Motif ID: ADNP_IRX_SIX_ZHX.p2

Z-value: 1.019


Transcription factors associated with ADNP_IRX_SIX_ZHX.p2:

Gene SymbolEntrez IDGene Name
ADNP 23394 activity-dependent neuroprotector homeobox
IRX4 50805 iroquois homeobox 4
IRX5 10265 iroquois homeobox 5
SIX2 10736 SIX homeobox 2
SIX5 147912 SIX homeobox 5
ZHX1 11244 zinc fingers and homeoboxes 1
ZHX2 22882 zinc fingers and homeoboxes 2
ZHX3 23051 zinc fingers and homeoboxes 3



Activity profile for motif ADNP_IRX_SIX_ZHX.p2.

activity profile for motif ADNP_IRX_SIX_ZHX.p2


Sorted Z-values histogram for motif ADNP_IRX_SIX_ZHX.p2

Sorted Z-values for motif ADNP_IRX_SIX_ZHX.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ADNP_IRX_SIX_ZHX.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_+_64414389 3.739 NM_015153
PHF3
PHD finger protein 3
chr7_-_132371208 2.298 EEF1G
eukaryotic translation elongation factor 1 gamma
chr3_-_33675484 1.973 CLASP2
cytoplasmic linker associated protein 2
chr10_+_129237602 1.733 NM_001030013
NPS
neuropeptide S
chr11_+_101488380 1.678 NM_001195045
YAP1
Yes-associated protein 1
chr9_-_14076901 1.672 NFIB
nuclear factor I/B
chr1_+_84402962 1.647 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr3_+_174598937 1.640 NM_014932
NLGN1
neuroligin 1
chrX_+_85404626 1.627 NM_001139515
DACH2
dachshund homolog 2 (Drosophila)
chr10_+_83627422 1.603 NM_001165973
NRG3
neuregulin 3
chr6_+_64344307 1.602 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr4_+_146250978 1.598 ABCE1
ATP-binding cassette, sub-family E (OABP), member 1
chr2_+_166137091 1.548 NM_024969
CSRNP3
cysteine-serine-rich nuclear protein 3
chr3_-_115380539 1.537 NM_000796
NM_033663
DRD3

dopamine receptor D3

chr9_+_102244005 1.516 NM_001198812
C9orf3-TMEFF1
C9orf30
C9orf3-TMEFF1 readthrough
chromosome 9 open reading frame 30
chrX_+_56772391 1.430 LOC550643
hypothetical LOC550643
chr4_+_74520796 1.424 NM_001134
AFP
alpha-fetoprotein
chr7_+_106897737 1.373 NM_005295
GPR22
G protein-coupled receptor 22
chr6_+_29249289 1.368 NM_030905
OR2J2
olfactory receptor, family 2, subfamily J, member 2
chrX_+_114734074 1.356 NM_001136025
NM_001172335
PLS3

plastin 3

chr15_+_47502666 1.341 NM_002009
FGF7
fibroblast growth factor 7
chr7_-_141604323 1.325 NM_001001317
TRYX3
trypsin X3
chr6_-_127882192 1.264 NM_001012279
C6orf174
chromosome 6 open reading frame 174
chrX_+_28515479 1.258 NM_014271
IL1RAPL1
interleukin 1 receptor accessory protein-like 1
chr6_+_144227265 1.237 NM_001013623
C6orf94
chromosome 6 open reading frame 94
chr2_-_210726539 1.205 C2orf67
chromosome 2 open reading frame 67
chr12_+_29267863 1.193 NM_018099
FAR2
fatty acyl CoA reductase 2
chr6_-_29163027 1.190 NM_001005226
OR2B3
olfactory receptor, family 2, subfamily B, member 3
chr3_-_27473248 1.116 NM_003615
SLC4A7
solute carrier family 4, sodium bicarbonate cotransporter, member 7
chr7_+_129057152 1.098 NM_001040110
NRF1
nuclear respiratory factor 1
chr14_+_19458580 1.089 NM_001005483
OR4K5
olfactory receptor, family 4, subfamily K, member 5
chr21_+_37713076 1.082 NM_130436
DYRK1A
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
chr3_-_166278969 1.074 NM_001041
SI
sucrase-isomaltase (alpha-glucosidase)
chr6_+_55300225 1.064 NM_207410
GFRAL
GDNF family receptor alpha like
chr7_+_115650240 1.060 NM_152829
TES
testis derived transcript (3 LIM domains)
chr4_-_79322295 1.053


chr8_+_17440664 1.008 NM_001164771
NM_003046
SLC7A2

solute carrier family 7 (cationic amino acid transporter, y+ system), member 2

chr1_+_78243181 0.994 NM_007034
DNAJB4
DnaJ (Hsp40) homolog, subfamily B, member 4
chr5_-_27074407 0.976 NM_016279
CDH9
cadherin 9, type 2 (T1-cadherin)
chr11_-_55661769 0.963 NM_001004064
OR8J3
olfactory receptor, family 8, subfamily J, member 3
chr1_+_74473672 0.955 NM_015978
TNNI3K
TNNI3 interacting kinase
chr3_-_57209319 0.954 NM_003865
HESX1
HESX homeobox 1
chr14_+_95915774 0.934 NM_016472
C14orf129
chromosome 14 open reading frame 129
chr16_+_68238460 0.918 NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr5_+_81636921 0.904 NM_001017971
ATP6AP1L
ATPase, H+ transporting, lysosomal accessory protein 1-like
chr6_-_25982418 0.904 NM_001098486
NM_006632
SLC17A3

solute carrier family 17 (sodium phosphate), member 3

chr2_-_210888010 0.887 NM_079420
MYL1
myosin, light chain 1, alkali; skeletal, fast
chr21_+_24722913 0.887 FLJ42200
FLJ42200 protein
chr5_+_161045235 0.884 NM_000811
GABRA6
gamma-aminobutyric acid (GABA) A receptor, alpha 6
chr15_+_100163424 0.880 NM_001005326
OR4F6
olfactory receptor, family 4, subfamily F, member 6
chr4_+_146820805 0.879 NM_001080531
C4orf51
chromosome 4 open reading frame 51
chr12_+_79362256 0.873 NM_001145026
PTPRQ
protein tyrosine phosphatase, receptor type, Q
chr2_-_121875610 0.871 CLASP1
cytoplasmic linker associated protein 1
chr12_+_9871343 0.851 NM_016523
KLRF1
killer cell lectin-like receptor subfamily F, member 1
chr5_-_168204430 0.847


chr4_-_152366970 0.845 NM_001009555
NM_001128923
SH3D19

SH3 domain containing 19

chr2_+_228064531 0.836 AGFG1
ArfGAP with FG repeats 1
chr5_-_88235624 0.836 NM_001131005
NM_001193347
MEF2C

myocyte enhancer factor 2C

chr6_-_133008834 0.832 NM_138327
TAAR1
trace amine associated receptor 1
chr6_-_109795925 0.831 CD164
CD164 molecule, sialomucin
chr6_-_49820030 0.819 NM_001190986
NM_006061
CRISP3

cysteine-rich secretory protein 3

chr17_-_36444626 0.819 NM_030966
KRTAP1-3
keratin associated protein 1-3
chr1_+_246635918 0.809 NM_030904
OR2T1
olfactory receptor, family 2, subfamily T, member 1
chr2_+_33592445 0.797 NM_015376
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr1_-_191422346 0.794 NM_003783
B3GALT2
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
chr1_-_103269356 0.783 COL11A1
collagen, type XI, alpha 1
chr16_+_68284252 0.780 NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr15_+_55298908 0.776 NM_207040
TCF12
transcription factor 12
chr6_+_136214495 0.772 NM_018945
PDE7B
phosphodiesterase 7B
chr4_-_20914626 0.770 NM_147183
KCNIP4
Kv channel interacting protein 4
chrX_+_110074124 0.768 NM_001128166
NM_001128167
PAK3

p21 protein (Cdc42/Rac)-activated kinase 3

chr15_-_53996597 0.764 NM_198400
NEDD4
neural precursor cell expressed, developmentally down-regulated 4
chr11_-_16454493 0.763 NM_033326
SOX6
SRY (sex determining region Y)-box 6
chrX_+_14813333 0.762 NM_001177475
MOSPD2
motile sperm domain containing 2
chr15_+_32048380 0.754 NM_012125
CHRM5
cholinergic receptor, muscarinic 5
chr15_-_23201740 0.743 NM_130838
UBE3A
ubiquitin protein ligase E3A
chr8_+_32698892 0.740 NM_001159996
NRG1
neuregulin 1
chr2_+_178893216 0.739 NM_145739
OSBPL6
oxysterol binding protein-like 6
chr5_+_73145098 0.729 RGNEF
190 kDa guanine nucleotide exchange factor
chr21_-_31995972 0.721 SCAF4
SR-related CTD-associated factor 4
chr1_+_202033273 0.712 NM_001174108
ZBED6
zinc finger, BED-type containing 6
chr5_+_71438796 0.708 NM_005909
MAP1B
microtubule-associated protein 1B
chr17_-_36165050 0.703 NM_181534
KRT25
keratin 25
chr15_+_46285789 0.697 NM_000338
NM_001184832
SLC12A1

solute carrier family 12 (sodium/potassium/chloride transporters), member 1

chr7_-_26202626 0.695 HNRNPA2B1
heterogeneous nuclear ribonucleoprotein A2/B1
chrX_+_123062143 0.691 STAG2
stromal antigen 2
chr7_+_113853790 0.683 NM_001172767
NM_148899
FOXP2

forkhead box P2

chr3_-_197726587 0.681 NM_001077657
C3orf43
chromosome 3 open reading frame 43
chr9_+_124836666 0.679 NM_005294
GPR21
G protein-coupled receptor 21
chr6_+_7524691 0.678 DSP
desmoplakin
chr17_-_10265991 0.675 NM_002472
MYH8
myosin, heavy chain 8, skeletal muscle, perinatal
chr12_+_84792203 0.673 NM_006183
NTS
neurotensin
chr12_-_11041740 0.664 NM_176889
TAS2R20
taste receptor, type 2, member 20
chr10_+_77212524 0.663 NM_032024
C10orf11
chromosome 10 open reading frame 11
chrX_+_16578201 0.663 NM_004057
S100G
S100 calcium binding protein G
chr6_+_49575629 0.662 NM_001010904
GLYATL3
glycine-N-acyltransferase-like 3
chr18_-_26996742 0.661 NM_004948
NM_024421
DSC1

desmocollin 1

chr12_-_11178109 0.658 NM_001097643
TAS2R30
taste receptor, type 2, member 30
chrX_-_115508164 0.658 NM_001017978
CXorf61
chromosome X open reading frame 61
chr17_-_36376663 0.658 NM_213656
KRT39
keratin 39
chr18_+_19826734 0.653 NM_153211
TTC39C
tetratricopeptide repeat domain 39C
chr5_-_160211623 0.653 NM_025153
ATP10B
ATPase, class V, type 10B
chr4_-_74307637 0.651 ANKRD17
ankyrin repeat domain 17
chr3_+_35658852 0.650 NM_016300
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr12_+_54172413 0.650 NM_001005519
OR6C68
olfactory receptor, family 6, subfamily C, member 68
chr12_+_49155798 0.645 LARP4
La ribonucleoprotein domain family, member 4
chr6_+_101948102 0.644


chr5_+_102493155 0.644 NM_015216
PPIP5K2
diphosphoinositol pentakisphosphate kinase 2
chr22_+_21006814 0.638


chr3_-_56673113 0.636 NM_015224
C3orf63
chromosome 3 open reading frame 63
chr2_-_21081694 0.636 APOB
apolipoprotein B (including Ag(x) antigen)
chr6_+_45404031 0.629 NM_001015051
NM_001024630
RUNX2

runt-related transcription factor 2

chr17_-_61655915 0.624 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr3_-_115960807 0.623 NM_001164344
NM_001164345
ZBTB20

zinc finger and BTB domain containing 20

chr9_-_27287106 0.622 NM_001161585
NM_020641
C9orf11

chromosome 9 open reading frame 11

chr6_+_163904564 0.617 QKI
quaking homolog, KH domain RNA binding (mouse)
chr6_-_2696152 0.617 NM_001012418
MYLK4
myosin light chain kinase family, member 4
chr3_-_171786468 0.613 NM_020949
SLC7A14
solute carrier family 7 (cationic amino acid transporter, y+ system), member 14
chr13_-_69580459 0.608 NM_020866
KLHL1
kelch-like 1 (Drosophila)
chr16_+_20370359 0.605 NM_001010845
ACSM2A
acyl-CoA synthetase medium-chain family member 2A
chrX_+_55666557 0.603 NM_198451
FOXR2
forkhead box R2
chr12_-_11106159 0.602 NM_176887
TAS2R46
taste receptor, type 2, member 46
chr1_+_165564904 0.601 NM_001198783
POU2F1
POU class 2 homeobox 1
chr14_-_105681377 0.596 IGHV4-31
IGHG1
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant gamma 1 (G1m marker)
chr4_+_46728051 0.594 NM_000812
GABRB1
gamma-aminobutyric acid (GABA) A receptor, beta 1
chr2_+_172252194 0.592 NM_001378
DYNC1I2
dynein, cytoplasmic 1, intermediate chain 2
chr6_+_157141565 0.591 ARID1B
AT rich interactive domain 1B (SWI1-like)
chr12_-_11030777 0.588 NM_176890
TAS2R50
taste receptor, type 2, member 50
chr12_-_78831821 0.583 NM_001143886
PPP1R12A
protein phosphatase 1, regulatory (inhibitor) subunit 12A
chr4_+_70896236 0.582 NM_001009181
NM_003154
STATH

statherin

chr2_+_102456193 0.582 NM_001011552
SLC9A4
solute carrier family 9 (sodium/hydrogen exchanger), member 4
chrX_-_33267646 0.581 NM_000109
DMD
dystrophin
chr13_-_102517196 0.580 NM_000452
SLC10A2
solute carrier family 10 (sodium/bile acid cotransporter family), member 2
chr1_+_157067729 0.578 NM_002432
MNDA
myeloid cell nuclear differentiation antigen
chr11_-_5766621 0.575 NM_001001913
OR52N1
olfactory receptor, family 52, subfamily N, member 1
chr4_-_153523113 0.572 NM_001013415
FBXW7
F-box and WD repeat domain containing 7
chr13_+_32488477 0.571 NM_004795
KL
klotho
chr21_-_26175068 0.571 APP
amyloid beta (A4) precursor protein
chr7_+_28418668 0.569 NM_182898
CREB5
cAMP responsive element binding protein 5
chr10_-_46039941 0.567 NM_001042357
NM_001042389
PTPN20B
PTPN20A
protein tyrosine phosphatase, non-receptor type 20B
protein tyrosine phosphatase, non-receptor type 20A
chrX_-_108611940 0.567 NM_001522
GUCY2F
guanylate cyclase 2F, retinal
chr21_-_30642794 0.564 NM_181624
KRTAP23-1
keratin associated protein 23-1
chr15_+_91244422 0.564 NM_001042572
NM_001271
CHD2

chromodomain helicase DNA binding protein 2

chr7_-_76667045 0.562 NM_006682
FGL2
fibrinogen-like 2
chr5_-_63293715 0.556 HTR1A
5-hydroxytryptamine (serotonin) receptor 1A
chr3_-_168674502 0.556 NM_006217
SERPINI2
serpin peptidase inhibitor, clade I (pancpin), member 2
chr1_-_157950898 0.553 NM_000567
CRP
C-reactive protein, pentraxin-related
chr6_+_132901119 0.552 NM_175057
TAAR9
trace amine associated receptor 9 (gene/pseudogene)
chr3_-_25654659 0.551 TOP2B
topoisomerase (DNA) II beta 180kDa
chr1_+_145892190 0.548 NM_001097616
GPR89C
G protein-coupled receptor 89C
chr2_-_29150630 0.546 NM_001029883
C2orf71
chromosome 2 open reading frame 71
chr11_+_89624017 0.544


chr13_-_101852028 0.542 NM_175929
FGF14
fibroblast growth factor 14
chr1_-_239865724 0.542 NM_001821
CHML
choroideremia-like (Rab escort protein 2)
chr4_-_44348414 0.541 NM_182592
YIPF7
Yip1 domain family, member 7
chr13_+_51933228 0.540 CKAP2
cytoskeleton associated protein 2
chr1_+_67404756 0.539 NM_144701
IL23R
interleukin 23 receptor
chrX_-_105169370 0.535 NM_000354
SERPINA7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr22_+_21065202 0.535


chr8_-_7207899 0.534 NM_001164457
ZNF705G
zinc finger protein 705G
chr11_+_59953637 0.531 NM_023945
MS4A5
membrane-spanning 4-domains, subfamily A, member 5
chr6_+_144654565 0.531 NM_007124
UTRN
utrophin
chr4_-_64957595 0.530 NM_001010874
TECRL
trans-2,3-enoyl-CoA reductase-like
chrX_+_51562894 0.529 NM_001005332
MAGED1
melanoma antigen family D, 1
chr22_+_21393107 0.528 IGLJ3
immunoglobulin lambda joining 3
chr9_+_71009746 0.526 NM_001170415
NM_001170416
TJP2

tight junction protein 2 (zona occludens 2)

chr6_+_88111289 0.526 NM_001010868
C6orf163
chromosome 6 open reading frame 163
chr11_+_5558682 0.526 NM_001005162
OR52B6
olfactory receptor, family 52, subfamily B, member 6
chr5_+_147775652 0.525 FBXO38
F-box protein 38
chr14_-_34252695 0.524 NM_021914
CFL2
cofilin 2 (muscle)
chr14_-_24173205 0.523 NM_004131
GZMB
granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
chr20_+_29420081 0.522 NM_054112
DEFB118
defensin, beta 118
chr14_-_19553191 0.521 NM_001004712
OR4K14
olfactory receptor, family 4, subfamily K, member 14
chr1_-_245988330 0.521 NM_012353
OR1C1
olfactory receptor, family 1, subfamily C, member 1
chr5_+_42792676 0.519 NM_001134848
CCDC152
coiled-coil domain containing 152
chr10_+_86121526 0.516 FAM190B
family with sequence similarity 190, member B
chr1_+_61642287 0.514 NFIA
nuclear factor I/A
chr15_+_91244563 0.513 CHD2
chromodomain helicase DNA binding protein 2
chr15_-_23204887 0.513 NM_000462
UBE3A
ubiquitin protein ligase E3A
chr5_+_65408500 0.511 ERBB2IP
erbb2 interacting protein
chr17_+_24394281 0.511 PIPOX
pipecolic acid oxidase
chr2_+_234302511 0.510 NM_019093
UGT1A3
UDP glucuronosyltransferase 1 family, polypeptide A3
chr22_+_21065134 0.510 LOC100290481
immunoglobulin lambda light chain-like
chr1_+_165565006 0.510 POU2F1
POU class 2 homeobox 1
chr4_-_2200755 0.508 NM_181808
POLN
polymerase (DNA directed) nu
chr2_+_86186815 0.508 NM_017952
PTCD3
Pentatricopeptide repeat domain 3
chr4_+_41395493 0.507 LIMCH1
LIM and calponin homology domains 1
chr4_-_152368492 0.506 SH3D19
SH3 domain containing 19
chr2_+_171280182 0.503


chr11_+_10729357 0.501 NM_014633
CTR9
Ctr9, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
chr8_-_40874485 0.501 NM_001135731
NM_024645
ZMAT4

zinc finger, matrin-type 4

chr4_+_123380569 0.495 KIAA1109
KIAA1109
chr2_+_166034402 0.495 NM_001172173
CSRNP3
cysteine-serine-rich nuclear protein 3
chr2_-_87906400 0.494 NM_001078170
RGPD2
RANBP2-like and GRIP domain containing 2
chr20_-_43601542 0.494 NM_080827
WFDC6
WAP four-disulfide core domain 6
chr18_-_55136673 0.493 NM_181654
CPLX4
complexin 4
chr16_+_24475129 0.487 RBBP6
retinoblastoma binding protein 6
chr6_-_76259976 0.487 NM_015687
FILIP1
filamin A interacting protein 1
chr20_+_5935897 0.485 NM_001127458
CRLS1
cardiolipin synthase 1
chr12_-_9123126 0.483 A2M
alpha-2-macroglobulin

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
3.21 1.21e-31 GO:0007606 sensory perception of chemical stimulus
3.32 1.96e-30 GO:0007608 sensory perception of smell
2.36 1.61e-23 GO:0007600 sensory perception
1.96 5.60e-21 GO:0050877 neurological system process
1.80 4.92e-19 GO:0003008 system process
1.23 4.66e-08 GO:0050896 response to stimulus
1.24 2.32e-06 GO:0032501 multicellular organismal process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.32 1.03e-09 GO:0005886 plasma membrane
1.31 2.09e-09 GO:0071944 cell periphery
1.17 2.49e-03 GO:0016021 integral to membrane
1.15 7.67e-03 GO:0031224 intrinsic to membrane
3.20 7.71e-03 GO:0034707 chloride channel complex
1.13 1.55e-02 GO:0044425 membrane part

Gene overrepresentation in function category:

enrichment   p-value GO term description
3.42 6.90e-32 GO:0004984 olfactory receptor activity
2.33 4.11e-24 GO:0004930 G-protein coupled receptor activity
1.91 1.14e-18 GO:0004888 transmembrane receptor activity
1.68 1.96e-14 GO:0004872 receptor activity
1.54 7.56e-12 GO:0004871 signal transducer activity
1.54 7.56e-12 GO:0060089 molecular transducer activity
2.43 8.34e-04 GO:0008509 anion transmembrane transporter activity
5.69 1.27e-03 GO:0004890 GABA-A receptor activity
3.04 2.82e-03 GO:0005254 chloride channel activity
2.84 5.55e-03 GO:0005253 anion channel activity
4.91 6.87e-03 GO:0016917 GABA receptor activity
4.24 1.35e-02 GO:0015020 glucuronosyltransferase activity