Motif ID: ZIC1..3.p2

Z-value: 2.335


Transcription factors associated with ZIC1..3.p2:

Gene SymbolEntrez IDGene Name
Zic1 22771 zinc finger protein of the cerebellum 1
Zic2 22772 zinc finger protein of the cerebellum 2
Zic3 22773 zinc finger protein of the cerebellum 3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zic1chr9_-_912605970.531.8e-14Click!
Zic3chrX_+_552838040.296.8e-05Click!
Zic2chr14_+_1228745980.191.2e-02Click!


Activity profile for motif ZIC1..3.p2.

activity profile for motif ZIC1..3.p2


Sorted Z-values histogram for motif ZIC1..3.p2

Sorted Z-values for motif ZIC1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ZIC1..3.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_101327849 59.890 NM_018884
 Pdzrn3
PDZ domain containing RING finger 3
chr9_+_50560862 52.242 NM_009964
 Cryab
crystallin, alpha B
chr9_+_50561381 51.178 Cryab
crystallin, alpha B
chr9_+_50561315 47.380 Cryab
crystallin, alpha B
chrX_-_91787338 42.442 Maged1
melanoma antigen, family D, 1
chrX_-_91787317 42.126 Maged1
melanoma antigen, family D, 1
chr7_+_138122822 40.843 Htra1
HtrA serine peptidase 1
chrX_-_91787353 40.394 Maged1
melanoma antigen, family D, 1
chr9_+_50561092 40.116 Cryab
crystallin, alpha B
chr9_+_50561121 39.531 Cryab
crystallin, alpha B
chrX_-_91787351 38.891 Maged1
melanoma antigen, family D, 1
chrX_-_91787372 37.669 NM_019791
 Maged1
melanoma antigen, family D, 1
chr19_-_38199737 34.337 NM_001159487
 Rbp4
retinol binding protein 4, plasma
chr7_+_106416854 33.756 NM_001043355
 Mtap6
microtubule-associated protein 6
chr11_-_116515361 31.104 Cygb
cytoglobin
chr12_+_110779204 29.191 Meg3
maternally expressed 3
chr1_+_72871060 29.080 NM_008342
 Igfbp2
insulin-like growth factor binding protein 2
chr11_+_101107635 28.566 NM_019444
 Ramp2
receptor (calcitonin) activity modifying protein 2
chr19_-_38199291 28.338 NM_011255
 Rbp4
retinol binding protein 4, plasma
chr11_+_101107726 27.806 Ramp2
receptor (calcitonin) activity modifying protein 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 164 entries
Enrichment   P-value GO Accession GO Term
6.27 3.96e-02 GO:0010596 negative regulation of endothelial cell migration
5.49 1.80e-04 GO:0045669 positive regulation of osteoblast differentiation
4.47 8.01e-03 GO:0043242 negative regulation of protein complex disassembly
4.17 1.93e-02 GO:0007269 neurotransmitter secretion
3.95 1.73e-02 GO:0043244 regulation of protein complex disassembly
3.94 4.14e-04 GO:0045667 regulation of osteoblast differentiation
3.78 1.49e-02 GO:0050808 synapse organization
3.67 1.40e-03 GO:0010810 regulation of cell-substrate adhesion
3.58 8.08e-03 GO:0051494 negative regulation of cytoskeleton organization
3.15 1.65e-02 GO:0030336 negative regulation of cell migration
3.15 1.65e-02 GO:2000146 negative regulation of cell motility
3.00 3.47e-06 GO:0043062 extracellular structure organization
2.99 1.32e-02 GO:0040013 negative regulation of locomotion
2.95 4.68e-02 GO:0006836 neurotransmitter transport
2.95 4.68e-02 GO:0051271 negative regulation of cellular component movement
2.91 1.79e-03 GO:0030324 lung development
2.87 2.47e-03 GO:0030323 respiratory tube development
2.80 2.53e-02 GO:0030278 regulation of ossification
2.72 4.12e-06 GO:0051129 negative regulation of cellular component organization
2.71 2.86e-02 GO:0030198 extracellular matrix organization

Gene overrepresentation in compartment category:

Showing 1 to 20 of 78 entries
Enrichment   P-value GO Accession GO Term
11.29 4.92e-02 GO:0008091 spectrin
5.46 2.52e-04 GO:0044304 main axon
4.87 7.39e-03 GO:0030672 synaptic vesicle membrane
4.20 1.16e-03 GO:0031256 leading edge membrane
3.58 3.30e-04 GO:0044309 neuron spine
3.57 9.01e-05 GO:0014069 postsynaptic density
3.48 9.78e-04 GO:0043197 dendritic spine
3.45 4.70e-05 GO:0043296 apical junction complex
3.40 4.05e-04 GO:0005923 tight junction
3.40 4.05e-04 GO:0070160 occluding junction
3.38 7.11e-05 GO:0016327 apicolateral plasma membrane
3.17 3.01e-14 GO:0030425 dendrite
3.14 5.20e-04 GO:0008021 synaptic vesicle
3.00 5.22e-07 GO:0031252 cell leading edge
2.92 1.56e-13 GO:0044456 synapse part
2.91 1.06e-04 GO:0019717 synaptosome
2.91 8.29e-03 GO:0030017 sarcomere
2.89 1.99e-04 GO:0033267 axon part
2.86 2.92e-02 GO:0044448 cell cortex part
2.84 4.33e-04 GO:0005912 adherens junction

Gene overrepresentation in function category:

Showing 1 to 14 of 14 entries
Enrichment   P-value GO Accession GO Term
7.06 4.96e-02 GO:0048407 platelet-derived growth factor binding
5.38 3.42e-02 GO:0005212 structural constituent of eye lens
4.41 2.93e-02 GO:0035254 glutamate receptor binding
3.23 1.49e-04 GO:0019838 growth factor binding
2.87 8.84e-04 GO:0005516 calmodulin binding
2.20 1.53e-08 GO:0008092 cytoskeletal protein binding
1.98 1.11e-02 GO:0003779 actin binding
1.95 3.17e-03 GO:0032403 protein complex binding
1.94 1.69e-03 GO:0005198 structural molecule activity
1.84 5.73e-04 GO:0019904 protein domain specific binding
1.53 2.53e-02 GO:0019899 enzyme binding
1.48 2.87e-25 GO:0005515 protein binding
1.48 2.43e-02 GO:0005102 receptor binding
1.24 3.98e-20 GO:0005488 binding