ISMARA results: DLX4

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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for DLX4_HOXD8

Z-value: 1.08

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Transcription factors associated with DLX4_HOXD8

Gene Symbol	Gene ID	Gene Info
DLX4 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000108813.9	distal-less homeobox 4
HOXD8 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000175879.7	homeobox D8

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
DLX4	hg19_v2_chr17_+_48046538_48046575	0.40	6.9e-10	Click!

Activity profile of DLX4_HOXD8 motif

Sorted Z-values of DLX4_HOXD8 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chrX_+_13671225 Show fit	17.76	ENST00000545566.1 ENST00000544987.1 ENST00000314720.4	TCEANC Ensembl NCBI GeneCards UniProt NextProt Show fit	transcription elongation factor A (SII) N-terminal and central domain containing
chr10_+_7745303 Show fit	17.73	ENST00000429820.1 ENST00000379587.4	ITIH2 Ensembl NCBI GeneCards UniProt NextProt Show fit	inter-alpha-trypsin inhibitor heavy chain 2
chr3_-_138763734 Show fit	16.49	ENST00000413199.1 ENST00000502927.2	PRR23C Ensembl NCBI GeneCards UniProt NextProt Show fit	proline rich 23C
chr6_-_52705641 Show fit	14.91	ENST00000370989.2	GSTA5 Ensembl NCBI GeneCards UniProt NextProt Show fit	glutathione S-transferase alpha 5
chr1_-_158656488 Show fit	13.10	ENST00000368147.4	SPTA1 Ensembl NCBI GeneCards UniProt NextProt Show fit	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
chr1_+_233086326 Show fit	12.99	ENST00000366628.5 ENST00000366627.4	NTPCR Ensembl NCBI GeneCards UniProt NextProt Show fit	nucleoside-triphosphatase, cancer-related
chr13_-_88323218 Show fit	12.90	ENST00000436290.2 ENST00000453832.2 ENST00000606590.1	MIR4500HG Ensembl NCBI GeneCards UniProt NextProt Show fit	MIR4500 host gene (non-protein coding)
chr2_-_86333244 Show fit	12.73	ENST00000263857.6 ENST00000409681.1	POLR1A Ensembl NCBI GeneCards UniProt NextProt Show fit	polymerase (RNA) I polypeptide A, 194kDa
chr11_-_5255861 Show fit	12.52	ENST00000380299.3	HBD Ensembl NCBI GeneCards UniProt NextProt Show fit	hemoglobin, delta
chr2_-_89399845 Show fit	11.80	ENST00000479981.1	IGKV1-16 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin kappa variable 1-16

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of DLX4_HOXD8

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	146.0	GO:0006958	complement activation, classical pathway(GO:0006958)
0.4	56.4	GO:0002377	immunoglobulin production(GO:0002377)
1.6	32.7	GO:0052695	cellular glucuronidation(GO:0052695)
2.4	25.9	GO:0051918	negative regulation of fibrinolysis(GO:0051918)
0.5	23.9	GO:0050911	detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.1	20.1	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.5	19.0	GO:0050869	negative regulation of B cell activation(GO:0050869)
1.9	18.8	GO:0043152	induction of bacterial agglutination(GO:0043152)
4.3	17.1	GO:0002503	peptide antigen assembly with MHC class II protein complex(GO:0002503)
1.7	15.6	GO:0038124	toll-like receptor TLR6:TLR2 signaling pathway(GO:0038124) response to diacyl bacterial lipopeptide(GO:0071724) cellular response to diacyl bacterial lipopeptide(GO:0071726)

Showing 1 to 10 of 502 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	181.7	GO:0005615	extracellular space(GO:0005615)
0.7	107.0	GO:0072562	blood microparticle(GO:0072562)
0.0	59.7	GO:0016021	integral component of membrane(GO:0016021)
0.0	40.4	GO:0031226	intrinsic component of plasma membrane(GO:0031226)
0.8	37.1	GO:0042571	immunoglobulin complex, circulating(GO:0042571)
1.0	25.0	GO:0042627	chylomicron(GO:0042627)
1.1	23.8	GO:0042613	MHC class II protein complex(GO:0042613)
1.5	19.7	GO:0005577	fibrinogen complex(GO:0005577)
0.1	18.6	GO:0009897	external side of plasma membrane(GO:0009897)
0.2	17.8	GO:0035578	azurophil granule lumen(GO:0035578)

Showing 1 to 10 of 171 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	207.1	GO:0003823	antigen binding(GO:0003823)
0.4	40.1	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
1.0	39.6	GO:0015020	glucuronosyltransferase activity(GO:0015020)
0.1	26.6	GO:0030674	protein binding, bridging(GO:0030674)
0.1	25.1	GO:0030695	GTPase regulator activity(GO:0030695)
0.0	24.7	GO:0003700	nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.5	22.2	GO:0004984	olfactory receptor activity(GO:0004984)
1.1	19.0	GO:0008329	signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
3.4	17.2	GO:0060230	lipoprotein lipase activator activity(GO:0060230)
0.3	16.9	GO:0004601	peroxidase activity(GO:0004601)

Showing 1 to 10 of 347 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	82.6	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.3	33.9	PID CMYB PATHWAY	C-MYB transcription factor network
0.2	32.3	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.3	27.1	PID RAC1 PATHWAY	RAC1 signaling pathway
0.3	21.1	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.6	20.1	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.4	20.0	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.2	19.1	PID IL12 2PATHWAY	IL12-mediated signaling events
0.1	16.3	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.2	12.9	NABA PROTEOGLYCANS	Genes encoding proteoglycans

Showing 1 to 10 of 67 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.8	47.7	REACTOME GLUCURONIDATION	Genes involved in Glucuronidation
0.5	29.0	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.5	25.1	REACTOME COMPLEMENT CASCADE	Genes involved in Complement cascade
0.7	25.0	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
0.7	22.2	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.4	22.1	REACTOME OLFACTORY SIGNALING PATHWAY	Genes involved in Olfactory Signaling Pathway
0.1	19.0	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.7	18.1	REACTOME HDL MEDIATED LIPID TRANSPORT	Genes involved in HDL-mediated lipid transport
0.6	16.1	REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES	Genes involved in Cytosolic sulfonation of small molecules
0.1	16.0	REACTOME G ALPHA Q SIGNALLING EVENTS	Genes involved in G alpha (q) signalling events

Showing 1 to 10 of 129 entries

Results for DLX4_HOXD8

Z-value: 1.08

Motif logo

Transcription factors associated with DLX4_HOXD8

Activity-expression correlation:

Activity profile of DLX4_HOXD8 motif

Sorted Z-values of DLX4_HOXD8 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of DLX4_HOXD8

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: