ISMARA results: GATA1

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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for GATA1_GATA4

Z-value: 1.82

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Transcription factors associated with GATA1_GATA4

Gene Symbol	Gene ID	Gene Info
GATA1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000102145.9	GATA binding protein 1
GATA4 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000136574.13	GATA binding protein 4

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
GATA1	hg19_v2_chrX_+_48644962_48644983	0.63	3.6e-25	Click!
GATA4	hg19_v2_chr8_+_11534462_11534475, hg19_v2_chr8_+_11561660_11561751	0.50	3.8e-15	Click!

Activity profile of GATA1_GATA4 motif

Sorted Z-values of GATA1_GATA4 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr15_-_43513187 Show fit	47.01	ENST00000540029.1 ENST00000441366.2	EPB42 Ensembl NCBI GeneCards UniProt NextProt Show fit	erythrocyte membrane protein band 4.2
chr12_-_54689532 Show fit	38.47	ENST00000540264.2 ENST00000312156.4	NFE2 Ensembl NCBI GeneCards UniProt NextProt Show fit	nuclear factor, erythroid 2
chr1_+_25598989 Show fit	36.13	ENST00000454452.2	RHD Ensembl NCBI GeneCards UniProt NextProt Show fit	Rh blood group, D antigen
chr19_-_13213662 Show fit	33.05	ENST00000264824.4	LYL1 Ensembl NCBI GeneCards UniProt NextProt Show fit	lymphoblastic leukemia derived sequence 1
chr10_-_99531709 Show fit	28.36	ENST00000266066.3	SFRP5 Ensembl NCBI GeneCards UniProt NextProt Show fit	secreted frizzled-related protein 5
chr16_+_202686 Show fit	27.39	ENST00000252951.2	HBZ Ensembl NCBI GeneCards UniProt NextProt Show fit	hemoglobin, zeta
chr19_-_12997995 Show fit	24.79	ENST00000264834.4	KLF1 Ensembl NCBI GeneCards UniProt NextProt Show fit	Kruppel-like factor 1 (erythroid)
chr11_-_5255861 Show fit	24.70	ENST00000380299.3	HBD Ensembl NCBI GeneCards UniProt NextProt Show fit	hemoglobin, delta
chr10_+_118305435 Show fit	23.47	ENST00000369221.2	PNLIP Ensembl NCBI GeneCards UniProt NextProt Show fit	pancreatic lipase
chr16_+_31539183 Show fit	22.23	ENST00000302312.4	AHSP Ensembl NCBI GeneCards UniProt NextProt Show fit	alpha hemoglobin stabilizing protein

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of GATA1_GATA4

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.1	99.1	GO:0015695	organic cation transport(GO:0015695)
3.4	77.8	GO:0044241	lipid digestion(GO:0044241)
6.8	74.4	GO:0043249	erythrocyte maturation(GO:0043249)
4.7	65.8	GO:0015671	oxygen transport(GO:0015671)
3.7	48.4	GO:0006782	protoporphyrinogen IX biosynthetic process(GO:0006782)
1.2	30.0	GO:0006337	nucleosome disassembly(GO:0006337)
2.9	29.1	GO:0001955	blood vessel maturation(GO:0001955)
7.1	28.4	GO:0044333	Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333)
0.4	26.8	GO:0060135	maternal process involved in female pregnancy(GO:0060135)
0.9	24.7	GO:0009235	cobalamin metabolic process(GO:0009235)

Showing 1 to 10 of 345 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	230.6	GO:0005887	integral component of plasma membrane(GO:0005887)
0.1	155.3	GO:0005615	extracellular space(GO:0005615)
7.6	106.3	GO:0005833	hemoglobin complex(GO:0005833)
0.3	60.0	GO:0032993	protein-DNA complex(GO:0032993)
0.1	50.3	GO:0005789	endoplasmic reticulum membrane(GO:0005789)
0.2	49.3	GO:0072562	blood microparticle(GO:0072562)
0.3	41.3	GO:0030863	cortical cytoskeleton(GO:0030863)
0.1	28.0	GO:0005759	mitochondrial matrix(GO:0005759)
0.7	22.4	GO:0031092	platelet alpha granule membrane(GO:0031092)
1.4	18.7	GO:1990712	HFE-transferrin receptor complex(GO:1990712)

Showing 1 to 10 of 128 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	112.6	GO:0004252	serine-type endopeptidase activity(GO:0004252)
3.4	99.1	GO:0008519	ammonium transmembrane transporter activity(GO:0008519)
7.2	93.2	GO:0005344	oxygen transporter activity(GO:0005344)
0.1	53.8	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
5.9	47.0	GO:0003810	protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
1.0	45.4	GO:0050699	WW domain binding(GO:0050699)
0.4	37.9	GO:0005518	collagen binding(GO:0005518)
0.1	36.6	GO:0000987	core promoter proximal region sequence-specific DNA binding(GO:0000987)
1.4	35.8	GO:0004806	triglyceride lipase activity(GO:0004806)
0.7	33.1	GO:0004364	glutathione transferase activity(GO:0004364)

Showing 1 to 10 of 227 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	94.1	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.8	43.7	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.6	43.4	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.7	36.0	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.1	30.8	NABA MATRISOME ASSOCIATED	Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors
0.3	27.0	PID REG GR PATHWAY	Glucocorticoid receptor regulatory network
0.1	18.8	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2	16.0	PID EPO PATHWAY	EPO signaling pathway
0.2	15.3	PID CMYB PATHWAY	C-MYB transcription factor network
0.2	13.8	PID HNF3A PATHWAY	FOXA1 transcription factor network

Showing 1 to 10 of 64 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	96.9	REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	Genes involved in Factors involved in megakaryocyte development and platelet production
1.6	66.0	REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D	Genes involved in Metabolism of steroid hormones and vitamins A and D
1.8	47.3	REACTOME METABOLISM OF PORPHYRINS	Genes involved in Metabolism of porphyrins
0.5	43.8	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.5	43.0	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
1.7	41.3	REACTOME HDL MEDIATED LIPID TRANSPORT	Genes involved in HDL-mediated lipid transport
2.2	38.7	REACTOME XENOBIOTICS	Genes involved in Xenobiotics
0.4	26.0	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.7	24.4	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
0.7	24.2	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins

Showing 1 to 10 of 90 entries

Results for GATA1_GATA4

Z-value: 1.82

Motif logo

Transcription factors associated with GATA1_GATA4

Activity-expression correlation:

Activity profile of GATA1_GATA4 motif

Sorted Z-values of GATA1_GATA4 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of GATA1_GATA4

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: