Motif ID: HNF1A.p2

Z-value: 1.411


Transcription factors associated with HNF1A.p2:

Gene SymbolEntrez IDGene Name
HNF1A 6927 HNF1 homeobox A



Activity profile for motif HNF1A.p2.

activity profile for motif HNF1A.p2


Sorted Z-values histogram for motif HNF1A.p2

Sorted Z-values for motif HNF1A.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HNF1A.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_750281 1.981 PTBP1
polypyrimidine tract binding protein 1
chr1_+_93830106 1.919 LOC100129046
hypothetical LOC100129046
chr1_+_93830169 1.688 LOC100129046
hypothetical LOC100129046
chr7_+_45894480 1.608 NM_000596
IGFBP1
insulin-like growth factor binding protein 1
chr4_+_74520796 1.466 NM_001134
AFP
alpha-fetoprotein
chr21_-_35153664 1.437 RUNX1
runt-related transcription factor 1
chr14_+_20226762 1.186 NM_001097577
NM_194431
ANG
RNASE4
angiogenin, ribonuclease, RNase A family, 5
ribonuclease, RNase A family, 4
chr3_+_120799411 1.158 NM_015900
PLA1A
phospholipase A1 member A
chr7_-_47545717 1.133 NM_022748
TNS3
tensin 3
chr4_+_74566325 1.083 NM_001133
AFM
afamin
chr20_+_42463419 1.031 HNF4A
hepatocyte nuclear factor 4, alpha
chr20_-_7869068 0.944 NM_017545
HAO1
hydroxyacid oxidase (glycolate oxidase) 1
chr20_+_42463350 0.944 HNF4A
hepatocyte nuclear factor 4, alpha
chr20_-_17589122 0.932 RRBP1
ribosome binding protein 1 homolog 180kDa (dog)
chrX_-_105169370 0.929 NM_000354
SERPINA7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr20_+_42463387 0.922 HNF4A
hepatocyte nuclear factor 4, alpha
chr3_-_168674502 0.873 NM_006217
SERPINI2
serpin peptidase inhibitor, clade I (pancpin), member 2
chr20_+_42463279 0.867 NM_000457
NM_178849
NM_178850
HNF4A


hepatocyte nuclear factor 4, alpha


chr11_-_117200618 0.854 NM_001127489
NM_001680
FXYD2

FXYD domain containing ion transport regulator 2

chr9_-_122852356 0.850 NM_001735
C5
complement component 5
chr4_+_74488910 0.797 ALB
albumin
chrX_+_107174855 0.789 NM_001170553
NM_182607
VSIG1

V-set and immunoglobulin domain containing 1

chr20_+_42417502 0.776 HNF4A
hepatocyte nuclear factor 4, alpha
chrX_-_33056464 0.770 NM_004010
NM_004009
DMD

dystrophin

chr17_+_71065478 0.768 LLGL2
lethal giant larvae homolog 2 (Drosophila)
chr4_+_74488947 0.762 ALB
albumin
chr16_-_54466709 0.760 NM_001143685
NM_145024
CES5A

carboxylesterase 5A

chr8_-_18585721 0.748 PSD3
pleckstrin and Sec7 domain containing 3
chr4_+_74488835 0.724 NM_000477
ALB
albumin
chr8_+_21967008 0.720 NM_001114137
EPB49
erythrocyte membrane protein band 4.9 (dematin)
chr22_+_43476710 0.701 NM_181333
PRR5
proline rich 5 (renal)
chr20_+_42417752 0.698 NM_001030003
NM_001030004
NM_175914
HNF4A


hepatocyte nuclear factor 4, alpha


chr5_+_175908948 0.698 NM_017675
CDHR2
cadherin-related family member 2
chr12_+_52697160 0.696 HOXC5
HOXC6
homeobox C5
homeobox C6
chr11_+_46697345 0.687 F2
coagulation factor II (thrombin)
chr21_-_46399900 0.685 NM_006657
NM_206965
FTCD

formiminotransferase cyclodeaminase

chr1_+_48460943 0.684 NM_001011547
NM_001135181
SLC5A9

solute carrier family 5 (sodium/glucose cotransporter), member 9

chr9_+_129900590 0.662 SLC25A25
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
chr11_+_46697335 0.659 F2
coagulation factor II (thrombin)
chr10_+_135190855 0.656 NM_000773
CYP2E1
cytochrome P450, family 2, subfamily E, polypeptide 1
chr3_-_166278969 0.645 NM_001041
SI
sucrase-isomaltase (alpha-glucosidase)
chr1_-_157950898 0.643 NM_000567
CRP
C-reactive protein, pentraxin-related
chr4_-_977163 0.642 NM_022042
NM_134425
NM_213613
SLC26A1


solute carrier family 26 (sulfate transporter), member 1


chr11_+_46697312 0.636 NM_000506
F2
coagulation factor II (thrombin)
chr9_+_129900637 0.636 NM_052901
NM_001006643
SLC25A25

solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25

chr1_+_15637521 0.633 NM_007272
CTRC
chymotrypsin C (caldecrin)
chr4_+_169250281 0.618 NM_007193
ANXA10
annexin A10
chr13_-_98757634 0.606 NM_004951
GPR183
G protein-coupled receptor 183
chr4_+_3413489 0.603 NM_001528
HGFAC
HGF activator
chr2_-_87102453 0.600 NM_002665
NM_001032392
PLGLB2
PLGLB1
plasminogen-like B2
plasminogen-like B1
chr5_-_147191334 0.599 SPINK1
serine peptidase inhibitor, Kazal type 1
chr2_-_63518589 0.598 NM_001042692
WDPCP
WD repeat containing planar cell polarity effector
chr4_+_74497998 0.580 ALB
albumin
chr22_-_36836478 0.575 BAIAP2L2
BAI1-associated protein 2-like 2
chr10_+_44726635 0.564 NM_001123376
TMEM72
transmembrane protein 72
chr22_-_36836620 0.552 NM_025045
BAIAP2L2
BAI1-associated protein 2-like 2
chrX_-_65752570 0.534 NM_021783
EDA2R
ectodysplasin A2 receptor
chr22_-_41685827 0.530 NM_001184971
PACSIN2
protein kinase C and casein kinase substrate in neurons 2
chr17_-_202557 0.529 RPH3AL
rabphilin 3A-like (without C2 domains)
chr7_+_94130673 0.529 PEG10
paternally expressed 10
chr5_-_147191428 0.523 NM_003122
SPINK1
serine peptidase inhibitor, Kazal type 1
chr3_+_187866464 0.519 NM_000412
HRG
histidine-rich glycoprotein
chr2_-_99284070 0.511 NM_174898
LYG1
lysozyme G-like 1
chr4_+_74498042 0.504 ALB
albumin
chr4_+_3413457 0.500 HGFAC
HGF activator
chr2_+_234266250 0.499 NM_001072
UGT1A6
UDP glucuronosyltransferase 1 family, polypeptide A6
chr10_+_101532450 0.485 NM_000392
ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr8_+_76482661 0.483 HNF4G
hepatocyte nuclear factor 4, gamma
chr9_-_21295311 0.478 NM_002169
IFNA5
interferon, alpha 5
chr3_+_185430910 0.467 NM_138345
VWA5B2
von Willebrand factor A domain containing 5B2
chr12_+_52696908 0.459 NM_014620
NM_153693
HOXC4
HOXC6
homeobox C4
homeobox C6
chr3_-_193928038 0.457 NM_004113
FGF12
fibroblast growth factor 12
chr6_+_54281161 0.454 NM_014464
TINAG
tubulointerstitial nephritis antigen
chr13_-_32658215 0.449 NM_178007
STARD13
StAR-related lipid transfer (START) domain containing 13
chr19_+_11211282 0.436 NM_018687
LOC55908
hepatocellular carcinoma-associated gene TD26
chr1_-_20014180 0.432 NM_019062
RNF186
ring finger protein 186
chr8_-_6407882 0.431 NM_001118887
NM_001118888
NM_001147
ANGPT2


angiopoietin 2


chr13_+_52500830 0.428 NM_006418
OLFM4
olfactomedin 4
chr10_+_111755715 0.403 NM_019903
ADD3
adducin 3 (gamma)
chr17_-_202617 0.402 NM_001190411
NM_001190412
NM_001190413
NM_006987
RPH3AL



rabphilin 3A-like (without C2 domains)



chr1_+_17779528 0.399 NM_001011722
ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr6_+_161043214 0.399 NM_000301
NM_001168338
PLG

plasminogen

chr11_+_551449 0.395 NM_001143994
NM_003475
RASSF7

Ras association (RalGDS/AF-6) domain family (N-terminal) member 7

chr21_-_18697829 0.392 NM_002772
TMPRSS15
transmembrane protease, serine 15
chr6_-_74284522 0.391 EEF1A1
eukaryotic translation elongation factor 1 alpha 1
chr1_+_81544432 0.391 LPHN2
latrophilin 2
chr20_+_41621119 0.384 SGK2
serum/glucocorticoid regulated kinase 2
chr12_+_21417068 0.379 NM_000415
IAPP
islet amyloid polypeptide
chr11_+_64079665 0.374 NM_018484
SLC22A11
solute carrier family 22 (organic anion/urate transporter), member 11
chr2_+_27573206 0.369 NM_001486
GCKR
glucokinase (hexokinase 4) regulator
chr16_+_21152516 0.364 NM_145865
ANKS4B
ankyrin repeat and sterile alpha motif domain containing 4B
chr19_+_44308224 0.357 NM_001014831
NM_001014832
NM_001014834
NM_001014835
NM_005884
PAK4




p21 protein (Cdc42/Rac)-activated kinase 4




chr14_+_38805251 0.353 NM_203356
CTAGE5
CTAGE family, member 5
chr2_+_234191029 0.353 NM_019076
UGT1A8
UDP glucuronosyltransferase 1 family, polypeptide A8
chr20_+_41621079 0.350 NM_170693
SGK2
serum/glucocorticoid regulated kinase 2
chr1_-_103269356 0.349 COL11A1
collagen, type XI, alpha 1
chr7_-_44547382 0.347 NM_001101648
NM_013389
NPC1L1

NPC1 (Niemann-Pick disease, type C1, gene)-like 1

chr1_-_195302973 0.341 NM_001994
F13B
coagulation factor XIII, B polypeptide
chr16_-_46826588 0.337 NM_032583
NM_145186
ABCC11

ATP-binding cassette, sub-family C (CFTR/MRP), member 11

chr6_+_64289585 0.336 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr11_-_121492010 0.334 NM_001001786
BLID
BH3-like motif containing, cell death inducer
chr17_+_71154240 0.332 NM_001162997
LOC100130933
hypothetical protein LOC100130933
chr20_+_9236446 0.324 NM_000933
PLCB4
phospholipase C, beta 4
chr5_+_176446425 0.323 NM_002011
NM_213647
FGFR4

fibroblast growth factor receptor 4

chr10_+_101532544 0.322 ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr7_-_87694218 0.315 NM_198901
SRI
sorcin
chr11_+_26310253 0.314 NM_031418
ANO3
anoctamin 3
chr1_+_198263352 0.308 NM_003822
NM_205860
NR5A2

nuclear receptor subfamily 5, group A, member 2

chr17_+_76549658 0.305 RPTOR
regulatory associated protein of MTOR, complex 1
chr10_+_115302767 0.301 NM_004132
HABP2
hyaluronan binding protein 2
chr11_+_63282639 0.300 RTN3
reticulon 3
chr4_-_155731288 0.298 NM_000508
NM_021871
FGA

fibrinogen alpha chain

chr4_+_154345039 0.292 NM_015271
TRIM2
tripartite motif containing 2
chr3_+_108578877 0.282 NM_032600
CCDC54
coiled-coil domain containing 54
chr17_-_19290745 0.282


chr10_+_114144512 0.279 ACSL5
acyl-CoA synthetase long-chain family member 5
chr16_+_74901235 0.277 NM_138994
CNTNAP4
contactin associated protein-like 4
chr16_-_20271530 0.276 NM_001008389
NM_003361
UMOD

uromodulin

chr14_-_91403609 0.267 NM_001128596
TC2N
tandem C2 domains, nuclear
chr12_+_10222823 0.263 NM_153022
C12orf59
chromosome 12 open reading frame 59
chr13_+_50813168 0.262 NM_001101320
SERPINE3
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3
chr10_+_5126613 0.260 AKR1C3
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr2_-_6924092 0.258 CMPK2
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr1_+_157824239 0.258 NM_001639
APCS
amyloid P component, serum
chrX_-_131375217 0.258 NM_001170701
NM_001170702
NM_001170703
MBNL3


muscleblind-like 3 (Drosophila)


chr15_-_42756377 0.258 NM_001145112
PATL2
protein associated with topoisomerase II homolog 2 (yeast)
chr11_-_8695974 0.251 ST5
suppression of tumorigenicity 5
chr1_-_42402973 0.249 NM_033553
GUCA2A
guanylate cyclase activator 2A (guanylin)
chrX_+_115215985 0.249 NM_000686
AGTR2
angiotensin II receptor, type 2
chr6_-_119512035 0.246 NM_001100411
FAM184A
family with sequence similarity 184, member A
chr14_+_21203136 0.244 NM_001001912
OR4E2
olfactory receptor, family 4, subfamily E, member 2
chr10_+_5126589 0.243 AKR1C3
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr17_+_38306339 0.242 NM_000151
G6PC
glucose-6-phosphatase, catalytic subunit
chr11_+_64114857 0.241 NM_144585
NM_153378
SLC22A12

solute carrier family 22 (organic anion/urate transporter), member 12

chr15_-_49184764 0.240 NM_207381
TNFAIP8L3
tumor necrosis factor, alpha-induced protein 8-like 3
chr16_+_88224175 0.240 DPEP1
dipeptidase 1 (renal)
chr10_+_5126556 0.236 NM_003739
AKR1C3
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr2_+_87828718 0.233 NM_002665
NM_001032392
PLGLB2
PLGLB1
plasminogen-like B2
plasminogen-like B1
chr1_-_202449659 0.230 NM_198447
GOLT1A
golgi transport 1A
chr7_+_72913424 0.230 NM_182504
WBSCR28
Williams-Beuren syndrome chromosome region 28
chr8_-_108579270 0.230 NM_001146
ANGPT1
angiopoietin 1
chr6_-_33862690 0.229 NM_001143944
LEMD2
LEM domain containing 2
chr22_+_30769211 0.229 SLC5A1
solute carrier family 5 (sodium/glucose cotransporter), member 1
chr4_-_100492854 0.229 NM_000669
ADH1C
alcohol dehydrogenase 1C (class I), gamma polypeptide
chr20_+_35406497 0.226 NM_005417
SRC
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
chr22_-_30981317 0.224 NM_014227
SLC5A4
solute carrier family 5 (low affinity glucose cotransporter), member 4
chr5_+_76470829 0.223


chr17_+_77910411 0.222 NM_207459
TEX19
testis expressed 19
chr11_+_65026382 0.220


chr4_+_155703581 0.220 NM_001184741
NM_005141
FGB

fibrinogen beta chain

chr16_+_56286212 0.218 NM_032269
CCDC135
coiled-coil domain containing 135
chr5_+_140509803 0.217 NM_018939
PCDHB6
protocadherin beta 6
chr13_-_40491405 0.214 ELF1
E74-like factor 1 (ets domain transcription factor)
chr16_+_79829794 0.213 NM_017429
BCMO1
beta-carotene 15,15'-monooxygenase 1
chr22_+_43476755 0.210 NM_181334
PRR5-ARHGAP8
PRR5
PRR5-ARHGAP8 readthrough
proline rich 5 (renal)
chr1_-_36562341 0.208 NM_018166
FAM176B
family with sequence similarity 176, member B
chr16_+_20682812 0.206 NM_005622
NM_202000
ACSM3

acyl-CoA synthetase medium-chain family member 3

chr19_-_63556632 0.204 NM_130786
A1BG
alpha-1-B glycoprotein
chr19_-_47790820 0.204 NM_001816
CEACAM8
carcinoembryonic antigen-related cell adhesion molecule 8
chr4_-_101658094 0.201 NM_001159694
NM_016242
EMCN

endomucin

chr8_-_87311624 0.198 NM_138817
SLC7A13
solute carrier family 7, (cationic amino acid transporter, y+ system) member 13
chr1_+_55044323 0.198 NM_001110533
NM_152607
C1orf177

chromosome 1 open reading frame 177

chr8_+_32905027 0.197


chr5_+_147775652 0.192 FBXO38
F-box protein 38
chr12_+_9871343 0.191 NM_016523
KLRF1
killer cell lectin-like receptor subfamily F, member 1
chrX_+_35974973 0.185 NM_173695
CXorf59
chromosome X open reading frame 59
chr6_+_131613196 0.184 NM_004842
NM_138633
AKAP7

A kinase (PRKA) anchor protein 7

chr1_-_157551072 0.182 NM_001004467
OR10J3
olfactory receptor, family 10, subfamily J, member 3
chr4_+_25267183 0.181 NM_001177999
SLC34A2
solute carrier family 34 (sodium phosphate), member 2
chr4_-_70861301 0.178 NM_001891
CSN2
casein beta
chr19_+_46201665 0.178 CYP2B6
cytochrome P450, family 2, subfamily B, polypeptide 6
chr6_-_165643064 0.176 NM_144980
C6orf118
chromosome 6 open reading frame 118
chr22_+_30769250 0.173 SLC5A1
solute carrier family 5 (sodium/glucose cotransporter), member 1
chr2_+_97696462 0.171 NM_001079
ZAP70
zeta-chain (TCR) associated protein kinase 70kDa
chr14_+_38772870 0.169 NM_054024
MIA2
melanoma inhibitory activity 2
chr2_-_1905508 0.164 MYT1L
myelin transcription factor 1-like
chr14_+_64240996 0.163 PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr2_-_1925880 0.162 MYT1L
myelin transcription factor 1-like
chr14_-_106170414 0.161 IGHG1
IGHG3
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
chr6_-_133008834 0.157 NM_138327
TAAR1
trace amine associated receptor 1
chr3_-_171070314 0.154 NM_024727
LRRC31
leucine rich repeat containing 31
chr16_-_21344158 0.154 NM_130464
NPIPL3
nuclear pore complex interacting protein-like 3
chr22_+_30769103 0.152 SLC5A1
solute carrier family 5 (sodium/glucose cotransporter), member 1
chr9_-_70345549 0.150 NM_153237
C9orf71
chromosome 9 open reading frame 71
chr16_+_88224276 0.150 DPEP1
dipeptidase 1 (renal)
chr4_+_124537334 0.150 NM_199327
SPRY1
sprouty homolog 1, antagonist of FGF signaling (Drosophila)
chr4_-_110942783 0.149 NM_000204
CFI
complement factor I
chr1_-_197173159 0.149 LOC100131234
familial acute myelogenous leukemia related factor
chr5_+_132460779 0.148 HSPA4
heat shock 70kDa protein 4
chr3_+_150675117 0.148 NM_004617
TM4SF4
transmembrane 4 L six family member 4
chr12_-_101398470 0.148 IGF1
insulin-like growth factor 1 (somatomedin C)
chr20_+_56848127 0.148 GNAS
GNAS complex locus
chr17_+_69781980 0.147 NM_001172810
NM_023036
DNAI2

dynein, axonemal, intermediate chain 2

chr3_-_127810087 0.147 NM_001039783
TXNRD3IT1
thioredoxin reductase 3 intronic transcript 1
chr3_+_150675169 0.143 TM4SF4
transmembrane 4 L six family member 4
chr17_-_10393664 0.142 NM_001100112
NM_017534
MYH2

myosin, heavy chain 2, skeletal muscle, adult

chr10_-_129581192 0.142 NM_152311
CLRN3
clarin 3
chr3_-_162572441 0.139 NM_001040100
C3orf57
chromosome 3 open reading frame 57
chr14_-_93829113 0.137 NM_016186
SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr6_+_25862905 0.137 NM_005495
SLC17A4
solute carrier family 17 (sodium phosphate), member 4

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
8.50 4.53e-03 GO:0061041 regulation of wound healing
25.49 1.14e-02 GO:0009750 response to fructose stimulus
10.93 1.69e-02 GO:0030195 negative regulation of blood coagulation
6.04 2.04e-02 GO:0009746 response to hexose stimulus
10.55 2.09e-02 GO:0050819 negative regulation of coagulation
5.96 2.27e-02 GO:0034284 response to monosaccharide stimulus
1.65 2.84e-02 GO:0042221 response to chemical stimulus
1.32 3.79e-02 GO:0050896 response to stimulus

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.93 3.52e-06 GO:0005576 extracellular region
2.64 5.43e-06 GO:0005615 extracellular space
2.30 3.66e-05 GO:0044421 extracellular region part
4.86 3.72e-05 GO:0016324 apical plasma membrane
4.11 1.69e-04 GO:0045177 apical part of cell
8.68 5.87e-04 GO:0031093 platelet alpha granule lumen
8.50 6.92e-04 GO:0034774 secretory granule lumen
8.16 9.52e-04 GO:0060205 cytoplasmic membrane-bounded vesicle lumen
7.85 1.29e-03 GO:0031983 vesicle lumen
7.03 2.97e-03 GO:0031091 platelet alpha granule
7.93 4.53e-03 GO:0005903 brush border

Gene overrepresentation in function category:

enrichment   p-value GO term description
10.93 4.21e-03 GO:0015020 glucuronosyltransferase activity
8.11 6.36e-03 GO:0043498 cell surface binding