ISMARA results: RORA

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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for RORA

Z-value: 0.98

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Transcription factors associated with RORA

Gene Symbol	Gene ID	Gene Info
RORA Ensembl NCBI GeneCards UniProt NextProt	ENSG00000069667.11	RAR related orphan receptor A

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
RORA	hg19_v2_chr15_-_60884706_60884743, hg19_v2_chr15_-_61521495_61521518	-0.05	4.6e-01	Click!

Activity profile of RORA motif

Sorted Z-values of RORA motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr20_+_3776371 Show fit	30.51	ENST00000245960.5	CDC25B Ensembl NCBI GeneCards UniProt NextProt Show fit	cell division cycle 25B
chr20_+_3776936 Show fit	29.46	ENST00000439880.2	CDC25B Ensembl NCBI GeneCards UniProt NextProt Show fit	cell division cycle 25B
chr16_-_88717423 Show fit	27.08	ENST00000568278.1 ENST00000569359.1 ENST00000567174.1	CYBA Ensembl NCBI GeneCards UniProt NextProt Show fit	cytochrome b-245, alpha polypeptide
chr1_+_43148625 Show fit	25.26	ENST00000436427.1	YBX1 Ensembl NCBI GeneCards UniProt NextProt Show fit	Y box binding protein 1
chr14_-_58893832 Show fit	22.30	ENST00000556007.2	TIMM9 Ensembl NCBI GeneCards UniProt NextProt Show fit	translocase of inner mitochondrial membrane 9 homolog (yeast)
chr7_+_112063192 Show fit	20.89	ENST00000005558.4	IFRD1 Ensembl NCBI GeneCards UniProt NextProt Show fit	interferon-related developmental regulator 1
chr1_-_150207017 Show fit	20.17	ENST00000369119.3	ANP32E Ensembl NCBI GeneCards UniProt NextProt Show fit	acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr6_-_41039567 Show fit	19.49	ENST00000468811.1	OARD1 Ensembl NCBI GeneCards UniProt NextProt Show fit	O-acyl-ADP-ribose deacylase 1
chr12_-_53320245 Show fit	19.47	ENST00000552150.1	KRT8 Ensembl NCBI GeneCards UniProt NextProt Show fit	keratin 8
chr9_-_35103105 Show fit	19.40	ENST00000452248.2 ENST00000356493.5	STOML2 Ensembl NCBI GeneCards UniProt NextProt Show fit	stomatin (EPB72)-like 2

Showing 1 to 10 of 140 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of RORA

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
6.0	60.0	GO:0007144	female meiosis I(GO:0007144)
6.1	42.4	GO:1904044	response to aldosterone(GO:1904044)
0.6	39.7	GO:0006120	mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
4.5	31.5	GO:0070934	CRD-mediated mRNA stabilization(GO:0070934)
0.6	24.5	GO:0042407	cristae formation(GO:0042407)
2.5	22.3	GO:0045039	protein import into mitochondrial inner membrane(GO:0045039)
1.1	22.1	GO:0033169	histone H3-K9 demethylation(GO:0033169)
1.8	21.3	GO:0046051	UTP biosynthetic process(GO:0006228) UTP metabolic process(GO:0046051)
7.0	20.9	GO:0007518	myoblast fate determination(GO:0007518)
0.4	20.2	GO:0043486	histone exchange(GO:0043486)

Showing 1 to 10 of 87 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	64.5	GO:0005758	mitochondrial intermembrane space(GO:0005758)
0.3	58.0	GO:0000922	spindle pole(GO:0000922)
0.2	44.0	GO:0101002	ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
3.9	31.5	GO:0071204	histone pre-mRNA 3'end processing complex(GO:0071204)
0.5	28.7	GO:0005747	mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.9	27.9	GO:0005753	mitochondrial proton-transporting ATP synthase complex(GO:0005753)
1.6	27.1	GO:0043020	NADPH oxidase complex(GO:0043020)
0.1	27.0	GO:0005759	mitochondrial matrix(GO:0005759)
5.6	22.3	GO:0042721	mitochondrial inner membrane protein insertion complex(GO:0042721)
1.0	20.2	GO:0000812	Swr1 complex(GO:0000812)

Showing 1 to 10 of 51 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	60.3	GO:0004725	protein tyrosine phosphatase activity(GO:0004725)
0.3	40.1	GO:0003697	single-stranded DNA binding(GO:0003697)
0.7	39.7	GO:0050136	NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0	32.9	GO:0008270	zinc ion binding(GO:0008270)
1.4	27.1	GO:0016175	superoxide-generating NADPH oxidase activity(GO:0016175)
0.2	22.3	GO:0008565	protein transporter activity(GO:0008565)
1.2	22.1	GO:0032454	histone demethylase activity (H3-K9 specific)(GO:0032454)
0.3	19.5	GO:0019213	deacetylase activity(GO:0019213)
2.2	19.4	GO:1901612	cardiolipin binding(GO:1901612)
0.2	19.0	GO:0097110	scaffold protein binding(GO:0097110)

Showing 1 to 10 of 76 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
4.3	60.0	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.3	33.1	PID PTP1B PATHWAY	Signaling events mediated by PTP1B
0.4	27.7	PID P38 ALPHA BETA DOWNSTREAM PATHWAY	Signaling mediated by p38-alpha and p38-beta
0.4	27.1	PID RAC1 PATHWAY	RAC1 signaling pathway
0.4	26.9	PID CERAMIDE PATHWAY	Ceramide signaling pathway
0.6	17.6	PID ARF6 DOWNSTREAM PATHWAY	Arf6 downstream pathway
0.0	14.7	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.3	14.0	PID INTEGRIN CS PATHWAY	Integrin family cell surface interactions
0.4	13.9	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.1	10.1	PID E2F PATHWAY	E2F transcription factor network

Showing 1 to 10 of 25 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	70.1	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
2.2	60.0	REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION	Genes involved in Cyclin A/B1 associated events during G2/M transition
1.1	35.7	REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.7	31.3	REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS	Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.2	28.7	REACTOME MRNA SPLICING	Genes involved in mRNA Splicing
0.5	27.7	REACTOME MITOCHONDRIAL PROTEIN IMPORT	Genes involved in Mitochondrial Protein Import
0.2	23.9	REACTOME INTEGRIN CELL SURFACE INTERACTIONS	Genes involved in Integrin cell surface interactions
0.1	18.8	REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	Genes involved in Factors involved in megakaryocyte development and platelet production
0.1	14.4	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.7	13.9	REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION	Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation

Showing 1 to 10 of 31 entries

Results for RORA

Z-value: 0.98

Motif logo

Transcription factors associated with RORA

Activity-expression correlation:

Activity profile of RORA motif

Sorted Z-values of RORA motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of RORA

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: