ISMARA results: SIN3A

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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for SIN3A_CHD1

Z-value: 1.72

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Transcription factors associated with SIN3A_CHD1

Gene Symbol	Gene ID	Gene Info
SIN3A Ensembl NCBI GeneCards UniProt NextProt	ENSG00000169375.11	SIN3 transcription regulator family member A
CHD1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000153922.6	chromodomain helicase DNA binding protein 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
CHD1	hg19_v2_chr5_-_98262240_98262240	0.30	5.7e-06	Click!
SIN3A	hg19_v2_chr15_-_75743991_75744011	0.20	2.4e-03	Click!

Activity profile of SIN3A_CHD1 motif

Sorted Z-values of SIN3A_CHD1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr7_-_140178775 Show fit	28.70	ENST00000474576.1 ENST00000473444.1 ENST00000471104.1	MKRN1 Ensembl NCBI GeneCards UniProt NextProt Show fit	makorin ring finger protein 1
chr13_-_77900814 Show fit	23.91	ENST00000544440.2	MYCBP2 Ensembl NCBI GeneCards UniProt NextProt Show fit	MYC binding protein 2, E3 ubiquitin protein ligase
chr2_+_87140935 Show fit	23.68	ENST00000398193.3	RGPD1 Ensembl NCBI GeneCards UniProt NextProt Show fit	RANBP2-like and GRIP domain containing 1
chr3_-_18466787 Show fit	23.03	ENST00000338745.6 ENST00000450898.1	SATB1 Ensembl NCBI GeneCards UniProt NextProt Show fit	SATB homeobox 1
chr13_-_77901177 Show fit	22.16	ENST00000407578.2 ENST00000357337.6 ENST00000360084.5	MYCBP2 Ensembl NCBI GeneCards UniProt NextProt Show fit	MYC binding protein 2, E3 ubiquitin protein ligase
chr17_+_36861735 Show fit	20.74	ENST00000378137.5 ENST00000325718.7	MLLT6 Ensembl NCBI GeneCards UniProt NextProt Show fit	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
chr11_-_46142948 Show fit	19.48	ENST00000257821.4	PHF21A Ensembl NCBI GeneCards UniProt NextProt Show fit	PHD finger protein 21A
chr16_-_58231782 Show fit	19.45	ENST00000565188.1 ENST00000262506.3	CSNK2A2 Ensembl NCBI GeneCards UniProt NextProt Show fit	casein kinase 2, alpha prime polypeptide
chr8_+_56014949 Show fit	18.48	ENST00000327381.6	XKR4 Ensembl NCBI GeneCards UniProt NextProt Show fit	XK, Kell blood group complex subunit-related family, member 4
chr20_+_57466629 Show fit	18.30	ENST00000371081.1 ENST00000338783.6	GNAS Ensembl NCBI GeneCards UniProt NextProt Show fit	GNAS complex locus

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of SIN3A_CHD1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	66.8	GO:0000209	protein polyubiquitination(GO:0000209)
0.5	66.4	GO:0006333	chromatin assembly or disassembly(GO:0006333)
1.6	45.1	GO:0000042	protein targeting to Golgi(GO:0000042)
11.2	44.9	GO:0071894	histone H2B conserved C-terminal lysine ubiquitination(GO:0071894)
2.5	40.2	GO:0043374	CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.5	36.8	GO:0006369	termination of RNA polymerase II transcription(GO:0006369)
0.4	36.4	GO:0007286	spermatid development(GO:0007286)
0.8	31.6	GO:0007214	gamma-aminobutyric acid signaling pathway(GO:0007214)
0.2	31.3	GO:0006325	chromatin organization(GO:0006325)
1.0	31.2	GO:0048268	clathrin coat assembly(GO:0048268)

Showing 1 to 10 of 982 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	163.5	GO:0016607	nuclear speck(GO:0016607)
0.1	108.4	GO:0005654	nucleoplasm(GO:0005654)
0.3	103.4	GO:0000785	chromatin(GO:0000785)
0.0	88.5	GO:0005634	nucleus(GO:0005634)
0.1	76.3	GO:0005730	nucleolus(GO:0005730)
0.3	57.7	GO:0005694	chromosome(GO:0005694)
0.5	57.6	GO:0016363	nuclear matrix(GO:0016363)
0.3	53.9	GO:0000793	condensed chromosome(GO:0000793)
0.2	51.0	GO:0000151	ubiquitin ligase complex(GO:0000151)
0.4	49.3	GO:0034705	voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)

Showing 1 to 10 of 363 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	169.3	GO:0003677	DNA binding(GO:0003677)
0.5	88.6	GO:0061659	ubiquitin-like protein ligase activity(GO:0061659)
1.5	87.9	GO:0004407	histone deacetylase activity(GO:0004407)
1.9	56.7	GO:0000993	RNA polymerase II core binding(GO:0000993)
0.2	50.2	GO:0005096	GTPase activator activity(GO:0005096)
1.3	47.1	GO:0031624	ubiquitin conjugating enzyme binding(GO:0031624)
0.5	42.1	GO:0101005	thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.5	37.6	GO:0042393	histone binding(GO:0042393)
0.4	36.6	GO:0004386	helicase activity(GO:0004386)
2.0	36.1	GO:0019992	diacylglycerol binding(GO:0019992)

Showing 1 to 10 of 565 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	60.1	PID AR TF PATHWAY	Regulation of Androgen receptor activity
1.0	56.0	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway
0.7	41.2	PID BCR 5PATHWAY	BCR signaling pathway
0.4	35.8	PID E2F PATHWAY	E2F transcription factor network
0.8	35.0	PID RAS PATHWAY	Regulation of Ras family activation
1.5	33.4	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.4	33.3	PID NOTCH PATHWAY	Notch signaling pathway
0.9	33.2	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
0.8	32.7	PID GMCSF PATHWAY	GMCSF-mediated signaling events
0.8	30.1	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II

Showing 1 to 10 of 97 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	80.3	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
1.2	53.2	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.7	38.6	REACTOME G1 PHASE	Genes involved in G1 Phase
1.0	37.8	REACTOME SIGNALING BY FGFR1 FUSION MUTANTS	Genes involved in Signaling by FGFR1 fusion mutants
1.2	34.7	REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	Genes involved in Trafficking of GluR2-containing AMPA receptors
1.1	30.7	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
0.6	30.1	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.4	29.6	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.7	28.8	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.6	27.7	REACTOME VOLTAGE GATED POTASSIUM CHANNELS	Genes involved in Voltage gated Potassium channels

Showing 1 to 10 of 158 entries

Results for SIN3A_CHD1

Z-value: 1.72

Motif logo

Transcription factors associated with SIN3A_CHD1

Activity-expression correlation:

Activity profile of SIN3A_CHD1 motif

Sorted Z-values of SIN3A_CHD1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of SIN3A_CHD1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: