Project
GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
Navigation
Downloads
Results for RELA
Z-value: 1.01
Motif logo
Transcription factors associated with RELA
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RELA | hg19_v2_chr11_-_65430554_65430579 | 0.57 | 5.2e-20 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of RELA
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 9.5 | 57.0 | GO:0070427 | nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427) |
| 18.8 | 56.4 | GO:0085032 | modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032) |
| 0.9 | 41.7 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
| 0.4 | 39.1 | GO:0060333 | interferon-gamma-mediated signaling pathway(GO:0060333) |
| 1.3 | 34.5 | GO:0090023 | positive regulation of neutrophil chemotaxis(GO:0090023) |
| 3.7 | 33.3 | GO:0070424 | regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070424) |
| 3.3 | 33.0 | GO:0002480 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480) |
| 0.9 | 29.0 | GO:0060334 | regulation of interferon-gamma-mediated signaling pathway(GO:0060334) |
| 3.1 | 28.1 | GO:0045075 | interleukin-12 biosynthetic process(GO:0042090) regulation of interleukin-12 biosynthetic process(GO:0045075) |
| 2.6 | 26.0 | GO:1900029 | positive regulation of ruffle assembly(GO:1900029) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.0 | 72.1 | GO:0033256 | I-kappaB/NF-kappaB complex(GO:0033256) |
| 0.1 | 36.4 | GO:0010008 | endosome membrane(GO:0010008) |
| 1.6 | 33.7 | GO:0042611 | MHC protein complex(GO:0042611) MHC class II protein complex(GO:0042613) |
| 3.0 | 33.0 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 0.1 | 29.8 | GO:0045121 | membrane raft(GO:0045121) membrane microdomain(GO:0098857) |
| 0.1 | 27.3 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.3 | 24.8 | GO:0030670 | phagocytic vesicle membrane(GO:0030670) |
| 0.3 | 21.4 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.1 | 20.5 | GO:0005764 | lytic vacuole(GO:0000323) lysosome(GO:0005764) |
| 0.1 | 20.2 | GO:0000793 | condensed chromosome(GO:0000793) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 56.4 | GO:0051019 | mitogen-activated protein kinase binding(GO:0051019) |
| 0.9 | 41.7 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 1.1 | 40.8 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.8 | 38.2 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 0.6 | 30.0 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 2.1 | 29.0 | GO:0032395 | MHC class II receptor activity(GO:0032395) |
| 0.1 | 28.6 | GO:0003924 | GTPase activity(GO:0003924) |
| 2.8 | 28.1 | GO:0061578 | Lys63-specific deubiquitinase activity(GO:0061578) |
| 1.6 | 26.1 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 2.2 | 26.0 | GO:0000774 | adenyl-nucleotide exchange factor activity(GO:0000774) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.7 | 111.8 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 1.1 | 46.3 | ST TUMOR NECROSIS FACTOR PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.6 | 32.4 | PID IL8 CXCR2 PATHWAY | IL8- and CXCR2-mediated signaling events |
| 0.4 | 26.7 | ST FAS SIGNALING PATHWAY | Fas Signaling Pathway |
| 0.5 | 24.4 | PID IL23 PATHWAY | IL23-mediated signaling events |
| 0.4 | 22.6 | PID IL12 2PATHWAY | IL12-mediated signaling events |
| 0.6 | 20.9 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.9 | 20.1 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.2 | 18.7 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.5 | 18.2 | ST GRANULE CELL SURVIVAL PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 72.1 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 1.9 | 46.1 | REACTOME REGULATION OF IFNG SIGNALING | Genes involved in Regulation of IFNG signaling |
| 0.9 | 44.2 | REACTOME SEMA4D IN SEMAPHORIN SIGNALING | Genes involved in Sema4D in semaphorin signaling |
| 0.8 | 34.8 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.5 | 34.3 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 3.3 | 33.0 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.4 | 26.7 | REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 | Genes involved in Autodegradation of the E3 ubiquitin ligase COP1 |
| 1.8 | 26.5 | REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL | Genes involved in NF-kB is activated and signals survival |
| 0.5 | 26.0 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 1.2 | 23.8 | REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |