ISMARA results for ENCODE cell lines, H4K20me1, averaged replicates (Ernst 2011)

ISMARA - Integrated System for Motif Actitivity Response Analysis is a free online tool that recognizes most important transcription factors that are changing their activity in a set of samples.

Averaging sample configuration

Sample Condition
Rep1_GM12878 GM12878
Rep1_HepG2 HepG2
Rep1_HMEC HMEC
Rep1_HSMM HSMM
Rep1_Huvec Huvec
Rep1_K562 K562
Rep1_NHEK NHEK
Rep1_NHLF NHLF
Rep2_GM12878 GM12878
Rep2_HepG2 HepG2
Rep2_HMEC HMEC
Rep2_HSMM HSMM
Rep2_Huvec Huvec
Rep2_K562 K562
Rep2_NHEK NHEK
Rep2_NHLF NHLF

All motifs sorted by activity significance

Motif name Z-value Associated genes Profile Logo
NFY{A,B,C}.p2 4.124 NFYC (CBF-C)
NFYB (CBF-A, HAP3)
NFYA (HAP2, CBF-B)
YY1.p2 4.122 YY1 (NF-E1, DELTA, UCRBP, YIN-YANG-1, INO80S)
NRF1.p2 3.239 NRF1 (EWG, ALPHA-PAL)
HMGA1,2.p2 3.146 HMGA1
HMGA2 (BABL, LIPO)
ZNF143.p2 3.133 ZNF143 (SBF, pHZ-1, STAF)
SP1.p2 3.035 SP1
ATF5_CREB3.p2 3.014 ATF5
CREB3 (LZIP, Luman)
SMAD1..7,9.p2 2.785 SMAD5 (Dwfc, JV5-1)
SMAD1 (MADR1, JV4-1)
SMAD3 (JV15-2, HsT17436)
SMAD4 (DPC4)
SMAD2 (MADR2, JV18-1)
SMAD6 (HsT17432)
SMAD7
SMAD9
EBF1.p2 2.680 EBF1 (OLF1)
HNF4A_NR2F1,2.p2 2.646 NR2F1 (EAR-3, COUP-TFI, TCFCOUP1, SVP44)
NR2F2 (COUP-TFII, COUPTFB, SVP40)
HNF4A (NR2A1, HNF4)
POU2F1..3.p2 2.633 POU2F2 (OCT2)
POU2F1 (OCT1)
POU2F3 (OCT11, PLA-1, Skn-1a, Epoc-1)
NKX3-1.p2 2.625 NKX3-1 (NKX3.1, BAPX2)
MYB.p2 2.609 MYB (c-myb)
MAFB.p2 2.533 MAFB
PRRX1,2.p2 2.516 PRRX2 (PRX2, PMX2)
PRRX1 (PHOX1)
ZBTB16.p2 2.475 ZBTB16 (PLZF)
NFKB1_REL_RELA.p2 2.462 RELA (p65)
REL (I-Rel)
NFKB1 (KBF1, p105)
AHR_ARNT_ARNT2.p2 2.456 ARNT (HIF-1beta, bHLHe2)
AHR
ARNT2 (KIAA0307, bHLHe1)
ELK1,4_GABP{A,B1}.p3 2.452 GABPA (E4TF1A, NFT2, NRF2, E4TF1-60, NRF2A)
GABPB1 (E4TF1-47, GABPB)
ELK4 (SAP1)
ELK1
CTCF.p2 2.385 CTCF
MZF1.p2 2.380 MZF1 (MZF1B, ZSCAN6, MZF-1, Zfp98)
EGR1..3.p2 2.332 EGR3 (PILOT)
EGR1 (TIS8, G0S30, NGFI-A, KROX-24, ZIF-268, AT225, ZNF225)
EGR2
HOX{A5,B5}.p2 2.287 HOXB5
HOXA5
CDC5L.p2 2.230 CDC5L (PCDC5RP, hCDC5, CEF1)
GATA6.p2 2.194 GATA6
MYOD1.p2 2.152 MYOD1 (PUM, MYOD, bHLHc1)
HBP1_HMGB_SSRP1_UBTF.p2 2.142 HMGB2
HMGB3 (HMG2A, MGC90319)
SSRP1 (FACT80)
UBTF (UBF, NOR-90)
HBP1
NFE2L1.p2 2.137 NFE2L1 (NRF1, LCR-F1, FLJ00380, TCF11)
KLF4.p3 2.080 KLF4 (EZF, GKLF)
RUNX1..3.p2 2.078 RUNX1 (PEBP2A2, AMLCR1)
RUNX3 (AML2, PEBP2A3)
RUNX2 (AML3, PEBP2A1, PEBP2aA1)
FOXN1.p2 2.070 FOXN1 (FKHL20)
NKX3-2.p2 2.064 NKX3-2 (NKX3B, NKX3.2)
GTF2A1,2.p2 2.048 GTF2A1 (TFIIA)
GTF2A2 (TFIIA, HsT18745)
TLX1..3_NFIC{dimer}.p2 2.041 TLX1
TLX3 (RNX)
GATA1..3.p2 2.039 GATA1 (ERYF1, NFE1)
GATA2 (NFE1B)
GATA3 (HDR)
TCF4_dimer.p2 2.029 TCF4 (E2-2, ITF2, PTHS, SEF2, SEF2-1, SEF2-1A, SEF2-1B, bHLHb19, MGC149723, MGC149724)
EN1,2.p2 2.023 EN1
EN2
ZNF148.p2 2.011 ZNF148 (BERF-1, ZBP-89, BFCOL1, HT-BETA, ZFP148, pHZ-52)
SNAI1..3.p2 2.009 SNAI2 (SLUGH1)
SNAI1 (SNA, SLUGH2, SNAH)
SNAI3 (SMUC, Zfp293)
ZNF423.p2 1.991 ZNF423 (KIAA0760, OAZ, Roaz, Ebfaz, Zfp104)
EHF.p2 1.985 EHF
GTF2I.p2 1.960 GTF2I (TFII-I, BAP-135, SPIN, BTKAP1, DIWS, IB291)
KLF12.p2 1.953 KLF12 (AP-2rep, HSPC122, AP2REP)
NFATC1..3.p2 1.924 NFATC3 (NFAT4, NFATX)
NFATC2 (NF-ATP, NFATp, NFAT1)
NFATC1 (NF-ATC, NFATc, NFAT2)
NR5A1,2.p2 1.912 NR5A1 (FTZ1, SF-1, ELP, AD4BP)
NR5A2 (FTZ-F1beta, hB1F, LRH-1, FTZ-F1, hB1F-2, B1F2)
MTF1.p2 1.886 MTF1
NFE2L2.p2 1.880 NFE2L2 (NRF2)
POU5F1_SOX2{dimer}.p2 1.879 POU5F1 (OCT3, Oct4, MGC22487)
SOX2
JUN.p2 1.875 JUN (c-Jun, AP-1)
JUND (AP-1)
JUNB
NFIX.p2 1.870 NFIX (NF1A)
FOX{D1,D2}.p2 1.869 FOXD2 (FREAC9)
FOXD1 (FREAC4)
BPTF.p2 1.849 BPTF (FAC1, NURF301)
FOX{I1,J2}.p2 1.842 FOXI1 (FREAC6)
FOXJ2 (FHX)
TFDP1.p2 1.841 TFDP1 (Dp-1, DRTF1, DP1)
POU1F1.p2 1.838 POU1F1 (GHF-1)
MAZ.p2 1.830 MAZ (ZF87, Pur-1, Zif87, ZNF801)
HSF1,2.p2 1.827 HSF1 (HSTF1)
HSF2
ETS1,2.p2 1.816 ETS2
ETS1 (FLJ10768, ETS-1)
TFCP2.p2 1.799 TFCP2 (CP2, LSF, LBP-1C, TFCP2C)
NHLH1,2.p2 1.795 NHLH1 (NSCL, NSCL1, bHLHa35)
NHLH2 (NSCL2, bHLHa34)
GLI1..3.p2 1.783 GLI1
GLI2 (THP2, HPE9, THP1)
GLI3 (PAP-A, PAPA, PAPA1, PAPB, ACLS, PPDIV)
HMX1.p2 1.781 HMX1 (H6, NKX5-3)
NKX2-2,8.p2 1.751 NKX2-2 (NKX2.2)
NKX2-8 (NKX2.8, Nkx2-9)
IKZF2.p2 1.750 IKZF2 (Helios)
CDX1,2,4.p2 1.744 CDX1
CDX2
CDX4
PAX5.p2 1.739 PAX5 (BSAP)
XBP1.p3 1.722 XBP1
TBP.p2 1.714 TBP (TFIID)
E2F1..5.p2 1.708 E2F4 (E2F-4)
E2F5
E2F2 (E2F-2)
E2F1 (RBP3)
E2F3
ZEB1.p2 1.694 ZEB1 (BZP, ZEB, AREB6, NIL-2-A, Zfhep, Zfhx1a)
TFAP2B.p2 1.690 TFAP2B (AP2-B)
BACH2.p2 1.687 BACH2
RREB1.p2 1.686 RREB1 (HNT)
ALX1.p2 1.678 ALX1
RFX1..5_RFXANK_RFXAP.p2 1.678 RFX1 (EF-C)
RFXAP
RFX5
RFXANK (BLS, RFX-B, ANKRA1, F14150_1, MGC138628)
RFX4
RFX3
RFX2 (FLJ14226)
FOXA2.p3 1.670 FOXA2
REST.p3 1.643 REST (NRSF, XBR)
CREB1.p2 1.641 CREB1
DBP.p2 1.635 DBP (DABP)
HIC1.p2 1.606 HIC1 (ZBTB29)
RXRG_dimer.p3 1.603 NR1H2 (NER, NER-I, RIP15, LXR-b)
RXRA (NR2B1)
PPARG (PPARG1, PPARG2, NR1C3, PPARgamma)
PPARA (hPPAR, NR1C1)
RXRB (NR2B2, H-2RIIBP, RCoR-1)
RXRG (NR2B3)
STAT5{A,B}.p2 1.570 STAT5B
STAT5A (MGF)
HAND1,2.p2 1.569 HAND1 (eHand, Thing1, Hxt, bHLHa27)
HAND2 (dHand, Thing2, Hed, bHLHa26)
SPI1.p2 1.562 SPI1 (PU.1, SPI-A, OF, SFPI1, SPI-1)
FOXO1,3,4.p2 1.532 FOXO1 (FKH1)
FOXO4 (AFX1)
FOXO3 (AF6q21, FOXO2)
SOX5.p2 1.525 SOX5 (L-SOX5, MGC35153)
EVI1.p2 1.516 EVI1 (MDS1-EVI1, PRDM3)
IRF1,2,7.p3 1.496 IRF1 (MAR, IRF-1)
IRF2 (IRF-2, DKFZp686F0244)
IRF7 (IRF7A, IRF-7H)
PITX1..3.p2 1.495 PITX2 (IGDS, RS, Brx1, Otlx2, ARP1)
PITX3
PITX1 (PTX1, POTX)
HES1.p2 1.487 HES1 (FLJ20408, HES-1, Hes1, bHLHb39)
LMO2.p2 1.483 LMO2 (TTG2, RHOM2, RBTN2)
PPARG.p2 1.457 PPARG (PPARG1, PPARG2, NR1C3, PPARgamma)
TGIF1.p2 1.437 TGIF1
SRY.p2 1.435 SRY (TDF)
FOXQ1.p2 1.432 FOXQ1 (HFH1)
SOX{8,9,10}.p2 1.421 SOX9 (SRA1)
SOX8
SOX10 (DOM, WS4, WS2E)
bHLH_family.p2 1.420 ARNTL (MOP3, JAP3, BMAL1, PASD3, bHLHe5)
MITF (WS2A, MI, bHLHe32)
MXI1 (MXD2, MAD2, MXI, bHLHc11)
TFE3 (TFEA, bHLHe33)
CLOCK (KIAA0334, KAT13D, bHLHe8)
OLIG2 (RACK17, OLIGO2, bHLHe19)
MXD4 (MAD4, MSTP149, MST149, bHLHc12)
HEY2 (bHLHb32)
HEY1 (HESR-1, CHF2, HESR1, HRT-1, CHF-2, HERP2, BHLHb31)
HEYL (bHLHb33)
MLXIPL (WS-bHLH, MIO, CHREBP, MONDOB)
HES6 (bHLHc23)
MXD3 (MAD3, bHLHc13)
ARNTL2 (BMAL2, MOP9, CLIF, PASD9, bHLHe6)
ID1 (dJ857M17.1.2, bHLHb24)
MNT (ROX, MXD6, MAD6, bHLHd3)
OLIG1 (BHLHB6, bHLHe21)
NPAS2 (MOP4, PASD4, bHLHe9)
HNF1A.p2 1.411 HNF1A (HNF1, LFB1)
FOXL1.p2 1.409 FOXL1 (FREAC7, FKH6)
HOX{A4,D4}.p2 1.403 HOXA4
HOXD4
PRDM1.p3 1.382 PRDM1 (PRDI-BF1)
FEV.p2 1.376 FEV (PET-1, HSRNAFEV)
ESRRA.p2 1.366 ESRRA (ERR1, ERRalpha, NR3B1, ERRa)
HOX{A6,A7,B6,B7}.p2 1.360 HOXB6
HOXA7
HOXB7
HOXA6
SPIB.p2 1.341 SPIB (SPI-B)
TFAP2{A,C}.p2 1.338 TFAP2C (AP2-GAMMA, ERF1, TFAP2G, hAP-2g)
TFAP2A (AP-2)
SOX17.p2 1.336 SOX17
NANOG.p2 1.333 NANOG (FLJ12581, FLJ40451)
ZNF384.p2 1.328 ZNF384 (CAGH1A, CIZ, NMP4, NP)
GFI1.p2 1.323 GFI1
ARID5B.p2 1.318 ARID5B (FLJ21150, MRF2)
ELF1,2,4.p2 1.318 ELF2 (EU32, NERF, NERF-2, NERF-1A, NERF-1B)
ELF1
ELF4 (MEF, ELFR)
ZFP161.p2 1.314 ZFP161 (ZNF478, ZBTB14)
DMAP1_NCOR{1,2}_SMARC.p2 1.314 SMARCA1 (SNF2LB, NURF140, ISWI, SWI)
SMARCC2 (BAF170, Rsc8, CRACC2)
SMARCA5 (hSNF2H, hISWI, ISWI)
NCOR1 (N-CoR, hCIT529I10, TRAC1, hN-CoR, KIAA1047, MGC104216)
NCOR2 (SMRT, SMRTE, TRAC-1, CTG26, TNRC14)
DMAP1 (DNMAP1, FLJ11543, KIAA1425, DNMTAP1, EAF2, SWC4)
TFAP4.p2 1.287 TFAP4 (AP-4)
FOSL2.p2 1.286 FOSL2 (FRA2, FLJ23306)
FOXP3.p2 1.286 FOXP3 (JM2, XPID, AIID, PIDX, DIETER, SCURFIN)
ZIC1..3.p2 1.273 ZIC1 (ZIC, ZNF201)
ZIC2 (HPE5)
ZIC3 (HTX, ZNF203)
RXR{A,B,G}.p2 1.272 RXRA (NR2B1)
RXRB (NR2B2, H-2RIIBP, RCoR-1)
RXRG (NR2B3)
TLX2.p2 1.270 TLX2 (Enx, Tlx2, NCX)
ATF4.p2 1.267 ATF4 (TAXREB67, CREB-2)
SREBF1,2.p2 1.264 SREBF1 (SREBP1, bHLHd1)
SREBF2 (SREBP2, bHLHd2)
TFEB.p2 1.259 TFEB
FOS_FOS{B,L1}_JUN{B,D}.p2 1.234 FOS (c-fos, AP-1)
JUNB
FOSL1 (fra-1)
JUND (AP-1)
FOSB (G0S3, GOSB, GOS3, AP-1, MGC42291, DKFZp686C0818)
MEF2{A,B,C,D}.p2 1.232 MEF2A (RSRFC4, RSRFC9)
MEF2C
MEF2D
MEF2BNB-MEF2B (MEF2B, LOC729991-MEF2B)
MEF2B (RSRFR2, FLJ32648)
RBPJ.p2 1.227 RBPJ (SUH, IGKJRB, RBPJK, KBF2, RBP-J, CBF1)
PAX4.p2 1.227 PAX4
TEAD1.p2 1.194 TEAD1 (TEF-1)
TEAD2 (ETF, TEF4, TEF-4, TEAD-2)
TEAD3 (TEF5, TEAD5, TEF-5, DTEF-1, ETFR-1, TEAD-3)
TEAD4 (TEF3, RTEF1, TEF-3, EFTR-2, TEFR-1, TCF13L1, hRTEF-1B)
EP300.p2 1.187 EP300 (p300, KAT3B)
NFIL3.p2 1.186 NFIL3 (E4BP4, NFIL3A, NF-IL3A)
CEBPA,B_DDIT3.p2 1.184 DDIT3 (CHOP10, GADD153, CHOP)
CEBPA (C/EBP-alpha)
CEBPB (LAP, CRP2, NFIL6, IL6DBP)
NANOG{mouse}.p2 1.167 NANOG (FLJ12581, FLJ40451)
NFE2.p2 1.159 NFE2 (NF-E2)
TBX4,5.p2 1.141 TBX5
TBX4
PATZ1.p2 1.136 PATZ1 (MAZR, dJ400N23, ZBTB19, ZSG, RIAZ, PATZ)
FOXD3.p2 1.134 FOXD3 (Genesis, HFH2)
GFI1B.p2 1.130 GFI1B
NKX2-1,4.p2 1.114 NKX2-1 (TTF-1)
NKX2-4 (NKX2.4)
LEF1_TCF7_TCF7L1,2.p2 1.106 TCF7 (TCF-1)
TCF7L2 (TCF-4)
LEF1 (TCF1ALPHA)
TCF7L1
SPZ1.p2 1.104 SPZ1 (NYD-TSP1, FLJ25709)
PAX2.p2 1.098 PAX2
PBX1.p2 1.092 PBX1
ATF6.p2 1.088 ATF6 (ATF6A)
ONECUT1,2.p2 1.071 ONECUT2 (OC-2)
ONECUT1 (HNF-6)
CRX.p2 1.054 CRX (CRD, LCA7, OTX3)
POU6F1.p2 1.031 POU6F1 (BRN5, MPOU, TCFB1)
NR1H4.p2 1.019 NR1H4 (FXR, RIP14, HRR1, HRR-1)
ADNP_IRX_SIX_ZHX.p2 1.019 SIX5
ZHX1
IRX4
ADNP (KIAA0784, ADNP1)
ZHX3 (KIAA0395)
ZHX2 (KIAA0854)
IRX5 (IRX-2a)
SIX2
T.p2 1.006 T
SRF.p3 0.983 SRF (MCM1)
EWSR1-FLI1.p2 0.979 FLI1 (EWSR2, SIC-1)
EWSR1 (EWS, K984G1.4)
NR3C1.p2 0.976 NR3C1 (GR)
ARNT_ARNT2_BHLHB2_MAX_MYC_USF1.p2 0.965 ARNT (HIF-1beta, bHLHe2)
MAX (bHLHd4)
MYC (c-Myc, bHLHe39)
USF1 (UEF, MLTFI, bHLHb11)
BHLHB2 (DEC1, bHLHe40)
ARNT2 (KIAA0307, bHLHe1)
POU3F1..4.p2 0.957 POU3F1 (OCT6, SCIP)
POU3F3 (BRN1, OTF8)
POU3F2 (POUF3, BRN2, OCT7)
POU3F4 (BRN4, OTF9)
FOX{C1,C2}.p2 0.952 FOXC1 (FREAC3, ARA, IGDA, IHG1)
FOXC2 (MFH-1)
HLF.p2 0.935 HLF (MGC33822)
NKX2-3_NKX2-5.p2 0.935 NKX2-5 (CSX1, NKX2.5, NKX4-1)
NKX2-3 (NKX2.3, CSX3, NKX4-3)
NKX6-1,2.p2 0.912 NKX6-1 (Nkx6.1)
NKX6-2 (NKX6B, GTX, NKX6.1)
IKZF1.p2 0.905 IKZF1 (hIk-1, LyF-1, Hs.54452, IKAROS)
ZNF238.p2 0.901 ZNF238 (C2H2-171, TAZ-1, RP58, ZBTB18)
ESR1.p2 0.886 ESR1 (NR3A1, Era)
LHX3,4.p2 0.869 LHX3
LHX4 (Gsh4)
RXRA_VDR{dimer}.p2 0.863 VDR (NR1I1)
MYFfamily.p2 0.824 MYOD1 (PUM, MYOD, bHLHc1)
MYF6 (MRF4, bHLHc4)
MYF5 (bHLHc2)
MYOG (bHLHc3)
HIF1A.p2 0.819 HIF1A (MOP1, HIF-1alpha, PASD8, HIF1)
NR6A1.p2 0.802 NR6A1 (GCNF1, RTR)
MYBL2.p2 0.802 MYBL2 (BMYB, B-MYB)
MSX1,2.p2 0.790 MSX1 (HYD1, OFC5)
MSX2 (CRS2, FPP, HOX8, MSH, PFM)
EOMES.p2 0.761 EOMES (TBR2)
CUX2.p2 0.759 CUX2 (KIAA0293, CDP2)
HOXA9_MEIS1.p2 0.756 MEIS1
HOXA9
STAT2,4,6.p2 0.750 STAT2 (STAT113)
STAT4
STAT6 (D12S1644, IL-4-STAT)
PAX6.p2 0.713 PAX6 (D11S812E, AN, WAGR)
POU5F1.p2 0.699 POU5F1 (OCT3, Oct4, MGC22487)
ZBTB6.p2 0.696 ZBTB6 (ZID)
ATF2.p2 0.677 ATF2 (TREB7, CRE-BP1, HB16)
STAT1,3.p3 0.674 STAT1 (STAT91, ISGF-3)
STAT3 (APRF)
FOX{F1,F2,J1}.p2 0.657 FOXF2 (FREAC2)
FOXJ1 (HFH-4, HFH4)
FOXF1 (FREAC1)
SOX2.p2 0.655 SOX2
RORA.p2 0.651 RORA (RZRA, ROR1, ROR2, ROR3, NR1F1)
AR.p2 0.630 AR (AIS, NR3C4, SMAX1, HUMARA)
AIRE.p2 0.581 AIRE (PGA1, APS1)
PDX1.p2 0.549 PDX1 (IDX-1, STF-1, PDX-1, MODY4)
GZF1.p2 0.470 GZF1 (dJ322G13.2, ZBTB23)
VSX1,2.p2 0.446 VSX2 (RET1)
VSX1 (PPD)
TAL1_TCF{3,4,12}.p2 0.396 TCF3 (E2A, ITF1, MGC129647, MGC129648, bHLHb21)
TCF4 (SEF2-1B, ITF2, bHLHb19)
TAL1 (SCL, bHLHa17)
TCF12 (HEB, HTF4, HsT17266, bHLHb20)
TP53.p2 0.315 TP53 (p53, LFS1)
PAX3,7.p2 0.274 PAX7 (Hup1)
PAX3 (HUP2)
PAX8.p2 0.109 PAX8

All samples sorted alphabetically


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Sample name Condition Replicate/Batch
GM12878
HepG2
HMEC
HSMM
Huvec
K562
NHEK
NHLF