Motif ID: RUNX1..3.p2

Z-value: 2.078


Transcription factors associated with RUNX1..3.p2:

Gene SymbolEntrez IDGene Name
RUNX1 861 runt-related transcription factor 1
RUNX2 860 runt-related transcription factor 2
RUNX3 864 runt-related transcription factor 3



Activity profile for motif RUNX1..3.p2.

activity profile for motif RUNX1..3.p2


Sorted Z-values histogram for motif RUNX1..3.p2

Sorted Z-values for motif RUNX1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RUNX1..3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_-_71285992 3.319 H3F3B
H3 histone, family 3B (H3.3B)
chr22_+_21318779 3.008 NM_199127
GGTLC2
gamma-glutamyltransferase light chain 2
chr1_+_20489998 2.809 NM_001039500
VWA5B1
von Willebrand factor A domain containing 5B1
chr9_+_129893948 2.740 NM_001006642
SLC25A25
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
chrX_-_131089552 2.676 NM_194277
FRMD7
FERM domain containing 7
chr1_+_154478574 2.499 NM_199173
BGLAP
bone gamma-carboxyglutamate (gla) protein
chr16_+_29582069 2.478 NM_003123
SPN
sialophorin
chr6_-_32121784 2.327 NM_032470
TNXB
tenascin XB
chrX_-_49008115 2.202 NM_001114377
NM_014009
FOXP3

forkhead box P3

chr1_+_207995999 2.136 NM_025228
TRAF3IP3
TRAF3 interacting protein 3
chr22_+_20101661 2.134 NM_015094
HIC2
hypermethylated in cancer 2
chrX_-_48655978 2.114 PIM2
pim-2 oncogene
chr22_+_17337970 2.037 DGCR5
DiGeorge syndrome critical region gene 5 (non-protein coding)
chr1_+_110456584 1.988 NM_203412
UBL4B
ubiquitin-like 4B
chr5_-_88155360 1.982 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr17_+_23818922 1.978


chr22_-_18635614 1.978 NM_023004
RTN4R
reticulon 4 receptor
chr16_+_29582065 1.940 SPN
sialophorin
chr20_-_23915431 1.930 NM_178312
GGTLC1
gamma-glutamyltransferase light chain 1
chr1_-_25164061 1.898 NM_001031680
RUNX3
runt-related transcription factor 3
chrX_+_71280758 1.836 NM_207422
FLJ44635
TPT1-like protein
chr3_+_46894239 1.745 NM_000316
PTH1R
parathyroid hormone 1 receptor
chr16_+_29942155 1.723 NM_001109659
NM_001109660
C16orf92

chromosome 16 open reading frame 92

chr22_+_20326591 1.716 SDF2L1
stromal cell-derived factor 2-like 1
chr1_-_24342158 1.714 NM_021258
IL22RA1
interleukin 22 receptor, alpha 1
chr11_+_1846478 1.714 NM_001013253
LSP1
lymphocyte-specific protein 1
chr22_+_20326541 1.688 NM_022044
SDF2L1
stromal cell-derived factor 2-like 1
chr22_+_20326572 1.687 SDF2L1
stromal cell-derived factor 2-like 1
chr22_+_20326615 1.683 SDF2L1
stromal cell-derived factor 2-like 1
chr12_+_52696908 1.680 NM_014620
NM_153693
HOXC4
HOXC6
homeobox C4
homeobox C6
chr2_+_127892459 1.664 NM_000312
PROC
protein C (inactivator of coagulation factors Va and VIIIa)
chr13_+_112789669 1.630 MCF2L
MCF.2 cell line derived transforming sequence-like
chr1_-_16812274 1.597 NM_017940
NBPF1
neuroblastoma breakpoint family, member 1
chr22_+_21484240 1.589


chr4_-_1185144 1.574 LOC100130872
hypothetical LOC100130872
chr8_+_143542378 1.558 NM_001702
BAI1
brain-specific angiogenesis inhibitor 1
chr1_+_153557263 1.556 NM_001105203
NM_001105204
RUSC1

RUN and SH3 domain containing 1

chr1_+_22176004 1.555 NM_007352
CELA3A
CELA3B
chymotrypsin-like elastase family, member 3A
chymotrypsin-like elastase family, member 3B
chr7_+_150376537 1.532 NM_004769
NM_020321
NM_020322
ACCN3


amiloride-sensitive cation channel 3


chr1_+_234624266 1.495 NM_145861
EDARADD
EDAR-associated death domain
chr2_+_85774924 1.476 NM_006433
NM_012483
GNLY

granulysin

chr22_+_21552897 1.461 LOC100290481
immunoglobulin lambda light chain-like
chrX_-_100015783 1.451 NM_007052
NM_013955
NOX1

NADPH oxidase 1

chr6_+_167624792 1.421 NM_001143947
NM_018974
UNC93A

unc-93 homolog A (C. elegans)

chr15_+_19883745 1.419 NM_001005241
OR4N4
olfactory receptor, family 4, subfamily N, member 4
chr19_+_59657440 1.414


chr6_+_155579788 1.398 NM_001010927
TIAM2
T-cell lymphoma invasion and metastasis 2
chr6_+_37030186 1.375 NM_153370
PI16
peptidase inhibitor 16
chr20_+_61394982 1.366 NM_020882
COL20A1
collagen, type XX, alpha 1
chr7_+_116447499 1.350 ST7
suppression of tumorigenicity 7
chr11_-_404975 1.349 NM_001135054
SIGIRR
single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
chr4_-_8180278 1.334 ABLIM2
actin binding LIM protein family, member 2
chr8_+_1940282 1.332 KBTBD11
kelch repeat and BTB (POZ) domain containing 11
chr8_-_134141586 1.321 NM_006748
SLA
Src-like-adaptor
chr17_+_31112028 1.317 NM_145272
C17orf50
chromosome 17 open reading frame 50
chr3_-_152403636 1.316 NM_013308
GPR171
G protein-coupled receptor 171
chr17_-_53961709 1.315 NM_004574
SEPT4
septin 4
chr21_-_35153664 1.290 RUNX1
runt-related transcription factor 1
chr1_+_9222489 1.271 H6PD
hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
chr12_+_47658502 1.269 NM_005430
WNT1
wingless-type MMTV integration site family, member 1
chr20_-_61669550 1.264 NM_033405
PRIC285
peroxisomal proliferator-activated receptor A interacting complex 285
chr6_-_31853027 1.262 NM_025258
C6orf27
chromosome 6 open reading frame 27
chr22_+_21384862 1.227 IGLV3-21
IGLJ3
IGLC1
immunoglobulin lambda variable 3-21
immunoglobulin lambda joining 3
immunoglobulin lambda constant 1 (Mcg marker)
chr7_+_116447527 1.219 ST7
suppression of tumorigenicity 7
chrX_+_46967360 1.212 NM_001170460
CDK16
cyclin-dependent kinase 16
chr7_+_150321771 1.208 NM_001160109
NM_001160110
NM_001160111
NOS3


nitric oxide synthase 3 (endothelial cell)


chr1_+_35104120 1.207


chr17_+_45598363 1.203 NM_000023
NM_001135697
SGCA

sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein)

chr17_-_3442871 1.202 NM_080706
TRPV1
transient receptor potential cation channel, subfamily V, member 1
chr2_-_26554413 1.183 NM_004802
NM_194322
NM_194323
OTOF


otoferlin


chr8_+_21956335 1.181 NM_003867
FGF17
fibroblast growth factor 17
chr2_+_127892489 1.167 PROC
protein C (inactivator of coagulation factors Va and VIIIa)
chr19_+_55985483 1.150 NM_033068
ACPT
acid phosphatase, testicular
chr11_+_63864263 1.135 NM_032251
CCDC88B
coiled-coil domain containing 88B
chr7_+_2518688 1.132 NM_001166355
LFNG
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr7_-_27171600 1.130 HOXA9
homeobox A9
chr10_+_70517823 1.122 NM_002727
SRGN
serglycin
chr19_-_60458915 1.083 PPP6R1
protein phosphatase 6, regulatory subunit 1
chr2_+_96566190 1.079 NM_212481
ARID5A
AT rich interactive domain 5A (MRF1-like)
chr1_+_22200735 1.075 NM_005747
CELA3A
chymotrypsin-like elastase family, member 3A
chr5_+_176807931 1.070 NM_001174102
PRR7
proline rich 7 (synaptic)
chr11_+_118710424 1.067 NM_032015
RNF26
ring finger protein 26
chr5_+_149977398 1.063 NM_001166209
SYNPO
synaptopodin
chr5_+_131437383 1.061 NM_000758
CSF2
colony stimulating factor 2 (granulocyte-macrophage)
chr17_-_1037312 1.047 NM_001159746
ABR
active BCR-related gene
chr7_+_129771865 1.039 NM_001127441
NM_001127442
NM_080385
CPA5


carboxypeptidase A5


chr12_+_52697160 1.030 HOXC5
HOXC6
homeobox C5
homeobox C6
chr9_-_94206648 1.025 NM_014057
NM_033014
OGN

osteoglycin

chr16_+_3642940 1.018 NM_005223
DNASE1
deoxyribonuclease I
chr16_+_65868913 1.006 NM_015432
PLEKHG4
pleckstrin homology domain containing, family G (with RhoGef domain) member 4
chr22_-_41672990 1.001 NM_007229
PACSIN2
protein kinase C and casein kinase substrate in neurons 2
chr16_-_65510230 0.996 NM_004062
CDH16
cadherin 16, KSP-cadherin
chr19_+_5641307 0.987 RPL36
ribosomal protein L36
chrX_+_106057984 0.971 CLDN2
claudin 2
chr4_+_89115862 0.966 SPP1
secreted phosphoprotein 1
chr5_+_149960820 0.962 NM_001166208
SYNPO
synaptopodin
chr6_-_86407875 0.958 NM_001159675
NM_001159676
SYNCRIP

synaptotagmin binding, cytoplasmic RNA interacting protein

chr13_+_113369470 0.952 NM_002929
GRK1
G protein-coupled receptor kinase 1
chr10_+_70517863 0.946 SRGN
serglycin
chr9_-_129580732 0.942 NM_170600
SH2D3C
SH2 domain containing 3C
chr3_-_10522267 0.942 NM_001001331
NM_001683
ATP2B2

ATPase, Ca++ transporting, plasma membrane 2

chr22_+_20350272 0.936 NM_014337
NM_148175
NM_148176
PPIL2


peptidylprolyl isomerase (cyclophilin)-like 2


chrX_-_54226364 0.935 NM_017848
NM_198456
FAM120C

family with sequence similarity 120C

chr4_-_153820535 0.928 NM_152680
TMEM154
transmembrane protein 154
chr11_+_65403859 0.926 NM_001335
CTSW
cathepsin W
chr1_+_34997928 0.924 NM_153212
GJB4
gap junction protein, beta 4, 30.3kDa
chr1_-_205012348 0.922 NM_000572
IL10
interleukin 10
chr17_+_21249040 0.920 NM_001194958
KCNJ18
potassium inwardly-rectifying channel, subfamily J, member 18
chr5_-_76970129 0.906 OTP
orthopedia homeobox
chr1_-_171441234 0.904 TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr22_-_28972683 0.903 NM_002309
LIF
leukemia inhibitory factor (cholinergic differentiation factor)
chr12_-_109842736 0.897 NM_000432
MYL2
myosin, light chain 2, regulatory, cardiac, slow
chr11_-_6600385 0.897 DCHS1
dachsous 1 (Drosophila)
chr19_+_5641270 0.893 NM_033643
RPL36
ribosomal protein L36
chrX_+_21960841 0.889 NM_000444
PHEX
phosphate regulating endopeptidase homolog, X-linked
chr17_+_77910411 0.883 NM_207459
TEX19
testis expressed 19
chr7_-_126679540 0.873 NM_001127323
GRM8
glutamate receptor, metabotropic 8
chr5_-_111119846 0.873 NM_001142483
C5orf13
chromosome 5 open reading frame 13
chr6_+_158653679 0.873 NM_001007466
NM_020245
TULP4

tubby like protein 4

chr1_+_205068844 0.873 NM_013371
IL19
interleukin 19
chr11_-_31782169 0.872 PAX6
paired box 6
chr17_-_45617899 0.863 COL1A1
collagen, type I, alpha 1
chr1_+_151442542 0.859 NM_001010857
LELP1
late cornified envelope-like proline-rich 1
chr15_-_53440069 0.857 CCPG1
cell cycle progression 1
chr19_-_46504831 0.855


chr10_-_48036698 0.854 NM_016204
GDF2
growth differentiation factor 2
chr21_+_43024936 0.849 PDE9A
phosphodiesterase 9A
chr15_+_39918302 0.846 NM_001114633
PLA2G4B
phospholipase A2, group IVB (cytosolic)
chrX_-_77801480 0.845 NM_152694
ZCCHC5
zinc finger, CCHC domain containing 5
chr3_+_46594079 0.844 NM_003212
TDGF1
teratocarcinoma-derived growth factor 1
chr1_+_32485404 0.843 NM_032648
FAM167B
family with sequence similarity 167, member B
chr19_-_50355247 0.843 NM_198478
NKPD1
NTPase, KAP family P-loop domain containing 1
chr1_+_199130571 0.841 NM_001142569
C1orf106
chromosome 1 open reading frame 106
chr17_-_77512346 0.841 NM_178493
NOTUM
notum pectinacetylesterase homolog (Drosophila)
chr17_+_71141108 0.840 NM_001162995
LOC643008
hypothetical protein LOC643008
chr7_+_120752656 0.836 NM_016087
WNT16
wingless-type MMTV integration site family, member 16
chr2_+_241456834 0.832 NM_000030
AGXT
alanine-glyoxylate aminotransferase
chr11_-_66961709 0.826 NM_005608
PTPRCAP
protein tyrosine phosphatase, receptor type, C-associated protein
chr1_+_196874839 0.819 PTPRC
protein tyrosine phosphatase, receptor type, C
chrX_+_54963953 0.818 NM_001039705
NM_016157
NM_177556
TRO


trophinin


chr12_-_101396459 0.818 NM_001111284
IGF1
insulin-like growth factor 1 (somatomedin C)
chr19_+_55164668 0.817 SIGLEC16
sialic acid binding Ig-like lectin 16 (gene/pseudogene)
chr1_+_19807168 0.817


chrX_-_19727828 0.814 NM_001024666
SH3KBP1
SH3-domain kinase binding protein 1
chr12_+_48443232 0.810 TMBIM6
transmembrane BAX inhibitor motif containing 6
chr19_+_56337368 0.810 NM_014385
NM_016543
SIGLEC7

sialic acid binding Ig-like lectin 7

chr5_-_76970264 0.806 NM_032109
OTP
orthopedia homeobox
chr1_+_158317967 0.803 NM_004983
KCNJ9
potassium inwardly-rectifying channel, subfamily J, member 9
chr3_-_71376919 0.802 FOXP1
forkhead box P1
chr12_+_103677388 0.802 CHST11
carbohydrate (chondroitin 4) sulfotransferase 11
chr1_-_199613427 0.797 NM_000364
NM_001001430
NM_001001431
NM_001001432
TNNT2



troponin T type 2 (cardiac)



chr11_+_6368213 0.795 NM_000543
NM_001007593
SMPD1

sphingomyelin phosphodiesterase 1, acid lysosomal

chr9_+_94749421 0.794 NM_001083536
FGD3
FYVE, RhoGEF and PH domain containing 3
chr20_+_42777298 0.792 NM_003881
WISP2
WNT1 inducible signaling pathway protein 2
chr1_+_32489426 0.790 NM_005356
LCK
lymphocyte-specific protein tyrosine kinase
chrX_+_71047344 0.787 NM_001013627
NHSL2
NHS-like 2
chr4_+_636965 0.785 NM_001145292
PDE6B
phosphodiesterase 6B, cGMP-specific, rod, beta
chr4_+_89115892 0.785 SPP1
secreted phosphoprotein 1
chr3_-_195571748 0.783 NM_001135057
NM_130830
LRRC15

leucine rich repeat containing 15

chr17_-_40401138 0.779 NM_006688
C1QL1
complement component 1, q subcomponent-like 1
chr12_-_113330574 0.779 NM_000192
NM_080717
TBX5

T-box 5

chr21_-_35343448 0.777 RUNX1
runt-related transcription factor 1
chr16_+_29581783 0.775 NM_001030288
SPN
sialophorin
chrX_+_48427103 0.772 NM_000377
WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr1_+_108794426 0.772 NM_001143987
NM_001143988
NBPF4
NBPF6

neuroblastoma breakpoint family, member 4
neuroblastoma breakpoint family, member 6

chr9_-_94226380 0.768 NM_005014
OMD
osteomodulin
chr1_-_205161821 0.767 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chr10_-_64698831 0.766 NM_004241
JMJD1C
jumonji domain containing 1C
chr17_+_76623540 0.763 NM_001144888
NM_006340
NM_017450
NM_017451
BAIAP2



BAI1-associated protein 2



chr17_+_77528699 0.761 NM_024083
ASPSCR1
alveolar soft part sarcoma chromosome region, candidate 1
chr15_+_73281249 0.760 NM_015492
C15orf39
chromosome 15 open reading frame 39
chr7_-_149631001 0.760 NM_001164459
ACTR3C
ARP3 actin-related protein 3 homolog C (yeast)
chr19_+_40474867 0.759 NM_002361
NM_080600
MAG

myelin associated glycoprotein

chr11_+_71388619 0.754 NM_001145055
IL18BP
interleukin 18 binding protein
chr11_-_2907169 0.753 NM_003311
PHLDA2
pleckstrin homology-like domain, family A, member 2
chr1_+_968522 0.752 AGRN
agrin
chr4_+_89115825 0.752 NM_000582
NM_001040058
NM_001040060
SPP1


secreted phosphoprotein 1


chr3_-_188936941 0.751 NM_001130845
BCL6
B-cell CLL/lymphoma 6
chr1_+_204710453 0.749 IKBKE
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
chr20_+_42776888 0.748 WISP2
WNT1 inducible signaling pathway protein 2
chr16_+_28413421 0.747 NM_018690
APOBR
apolipoprotein B receptor
chr15_+_73281288 0.743 C15orf39
chromosome 15 open reading frame 39
chr6_+_31651319 0.743 NM_000594
TNF
tumor necrosis factor
chr22_+_19248733 0.742 MED15
mediator complex subunit 15
chr14_+_75058591 0.741 BATF
basic leucine zipper transcription factor, ATF-like
chr19_+_59297953 0.741 NM_004542
NDUFA3
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa
chr22_-_17798998 0.740 HIRA
HIR histone cell cycle regulation defective homolog A (S. cerevisiae)
chr6_-_10527772 0.739 NM_001042425
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr17_-_1478293 0.737 SLC43A2
solute carrier family 43, member 2
chr1_+_20269239 0.734 NM_000929
PLA2G5
phospholipase A2, group V
chr16_+_28797309 0.733 NM_004320
NM_173201
ATP2A1

ATPase, Ca++ transporting, cardiac muscle, fast twitch 1

chr12_-_69317441 0.732 NM_001109754
PTPRB
protein tyrosine phosphatase, receptor type, B
chr11_-_119499188 0.728 TRIM29
tripartite motif containing 29
chr7_+_5598964 0.725 FSCN1
fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)
chr5_-_148738980 0.722 NM_014443
IL17B
interleukin 17B
chr19_+_531666 0.721 BSG
basigin (Ok blood group)
chr15_+_73281286 0.721 C15orf39
chromosome 15 open reading frame 39
chr8_+_22900863 0.721 NM_001160036
RHOBTB2
Rho-related BTB domain containing 2
chrX_-_152889815 0.713 NM_005334
HCFC1
host cell factor C1 (VP16-accessory protein)
chrX_-_19727775 0.713 SH3KBP1
SH3-domain kinase binding protein 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.32 4.09e-07 GO:0023052 signaling
1.22 1.30e-06 GO:0050896 response to stimulus
1.33 1.48e-06 GO:0007165 signal transduction
1.51 2.54e-04 GO:0002376 immune system process
1.24 4.39e-04 GO:0051716 cellular response to stimulus
1.82 7.50e-04 GO:0001775 cell activation
1.62 2.16e-03 GO:0006955 immune response
1.36 8.36e-03 GO:0007166 cell surface receptor linked signaling pathway
1.35 8.56e-03 GO:0048583 regulation of response to stimulus
1.13 9.01e-03 GO:0065007 biological regulation
1.32 9.07e-03 GO:0065008 regulation of biological quality
1.13 2.02e-02 GO:0050789 regulation of biological process
1.98 2.39e-02 GO:2000145 regulation of cell motility
1.17 3.27e-02 GO:0032501 multicellular organismal process
1.14 3.97e-02 GO:0050794 regulation of cellular process
1.96 3.97e-02 GO:0030334 regulation of cell migration
1.66 4.34e-02 GO:0008284 positive regulation of cell proliferation
1.26 4.60e-02 GO:0048518 positive regulation of biological process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.76 1.78e-07 GO:0005615 extracellular space
1.40 2.29e-06 GO:0044459 plasma membrane part
1.60 4.33e-06 GO:0044421 extracellular region part
1.39 9.66e-06 GO:0005576 extracellular region
1.25 1.69e-05 GO:0005886 plasma membrane
1.49 6.23e-05 GO:0031226 intrinsic to plasma membrane
1.23 7.36e-05 GO:0071944 cell periphery
1.48 1.38e-04 GO:0005887 integral to plasma membrane
2.16 4.03e-02 GO:0009897 external side of plasma membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.43 1.93e-02 GO:0005102 receptor binding
9.21 2.37e-02 GO:0003840 gamma-glutamyltransferase activity
2.03 3.61e-02 GO:0005126 cytokine receptor binding