
|
1.67e-09
|
GO:0010941
|
regulation of cell death
|
1.90
|
1.79e-09
|
GO:0034660
|
ncRNA metabolic process
|
1.24
|
1.90e-09
|
GO:0006810
|
transport
|
1.46
|
1.93e-09
|
GO:0051649
|
establishment of localization in cell
|
1.56
|
3.19e-09
|
GO:0045944
|
positive regulation of transcription from RNA polymerase II promoter
|
1.65
|
3.27e-09
|
GO:0022403
|
cell cycle phase
|
2.70
|
4.16e-09
|
GO:0051436
|
negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
|
1.41
|
4.24e-09
|
GO:0043067
|
regulation of programmed cell death
|
1.83
|
4.28e-09
|
GO:0051248
|
negative regulation of protein metabolic process
|
2.11
|
4.83e-09
|
GO:0031396
|
regulation of protein ubiquitination
|
1.48
|
5.05e-09
|
GO:0031327
|
negative regulation of cellular biosynthetic process
|
1.49
|
5.58e-09
|
GO:0010558
|
negative regulation of macromolecule biosynthetic process
|
1.84
|
5.62e-09
|
GO:0032269
|
negative regulation of cellular protein metabolic process
|
1.41
|
6.52e-09
|
GO:0042981
|
regulation of apoptosis
|
1.47
|
9.23e-09
|
GO:0009890
|
negative regulation of biosynthetic process
|
1.49
|
9.92e-09
|
GO:2000113
|
negative regulation of cellular macromolecule biosynthetic process
|
2.52
|
1.05e-08
|
GO:0051443
|
positive regulation of ubiquitin-protein ligase activity
|
1.44
|
1.36e-08
|
GO:0022607
|
cellular component assembly
|
2.61
|
1.49e-08
|
GO:0051352
|
negative regulation of ligase activity
|
2.61
|
1.49e-08
|
GO:0051444
|
negative regulation of ubiquitin-protein ligase activity
|
2.43
|
1.65e-08
|
GO:0031397
|
negative regulation of protein ubiquitination
|
1.53
|
1.92e-08
|
GO:0065003
|
macromolecular complex assembly
|
1.60
|
1.99e-08
|
GO:0070727
|
cellular macromolecule localization
|
1.31
|
2.15e-08
|
GO:0044281
|
small molecule metabolic process
|
2.32
|
2.17e-08
|
GO:0018205
|
peptidyl-lysine modification
|
2.40
|
2.27e-08
|
GO:0051438
|
regulation of ubiquitin-protein ligase activity
|
1.51
|
2.57e-08
|
GO:0043933
|
macromolecular complex subunit organization
|
2.24
|
3.14e-08
|
GO:0031398
|
positive regulation of protein ubiquitination
|
1.46
|
3.78e-08
|
GO:0031399
|
regulation of protein modification process
|
2.46
|
3.87e-08
|
GO:0051351
|
positive regulation of ligase activity
|
1.59
|
4.25e-08
|
GO:0034613
|
cellular protein localization
|
1.69
|
4.29e-08
|
GO:0051301
|
cell division
|
1.49
|
4.36e-08
|
GO:0033554
|
cellular response to stress
|
1.69
|
5.88e-08
|
GO:0006886
|
intracellular protein transport
|
2.34
|
7.25e-08
|
GO:0051340
|
regulation of ligase activity
|
1.48
|
7.62e-08
|
GO:0010629
|
negative regulation of gene expression
|
2.55
|
7.87e-08
|
GO:0051437
|
positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
|
1.47
|
8.48e-08
|
GO:0045934
|
negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
|
2.49
|
8.95e-08
|
GO:0051439
|
regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
|
1.46
|
1.47e-07
|
GO:0051172
|
negative regulation of nitrogen compound metabolic process
|
1.55
|
1.84e-07
|
GO:0006259
|
DNA metabolic process
|
1.96
|
2.50e-07
|
GO:0031400
|
negative regulation of protein modification process
|
1.48
|
3.68e-07
|
GO:0051253
|
negative regulation of RNA metabolic process
|
1.60
|
4.01e-07
|
GO:0006974
|
response to DNA damage stimulus
|
1.37
|
7.50e-07
|
GO:0006796
|
phosphate metabolic process
|
1.36
|
9.78e-07
|
GO:0006793
|
phosphorus metabolic process
|
1.57
|
1.02e-06
|
GO:0051247
|
positive regulation of protein metabolic process
|
1.29
|
1.18e-06
|
GO:0065009
|
regulation of molecular function
|
1.58
|
1.40e-06
|
GO:0032270
|
positive regulation of cellular protein metabolic process
|
1.71
|
1.42e-06
|
GO:0034622
|
cellular macromolecular complex assembly
|
1.46
|
1.60e-06
|
GO:0012501
|
programmed cell death
|
1.46
|
2.46e-06
|
GO:0006915
|
apoptosis
|
1.78
|
3.39e-06
|
GO:0051186
|
cofactor metabolic process
|
2.31
|
4.37e-06
|
GO:0006403
|
RNA localization
|
2.21
|
4.44e-06
|
GO:0006364
|
rRNA processing
|
1.45
|
4.45e-06
|
GO:0045892
|
negative regulation of transcription, DNA-dependent
|
1.75
|
5.85e-06
|
GO:0006091
|
generation of precursor metabolites and energy
|
1.32
|
5.98e-06
|
GO:0050790
|
regulation of catalytic activity
|
1.42
|
7.38e-06
|
GO:0016265
|
death
|
1.63
|
7.60e-06
|
GO:0034621
|
cellular macromolecular complex subunit organization
|
1.71
|
8.92e-06
|
GO:0010608
|
posttranscriptional regulation of gene expression
|
1.46
|
1.04e-05
|
GO:0071844
|
cellular component assembly at cellular level
|
1.75
|
1.09e-05
|
GO:0010564
|
regulation of cell cycle process
|
1.49
|
1.34e-05
|
GO:0043009
|
chordate embryonic development
|
2.30
|
1.39e-05
|
GO:0050657
|
nucleic acid transport
|
2.30
|
1.39e-05
|
GO:0050658
|
RNA transport
|
2.30
|
1.39e-05
|
GO:0051236
|
establishment of RNA localization
|
1.94
|
1.51e-05
|
GO:0006913
|
nucleocytoplasmic transport
|
1.82
|
1.54e-05
|
GO:0007346
|
regulation of mitotic cell cycle
|
1.43
|
1.61e-05
|
GO:0046483
|
heterocycle metabolic process
|
1.73
|
1.83e-05
|
GO:0000087
|
M phase of mitotic cell cycle
|
2.14
|
1.87e-05
|
GO:0016072
|
rRNA metabolic process
|
2.08
|
1.98e-05
|
GO:0022900
|
electron transport chain
|
1.41
|
2.05e-05
|
GO:0008219
|
cell death
|
1.71
|
2.35e-05
|
GO:0048285
|
organelle fission
|
1.73
|
2.50e-05
|
GO:0000280
|
nuclear division
|
1.73
|
2.50e-05
|
GO:0007067
|
mitosis
|
1.17
|
2.66e-05
|
GO:0032502
|
developmental process
|
1.87
|
3.51e-05
|
GO:0006260
|
DNA replication
|
1.19
|
4.24e-05
|
GO:0048856
|
anatomical structure development
|
1.90
|
4.41e-05
|
GO:0051169
|
nuclear transport
|
1.58
|
4.44e-05
|
GO:0031401
|
positive regulation of protein modification process
|
1.47
|
4.52e-05
|
GO:0009792
|
embryo development ending in birth or egg hatching
|
1.60
|
5.08e-05
|
GO:0070647
|
protein modification by small protein conjugation or removal
|
2.13
|
7.67e-05
|
GO:0015931
|
nucleobase, nucleoside, nucleotide and nucleic acid transport
|
2.06
|
7.90e-05
|
GO:0071156
|
regulation of cell cycle arrest
|
1.36
|
1.34e-04
|
GO:0045595
|
regulation of cell differentiation
|
2.00
|
1.41e-04
|
GO:0071103
|
DNA conformation change
|
1.47
|
1.67e-04
|
GO:0043066
|
negative regulation of apoptosis
|
2.27
|
1.90e-04
|
GO:0051028
|
mRNA transport
|
1.45
|
2.07e-04
|
GO:0060548
|
negative regulation of cell death
|
2.23
|
2.32e-04
|
GO:0018394
|
peptidyl-lysine acetylation
|
1.43
|
2.40e-04
|
GO:0055086
|
nucleobase, nucleoside and nucleotide metabolic process
|
2.08
|
2.56e-04
|
GO:0000075
|
cell cycle checkpoint
|
1.46
|
2.60e-04
|
GO:0043069
|
negative regulation of programmed cell death
|
1.54
|
3.10e-04
|
GO:0000279
|
M phase
|
2.16
|
3.27e-04
|
GO:0006473
|
protein acetylation
|
3.05
|
3.35e-04
|
GO:0043488
|
regulation of mRNA stability
|
1.58
|
3.79e-04
|
GO:0006281
|
DNA repair
|
2.06
|
3.91e-04
|
GO:0043543
|
protein acylation
|
1.76
|
4.25e-04
|
GO:0006605
|
protein targeting
|
2.20
|
5.24e-04
|
GO:0006475
|
internal protein amino acid acetylation
|
2.20
|
5.24e-04
|
GO:0018393
|
internal peptidyl-lysine acetylation
|
1.35
|
6.30e-04
|
GO:0006508
|
proteolysis
|
1.47
|
7.11e-04
|
GO:0000122
|
negative regulation of transcription from RNA polymerase II promoter
|
2.21
|
7.20e-04
|
GO:0016573
|
histone acetylation
|
1.33
|
7.45e-04
|
GO:0009790
|
embryo development
|
1.93
|
8.75e-04
|
GO:0048193
|
Golgi vesicle transport
|
1.55
|
9.05e-04
|
GO:0009259
|
ribonucleotide metabolic process
|
1.98
|
1.02e-03
|
GO:0051329
|
interphase of mitotic cell cycle
|
1.55
|
1.07e-03
|
GO:0009150
|
purine ribonucleotide metabolic process
|
1.96
|
1.09e-03
|
GO:0051325
|
interphase
|
1.32
|
1.44e-03
|
GO:0016310
|
phosphorylation
|
1.16
|
1.46e-03
|
GO:0007275
|
multicellular organismal development
|
1.81
|
1.47e-03
|
GO:0006417
|
regulation of translation
|
1.28
|
1.49e-03
|
GO:0050793
|
regulation of developmental process
|
2.18
|
1.61e-03
|
GO:0000377
|
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
|
2.18
|
1.61e-03
|
GO:0000398
|
nuclear mRNA splicing, via spliceosome
|
1.42
|
1.65e-03
|
GO:0006753
|
nucleoside phosphate metabolic process
|
1.42
|
1.65e-03
|
GO:0009117
|
nucleotide metabolic process
|
1.72
|
1.74e-03
|
GO:0006732
|
coenzyme metabolic process
|
1.18
|
1.89e-03
|
GO:0048731
|
system development
|
2.15
|
2.58e-03
|
GO:0000375
|
RNA splicing, via transesterification reactions
|
1.64
|
5.10e-03
|
GO:0033365
|
protein localization to organelle
|
2.74
|
5.18e-03
|
GO:0043487
|
regulation of RNA stability
|
1.19
|
5.58e-03
|
GO:0048869
|
cellular developmental process
|
1.20
|
5.99e-03
|
GO:0048513
|
organ development
|
1.55
|
6.34e-03
|
GO:0061061
|
muscle structure development
|
1.34
|
6.92e-03
|
GO:0019220
|
regulation of phosphate metabolic process
|
1.34
|
6.92e-03
|
GO:0051174
|
regulation of phosphorus metabolic process
|
1.39
|
7.28e-03
|
GO:0010942
|
positive regulation of cell death
|
1.31
|
7.33e-03
|
GO:0044093
|
positive regulation of molecular function
|
1.54
|
7.33e-03
|
GO:0032446
|
protein modification by small protein conjugation
|
3.77
|
7.58e-03
|
GO:0016180
|
snRNA processing
|
1.19
|
7.85e-03
|
GO:0030154
|
cell differentiation
|
1.72
|
8.22e-03
|
GO:0006457
|
protein folding
|
1.82
|
9.04e-03
|
GO:0006470
|
protein dephosphorylation
|
2.31
|
9.93e-03
|
GO:0006338
|
chromatin remodeling
|
1.38
|
1.10e-02
|
GO:0043068
|
positive regulation of programmed cell death
|
1.44
|
1.15e-02
|
GO:0044262
|
cellular carbohydrate metabolic process
|
3.09
|
1.21e-02
|
GO:0043489
|
RNA stabilization
|
3.09
|
1.21e-02
|
GO:0048255
|
mRNA stabilization
|
1.51
|
1.26e-02
|
GO:0009144
|
purine nucleoside triphosphate metabolic process
|
2.06
|
1.34e-02
|
GO:0002755
|
MyD88-dependent toll-like receptor signaling pathway
|
1.94
|
1.38e-02
|
GO:0006323
|
DNA packaging
|
1.40
|
1.49e-02
|
GO:0070271
|
protein complex biogenesis
|
1.50
|
1.61e-02
|
GO:0009141
|
nucleoside triphosphate metabolic process
|
2.27
|
1.70e-02
|
GO:0007093
|
mitotic cell cycle checkpoint
|
1.43
|
1.78e-02
|
GO:0010627
|
regulation of intracellular protein kinase cascade
|
1.40
|
1.85e-02
|
GO:0006461
|
protein complex assembly
|
1.55
|
2.02e-02
|
GO:0043193
|
positive regulation of gene-specific transcription
|
1.62
|
2.12e-02
|
GO:0010552
|
positive regulation of gene-specific transcription from RNA polymerase II promoter
|
1.81
|
2.27e-02
|
GO:0015980
|
energy derivation by oxidation of organic compounds
|
1.43
|
2.42e-02
|
GO:0006163
|
purine nucleotide metabolic process
|
1.41
|
2.50e-02
|
GO:0072521
|
purine-containing compound metabolic process
|
1.50
|
2.63e-02
|
GO:0009205
|
purine ribonucleoside triphosphate metabolic process
|
1.37
|
2.66e-02
|
GO:0043065
|
positive regulation of apoptosis
|
1.90
|
2.82e-02
|
GO:0009260
|
ribonucleotide biosynthetic process
|
1.33
|
2.94e-02
|
GO:0016192
|
vesicle-mediated transport
|
1.56
|
3.08e-02
|
GO:0018130
|
heterocycle biosynthetic process
|
1.49
|
3.78e-02
|
GO:0009199
|
ribonucleoside triphosphate metabolic process
|
1.51
|
3.79e-02
|
GO:0072523
|
purine-containing compound catabolic process
|
1.44
|
4.39e-02
|
GO:0044271
|
cellular nitrogen compound biosynthetic process
|
1.37
|
4.59e-02
|
GO:0071822
|
protein complex subunit organization
|
2.06
|
4.89e-02
|
GO:0045333
|
cellular respiration
|