Motif ID: EOMES.p2

Z-value: 0.761


Transcription factors associated with EOMES.p2:

Gene SymbolEntrez IDGene Name
EOMES 8320 eomesodermin



Activity profile for motif EOMES.p2.

activity profile for motif EOMES.p2


Sorted Z-values histogram for motif EOMES.p2

Sorted Z-values for motif EOMES.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EOMES.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_144149794 1.024 NM_006472
TXNIP
thioredoxin interacting protein
chr10_+_4995685 0.988 AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr10_+_4995597 0.932 AKR1C1
AKR1C3
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr2_+_152900076 0.924 FMNL2
formin-like 2
chr2_+_171280944 0.868 SP5
Sp5 transcription factor
chr2_+_171280046 0.854 NM_001003845
SP5
Sp5 transcription factor
chr2_+_171280182 0.836


chr6_-_29120930 0.773 NM_030903
OR2W1
olfactory receptor, family 2, subfamily W, member 1
chr2_+_228386800 0.699 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr4_+_8633116 0.692 NM_080819
GPR78
G protein-coupled receptor 78
chr2_+_65070030 0.691 SLC1A4
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr14_+_94148466 0.651 NM_001085
SERPINA3
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
chrX_+_69418746 0.606 NM_001032726
RAB41
RAB41, member RAS oncogene family
chr1_+_210848726 0.601 ATF3
activating transcription factor 3
chr3_-_71625318 0.592 FOXP1
forkhead box P1
chr20_+_55338221 0.583 NM_012444
NM_198265
SPO11

SPO11 meiotic protein covalently bound to DSB homolog (S. cerevisiae)

chr11_+_122214415 0.577 NM_019604
CRTAM
cytotoxic and regulatory T cell molecule
chr2_-_236837726 0.575 NM_212556
ASB18
ankyrin repeat and SOCS box containing 18
chr2_-_156897286 0.573 NM_006186
NR4A2
nuclear receptor subfamily 4, group A, member 2
chr2_+_65069986 0.566 NM_003038
SLC1A4
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr11_-_5227611 0.564 NM_000559
HBG1
HBG2
hemoglobin, gamma A
hemoglobin, gamma G
chr10_+_24537725 0.518 NM_001098501
NM_019590
KIAA1217

KIAA1217

chr1_+_210848763 0.515 ATF3
activating transcription factor 3
chr6_+_152168500 0.500 NM_001122741
ESR1
estrogen receptor 1
chr12_-_89873081 0.496 NM_152638
C12orf12
chromosome 12 open reading frame 12
chr10_+_24538094 0.488 KIAA1217
KIAA1217
chr10_+_44726635 0.470 NM_001123376
TMEM72
transmembrane protein 72
chr6_+_36754433 0.464 NM_000389
CDKN1A
cyclin-dependent kinase inhibitor 1A (p21, Cip1)
chr1_+_210848592 0.459 NM_001040619
NM_001674
ATF3

activating transcription factor 3

chr2_+_1397186 0.450 NM_175721
NM_175722
TPO

thyroid peroxidase

chr12_+_123339662 0.446 NM_181709
FAM101A
family with sequence similarity 101, member A
chr6_+_64339869 0.437 NM_003463
PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr20_-_43949644 0.426 NM_080608
C20orf165
chromosome 20 open reading frame 165
chr17_-_73867748 0.423 NM_003955
SOCS3
suppressor of cytokine signaling 3
chr20_+_42463350 0.417 HNF4A
hepatocyte nuclear factor 4, alpha
chr2_+_152899837 0.410 NM_052905
FMNL2
formin-like 2
chr3_+_10832867 0.405 NM_014229
SLC6A11
solute carrier family 6 (neurotransmitter transporter, GABA), member 11
chr6_+_36754467 0.401 CDKN1A
cyclin-dependent kinase inhibitor 1A (p21, Cip1)
chr20_+_42463279 0.399 NM_000457
NM_178849
NM_178850
HNF4A


hepatocyte nuclear factor 4, alpha


chr20_+_35406497 0.378 NM_005417
SRC
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
chr21_-_46528594 0.377 MCM3AP
minichromosome maintenance complex component 3 associated protein
chr16_-_20271530 0.370 NM_001008389
NM_003361
UMOD

uromodulin

chr4_+_144654005 0.364 NM_003601
SMARCA5
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
chr3_-_123584747 0.363 NM_001017928
CCDC58
coiled-coil domain containing 58
chr20_-_45410033 0.361 ZMYND8
zinc finger, MYND-type containing 8
chr6_-_13595751 0.361 NM_018988
GFOD1
glucose-fructose oxidoreductase domain containing 1
chr2_-_61551403 0.359 USP34
ubiquitin specific peptidase 34
chr3_+_139211639 0.348 NM_016369
CLDN18
claudin 18
chr14_-_22516271 0.343 NM_198086
JUB
jub, ajuba homolog (Xenopus laevis)
chr16_+_84202515 0.340 NM_001134473
KIAA0182
KIAA0182
chr11_-_5178505 0.332 NM_001004760
OR51V1
olfactory receptor, family 51, subfamily V, member 1
chr7_-_99604171 0.324 NM_024637
GAL3ST4
galactose-3-O-sulfotransferase 4
chr20_+_42463387 0.323 HNF4A
hepatocyte nuclear factor 4, alpha
chr2_-_61551350 0.322 NM_014709
USP34
ubiquitin specific peptidase 34
chr6_-_74284522 0.322 EEF1A1
eukaryotic translation elongation factor 1 alpha 1
chr3_-_49701085 0.322 NM_020998
MST1
macrophage stimulating 1 (hepatocyte growth factor-like)
chr1_-_243092581 0.322 HNRNPU
heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
chr6_-_39398293 0.321 NM_001135105
NM_001135106
NM_001135107
NM_032115
KCNK16



potassium channel, subfamily K, member 16



chr4_+_124537334 0.316 NM_199327
SPRY1
sprouty homolog 1, antagonist of FGF signaling (Drosophila)
chr7_-_5535349 0.315 ACTB
actin, beta
chr6_-_130224108 0.310 NM_001010876
C6orf191
chromosome 6 open reading frame 191
chr6_+_64340408 0.310 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr20_-_61669550 0.309 NM_033405
PRIC285
peroxisomal proliferator-activated receptor A interacting complex 285
chr5_+_156752739 0.307 CYFIP2
cytoplasmic FMR1 interacting protein 2
chr2_-_100088760 0.301 AFF3
AF4/FMR2 family, member 3
chr20_-_5243014 0.300 NM_144773
PROKR2
prokineticin receptor 2
chr20_+_42463419 0.299 HNF4A
hepatocyte nuclear factor 4, alpha
chrX_+_70359780 0.296 NM_000166
GJB1
gap junction protein, beta 1, 32kDa
chrX_+_152608159 0.294 NM_001142806
SLC6A8
solute carrier family 6 (neurotransmitter transporter, creatine), member 8
chr18_+_53863865 0.291 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr2_-_21084077 0.288 APOB
apolipoprotein B (including Ag(x) antigen)
chr1_-_8406288 0.286 NM_001042682
RERE
arginine-glutamic acid dipeptide (RE) repeats
chr6_-_31727460 0.285


chr2_-_74606819 0.284 NM_133637
DQX1
DEAQ box RNA-dependent ATPase 1
chr2_+_154436670 0.282 NM_052917
GALNT13
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13 (GalNAc-T13)
chr14_+_38805251 0.280 NM_203356
CTAGE5
CTAGE family, member 5
chr16_+_11966464 0.280 NM_001192
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr12_-_109842736 0.278 NM_000432
MYL2
myosin, light chain 2, regulatory, cardiac, slow
chr11_-_2138984 0.277 NM_000207
NM_001185097
NM_001185098
NM_001042376
INS


INS-IGF2
insulin


INS-IGF2 readthrough transcript
chr6_+_30402986 0.276 NM_172016
TRIM39
tripartite motif containing 39
chr11_-_7775064 0.276 NM_153444
OR5P2
olfactory receptor, family 5, subfamily P, member 2
chr2_-_127817143 0.276 NM_006609
MAP3K2
mitogen-activated protein kinase kinase kinase 2
chr12_-_51173238 0.275 NM_005554
KRT6A
keratin 6A
chr20_+_32926452 0.274 ACSS2
acyl-CoA synthetase short-chain family member 2
chr6_+_32240357 0.270 NM_030652
EGFL8
EGF-like-domain, multiple 8
chr6_-_159386007 0.262 NM_054114
NM_138810
NM_152133
TAGAP


T-cell activation RhoGTPase activating protein


chr8_+_1980564 0.261 NM_003970
MYOM2
myomesin (M-protein) 2, 165kDa
chr9_+_134884627 0.259 EEF1A1
eukaryotic translation elongation factor 1 alpha 1
chr20_-_60435983 0.258 NM_080833
C20orf151
chromosome 20 open reading frame 151
chr2_-_61098867 0.258 NM_144709
PUS10
pseudouridylate synthase 10
chr2_-_47650973 0.258 NM_022055
KCNK12
potassium channel, subfamily K, member 12
chr3_+_195336631 0.258 HES1
hairy and enhancer of split 1, (Drosophila)
chr2_+_62787534 0.253 NM_001142614
EHBP1
EH domain binding protein 1
chr17_-_59349867 0.252 NM_000515
NM_022559
NM_022560
NM_022561
NM_022562
GH1




growth hormone 1




chr3_-_12856948 0.251 NM_001007074
RPL32
ribosomal protein L32
chr5_+_147754467 0.250 FBXO38
F-box protein 38
chr3_-_188935363 0.249 NM_001134738
BCL6
B-cell CLL/lymphoma 6
chr15_-_56093477 0.247 NM_170697
ALDH1A2
aldehyde dehydrogenase 1 family, member A2
chr1_+_32889335 0.246 NM_001135255
NM_005610
NM_001135256
RBBP4


retinoblastoma binding protein 4


chr2_-_100125402 0.244 NM_002285
AFF3
AF4/FMR2 family, member 3
chr7_-_99604127 0.243 GAL3ST4
galactose-3-O-sulfotransferase 4
chr20_-_218957 0.243 C20orf96
chromosome 20 open reading frame 96
chr6_+_64340388 0.242 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr2_+_10103735 0.238


chr6_-_29431950 0.237 NM_030876
OR5V1
olfactory receptor, family 5, subfamily V, member 1
chr5_+_140573692 0.233 NM_018933
PCDHB13
protocadherin beta 13
chr10_+_129237602 0.232 NM_001030013
NPS
neuropeptide S
chrX_+_44617346 0.232 NM_021140
KDM6A
lysine (K)-specific demethylase 6A
chr9_+_114289178 0.232 KIAA1958
KIAA1958
chr3_+_47004457 0.230 NBEAL2
neurobeachin-like 2
chr2_+_207215386 0.230 NM_001102659
LOC200726
hCG1657980
chr1_+_144183811 0.229 ANKRD34A
ankyrin repeat domain 34A
chr20_+_2465252 0.228 NM_080751
TMC2
transmembrane channel-like 2
chr5_+_139869819 0.227


chr20_+_42007949 0.227 NM_001098798
TOX2
TOX high mobility group box family member 2
chr11_-_65869113 0.225 NM_001024957
NM_015399
BRMS1

breast cancer metastasis suppressor 1

chr19_-_42880184 0.225 ZNF607
zinc finger protein 607
chr11_-_30558495 0.223 NM_001584
MPPED2
metallophosphoesterase domain containing 2
chr1_-_16843764 0.222 CROCCP2
ciliary rootlet coiled-coil, rootletin pseudogene 2
chr22_-_14829803 0.221 NM_001005239
OR11H1
olfactory receptor, family 11, subfamily H, member 1
chr16_+_23560187 0.220 NM_001199011
NM_032486
DCTN5

dynactin 5 (p25)

chr14_-_20128228 0.220 NM_145250
RNASE11
ribonuclease, RNase A family, 11 (non-active)
chr8_-_28403652 0.219 NM_172366
FBXO16
ZNF395
F-box protein 16
zinc finger protein 395
chr4_+_25931282 0.219 RBPJ
recombination signal binding protein for immunoglobulin kappa J region
chr14_-_23734433 0.218 TM9SF1
transmembrane 9 superfamily member 1
chr12_+_54760211 0.218 ERBB3
v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
chr17_+_53761293 0.214 LOC100506779
hypothetical LOC100506779
chr18_-_22696532 0.213 NM_004028
AQP4
aquaporin 4
chr3_-_110155237 0.210 NM_005459
GUCA1C
guanylate cyclase activator 1C
chr2_+_17861266 0.210 NM_001105569
MSGN1
mesogenin 1
chr7_-_5535432 0.208 ACTB
actin, beta
chr2_+_218992053 0.208 NM_007127
VIL1
villin 1
chrX_+_70360184 0.207 GJB1
gap junction protein, beta 1, 32kDa
chr3_-_66634031 0.206 LRIG1
leucine-rich repeats and immunoglobulin-like domains 1
chr6_+_37030186 0.206 NM_153370
PI16
peptidase inhibitor 16
chr2_+_169021039 0.204 NM_203463
LASS6
LAG1 homolog, ceramide synthase 6
chr14_-_23107106 0.204 NM_003917
AP1G2
adaptor-related protein complex 1, gamma 2 subunit
chr2_+_99320181 0.204 NM_015904
EIF5B
eukaryotic translation initiation factor 5B
chr12_-_50971516 0.201 NM_002281
KRT81
keratin 81
chr1_+_12698704 0.199 NM_001103169
NM_001103170
AADACL3

arylacetamide deacetylase-like 3

chr14_-_22658078 0.198 NM_001805
CEBPE
CCAAT/enhancer binding protein (C/EBP), epsilon
chr16_-_66523255 0.198 NM_001907
CTRL
chymotrypsin-like
chr6_-_31246159 0.197 NM_002701
POU5F1
POU5F1B
POU5F1P3
POU class 5 homeobox 1
POU class 5 homeobox 1B
POU class 5 homeobox 1 pseudogene 3
chr11_-_2108035 0.196 IGF2
insulin-like growth factor 2 (somatomedin A)
chr1_-_16843744 0.196 CROCCP2
ciliary rootlet coiled-coil, rootletin pseudogene 2
chr3_-_186752952 0.194 NM_139248
LIPH
lipase, member H
chr4_+_75393053 0.194 NM_001013442
EPGN
epithelial mitogen homolog (mouse)
chr12_-_26169074 0.193 NM_030762
BHLHE41
basic helix-loop-helix family, member e41
chr7_-_135063461 0.193 NM_012450
SLC13A4
solute carrier family 13 (sodium/sulfate symporters), member 4
chr18_-_27594696 0.193 NM_001034172
MCART2
mitochondrial carrier triple repeat 2
chr17_+_55325268 0.192 RPS6KB1
ribosomal protein S6 kinase, 70kDa, polypeptide 1
chr7_-_87687302 0.191 NM_003130
SRI
sorcin
chr13_-_49554089 0.190 DLEU2
deleted in lymphocytic leukemia 2 (non-protein coding)
chr20_-_61317891 0.190 NM_017798
YTHDF1
YTH domain family, member 1
chr5_-_56814310 0.189 NM_001017992
ACTBL2
actin, beta-like 2
chr9_-_116190038 0.188 AKNA
AT-hook transcription factor
chr4_+_140806536 0.188 MGST2
microsomal glutathione S-transferase 2
chr2_+_131203112 0.187 NM_207364
GPR148
G protein-coupled receptor 148
chr16_-_23559978 0.187 NM_024675
PALB2
partner and localizer of BRCA2
chr6_+_87921980 0.187 NM_015021
ZNF292
zinc finger protein 292
chr1_+_42920755 0.187 YBX1
Y box binding protein 1
chr2_+_200879737 0.186 SPATS2L
spermatogenesis associated, serine-rich 2-like
chr16_-_87460514 0.186 NM_001080487
PABPN1L
poly(A) binding protein, nuclear 1-like (cytoplasmic)
chr14_+_20226762 0.186 NM_001097577
NM_194431
ANG
RNASE4
angiogenin, ribonuclease, RNase A family, 5
ribonuclease, RNase A family, 4
chr5_+_94752803 0.185 NM_152548
FAM81B
family with sequence similarity 81, member B
chr2_+_27652892 0.185 NM_032266
C2orf16
chromosome 2 open reading frame 16
chr13_-_35327798 0.185 NM_001195415
NM_001195416
NM_001195430
DCLK1


doublecortin-like kinase 1


chr7_+_107008439 0.184 NM_001008405
BCAP29
B-cell receptor-associated protein 29
chr1_+_17404206 0.184 NM_013358
PADI1
peptidyl arginine deiminase, type I
chr6_+_34867794 0.184 UHRF1BP1
UHRF1 binding protein 1
chr2_+_233029076 0.184 NM_001631
ALPI
alkaline phosphatase, intestinal
chr12_-_192752 0.184 NM_003044
SLC6A12
solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12
chr20_+_56722188 0.183


chr2_-_72906538 0.183 NM_015189
EXOC6B
exocyst complex component 6B
chr2_-_151052391 0.183 NM_005168
RND3
Rho family GTPase 3
chr1_+_42920685 0.183 YBX1
Y box binding protein 1
chr1_+_210525885 0.181 PPP2R5A
protein phosphatase 2, regulatory subunit B', alpha
chr1_+_170768914 0.180 NM_016227
C1orf9
chromosome 1 open reading frame 9
chr1_+_42920692 0.178 YBX1
Y box binding protein 1
chr1_+_42920683 0.178 YBX1
Y box binding protein 1
chr10_+_75606552 0.177 ADK
adenosine kinase
chr1_+_42920718 0.177 YBX1
Y box binding protein 1
chr2_+_69055208 0.176 NM_019617
GKN1
gastrokine 1
chrX_+_16714452 0.176 NM_001168683
NM_018360
TXLNG

taxilin gamma

chr5_-_148422799 0.176 NM_024577
SH3TC2
SH3 domain and tetratricopeptide repeats 2
chr20_+_22963949 0.175 NM_001052
SSTR4
somatostatin receptor 4
chr2_+_201385019 0.175 BZW1
basic leucine zipper and W2 domains 1
chr3_-_12916547 0.174 IQSEC1
IQ motif and Sec7 domain 1
chr11_-_44928803 0.173 NM_001076787
NM_006034
TP53I11

tumor protein p53 inducible protein 11

chr12_+_21417068 0.172 NM_000415
IAPP
islet amyloid polypeptide
chr7_-_5534252 0.171 ACTB
actin, beta
chr3_+_49701978 0.170 NM_022064
RNF123
ring finger protein 123
chr17_+_55325224 0.167 NM_003161
RPS6KB1
ribosomal protein S6 kinase, 70kDa, polypeptide 1
chr1_-_113059396 0.166 NM_005167
PPM1J
protein phosphatase, Mg2+/Mn2+ dependent, 1J
chr2_+_28469864 0.166 FOSL2
FOS-like antigen 2
chr1_+_213245507 0.165 NM_001017424
KCNK2
potassium channel, subfamily K, member 2
chr3_-_115380539 0.164 NM_000796
NM_033663
DRD3

dopamine receptor D3

chr1_+_42920635 0.163 NM_004559
YBX1
Y box binding protein 1
chr20_+_31713750 0.162 NM_080825
C20orf144
chromosome 20 open reading frame 144
chr1_+_170768635 0.161 NM_014283
C1orf9
chromosome 1 open reading frame 9

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.35 7.84e-06 GO:0023052 signaling
1.34 1.60e-04 GO:0007165 signal transduction
1.29 4.25e-04 GO:0051716 cellular response to stimulus
1.21 5.18e-04 GO:0050896 response to stimulus
1.65 1.08e-03 GO:0007154 cell communication
1.23 1.51e-03 GO:0032501 multicellular organismal process
1.16 6.72e-03 GO:0065007 biological regulation
1.64 3.08e-02 GO:0007267 cell-cell signaling

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.41 1.45e-04 GO:0044459 plasma membrane part
1.70 7.40e-03 GO:0030054 cell junction
1.22 9.93e-03 GO:0071944 cell periphery
1.21 2.37e-02 GO:0005886 plasma membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.79 3.85e-02 GO:0015267 channel activity
1.79 4.10e-02 GO:0022803 passive transmembrane transporter activity