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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for CCCUGAG

Z-value: 1.51

Motif logo

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miRNA associated with seed CCCUGAG

NamemiRBASE accession
hsa-miR-125a-5p
MIMAT0000443
hsa-miR-125b-5p
MIMAT0000423
hsa-miR-4319
MIMAT0016870

Activity profile of CCCUGAG motif

Sorted Z-values of CCCUGAG motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chrX_+_64708615 37.28 ENST00000338957.4
ENST00000423889.3
ZC3H12B
zinc finger CCCH-type containing 12B
chr15_+_31619013 30.24 ENST00000307145.3
KLF13
Kruppel-like factor 13
chr22_-_39548627 23.17 ENST00000216133.5
CBX7
chromobox homolog 7
chr15_+_74833518 21.55 ENST00000346246.5
ARID3B
AT rich interactive domain 3B (BRIGHT-like)
chr9_-_116102530 21.04 ENST00000374195.3
ENST00000341761.4
WDR31
WD repeat domain 31
chrX_-_103401649 20.71 ENST00000357421.4
SLC25A53
solute carrier family 25, member 53
chr4_-_2264015 18.86 ENST00000337190.2
MXD4
MAX dimerization protein 4
chr2_-_206950781 18.74 ENST00000403263.1
INO80D
INO80 complex subunit D
chr17_-_61777459 18.59 ENST00000578993.1
ENST00000583211.1
ENST00000259006.3
LIMD2
LIM domain containing 2
chr19_+_7968728 17.92 ENST00000397981.3
ENST00000545011.1
ENST00000397983.3
ENST00000397979.3
MAP2K7
mitogen-activated protein kinase kinase 7
chr3_-_57678772 17.40 ENST00000311128.5
DENND6A
DENN/MADD domain containing 6A
chr3_+_15468862 17.28 ENST00000396842.2
EAF1
ELL associated factor 1
chr16_+_1662326 16.64 ENST00000397412.3
CRAMP1L
Crm, cramped-like (Drosophila)
chr19_+_18794470 15.32 ENST00000321949.8
ENST00000338797.6
CRTC1
CREB regulated transcription coactivator 1
chr19_-_18632861 15.15 ENST00000262809.4
ELL
elongation factor RNA polymerase II
chr16_-_28936493 14.98 ENST00000544477.1
ENST00000357573.6
RABEP2
rabaptin, RAB GTPase binding effector protein 2
chr22_+_41777927 14.55 ENST00000266304.4
TEF
thyrotrophic embryonic factor
chr7_-_139876812 14.46 ENST00000397560.2
JHDM1D
lysine (K)-specific demethylase 7A
chr17_-_76713100 14.14 ENST00000585509.1
CYTH1
cytohesin 1
chr2_+_61293021 13.57 ENST00000402291.1
KIAA1841
KIAA1841
chr2_-_201936302 13.51 ENST00000453765.1
ENST00000452799.1
ENST00000446678.1
ENST00000418596.3
FAM126B
family with sequence similarity 126, member B
chr9_-_123476719 13.32 ENST00000373930.3
MEGF9
multiple EGF-like-domains 9
chr10_+_120967072 13.32 ENST00000392870.2
GRK5
G protein-coupled receptor kinase 5
chr6_+_106546808 13.22 ENST00000369089.3
PRDM1
PR domain containing 1, with ZNF domain
chr16_-_2264779 12.87 ENST00000333503.7
PGP
phosphoglycolate phosphatase
chr22_-_44258360 12.81 ENST00000330884.4
ENST00000249130.5
SULT4A1
sulfotransferase family 4A, member 1
chr1_+_203274639 12.71 ENST00000290551.4
BTG2
BTG family, member 2
chr11_-_62494821 12.62 ENST00000301785.5
HNRNPUL2
heterogeneous nuclear ribonucleoprotein U-like 2
chr4_+_7045042 12.57 ENST00000310074.7
ENST00000512388.1
TADA2B
transcriptional adaptor 2B
chr1_+_12227035 12.55 ENST00000376259.3
ENST00000536782.1
TNFRSF1B
tumor necrosis factor receptor superfamily, member 1B
chr3_+_47021168 12.54 ENST00000450053.3
ENST00000292309.5
ENST00000383740.2
NBEAL2
neurobeachin-like 2
chrX_+_110339439 12.40 ENST00000372010.1
ENST00000519681.1
ENST00000372007.5
PAK3
p21 protein (Cdc42/Rac)-activated kinase 3
chr5_-_159739532 12.36 ENST00000520748.1
ENST00000393977.3
ENST00000257536.7
CCNJL
cyclin J-like
chr3_+_183353356 12.34 ENST00000242810.6
ENST00000493074.1
ENST00000437402.1
ENST00000454495.2
ENST00000473045.1
ENST00000468101.1
ENST00000427201.2
ENST00000482138.1
ENST00000454652.2
KLHL24
kelch-like family member 24
chr11_-_117103208 12.23 ENST00000320934.3
ENST00000530269.1
PCSK7
proprotein convertase subtilisin/kexin type 7
chr11_-_22851367 12.18 ENST00000354193.4
SVIP
small VCP/p97-interacting protein
chr1_-_207224307 12.04 ENST00000315927.4
YOD1
YOD1 deubiquitinase
chr3_+_186648274 12.02 ENST00000169298.3
ST6GAL1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr16_+_4897632 11.90 ENST00000262376.6
UBN1
ubinuclein 1
chr6_+_138188551 11.43 ENST00000237289.4
ENST00000433680.1
TNFAIP3
tumor necrosis factor, alpha-induced protein 3
chr12_+_11802753 11.34 ENST00000396373.4
ETV6
ets variant 6
chr1_+_78245303 11.26 ENST00000370791.3
ENST00000443751.2
FAM73A
family with sequence similarity 73, member A
chr9_-_3525968 11.19 ENST00000382004.3
ENST00000302303.1
ENST00000449190.1
RFX3
regulatory factor X, 3 (influences HLA class II expression)
chr9_-_127533519 11.16 ENST00000487099.2
ENST00000344523.4
ENST00000373584.3
NR6A1
nuclear receptor subfamily 6, group A, member 1
chr6_+_391739 10.92 ENST00000380956.4
IRF4
interferon regulatory factor 4
chr15_-_72410109 10.87 ENST00000564571.1
MYO9A
myosin IXA
chr1_-_212208842 10.80 ENST00000366992.3
ENST00000366993.3
ENST00000440600.2
ENST00000366994.3
INTS7
integrator complex subunit 7
chr5_-_175964366 10.67 ENST00000274811.4
RNF44
ring finger protein 44
chr3_+_50712672 10.53 ENST00000266037.9
DOCK3
dedicator of cytokinesis 3
chr7_+_49813255 10.32 ENST00000340652.4
VWC2
von Willebrand factor C domain containing 2
chr17_-_36956155 10.11 ENST00000269554.3
PIP4K2B
phosphatidylinositol-5-phosphate 4-kinase, type II, beta
chr6_+_138483058 10.05 ENST00000251691.4
KIAA1244
KIAA1244
chr17_+_42836329 9.98 ENST00000200557.6
ADAM11
ADAM metallopeptidase domain 11
chr15_-_90358048 9.96 ENST00000300060.6
ENST00000560137.1
ANPEP
alanyl (membrane) aminopeptidase
chr15_+_81489213 9.89 ENST00000559383.1
ENST00000394660.2
IL16
interleukin 16
chr10_-_15762124 9.88 ENST00000378076.3
ITGA8
integrin, alpha 8
chr3_+_49591881 9.75 ENST00000296452.4
BSN
bassoon presynaptic cytomatrix protein
chr15_-_61521495 9.72 ENST00000335670.6
RORA
RAR-related orphan receptor A
chrX_+_153639856 9.57 ENST00000426834.1
ENST00000369790.4
ENST00000454722.1
ENST00000350743.4
ENST00000299328.5
ENST00000351413.4
TAZ
tafazzin
chr16_+_27561449 9.41 ENST00000261588.4
KIAA0556
KIAA0556
chr16_-_18937726 9.40 ENST00000389467.3
ENST00000446231.2
SMG1
SMG1 phosphatidylinositol 3-kinase-related kinase
chr4_-_25032501 9.34 ENST00000382114.4
LGI2
leucine-rich repeat LGI family, member 2
chr7_-_143059845 9.29 ENST00000443739.2
FAM131B
family with sequence similarity 131, member B
chr14_+_69865401 9.22 ENST00000556605.1
ENST00000336643.5
ENST00000031146.4
SLC39A9
solute carrier family 39, member 9
chr2_+_148602058 9.20 ENST00000241416.7
ENST00000535787.1
ENST00000404590.1
ACVR2A
activin A receptor, type IIA
chr16_-_71610985 9.14 ENST00000355962.4
TAT
tyrosine aminotransferase
chr3_-_13461807 9.01 ENST00000254508.5
NUP210
nucleoporin 210kDa
chr19_+_40697514 8.54 ENST00000253055.3
MAP3K10
mitogen-activated protein kinase kinase kinase 10
chr2_-_38604398 8.48 ENST00000443098.1
ENST00000449130.1
ENST00000378954.4
ENST00000539122.1
ENST00000419554.2
ENST00000451483.1
ENST00000406122.1
ATL2
atlastin GTPase 2
chr6_-_24911195 8.38 ENST00000259698.4
FAM65B
family with sequence similarity 65, member B
chr11_-_46940074 8.35 ENST00000378623.1
ENST00000534404.1
LRP4
low density lipoprotein receptor-related protein 4
chr12_-_120806960 8.33 ENST00000257552.2
MSI1
musashi RNA-binding protein 1
chr5_+_56111361 8.30 ENST00000399503.3
MAP3K1
mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
chr3_+_141205852 8.14 ENST00000286364.3
ENST00000452898.1
RASA2
RAS p21 protein activator 2
chr11_+_33278811 8.09 ENST00000303296.4
ENST00000379016.3
HIPK3
homeodomain interacting protein kinase 3
chr10_+_101088836 8.09 ENST00000356713.4
CNNM1
cyclin M1
chr10_+_104678032 8.05 ENST00000369878.4
ENST00000369875.3
CNNM2
cyclin M2
chr19_+_19322758 8.02 ENST00000252575.6
NCAN
neurocan
chr3_+_37493610 8.02 ENST00000264741.5
ITGA9
integrin, alpha 9
chr14_+_74111578 8.00 ENST00000554113.1
ENST00000555631.2
ENST00000553645.2
ENST00000311089.3
ENST00000555919.3
ENST00000554339.1
ENST00000554871.1
DNAL1
dynein, axonemal, light chain 1
chr11_-_118047376 7.91 ENST00000278947.5
SCN2B
sodium channel, voltage-gated, type II, beta subunit
chr1_+_32573636 7.85 ENST00000373625.3
KPNA6
karyopherin alpha 6 (importin alpha 7)
chr12_+_56401268 7.85 ENST00000262032.5
IKZF4
IKAROS family zinc finger 4 (Eos)
chr19_+_45596218 7.83 ENST00000421905.1
ENST00000221462.4
PPP1R37
protein phosphatase 1, regulatory subunit 37
chr5_+_112043186 7.79 ENST00000509732.1
ENST00000457016.1
ENST00000507379.1
APC
adenomatous polyposis coli
chr20_-_4982132 7.78 ENST00000338244.1
ENST00000424750.2
SLC23A2
solute carrier family 23 (ascorbic acid transporter), member 2
chr1_-_109940550 7.70 ENST00000256637.6
SORT1
sortilin 1
chr11_-_119252359 7.60 ENST00000455332.2
USP2
ubiquitin specific peptidase 2
chr12_-_42538657 7.58 ENST00000398675.3
GXYLT1
glucoside xylosyltransferase 1
chr10_+_82168240 7.53 ENST00000372187.5
ENST00000372185.1
FAM213A
family with sequence similarity 213, member A
chr18_+_32558208 7.34 ENST00000436190.2
MAPRE2
microtubule-associated protein, RP/EB family, member 2
chr1_-_21671968 7.33 ENST00000415912.2
ECE1
endothelin converting enzyme 1
chr20_+_55966444 7.31 ENST00000356208.5
ENST00000440234.2
RBM38
RNA binding motif protein 38
chr14_-_100070363 7.30 ENST00000380243.4
CCDC85C
coiled-coil domain containing 85C
chr2_-_103353277 7.25 ENST00000258436.5
MFSD9
major facilitator superfamily domain containing 9
chr1_-_36022979 7.20 ENST00000469892.1
ENST00000325722.3
KIAA0319L
KIAA0319-like
chr19_-_4066890 7.12 ENST00000322357.4
ZBTB7A
zinc finger and BTB domain containing 7A
chr1_-_211307315 7.11 ENST00000271751.4
KCNH1
potassium voltage-gated channel, subfamily H (eag-related), member 1
chr7_+_142985308 7.08 ENST00000310447.5
CASP2
caspase 2, apoptosis-related cysteine peptidase
chr2_-_9143786 7.07 ENST00000462696.1
ENST00000305997.3
MBOAT2
membrane bound O-acyltransferase domain containing 2
chr12_-_56727487 7.02 ENST00000548043.1
ENST00000425394.2
PAN2
PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)
chr19_-_47975417 6.99 ENST00000236877.6
SLC8A2
solute carrier family 8 (sodium/calcium exchanger), member 2
chr1_-_179198702 6.94 ENST00000502732.1
ABL2
c-abl oncogene 2, non-receptor tyrosine kinase
chr9_-_130829588 6.93 ENST00000373078.4
NAIF1
nuclear apoptosis inducing factor 1
chr12_+_13197218 6.74 ENST00000197268.8
KIAA1467
KIAA1467
chr3_-_133614597 6.66 ENST00000285208.4
ENST00000460865.3
RAB6B
RAB6B, member RAS oncogene family
chr9_+_35538616 6.65 ENST00000455600.1
RUSC2
RUN and SH3 domain containing 2
chr16_+_68298405 6.64 ENST00000219343.6
ENST00000566834.1
ENST00000566454.1
SLC7A6
solute carrier family 7 (amino acid transporter light chain, y+L system), member 6
chr11_+_94277017 6.63 ENST00000358752.2
FUT4
fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
chr8_-_67579418 6.61 ENST00000310421.4
VCPIP1
valosin containing protein (p97)/p47 complex interacting protein 1
chr12_+_5019061 6.56 ENST00000382545.3
KCNA1
potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)
chr16_-_75498553 6.43 ENST00000569276.1
ENST00000357613.4
ENST00000561878.1
ENST00000566980.1
ENST00000567194.1
TMEM170A
RP11-77K12.1
transmembrane protein 170A
Uncharacterized protein
chr2_-_213403565 6.38 ENST00000342788.4
ENST00000436443.1
ERBB4
v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4
chr15_+_68871308 6.38 ENST00000261861.5
CORO2B
coronin, actin binding protein, 2B
chr13_-_73356009 6.34 ENST00000377780.4
ENST00000377767.4
DIS3
DIS3 mitotic control homolog (S. cerevisiae)
chr15_-_73661605 6.31 ENST00000261917.3
HCN4
hyperpolarization activated cyclic nucleotide-gated potassium channel 4
chr17_-_48207157 6.22 ENST00000330175.4
ENST00000503131.1
SAMD14
sterile alpha motif domain containing 14
chr3_-_53381539 6.11 ENST00000606822.1
ENST00000294241.6
ENST00000607628.1
DCP1A
decapping mRNA 1A
chr14_+_56585048 6.08 ENST00000267460.4
PELI2
pellino E3 ubiquitin protein ligase family member 2
chr3_+_58223228 6.05 ENST00000478253.1
ENST00000295962.4
ABHD6
abhydrolase domain containing 6
chr1_-_23857698 6.02 ENST00000361729.2
E2F2
E2F transcription factor 2
chr17_-_66287257 5.96 ENST00000327268.4
SLC16A6
solute carrier family 16, member 6
chr10_-_50747064 5.95 ENST00000355832.5
ENST00000603152.1
ENST00000447839.2
ERCC6
PGBD3
ERCC6-PGBD3
excision repair cross-complementing rodent repair deficiency, complementation group 6
piggyBac transposable element derived 3
ERCC6-PGBD3 readthrough
chr10_+_102295616 5.94 ENST00000299163.6
HIF1AN
hypoxia inducible factor 1, alpha subunit inhibitor
chr15_-_79383102 5.93 ENST00000558480.2
ENST00000419573.3
RASGRF1
Ras protein-specific guanine nucleotide-releasing factor 1
chr19_-_49944806 5.87 ENST00000221485.3
SLC17A7
solute carrier family 17 (vesicular glutamate transporter), member 7
chr7_-_98741642 5.87 ENST00000361368.2
SMURF1
SMAD specific E3 ubiquitin protein ligase 1
chr10_+_73975742 5.79 ENST00000299381.4
ANAPC16
anaphase promoting complex subunit 16
chr6_-_100912785 5.79 ENST00000369208.3
SIM1
single-minded family bHLH transcription factor 1
chr1_+_205197304 5.78 ENST00000358024.3
TMCC2
transmembrane and coiled-coil domain family 2
chrX_+_24483338 5.76 ENST00000379162.4
ENST00000441463.2
PDK3
pyruvate dehydrogenase kinase, isozyme 3
chr3_+_5229356 5.75 ENST00000256497.4
EDEM1
ER degradation enhancer, mannosidase alpha-like 1
chr22_+_40390930 5.74 ENST00000333407.6
FAM83F
family with sequence similarity 83, member F
chr5_+_96271141 5.74 ENST00000231368.5
LNPEP
leucyl/cystinyl aminopeptidase
chr17_+_41177220 5.59 ENST00000587250.2
ENST00000544533.1
RND2
Rho family GTPase 2
chr22_-_50699701 5.58 ENST00000395780.1
MAPK12
mitogen-activated protein kinase 12
chr19_-_19754404 5.57 ENST00000587205.1
ENST00000445806.2
ENST00000203556.4
GMIP
GEM interacting protein
chr13_-_29292956 5.54 ENST00000266943.6
SLC46A3
solute carrier family 46, member 3
chr19_+_4969116 5.48 ENST00000588337.1
ENST00000159111.4
ENST00000381759.4
KDM4B
lysine (K)-specific demethylase 4B
chr2_-_50574856 5.47 ENST00000342183.5
NRXN1
neurexin 1
chr16_+_8768422 5.40 ENST00000268251.8
ENST00000564714.1
ABAT
4-aminobutyrate aminotransferase
chr17_-_27224621 5.40 ENST00000394906.2
ENST00000585169.1
ENST00000394908.4
FLOT2
flotillin 2
chr8_-_63998590 5.23 ENST00000260116.4
TTPA
tocopherol (alpha) transfer protein
chr1_+_26856236 5.23 ENST00000374168.2
ENST00000374166.4
RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr9_-_95432536 5.17 ENST00000287996.3
IPPK
inositol 1,3,4,5,6-pentakisphosphate 2-kinase
chr9_-_35650900 5.13 ENST00000259608.3
SIT1
signaling threshold regulating transmembrane adaptor 1
chr20_+_3827459 5.12 ENST00000416600.2
ENST00000428216.2
MAVS
mitochondrial antiviral signaling protein
chr17_-_42908155 5.12 ENST00000426548.1
ENST00000590758.1
ENST00000591424.1
GJC1
gap junction protein, gamma 1, 45kDa
chr11_-_128392085 5.11 ENST00000526145.2
ENST00000531611.1
ENST00000319397.6
ENST00000345075.4
ENST00000535549.1
ETS1
v-ets avian erythroblastosis virus E26 oncogene homolog 1
chr10_+_99258625 5.08 ENST00000370664.3
UBTD1
ubiquitin domain containing 1
chr18_+_55102917 4.99 ENST00000491143.2
ONECUT2
one cut homeobox 2
chr8_+_22857048 4.99 ENST00000251822.6
RHOBTB2
Rho-related BTB domain containing 2
chr17_+_61699766 4.93 ENST00000579585.1
ENST00000584573.1
ENST00000361733.3
ENST00000361357.3
MAP3K3
mitogen-activated protein kinase kinase kinase 3
chr17_-_8093471 4.92 ENST00000389017.4
C17orf59
chromosome 17 open reading frame 59
chr10_-_94003003 4.87 ENST00000412050.4
CPEB3
cytoplasmic polyadenylation element binding protein 3
chr9_-_19786926 4.80 ENST00000341998.2
ENST00000286344.3
SLC24A2
solute carrier family 24 (sodium/potassium/calcium exchanger), member 2
chr12_-_69326940 4.60 ENST00000549781.1
ENST00000548262.1
ENST00000551568.1
ENST00000548954.1
CPM
carboxypeptidase M
chr6_+_35227449 4.59 ENST00000373953.3
ENST00000440666.2
ENST00000339411.5
ZNF76
zinc finger protein 76
chr11_+_71640071 4.58 ENST00000533380.1
ENST00000393713.3
ENST00000545854.1
RNF121
ring finger protein 121
chr12_-_51717922 4.56 ENST00000452142.2
BIN2
bridging integrator 2
chr3_-_183735731 4.56 ENST00000334444.6
ABCC5
ATP-binding cassette, sub-family C (CFTR/MRP), member 5
chr8_-_145550571 4.54 ENST00000332324.4
DGAT1
diacylglycerol O-acyltransferase 1
chr11_+_58939965 4.54 ENST00000227451.3
DTX4
deltex homolog 4 (Drosophila)
chr12_+_53774423 4.48 ENST00000426431.2
SP1
Sp1 transcription factor
chr19_-_11450249 4.47 ENST00000222120.3
RAB3D
RAB3D, member RAS oncogene family
chr2_+_18059906 4.46 ENST00000304101.4
KCNS3
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3
chr5_-_141257954 4.28 ENST00000456271.1
ENST00000394536.3
ENST00000503492.1
ENST00000287008.3
PCDH1
protocadherin 1
chr14_-_92572894 4.26 ENST00000532032.1
ENST00000506466.1
ENST00000555381.1
ENST00000557311.1
ENST00000554592.1
ENST00000554672.1
ENST00000553491.1
ENST00000556220.1
ENST00000502250.1
ENST00000503767.1
ENST00000393287.5
ENST00000340660.6
ENST00000545170.1
ENST00000429774.2
ATXN3
ataxin 3
chr1_-_150552006 4.22 ENST00000307940.3
ENST00000369026.2
MCL1
myeloid cell leukemia sequence 1 (BCL2-related)
chr1_-_157108130 4.14 ENST00000368192.4
ETV3
ets variant 3
chr1_-_200379180 4.11 ENST00000294740.3
ZNF281
zinc finger protein 281
chr5_-_100238956 4.08 ENST00000231461.5
ST8SIA4
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
chr17_-_5372271 4.06 ENST00000225296.3
DHX33
DEAH (Asp-Glu-Ala-His) box polypeptide 33
chr10_+_14920843 4.06 ENST00000433779.1
ENST00000378325.3
ENST00000354919.6
ENST00000313519.5
ENST00000420416.1
SUV39H2
suppressor of variegation 3-9 homolog 2 (Drosophila)
chr1_-_23495340 4.06 ENST00000418342.1
LUZP1
leucine zipper protein 1
chr5_-_37839782 4.06 ENST00000326524.2
ENST00000515058.1
GDNF
glial cell derived neurotrophic factor
chr4_+_37455536 4.02 ENST00000381980.4
ENST00000508175.1
C4orf19
chromosome 4 open reading frame 19
chr20_+_5107420 3.98 ENST00000460006.1
CDS2
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2
chr3_-_170626418 3.94 ENST00000474096.1
ENST00000295822.2
EIF5A2
eukaryotic translation initiation factor 5A2
chr20_-_48099182 3.94 ENST00000371741.4
KCNB1
potassium voltage-gated channel, Shab-related subfamily, member 1
chr4_+_72204755 3.93 ENST00000512686.1
ENST00000340595.3
SLC4A4
solute carrier family 4 (sodium bicarbonate cotransporter), member 4
chr14_-_82000140 3.92 ENST00000555824.1
ENST00000557372.1
ENST00000336735.4
SEL1L
sel-1 suppressor of lin-12-like (C. elegans)
chr12_+_69633317 3.91 ENST00000435070.2
CPSF6
cleavage and polyadenylation specific factor 6, 68kDa
chr22_+_21771656 3.88 ENST00000407464.2
HIC2
hypermethylated in cancer 2
chr1_+_151584544 3.87 ENST00000458013.2
ENST00000368843.3
SNX27
sorting nexin family member 27
chr9_-_100935043 3.87 ENST00000343933.5
CORO2A
coronin, actin binding protein, 2A
chr15_+_85923856 3.84 ENST00000560302.1
ENST00000394518.2
ENST00000361243.2
ENST00000560256.1
AKAP13
A kinase (PRKA) anchor protein 13
chr6_-_90062543 3.83 ENST00000435041.2
UBE2J1
ubiquitin-conjugating enzyme E2, J1
chr17_-_40333099 3.81 ENST00000607371.1
KCNH4
potassium voltage-gated channel, subfamily H (eag-related), member 4
chr3_+_38495333 3.79 ENST00000352511.4
ACVR2B
activin A receptor, type IIB
chr8_-_8751068 3.77 ENST00000276282.6
MFHAS1
malignant fibrous histiocytoma amplified sequence 1
chr15_-_93199069 3.74 ENST00000327355.5
FAM174B
family with sequence similarity 174, member B
chr4_+_38665810 3.72 ENST00000261438.5
ENST00000514033.1
KLF3
Kruppel-like factor 3 (basic)
chr18_-_60987220 3.67 ENST00000398117.1
BCL2
B-cell CLL/lymphoma 2
chr9_+_79074068 3.63 ENST00000444201.2
ENST00000376730.4
GCNT1
glucosaminyl (N-acetyl) transferase 1, core 2
chr10_+_82213904 3.61 ENST00000429989.3
TSPAN14
tetraspanin 14
chr16_-_23521710 3.58 ENST00000562117.1
ENST00000567468.1
ENST00000562944.1
ENST00000309859.4
GGA2
golgi-associated, gamma adaptin ear containing, ARF binding protein 2
chr3_+_179065474 3.56 ENST00000471841.1
ENST00000280653.7
MFN1
mitofusin 1
chr1_+_178062855 3.54 ENST00000448150.3
RASAL2
RAS protein activator like 2
chr2_+_177053307 3.52 ENST00000331462.4
HOXD1
homeobox D1

Network of associatons between targets according to the STRING database.

First level regulatory network of CCCUGAG

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
5.1 15.3 GO:1902630 regulation of membrane hyperpolarization(GO:1902630)
4.1 12.2 GO:1903070 negative regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903070)
4.0 12.0 GO:1990168 protein K33-linked deubiquitination(GO:1990168)
3.9 19.4 GO:0035871 protein K11-linked deubiquitination(GO:0035871)
3.8 15.1 GO:0042796 snRNA transcription from RNA polymerase III promoter(GO:0042796)
3.7 11.2 GO:0072560 glandular epithelial cell maturation(GO:0002071) type B pancreatic cell maturation(GO:0072560)
3.6 10.9 GO:0045082 interleukin-4 biosynthetic process(GO:0042097) positive regulation of interleukin-10 biosynthetic process(GO:0045082) regulation of interleukin-4 biosynthetic process(GO:0045402) positive regulation of interleukin-4 biosynthetic process(GO:0045404)
3.2 12.9 GO:0006114 glycerol biosynthetic process(GO:0006114)
3.2 6.4 GO:2000366 regulation of STAT protein import into nucleus(GO:2000364) positive regulation of STAT protein import into nucleus(GO:2000366)
3.0 30.2 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)
2.8 8.3 GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
2.6 13.2 GO:0033078 extrathymic T cell differentiation(GO:0033078)
2.4 9.6 GO:0032049 cardiolipin biosynthetic process(GO:0032049)
2.2 17.9 GO:0035897 proteolysis in other organism(GO:0035897)
2.1 6.3 GO:0071043 CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043)
2.0 5.9 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
2.0 3.9 GO:0010701 positive regulation of norepinephrine secretion(GO:0010701)
2.0 5.9 GO:0042137 sequestering of neurotransmitter(GO:0042137)
2.0 5.9 GO:1902534 single-organism membrane invagination(GO:1902534)
1.9 13.3 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
1.9 11.3 GO:0007296 vitellogenesis(GO:0007296)
1.8 7.3 GO:0010814 substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959)
1.7 12.2 GO:0007256 activation of JNKK activity(GO:0007256)
1.6 4.9 GO:0045900 negative regulation of translational elongation(GO:0045900)
1.6 17.4 GO:2000049 positive regulation of cell-cell adhesion mediated by cadherin(GO:2000049)
1.6 10.9 GO:0000160 phosphorelay signal transduction system(GO:0000160)
1.5 9.2 GO:0042713 sperm ejaculation(GO:0042713)
1.5 6.1 GO:0008063 Toll signaling pathway(GO:0008063)
1.4 5.4 GO:0061528 negative regulation of gamma-aminobutyric acid secretion(GO:0014053) aspartate secretion(GO:0061528) regulation of aspartate secretion(GO:1904448) positive regulation of aspartate secretion(GO:1904450)
1.3 4.0 GO:0006655 phosphatidylglycerol biosynthetic process(GO:0006655)
1.3 7.9 GO:0046684 response to pyrethroid(GO:0046684)
1.3 5.2 GO:0090210 vitamin E metabolic process(GO:0042360) regulation of establishment of blood-brain barrier(GO:0090210) negative regulation of establishment of blood-brain barrier(GO:0090212)
1.3 9.1 GO:0006572 tyrosine catabolic process(GO:0006572)
1.3 3.8 GO:1900169 regulation of glucocorticoid mediated signaling pathway(GO:1900169)
1.2 6.0 GO:1990086 lens fiber cell apoptotic process(GO:1990086)
1.1 5.7 GO:1904154 positive regulation of retrograde protein transport, ER to cytosol(GO:1904154)
1.1 4.5 GO:0036155 acylglycerol acyl-chain remodeling(GO:0036155)
1.1 7.8 GO:1904885 beta-catenin destruction complex assembly(GO:1904885)
1.1 2.2 GO:0002384 hepatic immune response(GO:0002384)
1.1 4.3 GO:1904379 protein localization to cytosolic proteasome complex(GO:1904327) protein localization to cytosolic proteasome complex involved in ERAD pathway(GO:1904379)
1.1 6.3 GO:0071321 cellular response to cGMP(GO:0071321)
1.0 1.0 GO:0098904 regulation of AV node cell action potential(GO:0098904)
1.0 7.3 GO:0021987 cerebral cortex development(GO:0021987)
1.0 3.1 GO:0001743 optic placode formation(GO:0001743) optic placode formation involved in camera-type eye formation(GO:0046619)
1.0 5.1 GO:0035549 positive regulation of interferon-beta secretion(GO:0035549) regulation of peroxisome organization(GO:1900063)
1.0 5.1 GO:0086021 SA node cell to atrial cardiac muscle cell communication by electrical coupling(GO:0086021) AV node cell to bundle of His cell communication by electrical coupling(GO:0086053)
1.0 4.1 GO:0021784 postganglionic parasympathetic fiber development(GO:0021784)
1.0 7.1 GO:0001554 luteolysis(GO:0001554)
1.0 3.0 GO:0035621 ER to Golgi ceramide transport(GO:0035621)
1.0 3.0 GO:0005988 lactose metabolic process(GO:0005988) lactose biosynthetic process(GO:0005989) apoptotic process involved in mammary gland involution(GO:0060057) positive regulation of apoptotic process involved in mammary gland involution(GO:0060058) positive regulation of apoptotic process involved in morphogenesis(GO:1902339) regulation of mammary gland involution(GO:1903519) positive regulation of mammary gland involution(GO:1903521) positive regulation of apoptotic process involved in development(GO:1904747)
1.0 10.8 GO:0034472 snRNA 3'-end processing(GO:0034472)
1.0 3.8 GO:0070862 negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
0.9 6.6 GO:1903818 positive regulation of voltage-gated potassium channel activity(GO:1903818)
0.9 6.5 GO:0031086 nuclear-transcribed mRNA catabolic process, deadenylation-independent decay(GO:0031086) deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.9 12.0 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.9 3.7 GO:0043375 negative regulation of cellular pH reduction(GO:0032848) CD8-positive, alpha-beta T cell lineage commitment(GO:0043375) negative regulation of retinal cell programmed cell death(GO:0046671)
0.9 12.7 GO:0060213 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213)
0.9 5.4 GO:1903903 regulation of establishment of T cell polarity(GO:1903903)
0.9 4.5 GO:0018125 peptidyl-cysteine methylation(GO:0018125)
0.9 5.2 GO:2000491 positive regulation of hepatic stellate cell activation(GO:2000491)
0.9 6.0 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.8 10.1 GO:2000786 positive regulation of autophagosome assembly(GO:2000786)
0.8 5.8 GO:0097411 hypoxia-inducible factor-1alpha signaling pathway(GO:0097411)
0.8 3.2 GO:0090370 negative regulation of cholesterol efflux(GO:0090370)
0.8 7.7 GO:0051005 negative regulation of lipoprotein lipase activity(GO:0051005)
0.8 3.0 GO:0060023 soft palate development(GO:0060023)
0.7 9.7 GO:0021694 cerebellar Purkinje cell layer formation(GO:0021694) cerebellar Purkinje cell differentiation(GO:0021702)
0.7 4.5 GO:0036166 phenotypic switching(GO:0036166) regulation of phenotypic switching(GO:1900239)
0.7 3.0 GO:0097155 fasciculation of sensory neuron axon(GO:0097155)
0.7 2.2 GO:1901994 meiotic cell cycle phase transition(GO:0044771) regulation of meiotic cell cycle phase transition(GO:1901993) negative regulation of meiotic cell cycle phase transition(GO:1901994)
0.7 14.1 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.7 2.1 GO:1905075 proepicardium development(GO:0003342) septum transversum development(GO:0003343) occluding junction disassembly(GO:1905071) regulation of occluding junction disassembly(GO:1905073) positive regulation of occluding junction disassembly(GO:1905075)
0.7 4.2 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
0.7 5.5 GO:0070544 histone H3-K36 demethylation(GO:0070544)
0.7 5.5 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.7 8.0 GO:0036158 outer dynein arm assembly(GO:0036158)
0.7 6.0 GO:0035461 vitamin transmembrane transport(GO:0035461)
0.7 2.0 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.7 3.3 GO:2000035 positive regulation of somatic stem cell population maintenance(GO:1904674) regulation of stem cell division(GO:2000035)
0.7 3.3 GO:0010587 miRNA catabolic process(GO:0010587)
0.6 5.1 GO:0030578 PML body organization(GO:0030578)
0.6 7.0 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.6 1.9 GO:0042938 dipeptide transport(GO:0042938)
0.6 0.6 GO:0071926 endocannabinoid signaling pathway(GO:0071926)
0.6 4.8 GO:0036123 histone H3-K9 dimethylation(GO:0036123)
0.6 8.1 GO:1903830 magnesium ion transmembrane transport(GO:1903830)
0.6 5.7 GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480)
0.6 4.6 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
0.6 1.7 GO:1903028 positive regulation of opsonization(GO:1903028)
0.6 3.9 GO:0001767 establishment of lymphocyte polarity(GO:0001767)
0.5 2.2 GO:2001295 malonyl-CoA biosynthetic process(GO:2001295)
0.5 1.6 GO:0061113 pancreas morphogenesis(GO:0061113)
0.5 1.1 GO:0045925 positive regulation of female receptivity(GO:0045925)
0.5 12.3 GO:0045109 intermediate filament organization(GO:0045109)
0.5 3.6 GO:0060352 cell adhesion molecule production(GO:0060352)
0.5 12.4 GO:0010763 positive regulation of fibroblast migration(GO:0010763)
0.5 4.1 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.5 3.0 GO:0035881 amacrine cell differentiation(GO:0035881)
0.5 3.9 GO:0045905 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.5 2.4 GO:0090625 mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing by siRNA(GO:0090625) mRNA cleavage involved in gene silencing(GO:0098795)
0.5 1.4 GO:1903465 vacuolar phosphate transport(GO:0007037) positive regulation of mitotic cell cycle DNA replication(GO:1903465) positive regulation of parathyroid hormone secretion(GO:2000830)
0.5 7.6 GO:0045475 locomotor rhythm(GO:0045475)
0.5 9.9 GO:0050930 induction of positive chemotaxis(GO:0050930)
0.5 2.4 GO:1901490 regulation of lymphangiogenesis(GO:1901490)
0.5 1.4 GO:0003358 noradrenergic neuron development(GO:0003358)
0.5 6.4 GO:0071786 endoplasmic reticulum tubular network organization(GO:0071786)
0.4 3.0 GO:0002005 angiotensin catabolic process in blood(GO:0002005)
0.4 5.0 GO:0042354 fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355)
0.4 14.7 GO:0034035 purine ribonucleoside bisphosphate metabolic process(GO:0034035) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427)
0.4 8.1 GO:0043508 negative regulation of JUN kinase activity(GO:0043508)
0.4 12.8 GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846)
0.4 1.2 GO:0046016 carbon catabolite activation of transcription(GO:0045991) positive regulation of transcription by glucose(GO:0046016)
0.4 4.1 GO:0097012 cellular response to granulocyte macrophage colony-stimulating factor stimulus(GO:0097011) response to granulocyte macrophage colony-stimulating factor(GO:0097012)
0.4 5.6 GO:0006975 DNA damage induced protein phosphorylation(GO:0006975)
0.4 9.2 GO:0006829 zinc II ion transport(GO:0006829)
0.4 2.1 GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948)
0.3 8.7 GO:0030220 platelet formation(GO:0030220)
0.3 12.6 GO:0035066 positive regulation of histone acetylation(GO:0035066)
0.3 9.0 GO:0036152 phosphatidylethanolamine acyl-chain remodeling(GO:0036152)
0.3 12.2 GO:0016486 peptide hormone processing(GO:0016486)
0.3 4.1 GO:0001842 neural fold formation(GO:0001842)
0.3 2.7 GO:0034128 negative regulation of MyD88-independent toll-like receptor signaling pathway(GO:0034128)
0.3 5.9 GO:0035020 regulation of Rac protein signal transduction(GO:0035020)
0.3 1.6 GO:0099590 neurotransmitter receptor internalization(GO:0099590)
0.3 5.2 GO:0006020 inositol metabolic process(GO:0006020)
0.3 8.0 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
0.3 1.3 GO:0051944 glial cell-derived neurotrophic factor secretion(GO:0044467) positive regulation of neurotransmitter uptake(GO:0051582) positive regulation of dopamine uptake involved in synaptic transmission(GO:0051586) positive regulation of catecholamine uptake involved in synaptic transmission(GO:0051944) regulation of glial cell-derived neurotrophic factor secretion(GO:1900166) positive regulation of glial cell-derived neurotrophic factor secretion(GO:1900168)
0.3 1.6 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.3 3.8 GO:0060836 lymphatic endothelial cell differentiation(GO:0060836)
0.3 0.9 GO:1901339 activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.3 10.0 GO:0043171 peptide catabolic process(GO:0043171)
0.3 4.9 GO:1900745 positive regulation of p38MAPK cascade(GO:1900745)
0.3 4.6 GO:0097320 membrane tubulation(GO:0097320)
0.3 7.0 GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503)
0.3 8.5 GO:0007029 endoplasmic reticulum organization(GO:0007029)
0.3 0.5 GO:0051461 positive regulation of corticotropin secretion(GO:0051461)
0.3 11.9 GO:0006336 DNA replication-independent nucleosome assembly(GO:0006336) DNA replication-independent nucleosome organization(GO:0034724)
0.2 3.2 GO:0048535 lymph node development(GO:0048535)
0.2 3.0 GO:0015732 prostaglandin transport(GO:0015732)
0.2 6.1 GO:0050779 RNA destabilization(GO:0050779)
0.2 0.9 GO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.2 0.7 GO:0032345 negative regulation of aldosterone metabolic process(GO:0032345) negative regulation of aldosterone biosynthetic process(GO:0032348) dense core granule biogenesis(GO:0061110) negative regulation of cortisol biosynthetic process(GO:2000065) regulation of dense core granule biogenesis(GO:2000705)
0.2 3.9 GO:0030970 retrograde protein transport, ER to cytosol(GO:0030970)
0.2 3.3 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.2 10.8 GO:0071431 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.2 0.6 GO:0051534 negative regulation of NFAT protein import into nucleus(GO:0051534)
0.2 1.8 GO:0048712 negative regulation of astrocyte differentiation(GO:0048712)
0.2 3.0 GO:0051973 positive regulation of telomerase activity(GO:0051973)
0.2 1.4 GO:0002371 dendritic cell cytokine production(GO:0002371)
0.2 0.8 GO:0008628 hormone-mediated apoptotic signaling pathway(GO:0008628)
0.2 11.7 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580) negative regulation of small GTPase mediated signal transduction(GO:0051058)
0.2 1.7 GO:0038003 opioid receptor signaling pathway(GO:0038003)
0.2 3.4 GO:0070498 interleukin-1-mediated signaling pathway(GO:0070498)
0.2 4.1 GO:0010172 embryonic body morphogenesis(GO:0010172)
0.2 4.1 GO:0045943 positive regulation of transcription from RNA polymerase I promoter(GO:0045943)
0.2 5.6 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.2 0.9 GO:0046952 ketone body catabolic process(GO:0046952)
0.2 3.0 GO:0032464 positive regulation of protein homooligomerization(GO:0032464)
0.2 4.6 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.2 9.0 GO:0002755 MyD88-dependent toll-like receptor signaling pathway(GO:0002755)
0.2 5.1 GO:0043029 T cell homeostasis(GO:0043029)
0.2 6.6 GO:0010107 potassium ion import(GO:0010107)
0.2 4.1 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.2 6.6 GO:1902475 L-alpha-amino acid transmembrane transport(GO:1902475)
0.2 5.8 GO:1904667 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition(GO:0051437) regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051439) negative regulation of ubiquitin protein ligase activity(GO:1904667)
0.2 2.3 GO:0055089 fatty acid homeostasis(GO:0055089)
0.2 12.8 GO:0032204 regulation of telomere maintenance(GO:0032204)
0.2 6.9 GO:2000249 regulation of actin cytoskeleton reorganization(GO:2000249)
0.2 9.8 GO:0035418 protein localization to synapse(GO:0035418)
0.2 2.4 GO:0034656 nucleobase-containing small molecule catabolic process(GO:0034656)
0.1 0.6 GO:0009298 GDP-mannose biosynthetic process(GO:0009298)
0.1 7.5 GO:0045670 regulation of osteoclast differentiation(GO:0045670)
0.1 1.7 GO:0000183 chromatin silencing at rDNA(GO:0000183)
0.1 2.6 GO:2000785 regulation of autophagosome assembly(GO:2000785)
0.1 5.7 GO:0051646 mitochondrion localization(GO:0051646)
0.1 2.3 GO:0071218 cellular response to misfolded protein(GO:0071218)
0.1 1.2 GO:0048755 branching morphogenesis of a nerve(GO:0048755)
0.1 1.1 GO:0002467 germinal center formation(GO:0002467)
0.1 2.9 GO:0043536 positive regulation of blood vessel endothelial cell migration(GO:0043536)
0.1 2.9 GO:0009584 detection of visible light(GO:0009584)
0.1 4.4 GO:0030514 negative regulation of BMP signaling pathway(GO:0030514)
0.1 6.8 GO:0010830 regulation of myotube differentiation(GO:0010830)
0.1 0.7 GO:0007258 JUN phosphorylation(GO:0007258)
0.1 7.3 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.1 7.0 GO:0042982 amyloid precursor protein metabolic process(GO:0042982)
0.1 2.0 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.1 0.4 GO:0048014 Tie signaling pathway(GO:0048014) negative regulation of positive chemotaxis(GO:0050928)
0.1 3.1 GO:0070306 lens fiber cell differentiation(GO:0070306)
0.1 2.8 GO:0003338 metanephros morphogenesis(GO:0003338)
0.1 1.7 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.1 2.1 GO:0006098 pentose-phosphate shunt(GO:0006098)
0.1 0.6 GO:0060013 righting reflex(GO:0060013)
0.1 1.4 GO:0045577 regulation of B cell differentiation(GO:0045577)
0.1 1.6 GO:0050714 positive regulation of protein secretion(GO:0050714)
0.1 1.2 GO:0046602 regulation of mitotic centrosome separation(GO:0046602)
0.1 3.4 GO:0043966 histone H3 acetylation(GO:0043966)
0.1 3.3 GO:0043001 Golgi to plasma membrane protein transport(GO:0043001)
0.1 0.8 GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.1 1.8 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552)
0.1 1.6 GO:0003334 keratinocyte development(GO:0003334)
0.1 17.6 GO:0090305 nucleic acid phosphodiester bond hydrolysis(GO:0090305)
0.1 3.9 GO:0015701 bicarbonate transport(GO:0015701)
0.1 0.9 GO:0043981 histone H4-K5 acetylation(GO:0043981) histone H4-K8 acetylation(GO:0043982)
0.1 16.3 GO:0007601 visual perception(GO:0007601)
0.1 2.8 GO:0030433 ER-associated ubiquitin-dependent protein catabolic process(GO:0030433)
0.1 4.6 GO:0006501 C-terminal protein lipidation(GO:0006501)
0.1 6.8 GO:0030593 neutrophil chemotaxis(GO:0030593)
0.1 7.6 GO:0006368 transcription elongation from RNA polymerase II promoter(GO:0006368)
0.1 2.5 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.1 1.7 GO:0060732 positive regulation of inositol phosphate biosynthetic process(GO:0060732)
0.1 0.6 GO:0034378 chylomicron assembly(GO:0034378)
0.1 2.7 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.1 2.7 GO:0016032 viral process(GO:0016032) multi-organism cellular process(GO:0044764)
0.1 6.6 GO:0051291 protein heterooligomerization(GO:0051291)
0.1 4.5 GO:0032479 regulation of type I interferon production(GO:0032479)
0.0 0.1 GO:0051684 maintenance of Golgi location(GO:0051684)
0.0 3.5 GO:0051028 mRNA transport(GO:0051028)
0.0 7.8 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.0 3.5 GO:0019233 sensory perception of pain(GO:0019233)
0.0 3.2 GO:0008360 regulation of cell shape(GO:0008360)
0.0 6.0 GO:0015718 monocarboxylic acid transport(GO:0015718)
0.0 0.2 GO:0046836 glycolipid transport(GO:0046836)
0.0 0.5 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.0 2.2 GO:0019933 cAMP-mediated signaling(GO:0019933)
0.0 0.9 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.0 2.9 GO:0000724 double-strand break repair via homologous recombination(GO:0000724) recombinational repair(GO:0000725)
0.0 0.9 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.0 1.6 GO:0051865 protein autoubiquitination(GO:0051865)
0.0 1.7 GO:0042475 odontogenesis of dentin-containing tooth(GO:0042475)
0.0 1.4 GO:0001938 positive regulation of endothelial cell proliferation(GO:0001938)
0.0 0.4 GO:0097094 craniofacial suture morphogenesis(GO:0097094)
0.0 4.5 GO:0071805 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.0 0.3 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.0 1.6 GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886)
0.0 0.6 GO:0010842 retina layer formation(GO:0010842)
0.0 7.0 GO:0006839 mitochondrial transport(GO:0006839)
0.0 0.4 GO:0035162 embryonic hemopoiesis(GO:0035162)
0.0 0.7 GO:0045747 positive regulation of Notch signaling pathway(GO:0045747)
0.0 1.7 GO:0050729 positive regulation of inflammatory response(GO:0050729)
0.0 1.1 GO:0072164 ureteric bud development(GO:0001657) mesonephric epithelium development(GO:0072163) mesonephric tubule development(GO:0072164)
0.0 0.1 GO:0033008 positive regulation of mast cell activation involved in immune response(GO:0033008) positive regulation of mast cell degranulation(GO:0043306)
0.0 0.9 GO:0070997 neuron death(GO:0070997)
0.0 0.8 GO:0006520 cellular amino acid metabolic process(GO:0006520)
0.0 1.2 GO:0006310 DNA recombination(GO:0006310)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
3.3 9.9 GO:0034678 integrin alpha8-beta1 complex(GO:0034678)
2.3 7.0 GO:0031251 PAN complex(GO:0031251)
2.3 9.2 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
1.8 7.3 GO:0031302 intrinsic component of endosome membrane(GO:0031302)
1.7 23.2 GO:0035102 PRC1 complex(GO:0035102)
1.6 13.2 GO:0043196 varicosity(GO:0043196)
1.5 16.1 GO:0036513 Derlin-1 retrotranslocation complex(GO:0036513)
1.4 5.4 GO:0032144 4-aminobutyrate transaminase complex(GO:0032144)
1.2 10.8 GO:0032039 integrator complex(GO:0032039)
1.1 5.7 GO:0031905 early endosome lumen(GO:0031905)
1.0 8.0 GO:0036157 outer dynein arm(GO:0036157)
0.9 10.3 GO:0005614 interstitial matrix(GO:0005614)
0.8 3.2 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.8 12.6 GO:0030914 STAGA complex(GO:0030914)
0.8 10.9 GO:0000788 nuclear nucleosome(GO:0000788)
0.7 7.3 GO:0035371 microtubule plus-end(GO:0035371)
0.7 5.9 GO:0060203 clathrin-sculpted glutamate transport vesicle(GO:0060199) clathrin-sculpted glutamate transport vesicle membrane(GO:0060203)
0.7 10.9 GO:0016461 unconventional myosin complex(GO:0016461)
0.7 38.4 GO:0008023 transcription elongation factor complex(GO:0008023)
0.6 7.8 GO:1990909 catenin complex(GO:0016342) Wnt signalosome(GO:1990909)
0.6 11.7 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.6 6.3 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.6 2.2 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.6 3.9 GO:0071203 WASH complex(GO:0071203)
0.5 1.6 GO:0016938 kinesin I complex(GO:0016938)
0.5 3.0 GO:0000138 Golgi trans cisterna(GO:0000138)
0.5 3.9 GO:0042382 paraspeckles(GO:0042382)
0.5 2.4 GO:0033553 rDNA heterochromatin(GO:0033553)
0.5 6.6 GO:0033270 paranode region of axon(GO:0033270)
0.5 7.9 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.4 1.2 GO:0000137 Golgi cis cisterna(GO:0000137)
0.4 11.0 GO:0002080 acrosomal membrane(GO:0002080)
0.4 15.8 GO:0009925 basal plasma membrane(GO:0009925)
0.4 3.6 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.4 2.1 GO:0098554 cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)
0.3 3.4 GO:0070775 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.3 12.3 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.3 4.9 GO:0030014 CCR4-NOT complex(GO:0030014)
0.3 5.1 GO:0005922 connexon complex(GO:0005922)
0.3 1.6 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.3 7.7 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.3 23.9 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.3 2.4 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
0.2 28.5 GO:0008076 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.2 4.5 GO:0042588 zymogen granule(GO:0042588)
0.2 34.4 GO:0005923 bicellular tight junction(GO:0005923)
0.2 27.0 GO:0005643 nuclear pore(GO:0005643)
0.2 4.6 GO:0001891 phagocytic cup(GO:0001891)
0.2 9.8 GO:0048786 presynaptic active zone(GO:0048786)
0.2 2.1 GO:0097427 microtubule bundle(GO:0097427)
0.2 2.2 GO:0098799 outer mitochondrial membrane protein complex(GO:0098799)
0.2 5.8 GO:0005680 anaphase-promoting complex(GO:0005680)
0.2 12.3 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.2 2.3 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.2 0.9 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.1 1.0 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.1 4.0 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.1 1.7 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 12.5 GO:0101003 ficolin-1-rich granule membrane(GO:0101003)
0.1 2.5 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 6.4 GO:0005741 mitochondrial outer membrane(GO:0005741) outer membrane(GO:0019867) organelle outer membrane(GO:0031968)
0.1 2.7 GO:0031312 extrinsic component of organelle membrane(GO:0031312)
0.1 9.5 GO:0031594 neuromuscular junction(GO:0031594)
0.1 7.1 GO:0005795 Golgi stack(GO:0005795)
0.1 16.1 GO:0055037 recycling endosome(GO:0055037)
0.1 1.9 GO:0097225 sperm midpiece(GO:0097225)
0.1 13.2 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.1 10.1 GO:0005776 autophagosome(GO:0005776)
0.1 3.6 GO:0030131 clathrin adaptor complex(GO:0030131)
0.1 19.6 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 1.5 GO:0071437 invadopodium(GO:0071437)
0.1 5.8 GO:0005581 collagen trimer(GO:0005581)
0.1 0.7 GO:0000346 transcription export complex(GO:0000346)
0.1 1.2 GO:0000242 pericentriolar material(GO:0000242)
0.1 0.8 GO:0031209 SCAR complex(GO:0031209)
0.1 3.3 GO:0005796 Golgi lumen(GO:0005796)
0.1 2.0 GO:0001772 immunological synapse(GO:0001772)
0.1 30.2 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.1 16.6 GO:0031965 nuclear membrane(GO:0031965)
0.1 0.7 GO:0035631 CD40 receptor complex(GO:0035631)
0.1 2.9 GO:1990391 DNA repair complex(GO:1990391)
0.1 4.6 GO:0031225 anchored component of membrane(GO:0031225)
0.0 5.0 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 1.7 GO:0016592 mediator complex(GO:0016592)
0.0 2.5 GO:0015030 Cajal body(GO:0015030)
0.0 11.8 GO:0005768 endosome(GO:0005768)
0.0 2.0 GO:0005844 polysome(GO:0005844)
0.0 25.2 GO:0016604 nuclear body(GO:0016604)
0.0 5.3 GO:0019897 extrinsic component of plasma membrane(GO:0019897)
0.0 1.7 GO:0005802 trans-Golgi network(GO:0005802)
0.0 6.7 GO:0030667 secretory granule membrane(GO:0030667)
0.0 2.6 GO:0019898 extrinsic component of membrane(GO:0019898)
0.0 2.1 GO:0060170 ciliary membrane(GO:0060170)
0.0 0.1 GO:0030897 HOPS complex(GO:0030897)
0.0 12.5 GO:0031012 extracellular matrix(GO:0031012)
0.0 2.0 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 5.2 GO:0005667 transcription factor complex(GO:0005667)
0.0 2.1 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 9.9 GO:0005615 extracellular space(GO:0005615)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
4.4 13.3 GO:0047696 beta-adrenergic receptor kinase activity(GO:0047696)
4.3 12.9 GO:0098519 nucleotide phosphatase activity, acting on free nucleotides(GO:0098519)
4.0 12.0 GO:1904455 ubiquitin-specific protease activity involved in negative regulation of ERAD pathway(GO:1904455)
4.0 12.0 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
3.4 10.1 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
3.0 9.1 GO:0080130 L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
2.6 7.8 GO:0008523 sodium-dependent multivitamin transmembrane transporter activity(GO:0008523)
2.3 11.5 GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184)
2.0 15.7 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
1.9 13.0 GO:0017002 activin-activated receptor activity(GO:0017002)
1.8 10.9 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
1.8 7.1 GO:0047144 2-acylglycerol-3-phosphate O-acyltransferase activity(GO:0047144)
1.6 7.9 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
1.6 6.3 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
1.6 6.2 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
1.5 7.7 GO:0010465 nerve growth factor receptor activity(GO:0010465)
1.5 7.6 GO:0035252 UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
1.5 4.5 GO:0003846 2-acylglycerol O-acyltransferase activity(GO:0003846)
1.5 5.9 GO:0015319 sodium:inorganic phosphate symporter activity(GO:0015319)
1.4 5.8 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
1.4 9.7 GO:0008142 oxysterol binding(GO:0008142)
1.4 5.4 GO:0003867 4-aminobutyrate transaminase activity(GO:0003867) succinate-semialdehyde dehydrogenase binding(GO:0032145) (S)-3-amino-2-methylpropionate transaminase activity(GO:0047298)
1.3 4.0 GO:0004605 phosphatidate cytidylyltransferase activity(GO:0004605)
1.3 5.2 GO:0008431 vitamin E binding(GO:0008431)
1.2 3.6 GO:0003829 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
1.1 30.5 GO:0004708 MAP kinase kinase activity(GO:0004708)
1.0 5.1 GO:0086077 gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling(GO:0086020) gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling(GO:0086077)
1.0 15.3 GO:0008140 cAMP response element binding protein binding(GO:0008140)
1.0 4.8 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
1.0 4.8 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.8 5.9 GO:0071532 ankyrin repeat binding(GO:0071532)
0.8 6.6 GO:0046920 alpha-(1->3)-fucosyltransferase activity(GO:0046920)
0.8 18.7 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.8 3.2 GO:0017089 glycolipid transporter activity(GO:0017089)
0.8 2.3 GO:0050405 [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity(GO:0047322) [acetyl-CoA carboxylase] kinase activity(GO:0050405)
0.8 3.0 GO:0004461 lactose synthase activity(GO:0004461)
0.7 2.2 GO:0004915 interleukin-6 receptor activity(GO:0004915) interleukin-6 binding(GO:0019981)
0.7 7.9 GO:0051434 BH3 domain binding(GO:0051434)
0.7 7.0 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.7 5.5 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.7 2.1 GO:0017057 glucose-6-phosphate dehydrogenase activity(GO:0004345) 6-phosphogluconolactonase activity(GO:0017057)
0.7 15.0 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.7 3.4 GO:0010484 H3 histone acetyltransferase activity(GO:0010484)
0.6 1.8 GO:0035529 NADH pyrophosphatase activity(GO:0035529)
0.6 4.1 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.6 8.1 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.6 5.6 GO:0004707 MAP kinase activity(GO:0004707)
0.6 12.8 GO:0004062 aryl sulfotransferase activity(GO:0004062)
0.5 14.1 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.5 2.2 GO:0003989 acetyl-CoA carboxylase activity(GO:0003989)
0.5 6.7 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.5 1.5 GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.5 5.9 GO:0048185 activin binding(GO:0048185)
0.5 1.9 GO:0015563 uptake transmembrane transporter activity(GO:0015563)
0.5 6.4 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.5 4.1 GO:0000182 rDNA binding(GO:0000182)
0.4 9.9 GO:0042609 CD4 receptor binding(GO:0042609)
0.4 21.6 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.4 13.2 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.4 11.1 GO:0031489 myosin V binding(GO:0031489)
0.4 6.1 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.4 12.6 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.4 8.0 GO:0045504 dynein heavy chain binding(GO:0045504)
0.4 7.0 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.4 7.8 GO:0045295 gamma-catenin binding(GO:0045295)
0.4 3.1 GO:0050692 DBD domain binding(GO:0050692)
0.4 4.6 GO:0043225 anion transmembrane-transporting ATPase activity(GO:0043225)
0.4 6.6 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.4 5.1 GO:0050700 CARD domain binding(GO:0050700)
0.4 4.0 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.4 13.2 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.4 2.1 GO:0005114 transforming growth factor beta receptor activity, type I(GO:0005025) type II transforming growth factor beta receptor binding(GO:0005114)
0.4 18.9 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.3 5.5 GO:0097109 neuroligin family protein binding(GO:0097109)
0.3 1.7 GO:0004991 parathyroid hormone receptor activity(GO:0004991)
0.3 6.3 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
0.3 3.8 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.3 6.6 GO:0034185 apolipoprotein binding(GO:0034185)
0.3 4.9 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.3 0.9 GO:0003858 3-hydroxybutyrate dehydrogenase activity(GO:0003858)
0.3 4.6 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.3 0.6 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.3 4.1 GO:0017151 DEAD/H-box RNA helicase binding(GO:0017151)
0.3 12.8 GO:0042162 telomeric DNA binding(GO:0042162)
0.3 7.1 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.3 8.0 GO:0005540 hyaluronic acid binding(GO:0005540)
0.3 2.9 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.3 1.0 GO:0048763 calcium-induced calcium release activity(GO:0048763)
0.3 5.2 GO:0043236 laminin binding(GO:0043236)
0.3 17.2 GO:0035254 glutamate receptor binding(GO:0035254)
0.3 12.3 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.2 1.7 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.2 3.6 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.2 15.7 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.2 3.9 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.2 7.9 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.2 3.2 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.2 10.9 GO:0016279 lysine N-methyltransferase activity(GO:0016278) protein-lysine N-methyltransferase activity(GO:0016279)
0.2 1.2 GO:0008046 axon guidance receptor activity(GO:0008046)
0.2 1.4 GO:0050682 AF-2 domain binding(GO:0050682)
0.2 1.8 GO:0010385 double-stranded methylated DNA binding(GO:0010385)
0.2 2.6 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.2 17.4 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.2 3.0 GO:0015245 fatty acid transporter activity(GO:0015245)
0.2 2.7 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.2 2.4 GO:0017110 nucleoside-diphosphatase activity(GO:0017110)
0.2 4.5 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.2 25.7 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.2 7.7 GO:0019894 kinesin binding(GO:0019894)
0.2 2.8 GO:0101005 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.2 0.8 GO:0004994 somatostatin receptor activity(GO:0004994)
0.2 7.3 GO:0017046 peptide hormone binding(GO:0017046)
0.2 6.9 GO:0003785 actin monomer binding(GO:0003785)
0.1 5.2 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.1 9.1 GO:0017124 SH3 domain binding(GO:0017124)
0.1 4.0 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 1.4 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.1 18.4 GO:0004519 endonuclease activity(GO:0004519)
0.1 2.3 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.1 0.5 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.1 1.7 GO:0004985 opioid receptor activity(GO:0004985)
0.1 8.4 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.1 2.1 GO:0050321 tau-protein kinase activity(GO:0050321)
0.1 36.1 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.1 6.0 GO:0003678 DNA helicase activity(GO:0003678)
0.1 12.4 GO:0051117 ATPase binding(GO:0051117)
0.1 6.6 GO:0015179 L-amino acid transmembrane transporter activity(GO:0015179)
0.1 3.5 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.1 5.1 GO:0042169 SH2 domain binding(GO:0042169)
0.1 6.0 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.1 1.8 GO:0017091 AU-rich element binding(GO:0017091)
0.1 0.8 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.1 5.6 GO:0047485 protein N-terminus binding(GO:0047485)
0.1 0.9 GO:0070915 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.1 0.9 GO:0046972 histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
0.1 1.7 GO:0001163 RNA polymerase I regulatory region DNA binding(GO:0001013) RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163) RNA polymerase I CORE element sequence-specific DNA binding(GO:0001164)
0.1 2.0 GO:0019198 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.1 28.7 GO:0005096 GTPase activator activity(GO:0005096)
0.1 1.3 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.1 1.3 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.1 0.9 GO:0039706 co-receptor binding(GO:0039706)
0.1 0.5 GO:0030911 TPR domain binding(GO:0030911)
0.1 8.8 GO:0001047 core promoter binding(GO:0001047)
0.1 1.8 GO:0008536 Ran GTPase binding(GO:0008536)
0.1 3.0 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.1 2.1 GO:0046875 ephrin receptor binding(GO:0046875)
0.1 1.0 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.1 2.2 GO:0030552 cAMP binding(GO:0030552)
0.1 0.7 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.1 5.1 GO:0043130 ubiquitin binding(GO:0043130)
0.1 0.9 GO:0031005 filamin binding(GO:0031005)
0.1 0.3 GO:0008420 CTD phosphatase activity(GO:0008420)
0.0 0.6 GO:0016868 intramolecular transferase activity, phosphotransferases(GO:0016868)
0.0 3.5 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 12.2 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 2.9 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 0.8 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 1.7 GO:0043531 ADP binding(GO:0043531)
0.0 13.1 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 2.2 GO:0000976 transcription regulatory region sequence-specific DNA binding(GO:0000976)
0.0 0.2 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.0 0.9 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 0.6 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 2.5 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 0.1 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 3.2 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.0 8.3 GO:0005509 calcium ion binding(GO:0005509)
0.0 10.9 GO:0022857 transmembrane transporter activity(GO:0022857)
0.0 0.4 GO:0030971 receptor tyrosine kinase binding(GO:0030971)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 56.6 PID TNF PATHWAY TNF receptor signaling pathway
0.4 14.4 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.3 5.6 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.3 8.7 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.3 14.1 PID RAS PATHWAY Regulation of Ras family activation
0.3 15.5 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.3 12.4 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.3 8.0 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.3 3.2 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.3 10.7 PID HIV NEF PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.3 6.0 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.2 7.0 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.2 2.9 PID S1P S1P4 PATHWAY S1P4 pathway
0.2 9.2 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.2 2.0 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
0.2 7.7 PID ALK1 PATHWAY ALK1 signaling events
0.2 14.9 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.2 4.8 PID CONE PATHWAY Visual signal transduction: Cones
0.2 10.0 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.2 6.4 PID PI3KCI PATHWAY Class I PI3K signaling events
0.1 1.2 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.1 3.0 PID ATF2 PATHWAY ATF-2 transcription factor network
0.1 8.4 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.1 14.8 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.1 5.1 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.1 6.4 PID ERBB4 PATHWAY ErbB4 signaling events
0.1 14.8 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.1 2.2 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 10.0 PID CMYB PATHWAY C-MYB transcription factor network
0.1 1.3 ST G ALPHA I PATHWAY G alpha i Pathway
0.1 3.8 PID THROMBIN PAR1 PATHWAY PAR1-mediated thrombin signaling events
0.1 37.8 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.1 6.5 PID AP1 PATHWAY AP-1 transcription factor network
0.1 5.4 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 6.1 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 1.2 PID EPHA FWDPATHWAY EPHA forward signaling
0.1 4.4 PID LKB1 PATHWAY LKB1 signaling events
0.1 4.5 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.1 1.4 PID PI3K PLC TRK PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.1 15.3 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 0.4 PID EPO PATHWAY EPO signaling pathway
0.1 0.9 PID LPA4 PATHWAY LPA4-mediated signaling events
0.1 1.6 PID IL2 1PATHWAY IL2-mediated signaling events
0.1 1.4 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.0 1.7 PID INTEGRIN1 PATHWAY Beta1 integrin cell surface interactions
0.0 1.1 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.7 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.0 0.6 PID P53 REGULATION PATHWAY p53 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 19.3 REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.9 6.1 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.8 23.6 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.7 6.3 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.6 12.0 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.6 6.1 REACTOME DESTABILIZATION OF MRNA BY BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.6 5.7 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.5 25.9 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.5 5.1 REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.5 18.9 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.5 12.8 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.4 2.9 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.4 9.0 REACTOME ACYL CHAIN REMODELLING OF PE Genes involved in Acyl chain remodelling of PE
0.3 9.7 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.3 8.3 REACTOME TRAF6 MEDIATED NFKB ACTIVATION Genes involved in TRAF6 mediated NF-kB activation
0.3 15.1 REACTOME ELONGATION ARREST AND RECOVERY Genes involved in Elongation arrest and recovery
0.3 5.8 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.3 7.0 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.3 2.2 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.3 6.9 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.3 8.0 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.3 12.7 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.3 5.1 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.3 5.9 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.3 10.8 REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.3 6.0 REACTOME FORMATION OF TRANSCRIPTION COUPLED NER TC NER REPAIR COMPLEX Genes involved in Formation of transcription-coupled NER (TC-NER) repair complex
0.3 5.4 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.3 4.6 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.2 7.9 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.2 4.0 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.2 5.9 REACTOME REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
0.2 5.9 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.2 17.5 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.2 18.0 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.2 12.9 REACTOME POTASSIUM CHANNELS Genes involved in Potassium Channels
0.2 6.4 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.2 5.8 REACTOME G1 PHASE Genes involved in G1 Phase
0.2 3.7 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.2 1.4 REACTOME POST NMDA RECEPTOR ACTIVATION EVENTS Genes involved in Post NMDA receptor activation events
0.2 6.6 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.2 5.1 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.2 4.9 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.1 11.8 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.1 4.5 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.1 9.6 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 3.0 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.1 1.6 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.1 6.5 REACTOME SIGNAL TRANSDUCTION BY L1 Genes involved in Signal transduction by L1
0.1 1.0 REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript
0.1 2.1 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1 5.6 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.1 2.8 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.1 3.9 REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.1 4.4 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.1 7.8 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.1 5.7 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.1 14.9 REACTOME G ALPHA Q SIGNALLING EVENTS Genes involved in G alpha (q) signalling events
0.1 12.7 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 6.8 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 4.1 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 1.6 REACTOME TRAFFICKING OF AMPA RECEPTORS Genes involved in Trafficking of AMPA receptors
0.0 1.7 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 1.3 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 0.6 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 1.3 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.4 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 0.4 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 0.9 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 1.7 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 1.7 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)