ISMARA results: HMX3

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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for HMX3

Z-value: 1.41

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Transcription factors associated with HMX3

Gene Symbol	Gene ID	Gene Info
HMX3 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000188620.9	H6 family homeobox 3

Activity profile of HMX3 motif

Sorted Z-values of HMX3 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr5_+_150404904 Show fit	39.89	ENST00000521632.1	GPX3 Ensembl NCBI GeneCards UniProt NextProt Show fit	glutathione peroxidase 3 (plasma)
chr4_-_88450244 Show fit	35.92	ENST00000503414.1	SPARCL1 Ensembl NCBI GeneCards UniProt NextProt Show fit	SPARC-like 1 (hevin)
chr17_-_42992856 Show fit	35.30	ENST00000588316.1 ENST00000435360.2 ENST00000586793.1 ENST00000588735.1 ENST00000588037.1 ENST00000592320.1 ENST00000253408.5	GFAP Ensembl NCBI GeneCards UniProt NextProt Show fit	glial fibrillary acidic protein
chrX_+_38420783 Show fit	31.24	ENST00000422612.2 ENST00000286824.6 ENST00000545599.1	TSPAN7 Ensembl NCBI GeneCards UniProt NextProt Show fit	tetraspanin 7
chrX_+_38420623 Show fit	28.41	ENST00000378482.2	TSPAN7 Ensembl NCBI GeneCards UniProt NextProt Show fit	tetraspanin 7
chr5_+_140227048 Show fit	26.63	ENST00000532602.1	PCDHA9 Ensembl NCBI GeneCards UniProt NextProt Show fit	protocadherin alpha 9
chr9_-_116102562 Show fit	24.61	ENST00000374193.4 ENST00000465979.1	WDR31 Ensembl NCBI GeneCards UniProt NextProt Show fit	WD repeat domain 31
chr11_-_128894053 Show fit	24.59	ENST00000392657.3	ARHGAP32 Ensembl NCBI GeneCards UniProt NextProt Show fit	Rho GTPase activating protein 32
chr9_-_116102530 Show fit	24.05	ENST00000374195.3 ENST00000341761.4	WDR31 Ensembl NCBI GeneCards UniProt NextProt Show fit	WD repeat domain 31
chr5_-_42812143 Show fit	23.15	ENST00000514985.1	SEPP1 Ensembl NCBI GeneCards UniProt NextProt Show fit	selenoprotein P, plasma, 1

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of HMX3

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	58.4	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
8.0	40.0	GO:1903282	negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) regulation of peroxidase activity(GO:2000468) positive regulation of peroxidase activity(GO:2000470)
13.3	39.9	GO:0006982	response to lipid hydroperoxide(GO:0006982)
2.5	35.3	GO:1904714	regulation of chaperone-mediated autophagy(GO:1904714)
0.3	33.4	GO:0006334	nucleosome assembly(GO:0006334)
0.6	31.7	GO:0050911	detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
2.1	25.1	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.2	23.2	GO:0046718	viral entry into host cell(GO:0046718)
1.3	22.9	GO:0097151	positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828)
0.7	22.7	GO:1901685	glutathione derivative metabolic process(GO:1901685) glutathione derivative biosynthetic process(GO:1901687)

Showing 1 to 10 of 316 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	184.7	GO:0031224	intrinsic component of membrane(GO:0031224)
0.1	106.4	GO:0005887	integral component of plasma membrane(GO:0005887)
0.2	49.2	GO:0016323	basolateral plasma membrane(GO:0016323)
0.3	48.5	GO:0043204	perikaryon(GO:0043204)
1.4	44.4	GO:0031092	platelet alpha granule membrane(GO:0031092)
0.3	34.3	GO:0035578	azurophil granule lumen(GO:0035578)
0.3	31.1	GO:0005882	intermediate filament(GO:0005882)
0.0	30.6	GO:0005615	extracellular space(GO:0005615)
0.1	28.8	GO:0045211	postsynaptic membrane(GO:0045211)
0.1	26.8	GO:0005578	proteinaceous extracellular matrix(GO:0005578)

Showing 1 to 10 of 129 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	148.1	GO:0005509	calcium ion binding(GO:0005509)
0.3	49.0	GO:0005200	structural constituent of cytoskeleton(GO:0005200)
0.1	47.4	GO:0030695	GTPase regulator activity(GO:0030695)
3.8	41.7	GO:0008430	selenium binding(GO:0008430)
8.0	40.0	GO:0060961	phospholipase D inhibitor activity(GO:0060961)
0.6	40.0	GO:0050840	extracellular matrix binding(GO:0050840)
0.6	31.1	GO:0030507	spectrin binding(GO:0030507)
0.3	27.1	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.9	23.4	GO:0030169	low-density lipoprotein particle binding(GO:0030169)
0.2	22.5	GO:0004222	metalloendopeptidase activity(GO:0004222)

Showing 1 to 10 of 221 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	66.2	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.9	64.3	PID ALPHA SYNUCLEIN PATHWAY	Alpha-synuclein signaling
0.5	27.9	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.5	23.6	ST GAQ PATHWAY	G alpha q Pathway
0.4	20.9	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway
0.3	14.4	PID ECADHERIN NASCENT AJ PATHWAY	E-cadherin signaling in the nascent adherens junction
0.1	13.4	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.4	10.4	PID CXCR3 PATHWAY	CXCR3-mediated signaling events
0.3	9.8	PID P38 ALPHA BETA PATHWAY	Regulation of p38-alpha and p38-beta
0.2	9.5	PID BMP PATHWAY	BMP receptor signaling

Showing 1 to 10 of 50 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	95.2	REACTOME AMYLOIDS	Genes involved in Amyloids
1.0	31.1	REACTOME CHONDROITIN SULFATE BIOSYNTHESIS	Genes involved in Chondroitin sulfate biosynthesis
0.6	30.2	REACTOME OLFACTORY SIGNALING PATHWAY	Genes involved in Olfactory Signaling Pathway
0.8	27.0	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.4	26.4	REACTOME NUCLEAR SIGNALING BY ERBB4	Genes involved in Nuclear signaling by ERBB4
0.5	25.0	REACTOME ION TRANSPORT BY P TYPE ATPASES	Genes involved in Ion transport by P-type ATPases
0.4	24.0	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
1.3	22.9	REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.6	22.7	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
0.5	21.8	REACTOME CGMP EFFECTS	Genes involved in cGMP effects

Showing 1 to 10 of 84 entries

Results for HMX3

Z-value: 1.41

Motif logo

Transcription factors associated with HMX3

Activity profile of HMX3 motif

Sorted Z-values of HMX3 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of HMX3

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: