ISMARA results: MECOM

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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for MECOM

Z-value: 0.96

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Transcription factors associated with MECOM

Gene Symbol	Gene ID	Gene Info
MECOM Ensembl NCBI GeneCards UniProt NextProt	ENSG00000085276.13	MDS1 and EVI1 complex locus

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
MECOM	hg19_v2_chr3_-_168865522_168865536, hg19_v2_chr3_-_169381183_169381258, hg19_v2_chr3_-_168864427_168864464	-0.03	6.5e-01	Click!

Activity profile of MECOM motif

Sorted Z-values of MECOM motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr4_-_88450244 Show fit	33.21	ENST00000503414.1	SPARCL1 Ensembl NCBI GeneCards UniProt NextProt Show fit	SPARC-like 1 (hevin)
chr12_-_16758059 Show fit	19.10	ENST00000261169.6	LMO3 Ensembl NCBI GeneCards UniProt NextProt Show fit	LIM domain only 3 (rhombotin-like 2)
chr12_-_16758304 Show fit	18.74	ENST00000320122.6	LMO3 Ensembl NCBI GeneCards UniProt NextProt Show fit	LIM domain only 3 (rhombotin-like 2)
chr6_-_31514516 Show fit	16.95	ENST00000303892.5 ENST00000483251.1	ATP6V1G2 Ensembl NCBI GeneCards UniProt NextProt Show fit	ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
chr17_-_66951474 Show fit	16.25	ENST00000269080.2	ABCA8 Ensembl NCBI GeneCards UniProt NextProt Show fit	ATP-binding cassette, sub-family A (ABC1), member 8
chr8_-_27115931 Show fit	15.13	ENST00000523048.1	STMN4 Ensembl NCBI GeneCards UniProt NextProt Show fit	stathmin-like 4
chr6_-_52860171 Show fit	13.61	ENST00000370963.4	GSTA4 Ensembl NCBI GeneCards UniProt NextProt Show fit	glutathione S-transferase alpha 4
chr12_-_15038779 Show fit	13.15	ENST00000228938.5 ENST00000539261.1	MGP Ensembl NCBI GeneCards UniProt NextProt Show fit	matrix Gla protein
chr6_-_52859968 Show fit	12.97	ENST00000370959.1	GSTA4 Ensembl NCBI GeneCards UniProt NextProt Show fit	glutathione S-transferase alpha 4
chr10_+_106034884 Show fit	12.43	ENST00000369707.2 ENST00000429569.2	GSTO2 Ensembl NCBI GeneCards UniProt NextProt Show fit	glutathione S-transferase omega 2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of MECOM

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
6.3	37.8	GO:2000324	positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.1	28.7	GO:0043687	post-translational protein modification(GO:0043687)
0.5	26.7	GO:0007019	microtubule depolymerization(GO:0007019)
0.9	26.6	GO:1901687	glutathione derivative metabolic process(GO:1901685) glutathione derivative biosynthetic process(GO:1901687)
0.2	24.6	GO:0021510	spinal cord development(GO:0021510)
1.7	21.9	GO:0017121	phospholipid scrambling(GO:0017121)
0.1	17.3	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.5	17.0	GO:0090383	phagosome acidification(GO:0090383)
1.5	16.2	GO:0042908	xenobiotic transport(GO:0042908)
0.6	15.6	GO:0001502	cartilage condensation(GO:0001502)

Showing 1 to 10 of 113 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	62.2	GO:0005578	proteinaceous extracellular matrix(GO:0005578)
0.0	36.4	GO:0005887	integral component of plasma membrane(GO:0005887)
0.1	29.3	GO:0030426	growth cone(GO:0030426)
0.1	18.0	GO:0005923	bicellular tight junction(GO:0005923)
0.7	17.0	GO:0016471	vacuolar proton-transporting V-type ATPase complex(GO:0016471)
0.1	13.7	GO:0043204	perikaryon(GO:0043204)
0.0	13.7	GO:0030424	axon(GO:0030424)
0.6	11.9	GO:0031045	dense core granule(GO:0031045)
0.4	11.9	GO:0005868	cytoplasmic dynein complex(GO:0005868)
0.1	11.5	GO:0031093	platelet alpha granule lumen(GO:0031093)

Showing 1 to 10 of 45 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	34.0	GO:0050840	extracellular matrix binding(GO:0050840)
0.1	27.2	GO:0015631	tubulin binding(GO:0015631)
2.0	21.9	GO:0017128	phospholipid scramblase activity(GO:0017128)
0.1	17.0	GO:0016820	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances(GO:0016820)
0.5	16.4	GO:0015248	sterol transporter activity(GO:0015248)
2.0	16.2	GO:0008559	xenobiotic-transporting ATPase activity(GO:0008559)
0.1	16.2	GO:0004222	metalloendopeptidase activity(GO:0004222)
0.0	15.3	GO:0001077	transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
1.8	14.8	GO:0015349	thyroid hormone transmembrane transporter activity(GO:0015349)
0.3	14.8	GO:0004364	glutathione transferase activity(GO:0004364)

Showing 1 to 10 of 90 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	60.5	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.1	21.8	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.3	13.0	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.1	12.0	PID REG GR PATHWAY	Glucocorticoid receptor regulatory network
0.1	9.8	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.4	9.4	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.1	8.6	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.0	8.1	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1	7.9	PID INTEGRIN1 PATHWAY	Beta1 integrin cell surface interactions
0.1	6.7	PID ALK1 PATHWAY	ALK1 signaling events

Showing 1 to 10 of 27 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.1	39.0	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
0.1	27.6	REACTOME PEPTIDE LIGAND BINDING RECEPTORS	Genes involved in Peptide ligand-binding receptors
0.9	20.0	REACTOME TRANSPORT OF ORGANIC ANIONS	Genes involved in Transport of organic anions
0.1	18.7	REACTOME MHC CLASS II ANTIGEN PRESENTATION	Genes involved in MHC class II antigen presentation
0.6	17.0	REACTOME INSULIN RECEPTOR RECYCLING	Genes involved in Insulin receptor recycling
0.4	16.2	REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT	Genes involved in ABC-family proteins mediated transport
0.4	13.1	REACTOME STEROID HORMONES	Genes involved in Steroid hormones
0.2	11.8	REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS	Genes involved in Phase 1 - Functionalization of compounds
0.2	10.9	REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1	10.8	REACTOME INTEGRIN CELL SURFACE INTERACTIONS	Genes involved in Integrin cell surface interactions

Showing 1 to 10 of 33 entries

Results for MECOM

Z-value: 0.96

Motif logo

Transcription factors associated with MECOM

Activity-expression correlation:

Activity profile of MECOM motif

Sorted Z-values of MECOM motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of MECOM

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: