ISMARA results: NFKB1

Project

Illumina Body Map 2, young vs old

Navigation

Downloads

Results for NFKB1

Z-value: 1.67

Motif logo

Transcription factors associated with NFKB1

Gene Symbol	Gene ID	Gene Info
NFKB1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000109320.7	nuclear factor kappa B subunit 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
NFKB1	hg19_v2_chr4_+_103422499_103422632	0.65	5.0e-05	Click!

Activity profile of NFKB1 motif

Sorted Z-values of NFKB1 motif

Top targets:

Search:

Show entries

Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr2_+_219745020 Show fit	8.10	ENST00000258411.3	WNT10A Ensembl NCBI GeneCards UniProt NextProt Show fit	wingless-type MMTV integration site family, member 10A
chr6_-_31550192 Show fit	6.62	ENST00000429299.2 ENST00000446745.2	LTB Ensembl NCBI GeneCards UniProt NextProt Show fit	lymphotoxin beta (TNF superfamily, member 3)
chr19_+_42381173 Show fit	6.56	ENST00000221972.3	CD79A Ensembl NCBI GeneCards UniProt NextProt Show fit	CD79a molecule, immunoglobulin-associated alpha
chr6_+_31540056 Show fit	6.10	ENST00000418386.2	LTA Ensembl NCBI GeneCards UniProt NextProt Show fit	lymphotoxin alpha
chr19_+_17638059 Show fit	5.82	ENST00000599164.1 ENST00000449408.2 ENST00000600871.1 ENST00000599124.1	FAM129C Ensembl NCBI GeneCards UniProt NextProt Show fit	family with sequence similarity 129, member C
chr19_+_42381337 Show fit	5.77	ENST00000597454.1 ENST00000444740.2	CD79A Ensembl NCBI GeneCards UniProt NextProt Show fit	CD79a molecule, immunoglobulin-associated alpha
chr22_-_37640277 Show fit	5.66	ENST00000401529.3 ENST00000249071.6	RAC2 Ensembl NCBI GeneCards UniProt NextProt Show fit	ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr1_-_202130702 Show fit	5.47	ENST00000309017.3 ENST00000477554.1 ENST00000492451.1	PTPN7 Ensembl NCBI GeneCards UniProt NextProt Show fit	protein tyrosine phosphatase, non-receptor type 7
chr22_-_37640456 Show fit	5.40	ENST00000405484.1 ENST00000441619.1 ENST00000406508.1	RAC2 Ensembl NCBI GeneCards UniProt NextProt Show fit	ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr16_+_50730910 Show fit	5.30	ENST00000300589.2	NOD2 Ensembl NCBI GeneCards UniProt NextProt Show fit	nucleotide-binding oligomerization domain containing 2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of NFKB1

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.8	16.8	GO:0048535	lymph node development(GO:0048535)
0.1	14.1	GO:0042100	B cell proliferation(GO:0042100)
0.1	13.2	GO:0035335	peptidyl-tyrosine dephosphorylation(GO:0035335)
1.0	11.1	GO:0060753	regulation of mast cell chemotaxis(GO:0060753)
0.4	8.9	GO:0072540	T-helper 17 cell lineage commitment(GO:0072540)
0.1	8.9	GO:1904837	beta-catenin-TCF complex assembly(GO:1904837)
2.9	8.7	GO:1990108	protein linear deubiquitination(GO:1990108)
0.1	8.6	GO:0031295	lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
2.7	8.2	GO:0090222	centrosome-templated microtubule nucleation(GO:0090222)
0.5	8.1	GO:0048733	sebaceous gland development(GO:0048733)

Showing 1 to 10 of 191 entries

Gene overrepresentation in cellular_component category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	25.4	GO:0009898	cytoplasmic side of plasma membrane(GO:0009898)
0.0	18.6	GO:0009897	external side of plasma membrane(GO:0009897)
1.0	14.6	GO:0033256	I-kappaB/NF-kappaB complex(GO:0033256)
0.0	13.2	GO:0000790	nuclear chromatin(GO:0000790)
1.8	12.3	GO:0019815	B cell receptor complex(GO:0019815)
0.1	12.3	GO:0030670	phagocytic vesicle membrane(GO:0030670)
0.0	11.3	GO:0005925	focal adhesion(GO:0005925)
0.1	10.7	GO:0005834	heterotrimeric G-protein complex(GO:0005834)
0.1	9.4	GO:0008180	COP9 signalosome(GO:0008180)
0.1	8.7	GO:0097542	ciliary tip(GO:0097542)

Showing 1 to 10 of 88 entries

Gene overrepresentation in molecular_function category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.5	24.4	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
0.0	22.2	GO:0005525	GTP binding(GO:0005525)
0.1	18.0	GO:0004725	protein tyrosine phosphatase activity(GO:0004725)
0.8	15.4	GO:0061578	Lys63-specific deubiquitinase activity(GO:0061578)
0.1	11.5	GO:0070491	repressing transcription factor binding(GO:0070491)
0.2	11.1	GO:0005109	frizzled binding(GO:0005109)
0.1	10.6	GO:0031593	polyubiquitin binding(GO:0031593)
0.2	10.0	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.1	8.8	GO:0001205	transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.4	7.7	GO:0004568	chitinase activity(GO:0004568)

Showing 1 to 10 of 133 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.4	23.0	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.3	18.2	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.6	17.5	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.2	17.1	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.2	12.3	PID BCR 5PATHWAY	BCR signaling pathway
0.2	11.9	ST TUMOR NECROSIS FACTOR PATHWAY	Tumor Necrosis Factor Pathway.
0.1	11.1	WNT SIGNALING	Genes related to Wnt-mediated signal transduction
0.2	7.9	PID LYMPH ANGIOGENESIS PATHWAY	VEGFR3 signaling in lymphatic endothelium
0.3	7.7	PID IL5 PATHWAY	IL5-mediated signaling events
0.1	7.5	PID IL12 2PATHWAY	IL12-mediated signaling events

Showing 1 to 10 of 56 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.4	28.8	REACTOME NOD1 2 SIGNALING PATHWAY	Genes involved in NOD1/2 Signaling Pathway
0.1	21.5	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.5	15.1	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.1	12.8	REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.2	12.3	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.2	11.9	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1	8.8	REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS	Genes involved in Class B/2 (Secretin family receptors)
0.1	8.2	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.1	7.7	REACTOME ACTIVATION OF NF KAPPAB IN B CELLS	Genes involved in Activation of NF-kappaB in B Cells
0.7	6.5	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway

Showing 1 to 10 of 63 entries

Results for NFKB1

Z-value: 1.67

Motif logo

Transcription factors associated with NFKB1

Activity-expression correlation:

Activity profile of NFKB1 motif

Sorted Z-values of NFKB1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of NFKB1

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: