Motif ID: POU2F1..3.p2

Z-value: 2.633


Transcription factors associated with POU2F1..3.p2:

Gene SymbolEntrez IDGene Name
POU2F1 5451 POU class 2 homeobox 1
POU2F2 5452 POU class 2 homeobox 2
POU2F3 25833 POU class 2 homeobox 3



Activity profile for motif POU2F1..3.p2.

activity profile for motif POU2F1..3.p2


Sorted Z-values histogram for motif POU2F1..3.p2

Sorted Z-values for motif POU2F1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of POU2F1..3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr22_+_21407066 6.546


chr22_+_21370394 6.525 IGL@
immunoglobulin lambda locus
chr22_+_21495273 6.045


chr6_+_26232351 5.978 NM_003512
HIST1H2AC
histone cluster 1, H2ac
chr6_-_26232109 5.920 NM_003526
HIST1H2BG
HIST1H2BC
histone cluster 1, H2bg
histone cluster 1, H2bc
chr22_+_21340757 5.693


chr6_+_27969181 5.185 NM_003527
HIST1H2BO
histone cluster 1, H2bo
chr6_-_27968906 4.690 NM_003514
HIST1H2AM
histone cluster 1, H2am
chr22_+_20715340 4.522


chr22_+_21384862 4.423 IGLV3-21
IGLJ3
IGLC1
immunoglobulin lambda variable 3-21
immunoglobulin lambda joining 3
immunoglobulin lambda constant 1 (Mcg marker)
chr22_+_20880159 3.920 IGLV6-57
immunoglobulin lambda variable 6-57
chr22_+_20316968 3.825 NM_152612
CCDC116
coiled-coil domain containing 116
chr22_+_21094094 3.753


chr22_+_20899155 3.732


chr22_+_21116283 3.503


chr22_+_20880112 3.500


chr22_+_21042091 3.485 IGLV1-44
IGL@
immunoglobulin lambda variable 1-44
immunoglobulin lambda locus
chr16_+_23754822 3.347 PRKCB
protein kinase C, beta
chr16_+_23754860 3.262 PRKCB
protein kinase C, beta
chr16_+_23754772 3.136 NM_002738
NM_212535
PRKCB

protein kinase C, beta

chr16_+_23754997 2.962 PRKCB
protein kinase C, beta
chr22_+_21006814 2.917


chr6_+_37245860 2.893 NM_002648
PIM1
pim-1 oncogene
chr1_+_148089251 2.799 NM_001040874
NM_003516
HIST2H2AA4
HIST2H2AA3
histone cluster 2, H2aa4
histone cluster 2, H2aa3
chr1_+_67923331 2.765 NM_001924
GADD45A
growth arrest and DNA-damage-inducible, alpha
chr6_-_168222645 2.722 NM_024919
FRMD1
FERM domain containing 1
chr6_+_26266311 2.672 NM_021063
NM_138720
HIST1H2BD

histone cluster 1, H2bd

chr6_-_143307976 2.631 NM_006734
HIVEP2
human immunodeficiency virus type I enhancer binding protein 2
chr22_+_21065134 2.556 LOC100290481
immunoglobulin lambda light chain-like
chr22_+_21543671 2.539 IGLV4-3
immunoglobulin lambda variable 4-3
chr1_-_148080888 2.534 NM_001040874
NM_003516
HIST2H2AA4
HIST2H2AA3
histone cluster 2, H2aa4
histone cluster 2, H2aa3
chr22_+_21065202 2.502


chr22_+_21065207 2.238 IGLJ3
immunoglobulin lambda joining 3
chr3_+_153074118 2.201 NM_033050
SUCNR1
succinate receptor 1
chr1_+_67923660 2.102 GADD45A
growth arrest and DNA-damage-inducible, alpha
chr19_-_54835162 2.015 NM_006270
RRAS
related RAS viral (r-ras) oncogene homolog
chr2_+_173927783 1.986 NM_031942
NM_145810
CDCA7

cell division cycle associated 7

chr1_+_200246312 1.976 NM_001114309
NM_004433
ELF3

E74-like factor 3 (ets domain transcription factor, epithelial-specific )

chr6_+_26325124 1.903 NM_021052
HIST1H2AE
histone cluster 1, H2ae
chr6_+_27208763 1.886 NM_021064
HIST1H2AG
histone cluster 1, H2ag
chr1_+_67923680 1.860 GADD45A
growth arrest and DNA-damage-inducible, alpha
chr5_+_175041069 1.858 NM_022304
HRH2
histamine receptor H2
chr6_-_27208507 1.838 NM_021058
HIST1H2BJ
histone cluster 1, H2bj
chr1_+_200246370 1.835 ELF3
E74-like factor 3 (ets domain transcription factor, epithelial-specific )
chr19_-_48815572 1.811 ZNF428
zinc finger protein 428
chr1_+_165565006 1.801 POU2F1
POU class 2 homeobox 1
chr19_-_48815853 1.756 NM_182498
ZNF428
zinc finger protein 428
chrX_-_138742050 1.703 NM_001010986
NM_173694
ATP11C

ATPase, class VI, type 11C

chr7_+_142629251 1.698 NM_176882
TAS2R40
taste receptor, type 2, member 40
chr6_+_26291936 1.636 NM_003523
HIST1H2BE
histone cluster 1, H2be
chr1_+_165564904 1.553 NM_001198783
POU2F1
POU class 2 homeobox 1
chr6_-_168219380 1.550 NM_001122841
FRMD1
FERM domain containing 1
chr19_+_40541327 1.545 NM_005304
FFAR3
free fatty acid receptor 3
chr5_+_36644187 1.523 NM_001166695
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr12_+_120548831 1.468 NM_032790
ORAI1
ORAI calcium release-activated calcium modulator 1
chr6_+_43247179 1.457 SRF
serum response factor (c-fos serum response element-binding transcription factor)
chr21_-_38415273 1.424 NM_005867
DSCR4
Down syndrome critical region gene 4
chr6_+_27883877 1.408 NM_003509
HIST1H2AI
HIST1H3F
histone cluster 1, H2ai
histone cluster 1, H3f
chr6_+_43246897 1.406 NM_003131
SRF
serum response factor (c-fos serum response element-binding transcription factor)
chr6_+_155579788 1.363 NM_001010927
TIAM2
T-cell lymphoma invasion and metastasis 2
chr15_-_81037554 1.342 NM_001079533
NM_001079534
NM_001079535
CPEB1


cytoplasmic polyadenylation element binding protein 1


chr20_+_62266217 1.338 MYT1
myelin transcription factor 1
chr6_+_43247168 1.330 SRF
serum response factor (c-fos serum response element-binding transcription factor)
chr6_-_170442090 1.287


chr6_-_26324850 1.279 NM_003518
HIST1H2BG
NCALD
histone cluster 1, H2bg
neurocalcin delta
chr1_+_18680010 1.252 NM_152375
KLHDC7A
kelch domain containing 7A
chr1_+_226712430 1.235 NM_175055
HIST3H2BB
histone cluster 3, H2bb
chr15_-_53996597 1.207 NM_198400
NEDD4
neural precursor cell expressed, developmentally down-regulated 4
chr16_+_84202515 1.186 NM_001134473
KIAA0182
KIAA0182
chr22_+_21484240 1.156


chr20_+_62266270 1.148 NM_004535
MYT1
myelin transcription factor 1
chr6_-_27222556 1.147 NM_080593
HIST1H2BK
histone cluster 1, H2bk
chr10_-_64246129 1.133 NM_000399
NM_001136177
NM_001136179
EGR2


early growth response 2


chr1_+_201711505 1.132 NM_002725
NM_201348
PRELP

proline/arginine-rich end leucine-rich repeat protein

chr1_-_148124738 1.131 NM_003528
HIST2H2BE
histone cluster 2, H2be
chr10_-_64246080 1.074 EGR2
early growth response 2
chrX_+_123062143 1.056 STAG2
stromal antigen 2
chr6_-_170441493 1.045 NM_005618
DLL1
delta-like 1 (Drosophila)
chr2_+_173794692 1.040 ZAK
sterile alpha motif and leucine zipper containing kinase AZK
chr6_+_26359805 1.039 NM_003524
HIST1H2BH
histone cluster 1, H2bh
chr11_-_63841556 1.039 NM_016404
TRMT112
tRNA methyltransferase 11-2 homolog (S. cerevisiae)
chr1_+_66570363 1.022 NM_001037339
PDE4B
phosphodiesterase 4B, cAMP-specific
chr6_+_34313007 1.015 HMGA1
high mobility group AT-hook 1
chr19_+_3523950 0.988 HMG20B
high-mobility group 20B
chr17_+_70244553 0.987 NM_001163989
RAB37
RAB37, member RAS oncogene family
chr6_+_27323458 0.972 NM_005865
PRSS16
protease, serine, 16 (thymus)
chr14_-_105862080 0.972 IGHV4-31
IGHA1
IGHD
IGHG1
IGHG2
IGHG3
IGHM
SCFV
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant delta
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 2 (G2m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
immunoglobulin heavy constant mu
single-chain Fv fragment
chr5_-_88155360 0.966 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr7_-_27120015 0.964 HOXA3
homeobox A3
chr1_+_201711578 0.958 PRELP
proline/arginine-rich end leucine-rich repeat protein
chr5_-_75044001 0.953 NM_152408
POC5
POC5 centriolar protein homolog (Chlamydomonas)
chr21_+_38566298 0.949 NM_170737
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr17_-_8004671 0.928 VAMP2
vesicle-associated membrane protein 2 (synaptobrevin 2)
chr17_-_38529638 0.926 NM_007298
BRCA1
breast cancer 1, early onset
chr9_-_139316523 0.925 NM_001004354
NRARP
NOTCH-regulated ankyrin repeat protein
chr1_-_2447848 0.903 NM_018216
PANK4
pantothenate kinase 4
chr2_-_157890400 0.886 NM_020711
ERMN
ermin, ERM-like protein
chr6_+_27222839 0.886 NM_080596
HIST1H2AH
histone cluster 1, H2ah
chr6_+_170441715 0.880 FAM120B
family with sequence similarity 120B
chr1_-_203579932 0.851 KLHDC8A
kelch domain containing 8A
chr6_-_33016561 0.851 NM_002118
HLA-DMB
major histocompatibility complex, class II, DM beta
chr2_+_151922350 0.847 NM_007115
TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chr19_+_3523958 0.843 HMG20B
high-mobility group 20B
chr6_+_34312906 0.840 HMGA1
high mobility group AT-hook 1
chr1_+_148125090 0.821 NM_003517
HIST2H2AC
histone cluster 2, H2ac
chr6_+_25834983 0.815 NM_170610
HIST1H2BA
histone cluster 1, H2ba
chr6_-_25834733 0.813 NM_170745
HIST1H2AA
histone cluster 1, H2aa
chrX_+_69591639 0.805 NM_001166278
DLG3
discs, large homolog 3 (Drosophila)
chr7_-_141320041 0.798 NM_176817
TAS2R38
taste receptor, type 2, member 38
chr6_+_34312979 0.793 HMGA1
high mobility group AT-hook 1
chr7_+_116238309 0.746 CAPZA2
capping protein (actin filament) muscle Z-line, alpha 2
chrX_+_38545636 0.744 MID1IP1
MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish))
chrX_+_38545597 0.739 NM_001098790
NM_001098791
MID1IP1

MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish))

chr21_+_29322100 0.725 USP16
ubiquitin specific peptidase 16
chr19_+_1220244 0.724 NM_001280
CIRBP
cold inducible RNA binding protein
chr7_+_94130673 0.721 PEG10
paternally expressed 10
chr12_-_120270035 0.719 ANAPC5
anaphase promoting complex subunit 5
chr2_+_201755865 0.717 NM_001230
NM_032974
NM_032977
CASP10


caspase 10, apoptosis-related cysteine peptidase


chr5_-_73972055 0.705 ENC1
ectodermal-neural cortex 1 (with BTB-like domain)
chr17_+_70495318 0.700 NM_014603
CDR2L
cerebellar degeneration-related protein 2-like
chr1_-_148126089 0.697 NM_175065
HIST2H2AB
HIST2H2BE
histone cluster 2, H2ab
histone cluster 2, H2be
chr8_-_86441115 0.693 NM_001164830
CA1
carbonic anhydrase I
chr8_+_106400322 0.687 NM_012082
ZFPM2
zinc finger protein, multitype 2
chr12_+_60940404 0.675 NM_006313
USP15
ubiquitin specific peptidase 15
chr2_+_183290912 0.673 DNAJC10
DnaJ (Hsp40) homolog, subfamily C, member 10
chr6_-_53121540 0.662 NM_003643
GCM1
glial cells missing homolog 1 (Drosophila)
chr6_-_29563657 0.650 NM_052967
MAS1L
MAS1 oncogene-like
chr19_+_14554895 0.643 NM_207390
CLEC17A
C-type lectin domain family 17, member A
chr2_-_44440358 0.642 NM_001042385
NM_001042386
PREPL

prolyl endopeptidase-like

chr6_+_139136349 0.640 NM_015439
CCDC28A
coiled-coil domain containing 28A
chr6_+_12825022 0.639 PHACTR1
phosphatase and actin regulator 1
chr9_+_96561750 0.638 NM_001193329
C9orf3
chromosome 9 open reading frame 3
chr6_+_41118214 0.634 NM_001010873
NM_001159726
TSPO2

translocator protein 2

chr1_-_153098811 0.634 NM_170782
KCNN3
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
chr17_+_60563917 0.632 NM_001081955
NM_001165933
NM_003835
RGS9


regulator of G-protein signaling 9


chr7_+_120752656 0.632 NM_016087
WNT16
wingless-type MMTV integration site family, member 16
chr6_+_34312625 0.628 NM_145901
NM_145902
HMGA1

high mobility group AT-hook 1

chr6_+_26381122 0.627 NM_003525
HIST1H2BI
histone cluster 1, H2bi
chr16_+_2959362 0.625 PAQR4
progestin and adipoQ receptor family member IV
chr17_+_60563963 0.620 RGS9
regulator of G-protein signaling 9
chr14_-_105524207 0.619 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr12_-_54646061 0.618 NM_006928
PMEL
premelanosome protein
chr15_+_63124760 0.612 NM_178859
OSTBETA
organic solute transporter beta
chr1_+_61320213 0.609 NM_001134673
NM_005595
NFIA

nuclear factor I/A

chr6_+_34312667 0.608 HMGA1
high mobility group AT-hook 1
chr11_-_558419 0.605


chr17_-_59363352 0.603 NM_000626
NM_001039933
NM_021602
CD79B


CD79b molecule, immunoglobulin-associated beta


chr12_-_48902692 0.601 NM_001113547
LIMA1
LIM domain and actin binding 1
chr6_+_34312554 0.600 NM_002131
NM_145899
NM_145903
HMGA1


high mobility group AT-hook 1


chr6_+_34312633 0.598 HMGA1
high mobility group AT-hook 1
chr6_-_26141774 0.597 NM_003513
HIST1H2AB
histone cluster 1, H2ab
chr1_+_66570683 0.596 PDE4B
phosphodiesterase 4B, cAMP-specific
chr1_-_181889070 0.586 NM_203454
APOBEC4
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative)
chr4_-_186970366 0.581 NM_003603
NM_001145670
SORBS2

sorbin and SH3 domain containing 2

chr4_-_71751070 0.568 IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr7_-_112515035 0.564 GPR85
G protein-coupled receptor 85
chr18_+_75967902 0.560 NM_014913
ADNP2
ADNP homeobox 2
chr6_+_148705421 0.557 NM_015278
SASH1
SAM and SH3 domain containing 1
chr7_-_112515068 0.556 NM_001146265
NM_018970
GPR85

G protein-coupled receptor 85

chr12_-_47250069 0.552 NM_002289
LALBA
lactalbumin, alpha-
chr5_+_2805261 0.551 NM_178569
C5orf38
chromosome 5 open reading frame 38
chr16_+_2959342 0.550 NM_152341
PAQR4
progestin and adipoQ receptor family member IV
chr1_+_5975286 0.549 KCNAB2
potassium voltage-gated channel, shaker-related subfamily, beta member 2
chr2_+_54638957 0.545 NM_178313
SPTBN1
spectrin, beta, non-erythrocytic 1
chr7_-_41709191 0.542 NM_002192
INHBA
inhibin, beta A
chr6_-_33787479 0.542 NM_032340
C6orf125
chromosome 6 open reading frame 125
chr11_+_111551417 0.541 NM_031938
BCO2
beta-carotene oxygenase 2
chr7_-_112514990 0.530 GPR85
G protein-coupled receptor 85
chr6_-_27890496 0.527 NM_021066
HIST1H2AJ
histone cluster 1, H2aj
chr6_+_12824873 0.527 PHACTR1
phosphatase and actin regulator 1
chr2_+_170392146 0.525 NM_172070
UBR3
ubiquitin protein ligase E3 component n-recognin 3 (putative)
chr1_+_202000906 0.522 NM_001136190
NM_017773
LAX1

lymphocyte transmembrane adaptor 1

chr1_-_147665783 0.521 HIST2H2BF
histone cluster 2, H2bf
chr6_+_34312641 0.520 HMGA1
high mobility group AT-hook 1
chr1_+_5975345 0.519 KCNAB2
potassium voltage-gated channel, shaker-related subfamily, beta member 2
chr6_+_27941012 0.516 NM_003511
HIST1H2AI
HIST1H2AL
histone cluster 1, H2ai
histone cluster 1, H2al
chr1_+_168898898 0.511 PRRX1
paired related homeobox 1
chr16_-_73365975 0.503 FA2H
fatty acid 2-hydroxylase
chr12_+_130878870 0.500 NM_016155
MMP17
matrix metallopeptidase 17 (membrane-inserted)
chr1_+_165075304 0.495 POGK
pogo transposable element with KRAB domain
chr1_-_6537139 0.492 NOL9
nucleolar protein 9
chr7_-_102576570 0.486 NM_001122838
NM_198990
NAPEPLD

N-acyl phosphatidylethanolamine phospholipase D

chr12_+_108452117 0.471 UBE3B
ubiquitin protein ligase E3B
chr1_-_5975068 0.468 NM_015102
NPHP4
nephronophthisis 4
chr17_+_20712337 0.463


chr1_-_5974997 0.461 NPHP4
nephronophthisis 4
chr1_-_6537171 0.458 NM_024654
NOL9
nucleolar protein 9
chr6_+_10693964 0.456 NM_145655
GCNT2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
chr16_-_54466709 0.456 NM_001143685
NM_145024
CES5A

carboxylesterase 5A

chr18_+_75968133 0.456 ADNP2
ADNP homeobox 2
chr6_+_148705646 0.455 SASH1
SAM and SH3 domain containing 1
chr3_-_42892195 0.455 CYP8B1
cytochrome P450, family 8, subfamily B, polypeptide 1
chr12_+_91620749 0.455 NM_001037671
NM_001178097
C12orf74

chromosome 12 open reading frame 74

chr12_+_47584159 0.452 NM_033124
CCDC65
coiled-coil domain containing 65
chr2_+_96790298 0.452 NM_020184
CNNM4
cyclin M4
chr1_+_154386358 0.446 NM_001193301
SEMA4A
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr22_-_20551953 0.446 NM_002745
NM_138957
MAPK1

mitogen-activated protein kinase 1

chr22_+_20929199 0.446 NM_007128
VPREB1
pre-B lymphocyte 1
chr2_-_96769526 0.446 NM_001142292
NM_030805
LMAN2L

lectin, mannose-binding 2-like

chr16_+_10878539 0.444 NM_000246
CIITA
class II, major histocompatibility complex, transactivator

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
10.77 2.46e-16 GO:0006334 nucleosome assembly
10.11 2.61e-16 GO:0034728 nucleosome organization
10.22 9.94e-16 GO:0031497 chromatin assembly
9.22 3.24e-15 GO:0071824 protein-DNA complex subunit organization
9.36 9.94e-15 GO:0065004 protein-DNA complex assembly
7.90 4.91e-14 GO:0006333 chromatin assembly or disassembly
7.83 9.36e-13 GO:0006323 DNA packaging
6.99 4.27e-12 GO:0071103 DNA conformation change
3.24 9.02e-07 GO:0006325 chromatin organization
3.41 9.02e-06 GO:0034622 cellular macromolecular complex assembly
2.92 3.69e-05 GO:0034621 cellular macromolecular complex subunit organization
2.56 2.29e-04 GO:0051276 chromosome organization
2.33 1.67e-03 GO:0065003 macromolecular complex assembly
1.30 3.70e-03 GO:0050896 response to stimulus
2.21 3.96e-03 GO:0006955 immune response
1.58 5.89e-03 GO:0006950 response to stress
2.11 9.43e-03 GO:0006952 defense response
2.06 1.64e-02 GO:0043933 macromolecular complex subunit organization
1.51 1.89e-02 GO:0071841 cellular component organization or biogenesis at cellular level
1.70 2.01e-02 GO:0006996 organelle organization
1.82 2.25e-02 GO:0002376 immune system process
1.49 4.23e-02 GO:0071842 cellular component organization at cellular level
2.39 4.43e-02 GO:0009628 response to abiotic stimulus
2.06 4.43e-02 GO:0071844 cellular component assembly at cellular level

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
15.51 1.01e-20 GO:0000786 nucleosome
9.91 1.64e-15 GO:0032993 protein-DNA complex
5.68 6.90e-14 GO:0000785 chromatin
3.04 5.30e-08 GO:0005694 chromosome
3.26 6.55e-08 GO:0044427 chromosomal part
1.52 9.47e-04 GO:0043228 non-membrane-bounded organelle
1.52 9.47e-04 GO:0043232 intracellular non-membrane-bounded organelle

Gene overrepresentation in function category:

enrichment   p-value GO term description
12.02 3.55e-08 GO:0003823 antigen binding
1.58 1.29e-03 GO:0003677 DNA binding