Motif ID: GLI1..3.p2

Z-value: 1.783


Transcription factors associated with GLI1..3.p2:

Gene SymbolEntrez IDGene Name
GLI1 2735 glioma-associated oncogene homolog 1 (zinc finger protein)
GLI2 2736 GLI-Kruppel family member GLI2
GLI3 2737 GLI-Kruppel family member GLI3



Activity profile for motif GLI1..3.p2.

activity profile for motif GLI1..3.p2


Sorted Z-values histogram for motif GLI1..3.p2

Sorted Z-values for motif GLI1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of GLI1..3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_+_566482 6.628 NM_020901
PHRF1
PHD and ring finger domains 1
chr16_+_2461500 2.748 NM_006181
NTN3
netrin 3
chr7_-_100009205 2.537 NM_001168682
SAP25
sin3A-binding protein 25
chr15_+_65217412 2.504 NM_001145103
SMAD3
SMAD family member 3
chr4_+_1764802 2.456 NM_000142
NM_001163213
NM_022965
FGFR3


fibroblast growth factor receptor 3


chr1_+_148090804 2.323 NM_021059
NM_001005464
HIST2H3C
HIST2H3A
histone cluster 2, H3c
histone cluster 2, H3a
chr11_-_72057755 2.297 NM_001146209
PDE2A
phosphodiesterase 2A, cGMP-stimulated
chr11_+_1848674 2.216 NM_001013254
NM_001013255
LSP1

lymphocyte-specific protein 1

chr22_+_18090118 2.067 SEPT5-GP1BB
SEPT5-GP1BB read-through transcript
chr13_+_112789669 2.040 MCF2L
MCF.2 cell line derived transforming sequence-like
chr22_-_17892001 2.033 CLDN5
claudin 5
chr12_+_110328126 2.029 NM_005475
SH2B3
SH2B adaptor protein 3
chr11_+_76491532 1.946 NM_006189
OMP
olfactory marker protein
chr19_-_51010272 1.936 NM_030785
RSPH6A
radial spoke head 6 homolog A (Chlamydomonas)
chr11_-_404975 1.935 NM_001135054
SIGIRR
single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
chr16_+_2138608 1.898 NM_014353
RAB26
RAB26, member RAS oncogene family
chr6_-_34209250 1.869 NM_000841
GRM4
glutamate receptor, metabotropic 4
chr5_+_176170041 1.803 NM_133369
UNC5A
unc-5 homolog A (C. elegans)
chr19_+_482737 1.803 CDC34
cell division cycle 34 homolog (S. cerevisiae)
chr19_+_3490154 1.794 NM_001135580
C19orf71
chromosome 19 open reading frame 71
chr16_+_87232501 1.761 NM_013278
IL17C
interleukin 17C
chr11_+_1897374 1.755 NM_001042780
NM_001042781
NM_001042782
NM_006757
TNNT3



troponin T type 3 (skeletal, fast)



chr7_+_149699185 1.754 NM_014374
REPIN1
replication initiator 1
chr7_-_150515851 1.749 NM_080871
ASB10
ankyrin repeat and SOCS box containing 10
chr1_-_12599934 1.745 NM_004753
DHRS3
dehydrogenase/reductase (SDR family) member 3
chr22_-_17891777 1.705 CLDN5
claudin 5
chr22_-_26527469 1.692 NM_002430
MN1
meningioma (disrupted in balanced translocation) 1
chr2_+_128119908 1.679 NM_001161415
NM_001161416
NM_001161417
NM_005291
GPR17



G protein-coupled receptor 17



chr5_-_1165106 1.665 NM_006598
SLC12A7
solute carrier family 12 (potassium/chloride transporters), member 7
chr16_+_88214500 1.623 NM_004413
DPEP1
dipeptidase 1 (renal)
chr17_+_15788955 1.598 NM_000676
ADORA2B
adenosine A2b receptor
chr3_-_38046034 1.587 NM_006225
PLCD1
phospholipase C, delta 1
chr7_+_101978777 1.572 NM_001166339
NM_001031618
SPDYE2L
SPDYE2
WBSCR19-like protein 3
speedy homolog E2 (Xenopus laevis)
chr11_+_183079 1.563 NM_145651
SCGB1C1
secretoglobin, family 1C, member 1
chr8_-_142080169 1.557 NM_005607
NM_153831
PTK2

PTK2 protein tyrosine kinase 2

chr1_-_24307514 1.543 MYOM3
myomesin family, member 3
chr2_+_220200530 1.509 NM_005070
NM_201574
SLC4A3

solute carrier family 4, anion exchanger, member 3

chrX_-_135941498 1.509 NM_054021
GPR101
G protein-coupled receptor 101
chr22_+_45401321 1.506 NM_015124
GRAMD4
GRAM domain containing 4
chr20_-_48686832 1.503 NM_080829
FAM65C
family with sequence similarity 65, member C
chr17_+_35751796 1.500 NM_001024809
RARA
retinoic acid receptor, alpha
chr1_-_16812274 1.499 NM_017940
NBPF1
neuroblastoma breakpoint family, member 1
chr1_+_3597092 1.492 NM_001126240
NM_001126241
NM_001126242
TP73


tumor protein p73


chr17_+_44927591 1.492 NM_002507
NGFR
nerve growth factor receptor
chr2_+_242460553 1.482 NM_173821
C2orf85
chromosome 2 open reading frame 85
chr3_+_42702014 1.465 NM_152393
KBTBD5
kelch repeat and BTB (POZ) domain containing 5
chr9_+_130620540 1.464 NM_004435
ENDOG
endonuclease G
chr2_+_96845704 1.457 NM_017623
NM_199078
CNNM3

cyclin M3

chr1_-_9040141 1.421 SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr6_-_168222645 1.396 NM_024919
FRMD1
FERM domain containing 1
chr7_-_1562272 1.381 NM_001097620
TMEM184A
transmembrane protein 184A
chr7_-_127833231 1.371 NM_001142573
NM_001142574
NM_001142575
IMPDH1


IMP (inosine 5'-monophosphate) dehydrogenase 1


chr20_+_42776888 1.370 WISP2
WNT1 inducible signaling pathway protein 2
chr17_+_7728819 1.370 NM_001005271
CHD3
chromodomain helicase DNA binding protein 3
chr11_+_76455574 1.370 NM_004055
CAPN5
calpain 5
chr16_+_29892714 1.364 NM_004783
NM_016151
TAOK2

TAO kinase 2

chr22_+_35777561 1.359 NM_024681
KCTD17
potassium channel tetramerisation domain containing 17
chr17_-_40674883 1.356


chr20_+_61798446 1.354 NM_003823
TNFRSF6B
tumor necrosis factor receptor superfamily, member 6b, decoy
chr19_+_48729127 1.354 NM_174945
ZNF575
zinc finger protein 575
chr20_+_42777298 1.352 NM_003881
WISP2
WNT1 inducible signaling pathway protein 2
chr7_+_2525922 1.345 NM_001040167
NM_001040168
LFNG

LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

chr1_+_19842309 1.335 NM_182744
NBL1
neuroblastoma, suppression of tumorigenicity 1
chr20_+_61798512 1.330 TNFRSF6B
tumor necrosis factor receptor superfamily, member 6b, decoy
chr12_-_55920741 1.326 NM_020142
NDUFA4L2
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
chr15_-_70277163 1.314 NM_001012642
GRAMD2
GRAM domain containing 2
chr15_+_38520594 1.297 NM_014952
BAHD1
bromo adjacent homology domain containing 1
chrX_-_152871351 1.296 HCFC1
host cell factor C1 (VP16-accessory protein)
chr17_+_73738985 1.290 NM_001145529
TMEM235
transmembrane protein 235
chr9_+_138677197 1.287 NM_201446
NM_016215
EGFL7

EGF-like-domain, multiple 7

chr1_+_1104939 1.283 NM_153254
TTLL10
tubulin tyrosine ligase-like family, member 10
chr19_+_4920123 1.277 NM_015015
KDM4B
lysine (K)-specific demethylase 4B
chr17_-_45617899 1.276 COL1A1
collagen, type I, alpha 1
chr10_+_47216925 1.273 NM_001630
ANXA8L2
ANXA8
annexin A8-like 2
annexin A8
chr16_+_705080 1.267 NM_024042
METRN
meteorin, glial cell differentiation regulator
chr12_+_6517600 1.264


chr20_+_44070946 1.264 NM_004994
MMP9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
chr16_+_30583278 1.264 NM_001105079
FBRS
fibrosin
chr5_-_1397941 1.263 NM_030782
CLPTM1L
CLPTM1-like
chr9_+_114552871 1.261 NM_001012994
SNX30
sorting nexin family member 30
chr20_-_60228665 1.259 NM_007232
HRH3
histamine receptor H3
chr19_+_4920126 1.257 KDM4B
lysine (K)-specific demethylase 4B
chr1_+_148788410 1.244 NM_019032
NM_025008
ADAMTSL4

ADAMTS-like 4

chr16_+_87021379 1.218 NM_001127464
ZNF469
zinc finger protein 469
chr17_+_45617676 1.217


chr19_+_40900965 1.203 MLL4
myeloid/lymphoid or mixed-lineage leukemia 4
chr19_-_53868075 1.202 NM_145807
NTN5
netrin 5
chr16_+_85169615 1.202 NM_005250
FOXL1
forkhead box L1
chr9_+_135213235 1.201 NM_017503
SURF2
surfeit 2
chr16_+_29942155 1.199 NM_001109659
NM_001109660
C16orf92

chromosome 16 open reading frame 92

chrX_+_152608159 1.190 NM_001142806
SLC6A8
solute carrier family 6 (neurotransmitter transporter, creatine), member 8
chr11_+_2355119 1.178 NM_004356
CD81
CD81 molecule
chr10_+_80743769 1.175 ZMIZ1
zinc finger, MIZ-type containing 1
chr20_+_61655934 1.173


chr17_-_37022465 1.172 NM_005557
KRT16
keratin 16
chr19_+_40900757 1.166 NM_014727
MLL4
myeloid/lymphoid or mixed-lineage leukemia 4
chr20_+_60558104 1.143 NM_178463
C20orf166
chromosome 20 open reading frame 166
chr16_-_2258067 1.141 RNPS1
RNA binding protein S1, serine-rich domain
chr14_+_105012106 1.140 NM_001312
CRIP2
cysteine-rich protein 2
chr1_+_43837096 1.138 PTPRF
protein tyrosine phosphatase, receptor type, F
chr16_+_30583599 1.133 FBRS
fibrosin
chr4_-_140696740 1.133 NM_030648
SETD7
SET domain containing (lysine methyltransferase) 7
chr12_-_51514328 1.127 NM_175834
KRT79
keratin 79
chr16_+_82782223 1.122 NM_001145400
NM_139174
ADAD2

adenosine deaminase domain containing 2

chr22_-_49050847 1.122 NM_002751
MAPK11
mitogen-activated protein kinase 11
chr19_+_16296632 1.119 NM_016270
KLF2
Kruppel-like factor 2 (lung)
chr1_-_38285033 1.115 NM_002699
POU3F1
POU class 3 homeobox 1
chr1_-_150065176 1.112 NM_001001523
RORC
RAR-related orphan receptor C
chr6_+_44076281 1.109 NM_001171992
NM_153246
C6orf223

chromosome 6 open reading frame 223

chr6_+_41622267 1.109 FOXP4
forkhead box P4
chr1_+_101475149 1.108 S1PR1
sphingosine-1-phosphate receptor 1
chr17_+_71141108 1.104 NM_001162995
LOC643008
hypothetical protein LOC643008
chr1_+_200358594 1.103 NM_004767
GPR37L1
G protein-coupled receptor 37 like 1
chr22_+_18388656 1.100 C22orf25
chromosome 22 open reading frame 25
chr15_+_72397934 1.097 NM_182791
CCDC33
coiled-coil domain containing 33
chr11_-_3104413 1.086 OSBPL5
oxysterol binding protein-like 5
chr8_+_21956335 1.078 NM_003867
FGF17
fibroblast growth factor 17
chr12_-_6668880 1.075 NM_001039917
NM_001039919
NM_001039920
NM_001135734
ZNF384



zinc finger protein 384



chr16_-_73842884 1.070 NM_001170717
NM_014567
BCAR1

breast cancer anti-estrogen resistance 1

chr9_-_138757175 1.069 NM_001001712
LCN10
lipocalin 10
chr20_+_42777419 1.054 WISP2
WNT1 inducible signaling pathway protein 2
chr3_+_50272648 1.046


chr18_-_72221228 1.044 ZNF516
zinc finger protein 516
chrX_-_19598912 1.041 NM_001184960
SH3KBP1
SH3-domain kinase binding protein 1
chr9_+_130056513 1.040


chr20_+_44180355 1.036 CD40
CD40 molecule, TNF receptor superfamily member 5
chr19_+_1236766 1.033 NM_001405
EFNA2
ephrin-A2
chr2_+_232281470 1.028 NM_001099285
NM_002823
PTMA

prothymosin, alpha

chr20_+_61654816 1.026 NM_024059
C20orf195
chromosome 20 open reading frame 195
chr22_+_18388633 1.026 C22orf25
chromosome 22 open reading frame 25
chr20_-_42457717 1.023


chr16_+_29581783 1.023 NM_001030288
SPN
sialophorin
chr10_+_80740584 1.018 ZMIZ1
zinc finger, MIZ-type containing 1
chr11_+_113351006 1.006 NM_000869
NM_213621
HTR3A

5-hydroxytryptamine (serotonin) receptor 3A

chr9_+_130909926 1.004


chr17_+_24095135 1.001 NM_004295
TRAF4
TNF receptor-associated factor 4
chr19_+_811615 0.991 CFD
complement factor D (adipsin)
chr12_-_6668680 0.990 ZNF384
zinc finger protein 384
chr1_+_11674365 0.988 NM_198545
C1orf187
chromosome 1 open reading frame 187
chr19_+_627346 0.985 NM_005860
FSTL3
follistatin-like 3 (secreted glycoprotein)
chr6_-_39390073 0.983 NM_031460
NM_001135111
KCNK17

potassium channel, subfamily K, member 17

chr11_+_65754476 0.981 PACS1
phosphofurin acidic cluster sorting protein 1
chr20_+_44180296 0.981 NM_001250
NM_152854
CD40

CD40 molecule, TNF receptor superfamily member 5

chr11_+_65236261 0.975 KAT5
K(lysine) acetyltransferase 5
chrX_+_69581429 0.966 NM_021120
DLG3
discs, large homolog 3 (Drosophila)
chr17_-_24302597 0.965 NM_001033561
NM_020889
PHF12

PHD finger protein 12

chr8_-_37847095 0.962 RAB11FIP1
RAB11 family interacting protein 1 (class I)
chr19_+_935316 0.958 NM_024100
WDR18
WD repeat domain 18
chr11_-_118693021 0.955 NM_006500
MCAM
melanoma cell adhesion molecule
chr8_-_22070208 0.953 NM_139278
LGI3
leucine-rich repeat LGI family, member 3
chr2_+_232281491 0.951 PTMA
prothymosin, alpha
chr17_-_17340219 0.948 NM_016084
RASD1
RAS, dexamethasone-induced 1
chr20_+_56861430 0.940 NM_001077490
NM_080425
GNAS

GNAS complex locus

chr19_+_63670148 0.936 NM_014347
ZNF324
zinc finger protein 324
chr19_+_10900502 0.932 C19orf52
chromosome 19 open reading frame 52
chr17_-_7078446 0.926 NM_004422
DVL2
dishevelled, dsh homolog 2 (Drosophila)
chr11_+_66367458 0.918 NM_001032279
NM_005133
RCE1

RCE1 homolog, prenyl protein peptidase (S. cerevisiae)

chr12_-_6668787 0.918 NM_001039918
NM_133476
ZNF384

zinc finger protein 384

chr3_-_185578621 0.918 NM_000460
NM_001177597
NM_001177598
THPO


thrombopoietin


chr19_+_13124889 0.917 IER2
immediate early response 2
chr17_-_74231240 0.917 CYTH1
cytohesin 1
chr22_+_18388602 0.914 NM_152906
C22orf25
chromosome 22 open reading frame 25
chr17_+_77603064 0.911 GPS1
G protein pathway suppressor 1
chr11_-_66367279 0.909


chr10_+_80672842 0.909 ZMIZ1
zinc finger, MIZ-type containing 1
chr1_+_3378030 0.908 ARHGEF16
Rho guanine nucleotide exchange factor (GEF) 16
chr20_-_62208627 0.907 NM_005286
NPBWR2
neuropeptides B/W receptor 2
chr17_+_18069593 0.903 NM_004140
LLGL1
lethal giant larvae homolog 1 (Drosophila)
chr22_-_17546234 0.898 SLC25A1
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
chrX_+_151837064 0.896 NM_001178113
ZNF185
zinc finger protein 185 (LIM domain)
chr14_+_99181232 0.894 NM_001127258
NM_032425
HHIPL1

HHIP-like 1

chr22_-_17546296 0.893 NM_005984
SLC25A1
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
chr12_+_124115877 0.891 NM_023928
AACS
acetoacetyl-CoA synthetase
chr22_-_17546276 0.889 SLC25A1
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
chr16_+_11669736 0.883 NM_003498
SNN
stannin
chr17_-_40401138 0.876 NM_006688
C1QL1
complement component 1, q subcomponent-like 1
chr19_-_3820012 0.876 NM_001145640
NM_015174
ZFR2

zinc finger RNA binding protein 2

chr16_-_82778071 0.874 NM_005679
NM_139353
TAF1C

TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa

chr1_+_32251988 0.872 NM_006559
KHDRBS1
KH domain containing, RNA binding, signal transduction associated 1
chr19_+_16296734 0.867 KLF2
Kruppel-like factor 2 (lung)
chr17_+_14145051 0.865 NM_006041
HS3ST3B1
heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1
chr8_-_144726064 0.864 NM_001100878
C8orf73
chromosome 8 open reading frame 73
chr11_+_65815940 0.862 NM_153266
TMEM151A
transmembrane protein 151A
chr1_+_1256585 0.862 NM_152228
TAS1R3
taste receptor, type 1, member 3
chr19_-_10900086 0.861 NM_024029
YIPF2
Yip1 domain family, member 2
chr19_+_13124870 0.852 IER2
immediate early response 2
chr4_+_8633116 0.848 NM_080819
GPR78
G protein-coupled receptor 78
chr10_+_85944383 0.848 NM_001171971
NM_033100
CDHR1

cadherin-related family member 1

chr12_+_124115928 0.846 AACS
acetoacetyl-CoA synthetase
chr1_+_203106600 0.844 NFASC
neurofascin
chr12_-_131256525 0.842 NM_021808
GALNT9
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 9 (GalNAc-T9)
chr19_-_18910790 0.835 NM_001145724
HOMER3
homer homolog 3 (Drosophila)
chr21_-_32573195 0.833 NM_018944
MIS18A
MIS18 kinetochore protein homolog A (S. pombe)
chr5_-_179951071 0.830 NM_052863
SCGB3A1
secretoglobin, family 3A, member 1
chr2_+_220087135 0.826 NM_018674
NM_182847
ACCN4

amiloride-sensitive cation channel 4, pituitary

chr4_+_134289893 0.825 NM_020815
NM_032961
PCDH10

protocadherin 10

chr6_+_32240357 0.825 NM_030652
EGFL8
EGF-like-domain, multiple 8
chr19_-_59676153 0.825 NM_145057
CDC42EP5
CDC42 effector protein (Rho GTPase binding) 5
chr8_-_10550026 0.818 NM_178857
RP1L1
retinitis pigmentosa 1-like 1
chr17_-_1342700 0.818 NM_001080779
MYO1C
myosin IC

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.41 1.32e-06 GO:0023051 regulation of signaling
1.44 1.99e-06 GO:0009966 regulation of signal transduction
1.36 5.26e-06 GO:0048583 regulation of response to stimulus
1.37 1.78e-04 GO:0009653 anatomical structure morphogenesis
1.12 1.92e-04 GO:0065007 biological regulation
1.37 2.36e-04 GO:0007399 nervous system development
1.25 2.92e-04 GO:0048731 system development
1.13 3.00e-04 GO:0050794 regulation of cellular process
1.49 4.06e-04 GO:0048699 generation of neurons
1.29 6.10e-04 GO:0048869 cellular developmental process
1.12 6.63e-04 GO:0050789 regulation of biological process
1.29 9.24e-04 GO:0030154 cell differentiation
1.22 9.46e-04 GO:0048856 anatomical structure development
1.45 1.52e-03 GO:0022008 neurogenesis
1.19 2.54e-03 GO:0023052 signaling
1.69 5.05e-03 GO:0051056 regulation of small GTPase mediated signal transduction
1.20 6.06e-03 GO:0007275 multicellular organismal development
1.22 1.20e-02 GO:0048518 positive regulation of biological process
1.23 1.54e-02 GO:0048522 positive regulation of cellular process
1.47 1.59e-02 GO:0030182 neuron differentiation
1.37 1.87e-02 GO:0010646 regulation of cell communication
1.17 2.21e-02 GO:0032502 developmental process
1.39 2.93e-02 GO:0048468 cell development
1.30 3.65e-02 GO:0065009 regulation of molecular function
1.59 4.01e-02 GO:0007409 axonogenesis
1.36 4.77e-02 GO:0007154 cell communication
1.77 4.91e-02 GO:0046578 regulation of Ras protein signal transduction

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.13 6.40e-05 GO:0005515 protein binding
1.80 4.89e-04 GO:0005083 small GTPase regulator activity
1.45 7.64e-03 GO:0043565 sequence-specific DNA binding
1.54 1.01e-02 GO:0030695 GTPase regulator activity
1.73 1.34e-02 GO:0005096 GTPase activator activity
1.50 2.99e-02 GO:0060589 nucleoside-triphosphatase regulator activity