Project
GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
Navigation
Downloads
Results for POU3F3_POU3F4
Z-value: 1.37
Motif logo
Transcription factors associated with POU3F3_POU3F4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| POU3F3 | hg19_v2_chr2_+_105471969_105471969 | 0.38 | 7.2e-09 | Click! |
| POU3F4 | hg19_v2_chrX_+_82763265_82763283 | 0.35 | 1.2e-07 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_+_158142750 Show fit | 71.76 |
ENST00000505888.1
ENST00000449365.1 |
glutamate receptor, ionotropic, AMPA 2 |
|
| chr4_+_158141899 Show fit | 66.41 |
ENST00000264426.9
ENST00000506284.1 |
glutamate receptor, ionotropic, AMPA 2 |
|
| chr15_-_45670924 Show fit | 66.02 |
ENST00000396659.3
|
glycine amidinotransferase (L-arginine:glycine amidinotransferase) |
|
| chr3_-_58613323 Show fit | 50.77 |
ENST00000474531.1
ENST00000465970.1 |
family with sequence similarity 107, member A |
|
| chr5_+_140762268 Show fit | 44.45 |
ENST00000518325.1
|
protocadherin gamma subfamily A, 7 |
|
| chr6_-_46459675 Show fit | 40.38 |
ENST00000306764.7
|
regulator of calcineurin 2 |
|
| chr14_-_60097297 Show fit | 34.73 |
ENST00000395090.1
|
reticulon 1 |
|
| chr14_-_21270561 Show fit | 32.56 |
ENST00000412779.2
|
ribonuclease, RNase A family, 1 (pancreatic) |
|
| chr14_-_21270995 Show fit | 29.58 |
ENST00000555698.1
ENST00000397970.4 ENST00000340900.3 |
ribonuclease, RNase A family, 1 (pancreatic) |
|
| chr5_-_11588907 Show fit | 28.42 |
ENST00000513598.1
ENST00000503622.1 |
catenin (cadherin-associated protein), delta 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of POU3F3_POU3F4
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.4 | 165.1 | GO:0035235 | ionotropic glutamate receptor signaling pathway(GO:0035235) |
| 0.5 | 76.3 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 6.0 | 66.0 | GO:0006600 | creatine metabolic process(GO:0006600) |
| 0.1 | 56.9 | GO:0001558 | regulation of cell growth(GO:0001558) |
| 0.8 | 56.3 | GO:0090502 | RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502) |
| 0.7 | 50.0 | GO:0060997 | dendritic spine morphogenesis(GO:0060997) |
| 2.3 | 28.1 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 2.8 | 25.3 | GO:0003190 | atrioventricular valve formation(GO:0003190) |
| 0.1 | 24.7 | GO:0034605 | cellular response to heat(GO:0034605) |
| 2.2 | 24.6 | GO:0006554 | lysine catabolic process(GO:0006554) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 32.3 | 161.3 | GO:0098843 | postsynaptic endocytic zone(GO:0098843) |
| 0.7 | 67.5 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.3 | 52.3 | GO:0043204 | perikaryon(GO:0043204) |
| 0.1 | 43.0 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.3 | 41.4 | GO:0031227 | intrinsic component of endoplasmic reticulum membrane(GO:0031227) |
| 0.1 | 29.8 | GO:0043025 | neuronal cell body(GO:0043025) |
| 2.0 | 28.1 | GO:0005589 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 1.2 | 25.3 | GO:0044295 | axonal growth cone(GO:0044295) |
| 2.6 | 23.4 | GO:0005955 | calcineurin complex(GO:0005955) |
| 0.4 | 23.4 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 13.4 | 161.3 | GO:0004971 | AMPA glutamate receptor activity(GO:0004971) |
| 2.6 | 66.0 | GO:0016769 | transferase activity, transferring nitrogenous groups(GO:0016769) |
| 10.4 | 62.1 | GO:0004522 | ribonuclease A activity(GO:0004522) |
| 0.1 | 52.1 | GO:0005509 | calcium ion binding(GO:0005509) |
| 6.7 | 40.4 | GO:0008597 | calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597) |
| 0.3 | 39.0 | GO:0008013 | beta-catenin binding(GO:0008013) |
| 0.1 | 30.1 | GO:0005516 | calmodulin binding(GO:0005516) |
| 0.4 | 28.1 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 2.0 | 26.3 | GO:0001087 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 6.2 | 24.6 | GO:0016639 | oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.8 | 161.3 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.9 | 49.5 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.5 | 25.8 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.2 | 24.4 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.4 | 17.7 | ST GRANULE CELL SURVIVAL PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
| 0.2 | 17.7 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.2 | 16.5 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.2 | 12.9 | PID ATR PATHWAY | ATR signaling pathway |
| 0.1 | 5.2 | SIG BCR SIGNALING PATHWAY | Members of the BCR signaling pathway |
| 0.1 | 5.1 | PID ENDOTHELIN PATHWAY | Endothelins |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.7 | 161.3 | REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION | Genes involved in Unblocking of NMDA receptor, glutamate binding and activation |
| 0.2 | 51.4 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 1.0 | 28.1 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.5 | 26.3 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.6 | 21.4 | REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT | Genes involved in ABC-family proteins mediated transport |
| 0.4 | 20.4 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.5 | 20.2 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.3 | 18.5 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 1.6 | 17.3 | REACTOME DIGESTION OF DIETARY CARBOHYDRATE | Genes involved in Digestion of dietary carbohydrate |
| 0.8 | 16.0 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |