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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for EN1_ESX1_GBX1
Z-value: 0.93
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Transcription factors associated with EN1_ESX1_GBX1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GBX1 | hg19_v2_chr7_-_150864635_150864785 | -0.19 | 4.5e-03 | Click! |
| EN1 | hg19_v2_chr2_-_119605253_119605264 | 0.18 | 6.3e-03 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_-_111794446 Show fit | 32.90 |
ENST00000527950.1
|
crystallin, alpha B |
|
| chrX_-_13835147 Show fit | 28.51 |
ENST00000493677.1
ENST00000355135.2 |
glycoprotein M6B |
|
| chr3_+_111718036 Show fit | 27.74 |
ENST00000455401.2
|
transgelin 3 |
|
| chr3_+_111718173 Show fit | 25.42 |
ENST00000494932.1
|
transgelin 3 |
|
| chr3_+_111717600 Show fit | 25.31 |
ENST00000273368.4
|
transgelin 3 |
|
| chr3_+_111717511 Show fit | 24.32 |
ENST00000478951.1
ENST00000393917.2 |
transgelin 3 |
|
| chr3_+_115342349 Show fit | 22.62 |
ENST00000393780.3
|
growth associated protein 43 |
|
| chr11_-_117747434 Show fit | 21.52 |
ENST00000529335.2
ENST00000530956.1 ENST00000260282.4 |
FXYD domain containing ion transport regulator 6 |
|
| chr11_-_117747607 Show fit | 21.49 |
ENST00000540359.1
ENST00000539526.1 |
FXYD domain containing ion transport regulator 6 |
|
| chr12_-_6233828 Show fit | 21.46 |
ENST00000572068.1
ENST00000261405.5 |
von Willebrand factor |
Network of associatons between targets according to the STRING database.
First level regulatory network of EN1_ESX1_GBX1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 60.3 | GO:2000649 | regulation of sodium ion transmembrane transporter activity(GO:2000649) |
| 0.0 | 33.2 | GO:0007417 | central nervous system development(GO:0007417) |
| 0.2 | 31.5 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 1.6 | 28.7 | GO:0097151 | positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828) |
| 2.9 | 28.5 | GO:0051581 | negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 1.5 | 26.3 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 1.1 | 25.6 | GO:0007597 | blood coagulation, intrinsic pathway(GO:0007597) |
| 2.5 | 25.0 | GO:0014894 | response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894) |
| 2.9 | 23.1 | GO:1900113 | negative regulation of histone H3-K9 trimethylation(GO:1900113) |
| 2.3 | 22.6 | GO:0016198 | axon choice point recognition(GO:0016198) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 95.7 | GO:0043209 | myelin sheath(GO:0043209) |
| 2.1 | 32.9 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.1 | 31.7 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 0.6 | 28.7 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 3.1 | 25.0 | GO:0014802 | terminal cisterna(GO:0014802) |
| 0.9 | 23.1 | GO:0005721 | pericentric heterochromatin(GO:0005721) |
| 0.2 | 22.7 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 3.2 | 22.6 | GO:0032584 | growth cone membrane(GO:0032584) |
| 0.7 | 17.8 | GO:0034451 | centriolar satellite(GO:0034451) |
| 1.0 | 16.8 | GO:0045277 | respiratory chain complex IV(GO:0045277) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 89.7 | GO:0051015 | actin filament binding(GO:0051015) |
| 1.1 | 61.0 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.2 | 48.0 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.1 | 45.6 | GO:0005509 | calcium ion binding(GO:0005509) |
| 1.2 | 37.7 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.9 | 24.5 | GO:0019865 | immunoglobulin binding(GO:0019865) |
| 0.1 | 23.3 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 1.2 | 23.1 | GO:0032454 | histone demethylase activity (H3-K9 specific)(GO:0032454) |
| 2.3 | 22.6 | GO:0035727 | lysophosphatidic acid binding(GO:0035727) |
| 0.2 | 21.9 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 22.7 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.4 | 21.3 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 20.1 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 18.1 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 17.2 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.5 | 16.0 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.2 | 11.8 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.2 | 11.4 | PID IFNG PATHWAY | IFN-gamma pathway |
| 0.8 | 9.5 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.2 | 8.5 | NABA COLLAGENS | Genes encoding collagen proteins |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 21.5 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.4 | 17.7 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.9 | 17.0 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.4 | 13.7 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.5 | 13.2 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.1 | 13.2 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.2 | 11.2 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.4 | 9.4 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.2 | 9.0 | REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.2 | 8.2 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |