Motif ID: bHLH_family.p2

Z-value: 2.198


Transcription factors associated with bHLH_family.p2:

Gene SymbolEntrez IDGene Name
Arntl 11865 aryl hydrocarbon receptor nuclear translocator-like
Arntl2 272322 aryl hydrocarbon receptor nuclear translocator-like 2
Clock 12753 circadian locomotor output cycles kaput
Hes6 55927 hairy and enhancer of split 6 (Drosophila)
Hey1 15213 hairy/enhancer-of-split related with YRPW motif 1
Hey2 15214 hairy/enhancer-of-split related with YRPW motif 2
Heyl 56198 hairy/enhancer-of-split related with YRPW motif-like
Id1 15901 inhibitor of DNA binding 1
Mitf 17342 microphthalmia-associated transcription factor
Mlxipl 58805 MLX interacting protein-like
Mnt 17428 max binding protein
Mxd3 17121 Max dimerization protein 3
Mxd4 17122 Max dimerization protein 4
Mxi1 17859 Max interacting protein 1
Npas2 18143 neuronal PAS domain protein 2
Olig1 50914 oligodendrocyte transcription factor 1
Olig2 50913 oligodendrocyte transcription factor 2
Tcfe3 209446 transcription factor E3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hey1chr3_-_8667013-0.492.7e-12Click!
Clockchr5_-_76733770-0.443.5e-10Click!
Hes6chr1_-_933097130.424.4e-09Click!
Npas2chr1_+_39251056-0.403.0e-08Click!
Olig1chr16_+_91270319,
chr16_+_91270009		-0.351.6e-06Click!
Hey2chr10_-_30562434-0.342.3e-06Click!
Olig2chr16_+_91225794-0.303.3e-05Click!
Mxd3chr13_-_554310270.298.1e-05Click!
Tcfe3chrX_+_73411080.271.8e-04Click!
Mxd4chr5_-_34517234-0.248.7e-04Click!
Arntl2chr6_+_1467540510.241.2e-03Click!
Mlxiplchr5_+_1355827540.223.2e-03Click!
Mntchr11_+_746444790.172.1e-02Click!
Arntlchr7_+_120350963-0.121.1e-01Click!
Id1chr2_+_1525619830.111.2e-01Click!
Mxi1chr19_+_53384990-0.111.3e-01Click!
Mitfchr6_+_97757012-0.073.6e-01Click!
Heylchr4_+_122910798-0.036.9e-01Click!


Activity profile for motif bHLH_family.p2.

activity profile for motif bHLH_family.p2


Sorted Z-values histogram for motif bHLH_family.p2

Sorted Z-values for motif bHLH_family.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of bHLH_family.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_126500607 68.009 NM_009870
 Cdk4
cyclin-dependent kinase 4
chr4_+_147965596 28.023 NM_009272
 Srm
spermidine synthase
chr17_+_45701100 24.088 NM_028662
 Slc35b2
solute carrier family 35, member B2
chr11_+_117670970 23.861 NM_009304
 Syngr2
synaptogyrin 2
chr2_-_28771940 22.700 NM_019446
NM_001164186
 Barhl1

BarH-like 1 (Drosophila)

chr19_+_7049425 22.289 NM_008889
 Ppp1r14b
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr11_-_60624592 22.026 Shmt1
serine hydroxymethyltransferase 1 (soluble)
chr11_-_60624733 21.743 NM_009171
 Shmt1
serine hydroxymethyltransferase 1 (soluble)
chr11_-_99527240 21.498 NM_026834
 Krtap4-6
keratin associated protein 4-6
chr3_+_41368801 19.491 NM_001130186
 Phf17
PHD finger protein 17
chr15_+_59205752 19.291 NM_001164604
NM_026746
 Nsmce2

non-SMC element 2 homolog (MMS21, S. cerevisiae)

chr17_-_45732442 19.076 Slc29a1
solute carrier family 29 (nucleoside transporters), member 1
chr19_-_60656627 18.929 NM_001172096
NM_001172097
NM_030197
 2700078E11Rik


RIKEN cDNA 2700078E11 gene


chr17_+_45700882 18.871 Slc35b2
solute carrier family 35, member B2
chrX_-_131076136 18.612 NM_013898
 Timm8a1
translocase of inner mitochondrial membrane 8 homolog a1 (yeast)
chr9_+_21172314 18.490 NM_001042707
NM_001042708
NM_001042709
NM_010561
 Ilf3



interleukin enhancer binding factor 3



chr10_+_79317316 18.298 NM_001077363
NM_008956
 Ptbp1

polypyrimidine tract binding protein 1

chr11_+_99725789 18.270 NM_001177484
 Gm11559
predicted gene 11559
chr17_+_29627950 18.254 NM_008842
 Pim1
proviral integration site 1
chr19_+_7049639 17.043 Ppp1r14b
protein phosphatase 1, regulatory (inhibitor) subunit 14B

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 160 entries
Enrichment   P-value GO Accession GO Term
4.56 4.99e-02 GO:0031365 N-terminal protein amino acid modification
2.90 1.06e-02 GO:0017148 negative regulation of translation
2.85 2.60e-03 GO:0043401 steroid hormone mediated signaling pathway
2.71 4.94e-05 GO:0048704 embryonic skeletal system morphogenesis
2.66 3.21e-02 GO:0034329 cell junction assembly
2.47 1.37e-04 GO:0045787 positive regulation of cell cycle
2.41 1.64e-02 GO:0071383 cellular response to steroid hormone stimulus
2.39 2.90e-08 GO:0048705 skeletal system morphogenesis
2.37 7.78e-03 GO:0050657 nucleic acid transport
2.37 7.78e-03 GO:0050658 RNA transport
2.37 7.78e-03 GO:0051236 establishment of RNA localization
2.36 6.05e-03 GO:0006403 RNA localization
2.36 4.04e-02 GO:0009755 hormone-mediated signaling pathway
2.36 4.04e-02 GO:0048771 tissue remodeling
2.34 7.09e-04 GO:0048706 embryonic skeletal system development
2.28 3.16e-05 GO:0042254 ribosome biogenesis
2.27 5.14e-03 GO:0015931 nucleobase, nucleoside, nucleotide and nucleic acid transport
2.22 7.02e-03 GO:0030879 mammary gland development
2.16 8.57e-07 GO:0009952 anterior/posterior pattern formation
2.16 2.71e-02 GO:0006662 glycerol ether metabolic process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 40 entries
Enrichment   P-value GO Accession GO Term
2.63 1.50e-02 GO:0005643 nuclear pore
2.37 1.65e-02 GO:0046930 pore complex
1.93 1.71e-10 GO:0005730 nucleolus
1.90 2.59e-04 GO:0005635 nuclear envelope
1.73 4.19e-05 GO:0005667 transcription factor complex
1.69 2.06e-04 GO:0005792 microsome
1.68 1.06e-10 GO:0044451 nucleoplasm part
1.68 1.71e-04 GO:0042598 vesicular fraction
1.65 3.58e-15 GO:0005654 nucleoplasm
1.64 2.20e-26 GO:0031974 membrane-enclosed lumen
1.64 4.81e-26 GO:0043233 organelle lumen
1.64 6.24e-26 GO:0070013 intracellular organelle lumen
1.64 2.09e-22 GO:0031981 nuclear lumen
1.60 1.19e-24 GO:0044428 nuclear part
1.55 1.86e-04 GO:0030529 ribonucleoprotein complex
1.53 1.23e-05 GO:0031967 organelle envelope
1.52 1.96e-05 GO:0031975 envelope
1.45 4.09e-11 GO:0005739 mitochondrion
1.43 5.97e-03 GO:0044429 mitochondrial part
1.42 4.71e-43 GO:0005634 nucleus

Gene overrepresentation in function category:

Showing 1 to 20 of 35 entries
Enrichment   P-value GO Accession GO Term
2.74 1.55e-03 GO:0004879 ligand-dependent nuclear receptor activity
2.68 4.31e-03 GO:0003707 steroid hormone receptor activity
2.58 2.26e-03 GO:0003743 translation initiation factor activity
2.48 1.89e-05 GO:0008135 translation factor activity, nucleic acid binding
2.01 4.92e-02 GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
1.89 9.02e-21 GO:0001071 nucleic acid binding transcription factor activity
1.89 9.02e-21 GO:0003700 sequence-specific DNA binding transcription factor activity
1.86 1.71e-16 GO:0043565 sequence-specific DNA binding
1.79 7.04e-06 GO:0008134 transcription factor binding
1.77 4.72e-03 GO:0003682 chromatin binding
1.75 2.98e-05 GO:0016564 transcription repressor activity
1.74 1.10e-02 GO:0043566 structure-specific DNA binding
1.73 1.67e-02 GO:0010843 promoter binding
1.72 9.98e-17 GO:0030528 transcription regulator activity
1.71 5.07e-05 GO:0016563 transcription activator activity
1.68 3.88e-11 GO:0003723 RNA binding
1.53 9.43e-30 GO:0003676 nucleic acid binding
1.50 1.61e-16 GO:0003677 DNA binding
1.41 2.10e-04 GO:0019899 enzyme binding
1.41 1.63e-03 GO:0046983 protein dimerization activity