Motif ID: ZBTB16.p2

Z-value: 2.475


Transcription factors associated with ZBTB16.p2:

Gene SymbolEntrez IDGene Name
ZBTB16 7704 zinc finger and BTB domain containing 16



Activity profile for motif ZBTB16.p2.

activity profile for motif ZBTB16.p2


Sorted Z-values histogram for motif ZBTB16.p2

Sorted Z-values for motif ZBTB16.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ZBTB16.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr21_-_26345294 6.242


chr11_-_104332631 5.622 NM_033306
CASP4
caspase 4, apoptosis-related cysteine peptidase
chr12_-_78831821 5.277 NM_001143886
PPP1R12A
protein phosphatase 1, regulatory (inhibitor) subunit 12A
chr12_-_88573949 4.917 NM_001001323
NM_001682
ATP2B1

ATPase, Ca++ transporting, plasma membrane 1

chr9_-_21340885 4.892 NM_021002
IFNA6
interferon, alpha 6
chr12_-_10953427 4.704 NM_023920
TAS2R13
taste receptor, type 2, member 13
chr18_+_59733724 3.870 NM_005024
SERPINB10
serpin peptidase inhibitor, clade B (ovalbumin), member 10
chr9_-_21375258 3.629 NM_000605
IFNA2
interferon, alpha 2
chr19_-_20399601 3.490 ZNF826P
zinc finger protein 826, pseudogene
chr9_-_21229975 3.306 NM_002172
IFNA14
interferon, alpha 14
chr1_-_108536885 3.294 NM_213651
SLC25A24
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24
chr3_+_99288706 3.290 NM_054106
OR5AC2
olfactory receptor, family 5, subfamily AC, member 2
chr3_-_56784634 3.280 NM_001128616
ARHGEF3
Rho guanine nucleotide exchange factor (GEF) 3
chr2_+_228064531 3.196 AGFG1
ArfGAP with FG repeats 1
chr2_-_17563186 2.876 NM_001099218
RAD51AP2
RAD51 associated protein 2
chr10_-_98315090 2.866 TM9SF3
transmembrane 9 superfamily member 3
chr9_+_124551839 2.761 NM_001004453
OR1L6
olfactory receptor, family 1, subfamily L, member 6
chr9_+_21430439 2.709 NM_024013
IFNA1
interferon, alpha 1
chr6_-_88095714 2.696 NM_198568
GJB7
gap junction protein, beta 7, 25kDa
chr1_-_111771877 2.674 NM_002557
OVGP1
oviductal glycoprotein 1, 120kDa
chr10_-_33264491 2.657 NM_033668
ITGB1
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
chr12_-_10870134 2.614 NM_023921
TAS2R10
taste receptor, type 2, member 10
chr12_+_58369392 2.600 NM_004731
SLC16A7
solute carrier family 16, member 7 (monocarboxylic acid transporter 2)
chr1_+_246578699 2.582 NM_001001918
OR14C36
olfactory receptor, family 14, subfamily C, member 36
chr8_+_104900591 2.581 NM_014677
RIMS2
regulating synaptic membrane exocytosis 2
chr19_+_42409205 2.539 NM_152604
ZNF383
zinc finger protein 383
chr3_-_131081910 2.530 NM_001017395
TMCC1
transmembrane and coiled-coil domain family 1
chr19_+_20138991 2.513 NM_052852
ZNF486
zinc finger protein 486
chr3_+_173954940 2.503 NM_018098
ECT2
epithelial cell transforming sequence 2 oncogene
chr4_+_71126376 2.496 NM_152997
C4orf7
chromosome 4 open reading frame 7
chr2_-_210726539 2.485 C2orf67
chromosome 2 open reading frame 67
chr9_-_21218132 2.484 NM_021268
IFNA17
interferon, alpha 17
chr1_+_195123766 2.483 NM_006684
CFHR4
complement factor H-related 4
chr12_-_10479810 2.471 NM_002260
KLRC2
KLRC3
killer cell lectin-like receptor subfamily C, member 2
killer cell lectin-like receptor subfamily C, member 3
chr6_+_130799954 2.429 NM_052913
TMEM200A
transmembrane protein 200A
chr19_-_20540380 2.403 NM_001159293
ZNF737
zinc finger protein 737
chr8_-_102005697 2.402 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chrX_+_114734074 2.363 NM_001136025
NM_001172335
PLS3

plastin 3

chr5_+_57823017 2.350 NM_152687
GAPT
GRB2-binding adaptor protein, transmembrane
chrX_-_23955223 2.336 NM_030624
KLHL15
kelch-like 15 (Drosophila)
chr8_-_114458557 2.322 NM_198124
CSMD3
CUB and Sushi multiple domains 3
chr10_+_28918672 2.263 WAC
WW domain containing adaptor with coiled-coil
chr4_+_71298187 2.165 NM_021225
PROL1
proline rich, lacrimal 1
chr22_-_15682555 2.152 NM_175878
XKR3
XK, Kell blood group complex subunit-related family, member 3
chr9_+_102987137 2.122 NM_017753
LPPR1
lipid phosphate phosphatase-related protein type 1
chr8_-_93099040 2.114 NM_175636
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr12_-_10464308 2.079 NM_002261
NM_007333
KLRC3

killer cell lectin-like receptor subfamily C, member 3

chr7_-_83108682 2.025 NM_001178129
SEMA3E
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
chr11_+_33319680 2.009 HIPK3
homeodomain interacting protein kinase 3
chr4_+_123311207 1.977 NM_015312
KIAA1109
KIAA1109
chr9_-_21358005 1.971 NM_006900
IFNA1
IFNA13
interferon, alpha 1
interferon, alpha 13
chr13_-_32678142 1.959 NM_052851
STARD13
StAR-related lipid transfer (START) domain containing 13
chr17_+_58440629 1.937 NM_025185
TANC2
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
chr4_+_69996780 1.918 NM_001074
UGT2B7
UDP glucuronosyltransferase 2 family, polypeptide B7
chr10_+_129237602 1.887 NM_001030013
NPS
neuropeptide S
chr9_-_21156609 1.862 NM_002175
IFNA21
interferon, alpha 21
chr7_+_111879348 1.850 NM_001197079
IFRD1
interferon-related developmental regulator 1
chr12_-_15757114 1.847 EPS8
epidermal growth factor receptor pathway substrate 8
chr12_+_10351683 1.840 NM_002262
NM_007334
KLRD1

killer cell lectin-like receptor subfamily D, member 1

chr9_+_104797413 1.817 NM_001340
CYLC2
cylicin, basic protein of sperm head cytoskeleton 2
chr21_-_30774502 1.813 NM_181607
KRTAP19-1
keratin associated protein 19-1
chr12_-_44644216 1.809


chr5_-_41297296 1.804 NM_001115131
C6
complement component 6
chr15_+_64481270 1.804 MAP2K1
mitogen-activated protein kinase kinase 1
chr8_-_59575249 1.791 NM_000780
CYP7A1
cytochrome P450, family 7, subfamily A, polypeptide 1
chr11_+_55700669 1.790 NM_001005492
OR5J2
olfactory receptor, family 5, subfamily J, member 2
chr14_-_105549177 1.737 IGHV4-31
IGHD
IGHG3
IGHM
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant delta
immunoglobulin heavy constant gamma 3 (G3m marker)
immunoglobulin heavy constant mu
chr19_-_9087438 1.733 NM_001005192
OR7G1
olfactory receptor, family 7, subfamily G, member 1
chr18_-_62422195 1.723 NM_021153
CDH19
cadherin 19, type 2
chr18_-_49944986 1.715 MBD2
methyl-CpG binding domain protein 2
chrX_-_6463158 1.715 NM_016379
VCX2
VCX3A
variable charge, X-linked 2
variable charge, X-linked 3A
chr1_+_190871868 1.712 NM_002927
NM_144766
RGS13

regulator of G-protein signaling 13

chr7_+_134114957 1.707 CALD1
caldesmon 1
chr2_-_231697999 1.673 NM_000867
HTR2B
5-hydroxytryptamine (serotonin) receptor 2B
chr8_+_55533047 1.664 NM_022454
SOX17
SRY (sex determining region Y)-box 17
chr18_-_39111243 1.657 NM_020783
SYT4
synaptotagmin IV
chr10_+_124141808 1.655 NM_021622
PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr15_+_38082041 1.635 EIF2AK4
eukaryotic translation initiation factor 2 alpha kinase 4
chr12_-_10453409 1.613 NM_013431
KLRC4-KLRK1
KLRC4
KLRC4-KLRK1 read-through transcript
killer cell lectin-like receptor subfamily C, member 4
chr5_-_27074407 1.602 NM_016279
CDH9
cadherin 9, type 2 (T1-cadherin)
chr2_+_201833467 1.601 NM_033356
CASP8
caspase 8, apoptosis-related cysteine peptidase
chr21_+_30929425 1.601 NM_181616
KRTAP20-2
keratin associated protein 20-2
chr3_+_150028130 1.600 NM_001871
CPB1
carboxypeptidase B1 (tissue)
chr21_+_30895276 1.595 NM_181620
KRTAP22-1
keratin associated protein 22-1
chr4_-_100492854 1.591 NM_000669
ADH1C
alcohol dehydrogenase 1C (class I), gamma polypeptide
chr9_-_21192201 1.574 NM_021057
IFNA7
interferon, alpha 7
chr1_+_114298021 1.569 NM_181358
HIPK1
homeodomain interacting protein kinase 1
chr3_-_52688768 1.568 NM_018165
NM_181042
PBRM1

polybromo 1

chr12_+_63510481 1.567


chr21_+_44902276 1.553 NM_198697
KRTAP12-3
keratin associated protein 12-3
chr5_+_179065282 1.551 CANX
calnexin
chr5_-_41107161 1.536 NM_173489
HEATR7B2
HEAT repeat family member 7B2
chr12_+_16397617 1.531 NM_145764
MGST1
microsomal glutathione S-transferase 1
chr18_+_64616296 1.530 NM_024781
CCDC102B
coiled-coil domain containing 102B
chr7_-_26202626 1.518 HNRNPA2B1
heterogeneous nuclear ribonucleoprotein A2/B1
chr8_-_62764839 1.510 NM_001164750
NM_001164751
NM_001164752
NM_001164753
NM_020164
NM_032467
NM_032468
ASPH






aspartate beta-hydroxylase






chr4_+_70928718 1.508 NM_000200
HTN3
histatin 3
chr4_-_38460983 1.501 NM_001017388
NM_001195106
NM_001195107
NM_001195108
NM_030956
TLR10




toll-like receptor 10




chr12_-_55432348 1.496 NM_000946
PRIM1
primase, DNA, polypeptide 1 (49kDa)
chr8_-_66863841 1.474 NM_002603
PDE7A
phosphodiesterase 7A
chr4_+_70831387 1.465 NM_001025104
NM_001890
CSN1S1

casein alpha s1

chr4_+_74520796 1.460 NM_001134
AFP
alpha-fetoprotein
chr12_+_14429499 1.448 ATF7IP
activating transcription factor 7 interacting protein
chr12_+_54080480 1.448 NM_001005518
OR6C65
olfactory receptor, family 6, subfamily C, member 65
chr10_+_96433240 1.444 NM_000772
NM_001128925
CYP2C18

cytochrome P450, family 2, subfamily C, polypeptide 18

chr6_+_153113624 1.436 NM_003381
NM_194435
VIP

vasoactive intestinal peptide

chr7_+_17349425 1.429 AHR
aryl hydrocarbon receptor
chr1_-_157551072 1.428 NM_001004467
OR10J3
olfactory receptor, family 10, subfamily J, member 3
chr6_-_127822227 1.428 NM_014702
KIAA0408
KIAA0408
chr10_-_27097782 1.427 ABI1
abl-interactor 1
chr10_+_123738678 1.426 NM_206861
NM_206862
TACC2

transforming, acidic coiled-coil containing protein 2

chr14_-_105785639 1.417


chr4_-_80548378 1.407 NM_033214
GK2
glycerol kinase 2
chr2_-_47969350 1.400 NM_025133
FBXO11
F-box protein 11
chr12_-_12182641 1.394 LRP6
low density lipoprotein receptor-related protein 6
chr2_-_202192141 1.377 NM_001168216
NM_001168217
NM_001168221
NM_152525
ALS2CR11



amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 11



chr9_-_36365965 1.377 RNF38
ring finger protein 38
chr6_+_134315940 1.370 NM_004865
TBPL1
TBP-like 1
chr14_-_20969706 1.368 NM_001170629
CHD8
chromodomain helicase DNA binding protein 8
chr11_-_5110383 1.365 NM_001005160
OR52A5
olfactory receptor, family 52, subfamily A, member 5
chr19_+_21056792 1.359 NM_182515
ZNF714
zinc finger protein 714
chr14_-_46190690 1.347 NM_080746
RPL10L
ribosomal protein L10-like
chr8_+_18072250 1.344 NM_001160179
NAT1
N-acetyltransferase 1 (arylamine N-acetyltransferase)
chr3_-_174341653 1.341 NM_031955
SPATA16
spermatogenesis associated 16
chr3_-_188339882 1.330 NM_052969
RPL39L
ribosomal protein L39-like
chr9_+_95273241 1.328 FAM120A
family with sequence similarity 120A
chr2_+_172252194 1.324 NM_001378
DYNC1I2
dynein, cytoplasmic 1, intermediate chain 2
chr3_+_99334230 1.324 NM_001005338
OR5H1
olfactory receptor, family 5, subfamily H, member 1
chr12_-_25041639 1.322 NM_001101339
C12orf77
chromosome 12 open reading frame 77
chr11_-_89181390 1.319 NM_020358
TRIM49
tripartite motif containing 49
chr3_-_114643008 1.317 NM_001164496
NM_018338
WDR52

WD repeat domain 52

chr21_+_29374743 1.317 NM_020152
C21orf7
chromosome 21 open reading frame 7
chrX_+_35847771 1.307 NM_152632
CXorf22
chromosome X open reading frame 22
chr11_-_121492010 1.305 NM_001001786
BLID
BH3-like motif containing, cell death inducer
chr17_+_36665161 1.299 NM_030975
KRTAP9-9
keratin associated protein 9-9
chr14_-_105681377 1.299 IGHV4-31
IGHG1
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant gamma 1 (G1m marker)
chr3_+_99699137 1.297 NM_001004737
OR5K2
olfactory receptor, family 5, subfamily K, member 2
chr7_-_18033970 1.289 NM_175886
PRPS1L1
phosphoribosyl pyrophosphate synthetase 1-like 1
chr14_+_28311740 1.288 C14orf23
chromosome 14 open reading frame 23
chr1_+_78243181 1.275 NM_007034
DNAJB4
DnaJ (Hsp40) homolog, subfamily B, member 4
chr11_-_7906784 1.274 NM_001004461
OR10A6
olfactory receptor, family 10, subfamily A, member 6
chr2_-_202192097 1.273 ALS2CR11
amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 11
chr8_+_24354387 1.272 NM_003817
ADAM7
ADAM metallopeptidase domain 7
chr14_+_67238355 1.271 NM_152443
RDH12
retinol dehydrogenase 12 (all-trans/9-cis/11-cis)
chr9_+_74956601 1.271 ANXA1
annexin A1
chr13_-_38462857 1.268 NM_001144033
NM_145286
STOML3

stomatin (EPB72)-like 3

chr2_-_207291364 1.268 NM_001093730
DYTN
dystrotelin
chr3_-_69381995 1.258 FRMD4B
FERM domain containing 4B
chr6_+_49575629 1.251 NM_001010904
GLYATL3
glycine-N-acyltransferase-like 3
chr17_+_29621352 1.251 NM_006273
CCL7
chemokine (C-C motif) ligand 7
chr9_+_71009746 1.245 NM_001170415
NM_001170416
TJP2

tight junction protein 2 (zona occludens 2)

chr15_+_100175888 1.236 NM_001001674
OR4F15
olfactory receptor, family 4, subfamily F, member 15
chr3_+_149898347 1.235 NM_000685
NM_004835
NM_009585
NM_031850
AGTR1



angiotensin II receptor, type 1



chr6_-_25982418 1.233 NM_001098486
NM_006632
SLC17A3

solute carrier family 17 (sodium phosphate), member 3

chr5_-_43326922 1.226 HMGCS1
3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
chr3_+_85858321 1.222 NM_153184
CADM2
cell adhesion molecule 2
chr7_+_111908143 1.219 NM_001134468
NM_182597
C7orf53

chromosome 7 open reading frame 53

chr4_+_74825138 1.210 NM_000584
IL8
interleukin 8
chr2_-_179367925 1.207 TTN
titin
chr8_+_86287161 1.206 NM_001083589
E2F5
E2F transcription factor 5, p130-binding
chr6_-_88917600 1.205 NM_001160260
CNR1
cannabinoid receptor 1 (brain)
chr1_+_42934910 1.202 YBX1
Y box binding protein 1
chr4_+_71330797 1.202 NM_001145006
MUC7
mucin 7, secreted
chr10_+_116571485 1.201 NM_001135051
NM_020940
FAM160B1

family with sequence similarity 160, member B1

chr3_-_166278969 1.200 NM_001041
SI
sucrase-isomaltase (alpha-glucosidase)
chr2_-_190336168 1.187 NM_022353
OSGEPL1
O-sialoglycoprotein endopeptidase-like 1
chr9_+_74956494 1.182 NM_000700
ANXA1
annexin A1
chr10_-_98326435 1.176 TM9SF3
transmembrane 9 superfamily member 3
chr4_+_176076083 1.174 NM_001130703
NM_001130704
NM_001130705
NM_014269
ADAM29



ADAM metallopeptidase domain 29



chr4_-_70547962 1.167 NM_006798
UGT2A1
UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus
chr5_+_171553780 1.162 NM_001171183
EFCAB9
EF-hand calcium binding domain 9
chr1_+_28637247 1.159 NM_023923
PHACTR4
phosphatase and actin regulator 4
chrX_-_101581504 1.155 NM_022053
NXF2
nuclear RNA export factor 2
chr9_-_21295311 1.151 NM_002169
IFNA5
interferon, alpha 5
chr2_-_97775300 1.148 TMEM131
transmembrane protein 131
chr12_-_53975282 1.147 NM_001005493
OR6C6
olfactory receptor, family 6, subfamily C, member 6
chr16_+_55373241 1.143 NUP93
nucleoporin 93kDa
chr19_-_23661779 1.142 NM_138330
ZNF675
zinc finger protein 675
chr19_-_58486686 1.139 NM_033341
BIRC8
baculoviral IAP repeat containing 8
chr8_-_120720200 1.138 NM_001040092
NM_001130863
NM_006209
ENPP2


ectonucleotide pyrophosphatase/phosphodiesterase 2


chr9_-_21197141 1.137 NM_002171
IFNA10
interferon, alpha 10
chr12_+_9871343 1.135 NM_016523
KLRF1
killer cell lectin-like receptor subfamily F, member 1
chr2_+_183316574 1.134 DNAJC10
DnaJ (Hsp40) homolog, subfamily C, member 10
chr12_+_63090008 1.130 XPOT
exportin, tRNA (nuclear export receptor for tRNAs)
chr11_-_55757236 1.126 NM_001004746
OR5T2
olfactory receptor, family 5, subfamily T, member 2
chr12_-_9987277 1.124 LOC100506159
hypothetical LOC100506159
chr5_+_115415061 1.121 NM_001195581
LOC644100
hypothetical LOC644100
chr1_+_198278339 1.120 NR5A2
nuclear receptor subfamily 5, group A, member 2
chr8_+_24297742 1.119 NM_001145271
NM_001145272
NM_014479
ADAMDEC1


ADAM-like, decysin 1


chr7_+_38984133 1.119 NM_001166018
NM_007252
POU6F2

POU class 6 homeobox 2

chr2_-_210876560 1.119 NM_079422
MYL1
myosin, light chain 1, alkali; skeletal, fast
chr6_-_133008834 1.119 NM_138327
TAAR1
trace amine associated receptor 1
chrX_-_76700873 1.118 ATRX
alpha thalassemia/mental retardation syndrome X-linked
chr14_-_20098929 1.115 NM_001001673
NM_001110356
NM_001110357
NM_001110358
NM_001110359
NM_001110360
NM_001110361
RNASE9






ribonuclease, RNase A family, 9 (non-active)






chr10_+_90552466 1.115 NM_001128215
LIPM
lipase, family member M
chr5_+_159781454 1.115 PTTG1
pituitary tumor-transforming 1
chr14_+_38719462 1.111 PNN
pinin, desmosome associated protein
chr19_+_20049800 1.111 NM_007138
ZNF90
zinc finger protein 90
chr11_+_55842358 1.107 NM_001005202
OR8K3
olfactory receptor, family 8, subfamily K, member 3
chr1_-_100003936 1.099 NM_001013660
FRRS1
ferric-chelate reductase 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
3.30 4.12e-31 GO:0007606 sensory perception of chemical stimulus
3.42 3.08e-30 GO:0007608 sensory perception of smell
2.30 1.13e-19 GO:0007600 sensory perception
1.68 2.24e-09 GO:0050877 neurological system process
1.52 4.79e-07 GO:0003008 system process
5.03 9.76e-04 GO:0060338 regulation of type I interferon-mediated signaling pathway
2.04 9.87e-04 GO:0031347 regulation of defense response
1.77 2.85e-02 GO:0051707 response to other organism
1.15 3.95e-02 GO:0050896 response to stimulus
2.20 4.02e-02 GO:0045088 regulation of innate immune response
1.72 4.79e-02 GO:0050776 regulation of immune response

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.24 5.52e-05 GO:0071944 cell periphery
1.23 1.01e-04 GO:0005886 plasma membrane
1.16 8.10e-03 GO:0016021 integral to membrane
1.15 1.26e-02 GO:0031224 intrinsic to membrane
1.13 1.70e-02 GO:0044425 membrane part

Gene overrepresentation in function category:

enrichment   p-value GO term description
3.55 2.55e-32 GO:0004984 olfactory receptor activity
2.32 8.05e-22 GO:0004930 G-protein coupled receptor activity
1.84 8.06e-15 GO:0004888 transmembrane receptor activity
1.69 4.21e-14 GO:0004872 receptor activity
1.52 3.57e-10 GO:0004871 signal transducer activity
1.52 3.57e-10 GO:0060089 molecular transducer activity
10.16 1.45e-04 GO:0005132 interferon-alpha/beta receptor binding