Motif ID: ADNP_IRX_SIX_ZHX.p2

Z-value: 1.019


Transcription factors associated with ADNP_IRX_SIX_ZHX.p2:

Gene SymbolEntrez IDGene Name
ADNP 23394 activity-dependent neuroprotector homeobox
IRX4 50805 iroquois homeobox 4
IRX5 10265 iroquois homeobox 5
SIX2 10736 SIX homeobox 2
SIX5 147912 SIX homeobox 5
ZHX1 11244 zinc fingers and homeoboxes 1
ZHX2 22882 zinc fingers and homeoboxes 2
ZHX3 23051 zinc fingers and homeoboxes 3



Activity profile for motif ADNP_IRX_SIX_ZHX.p2.

activity profile for motif ADNP_IRX_SIX_ZHX.p2


Sorted Z-values histogram for motif ADNP_IRX_SIX_ZHX.p2

Sorted Z-values for motif ADNP_IRX_SIX_ZHX.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ADNP_IRX_SIX_ZHX.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_64414389 3.739 NM_015153
 PHF3
PHD finger protein 3
chr7_-_132371208 2.298 EEF1G
eukaryotic translation elongation factor 1 gamma
chr3_-_33675484 1.973 CLASP2
cytoplasmic linker associated protein 2
chr10_+_129237602 1.733 NM_001030013
 NPS
neuropeptide S
chr11_+_101488380 1.678 NM_001195045
 YAP1
Yes-associated protein 1
chr9_-_14076901 1.672 NFIB
nuclear factor I/B
chr1_+_84402962 1.647 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr3_+_174598937 1.640 NM_014932
 NLGN1
neuroligin 1
chrX_+_85404626 1.627 NM_001139515
 DACH2
dachshund homolog 2 (Drosophila)
chr10_+_83627422 1.603 NM_001165973
 NRG3
neuregulin 3
chr6_+_64344307 1.602 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr4_+_146250978 1.598 ABCE1
ATP-binding cassette, sub-family E (OABP), member 1
chr2_+_166137091 1.548 NM_024969
 CSRNP3
cysteine-serine-rich nuclear protein 3
chr3_-_115380539 1.537 NM_000796
NM_033663
 DRD3

dopamine receptor D3

chr9_+_102244005 1.516 NM_001198812
 C9orf3-TMEFF1
C9orf30
C9orf3-TMEFF1 readthrough
chromosome 9 open reading frame 30
chrX_+_56772391 1.430 LOC550643
hypothetical LOC550643
chr4_+_74520796 1.424 NM_001134
 AFP
alpha-fetoprotein
chr7_+_106897737 1.373 NM_005295
 GPR22
G protein-coupled receptor 22
chr6_+_29249289 1.368 NM_030905
 OR2J2
olfactory receptor, family 2, subfamily J, member 2
chrX_+_114734074 1.356 NM_001136025
NM_001172335
 PLS3

plastin 3


Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 7 of 7 entries
enrichment   p-value GO term description
3.32 1.96e-30 GO:0007608 sensory perception of smell
3.21 1.21e-31 GO:0007606 sensory perception of chemical stimulus
2.36 1.61e-23 GO:0007600 sensory perception
1.96 5.60e-21 GO:0050877 neurological system process
1.80 4.92e-19 GO:0003008 system process
1.24 2.32e-06 GO:0032501 multicellular organismal process
1.23 4.66e-08 GO:0050896 response to stimulus

Gene overrepresentation in compartment category:

Showing 1 to 6 of 6 entries
enrichment   p-value GO term description
3.20 7.71e-03 GO:0034707 chloride channel complex
1.32 1.03e-09 GO:0005886 plasma membrane
1.31 2.09e-09 GO:0071944 cell periphery
1.17 2.49e-03 GO:0016021 integral to membrane
1.15 7.67e-03 GO:0031224 intrinsic to membrane
1.13 1.55e-02 GO:0044425 membrane part

Gene overrepresentation in function category:

Showing 1 to 12 of 12 entries
enrichment   p-value GO term description
5.69 1.27e-03 GO:0004890 GABA-A receptor activity
4.91 6.87e-03 GO:0016917 GABA receptor activity
4.24 1.35e-02 GO:0015020 glucuronosyltransferase activity
3.42 6.90e-32 GO:0004984 olfactory receptor activity
3.04 2.82e-03 GO:0005254 chloride channel activity
2.84 5.55e-03 GO:0005253 anion channel activity
2.43 8.34e-04 GO:0008509 anion transmembrane transporter activity
2.33 4.11e-24 GO:0004930 G-protein coupled receptor activity
1.91 1.14e-18 GO:0004888 transmembrane receptor activity
1.68 1.96e-14 GO:0004872 receptor activity
1.54 7.56e-12 GO:0004871 signal transducer activity
1.54 7.56e-12 GO:0060089 molecular transducer activity