Motif ID: AIRE.p2

Z-value: 0.581


Transcription factors associated with AIRE.p2:

Gene SymbolEntrez IDGene Name
AIRE 326 autoimmune regulator



Activity profile for motif AIRE.p2.

activity profile for motif AIRE.p2


Sorted Z-values histogram for motif AIRE.p2

Sorted Z-values for motif AIRE.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of AIRE.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_199732323 0.631 NM_001193572
CSRP1
cysteine and glycine-rich protein 1
chr5_-_39430180 0.583 DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr17_-_37275142 0.538 NM_018143
KLHL11
kelch-like 11 (Drosophila)
chr5_-_177140071 0.466 NM_173663
FAM153A
FAM153C
family with sequence similarity 153, member A
family with sequence similarity 153, member C
chr7_+_111908143 0.452 NM_001134468
NM_182597
C7orf53

chromosome 7 open reading frame 53

chr17_+_58440629 0.441 NM_025185
TANC2
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
chr19_+_23889496 0.405 NM_001190829
ZNF726
zinc finger protein 726
chr7_-_38279757 0.370 NM_001003799
NM_001003806
TARP

TRGV9
TCR gamma alternate reading frame protein

T cell receptor gamma variable 9
chr11_+_7066740 0.366 NM_014469
RBMXL2
RNA binding motif protein, X-linked-like 2
chr2_-_215998181 0.343 FN1
fibronectin 1
chr15_+_43036194 0.342 NM_152448
C15orf43
chromosome 15 open reading frame 43
chr7_-_64104441 0.307 NM_001007253
ERV3
ZNF117
endogenous retroviral sequence 3
zinc finger protein 117
chr7_+_77307382 0.298 NM_001127357
NM_001127359
NM_020432
PHTF2


putative homeodomain transcription factor 2


chr4_+_74566325 0.292 NM_001133
AFM
afamin
chr19_+_21056792 0.284 NM_182515
ZNF714
zinc finger protein 714
chr19_-_14646626 0.281 NM_032571
EMR3
egf-like module containing, mucin-like, hormone receptor-like 3
chr1_-_168310232 0.272 NM_014970
KIFAP3
kinesin-associated protein 3
chr2_-_176656935 0.271 NM_001080458
EVX2
even-skipped homeobox 2
chr5_+_176744037 0.271 NM_001167579
NM_003052
SLC34A1

solute carrier family 34 (sodium phosphate), member 1

chr17_+_72692889 0.271 NM_001144001
SEC14L1
SEC14-like 1 (S. cerevisiae)
chr12_+_132124125 0.251 ZNF84
zinc finger protein 84
chr4_-_70115037 0.248 NM_001073
UGT2B11
UDP glucuronosyltransferase 2 family, polypeptide B11
chr12_+_132124211 0.240 ZNF84
zinc finger protein 84
chr1_-_21249974 0.237 EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr9_+_102244005 0.235 NM_001198812
C9orf3-TMEFF1
C9orf30
C9orf3-TMEFF1 readthrough
chromosome 9 open reading frame 30
chr5_+_65408500 0.234 ERBB2IP
erbb2 interacting protein
chr8_+_144802972 0.233 NM_014789
ZNF623
zinc finger protein 623
chr11_+_55899675 0.232 NM_001005204
NM_001013356
OR8U1
OR8U8
olfactory receptor, family 8, subfamily U, member 1
olfactory receptor, family 8, subfamily U, member 8
chr19_+_56958452 0.228 NM_001462
FPR2
formyl peptide receptor 2
chr16_-_1434490 0.218 NM_001143980
CCDC154
coiled-coil domain containing 154
chr19_-_9186512 0.217 NM_001005191
OR7D4
olfactory receptor, family 7, subfamily D, member 4
chr19_+_2340768 0.214 NM_182973
TMPRSS9
transmembrane protease, serine 9
chr1_+_246635918 0.214 NM_030904
OR2T1
olfactory receptor, family 2, subfamily T, member 1
chrX_-_70045285 0.213 NM_001003811
NM_031276
TEX11

testis expressed 11

chr10_-_93992982 0.210 NM_001178137
CPEB3
cytoplasmic polyadenylation element binding protein 3
chr12_-_89976261 0.207 NM_007035
KERA
keratocan
chr12_-_55979413 0.205


chr14_-_105785639 0.202


chr7_-_122126422 0.200 NM_139175
RNF133
ring finger protein 133
chr11_+_123639909 0.199 NM_001005198
OR8G5
olfactory receptor, family 8, subfamily G, member 5
chr3_-_152403636 0.199 NM_013308
GPR171
G protein-coupled receptor 171
chr3_+_173954940 0.196 NM_018098
ECT2
epithelial cell transforming sequence 2 oncogene
chr4_-_139382672 0.195 NM_014331
SLC7A11
solute carrier family 7, (cationic amino acid transporter, y+ system) member 11
chr6_-_99955987 0.195 SFRS18
splicing factor, arginine/serine-rich 18
chr10_+_123738678 0.194 NM_206861
NM_206862
TACC2

transforming, acidic coiled-coil containing protein 2

chr5_-_64813459 0.193 NM_197941
ADAMTS6
ADAM metallopeptidase with thrombospondin type 1 motif, 6
chr18_+_27425727 0.192 NM_000371
TTR
transthyretin
chr19_-_42355407 0.191 NM_152655
ZNF585A
zinc finger protein 585A
chr5_+_138657317 0.183 NM_001194955
NM_001194956
MATR3

matrin 3

chr19_-_9276794 0.177 NM_198535
ZNF266
ZNF699
zinc finger protein 266
zinc finger protein 699
chr17_-_6924227 0.177 NM_006344
NM_182906
CLEC10A

C-type lectin domain family 10, member A

chr1_+_20353284 0.174


chr16_+_20328355 0.171 NM_017888
ACSM5
acyl-CoA synthetase medium-chain family member 5
chr19_-_44618375 0.171 NM_001020
RPS16
ribosomal protein S16
chr1_-_89437098 0.169 NM_052941
GBP4
guanylate binding protein 4
chr10_-_101831579 0.166 NM_001308
CPN1
carboxypeptidase N, polypeptide 1
chr4_+_53975597 0.165 FIP1L1
FIP1 like 1 (S. cerevisiae)
chr5_-_41297296 0.164 NM_001115131
C6
complement component 6
chr1_-_159474503 0.163 NM_001077469
NM_001077470
NM_001077471
NM_001077472
NM_001077473
NM_001077474
NM_001077475
NM_001077476
NM_001077477
NM_001077478
NM_001077479
NM_001077480
NM_001077481
NM_001077482
NM_005122
NR1I3














nuclear receptor subfamily 1, group I, member 3














chr3_+_109498082 0.163 HHLA2
HERV-H LTR-associating 2
chr21_-_42219849 0.162 NM_199050
C2CD2
C2 calcium-dependent domain containing 2
chr8_+_18123456 0.157 NM_001160174
NAT1
N-acetyltransferase 1 (arylamine N-acetyltransferase)
chr4_+_70180805 0.156 NM_053039
UGT2B28
UDP glucuronosyltransferase 2 family, polypeptide B28
chr11_-_59369501 0.153 NM_005142
GIF
gastric intrinsic factor (vitamin B synthesis)
chr19_-_14800275 0.152 NM_017506
OR7A5
olfactory receptor, family 7, subfamily A, member 5
chr15_-_23204887 0.152 NM_000462
UBE3A
ubiquitin protein ligase E3A
chr2_-_202192141 0.151 NM_001168216
NM_001168217
NM_001168221
NM_152525
ALS2CR11



amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 11



chr19_+_18069596 0.149 NM_015016
MAST3
microtubule associated serine/threonine kinase 3
chr16_-_70080678 0.148 NM_006961
ZNF19
zinc finger protein 19
chr12_-_30740072 0.145 NM_006390
IPO8
importin 8
chr18_+_8708448 0.144


chr4_+_69716298 0.142 NM_001075
NM_001144767
UGT2B10

UDP glucuronosyltransferase 2 family, polypeptide B10

chr1_-_242073094 0.141 NM_005465
NM_181690
AKT3

v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)

chr4_+_128773529 0.140 NM_015693
INTU
inturned planar cell polarity effector homolog (Drosophila)
chr18_-_59462469 0.139 NM_002974
SERPINB4
serpin peptidase inhibitor, clade B (ovalbumin), member 4
chr4_+_123380569 0.136 KIAA1109
KIAA1109
chr12_-_53064723 0.135 NM_015481
ZNF385A
zinc finger protein 385A
chr9_+_74956601 0.134 ANXA1
annexin A1
chr1_-_167947301 0.133 NM_000655
SELL
selectin L
chr13_-_32757835 0.132 NM_178006
STARD13
StAR-related lipid transfer (START) domain containing 13
chr9_+_74956494 0.131 NM_000700
ANXA1
annexin A1
chr7_-_38915306 0.130 NM_014396
NM_080631
VPS41

vacuolar protein sorting 41 homolog (S. cerevisiae)

chr19_+_22027118 0.130 ZNF257
zinc finger protein 257
chr12_-_55405209 0.126 NM_001113201
NM_005594
NACA

nascent polypeptide-associated complex alpha subunit

chr19_+_22027093 0.126 NM_033468
ZNF257
zinc finger protein 257
chr12_+_61240542 0.125 MON2
MON2 homolog (S. cerevisiae)
chr15_-_43458247 0.125 NM_001482
GATM
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr12_+_108035424 0.123


chr3_+_38238080 0.123 OXSR1
oxidative-stress responsive 1
chr19_-_44518516 0.122 NM_004877
GMFG
glia maturation factor, gamma
chr9_-_98580148 0.121 NM_014930
ZNF510
zinc finger protein 510
chr1_+_157067729 0.120 NM_002432
MNDA
myeloid cell nuclear differentiation antigen
chr19_+_42409205 0.119 NM_152604
ZNF383
zinc finger protein 383
chr9_-_21358005 0.119 NM_006900
IFNA1
IFNA13
interferon, alpha 1
interferon, alpha 13
chr7_+_75947762 0.119 NM_001102596
DTX2
deltex homolog 2 (Drosophila)
chr1_-_245334248 0.119 NM_001142572
NM_024804
ZNF669

zinc finger protein 669

chr17_+_59875623 0.117 NM_001085423
C17orf60
chromosome 17 open reading frame 60
chr15_+_97990705 0.117 NM_001130928
MEF2A
myocyte enhancer factor 2A
chr2_+_12775814 0.116


chr17_+_63367052 0.116 BPTF
bromodomain PHD finger transcription factor
chr4_-_185376012 0.116 NM_153343
ENPP6
ectonucleotide pyrophosphatase/phosphodiesterase 6
chr17_-_18207416 0.116 NM_004169
NM_148918
SHMT1

serine hydroxymethyltransferase 1 (soluble)

chr19_-_17432724 0.114 NM_138454
NXNL1
nucleoredoxin-like 1
chr3_+_29297806 0.114 NM_001003792
NM_001003793
NM_001177711
NM_001177712
NM_014483
RBMS3




RNA binding motif, single stranded interacting protein 3




chr15_-_40537002 0.114 NM_022473
ZFP106
zinc finger protein 106 homolog (mouse)
chr19_+_39402167 0.112 LSM14A
LSM14A, SCD6 homolog A (S. cerevisiae)
chr1_+_43055362 0.112 NM_001017922
ERMAP
erythroblast membrane-associated protein (Scianna blood group)
chr9_+_42707229 0.111 NM_001099279
NM_199244
FOXD4L2
FOXD4L4
forkhead box D4-like 2
forkhead box D4-like 4
chr2_-_202192097 0.111 ALS2CR11
amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 11
chr4_+_123311207 0.111 NM_015312
KIAA1109
KIAA1109
chr12_+_28301399 0.111 NM_018318
CCDC91
coiled-coil domain containing 91
chr1_-_57057956 0.110 NM_001004303
C1orf168
chromosome 1 open reading frame 168
chr5_+_115415061 0.108 NM_001195581
LOC644100
hypothetical LOC644100
chr22_-_34886727 0.108 NM_145640
APOL3
apolipoprotein L, 3
chr1_-_245988330 0.108 NM_012353
OR1C1
olfactory receptor, family 1, subfamily C, member 1
chr5_-_156502363 0.108 NM_001100816
NM_004270
MED7

mediator complex subunit 7

chr1_+_15941503 0.108 NM_001013641
TMEM82
transmembrane protein 82
chr7_-_102070473 0.107 NM_001114403
UPK3BL
POLR2J2
uroplakin 3B-like
polymerase (RNA) II (DNA directed) polypeptide J2
chr19_-_60320592 0.107 NM_017607
PPP1R12C
protein phosphatase 1, regulatory (inhibitor) subunit 12C
chr5_+_34723420 0.105 NM_001145523
RAI14
retinoic acid induced 14
chr12_-_47031287 0.105 NM_001172682
ZNF641
zinc finger protein 641
chr15_-_48198697 0.103 NM_024837
ATP8B4
ATPase, class I, type 8B, member 4
chr17_-_8364942 0.103 MYH10
myosin, heavy chain 10, non-muscle
chr8_+_133060353 0.103 EFR3A
EFR3 homolog A (S. cerevisiae)
chr11_+_61794205 0.102 NM_002411
SCGB2A2
secretoglobin, family 2A, member 2
chr7_-_45117822 0.102 NM_004749
NM_030900
NM_199122
TBRG4


transforming growth factor beta regulator 4


chr4_+_187424336 0.101 F11
coagulation factor XI
chr12_+_26017954 0.101 NM_001164747
RASSF8
Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
chr12_+_100512877 0.101 NM_002465
NM_206819
NM_206820
NM_206821
MYBPC1



myosin binding protein C, slow type



chr7_-_45117797 0.101 TBRG4
transforming growth factor beta regulator 4
chr19_-_23661779 0.101 NM_138330
ZNF675
zinc finger protein 675
chr9_+_4652285 0.100 NM_203453
PPAPDC2
phosphatidic acid phosphatase type 2 domain containing 2
chr1_-_159543847 0.100 MPZ
myelin protein zero
chr7_-_63660889 0.100 NM_001130022
NM_178558
ZNF680

zinc finger protein 680

chr8_-_13178327 0.099


chr3_+_46370228 0.099 NM_001123041
NM_001123396
CCR2

chemokine (C-C motif) receptor 2

chr9_+_6710862 0.098 NM_001146696
KDM4C
lysine (K)-specific demethylase 4C
chr11_-_58255944 0.096 NM_005838
NM_201648
GLYAT

glycine-N-acyltransferase

chr1_-_21288259 0.094 EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr12_+_32723539 0.094 DNM1L
dynamin 1-like
chr15_-_53587723 0.094 NM_001033559
NM_001033560
NM_130810
DYX1C1


dyslexia susceptibility 1 candidate 1


chr9_+_130719034 0.091 LRRC8A
leucine rich repeat containing 8 family, member A
chr11_+_125262164 0.091 NM_001134793
HYLS1
hydrolethalus syndrome 1
chr15_+_63124760 0.091 NM_178859
OSTBETA
organic solute transporter beta
chr2_-_32344192 0.089 NM_021209
NLRC4
NLR family, CARD domain containing 4
chr4_+_69996780 0.089 NM_001074
UGT2B7
UDP glucuronosyltransferase 2 family, polypeptide B7
chr19_+_21371724 0.088 NM_001076678
NM_145326
NM_175910
ZNF493


zinc finger protein 493


chr12_+_111375382 0.088 PTPN11
protein tyrosine phosphatase, non-receptor type 11
chr8_+_24830492 0.087 NEFM
neurofilament, medium polypeptide
chr4_-_160175782 0.087 NM_152543
C4orf45
chromosome 4 open reading frame 45
chr11_-_73371531 0.087 NM_003355
UCP2
uncoupling protein 2 (mitochondrial, proton carrier)
chr19_-_53444733 0.086 NM_001184901
NM_001184903
NM_014959
CARD8


caspase recruitment domain family, member 8


chr2_-_37397669 0.086 NM_005813
PRKD3
protein kinase D3
chr15_+_56217686 0.086 NM_020980
AQP9
aquaporin 9
chr19_+_57540493 0.086 NM_173530
ZNF610
zinc finger protein 610
chr5_+_140509803 0.085 NM_018939
PCDHB6
protocadherin beta 6
chr3_+_46628928 0.085 NM_001195442
LOC100132146
hypothetical LOC100132146
chr19_-_9087438 0.085 NM_001005192
OR7G1
olfactory receptor, family 7, subfamily G, member 1
chr12_+_21059896 0.084 NM_001009562
LST-3TM12
organic anion transporter LST-3b
chr9_-_103187082 0.083 NM_001701
BAAT
bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)
chr8_-_7710547 0.082 NM_001037668
NM_001040705
DEFB107A
DEFB107B
defensin, beta 107A
defensin, beta 107B
chr19_-_10474767 0.082 NM_203500
KEAP1
kelch-like ECH-associated protein 1
chr6_-_37575599 0.081 C6orf129
chromosome 6 open reading frame 129
chr21_-_34806373 0.080 KCNE1
potassium voltage-gated channel, Isk-related family, member 1
chr11_-_57792206 0.080 NM_207374
OR10W1
olfactory receptor, family 10, subfamily W, member 1
chr1_+_938709 0.080 NM_005101
ISG15
ISG15 ubiquitin-like modifier
chr1_-_109420091 0.078 NM_005645
TAF13
TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
chr21_-_26294332 0.078 APP
amyloid beta (A4) precursor protein
chr8_-_102034777 0.077 NM_003406
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr8_-_13178399 0.077 DLC1
deleted in liver cancer 1
chr4_+_3285671 0.076 NM_002926
NM_198229
RGS12

regulator of G-protein signaling 12

chr12_-_65359019 0.076 GRIP1
glutamate receptor interacting protein 1
chr1_+_28637247 0.076 NM_023923
PHACTR4
phosphatase and actin regulator 4
chr11_-_104274606 0.076 NM_001191016
CASP12
caspase 12 (gene/pseudogene)
chr6_+_163904564 0.075 QKI
quaking homolog, KH domain RNA binding (mouse)
chr10_+_63950212 0.074 NM_199452
ZNF365
zinc finger protein 365
chr1_-_246912227 0.074 NM_001004734
OR14I1
olfactory receptor, family 14, subfamily I, member 1
chr2_+_231829021 0.073


chr19_+_53189719 0.073 NM_022142
ELSPBP1
epididymal sperm binding protein 1
chr5_+_43645018 0.073 NNT
nicotinamide nucleotide transhydrogenase
chr13_-_35686665 0.073 NM_017826
SOHLH2
spermatogenesis and oogenesis specific basic helix-loop-helix 2
chr16_-_69880591 0.073 NM_001099642
NM_018348
FTSJD1

FtsJ methyltransferase domain containing 1

chr19_+_13999959 0.072 NM_080864
RLN3
relaxin 3
chr12_+_20854904 0.071 NM_019844
SLCO1B3
solute carrier organic anion transporter family, member 1B3
chr21_+_39117064 0.071 ETS2
v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)
chr11_+_114054409 0.069 NM_182495
FAM55B
family with sequence similarity 55, member B
chr1_-_246857051 0.069 NM_001001964
OR2T11
olfactory receptor, family 2, subfamily T, member 11
chr17_-_30414789 0.069 NM_001017368
RFFL
ring finger and FYVE-like domain containing 1
chr21_-_18697829 0.069 NM_002772
TMPRSS15
transmembrane protease, serine 15
chr12_+_109536214 0.068 NM_001082537
NM_001082538
NM_001173976
NM_024549
NM_001173975
TCTN1




tectonic family member 1




chr13_-_102209422 0.067 NM_001146197
C13orf40
chromosome 13 open reading frame 40
chr5_-_32439067 0.067 ZFR
zinc finger RNA binding protein
chr11_-_57728228 0.067 NM_001004459
OR1S2
olfactory receptor, family 1, subfamily S, member 2
chr14_-_87863003 0.066 NM_021161
KCNK10
potassium channel, subfamily K, member 10
chr13_-_40491491 0.066 NM_172373
ELF1
E74-like factor 1 (ets domain transcription factor)
chr5_-_149772563 0.066 CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr19_-_50977592 0.066 NM_001081560
NM_001081562
NM_004409
DMPK


dystrophia myotonica-protein kinase


chr1_+_179269183 0.065 NM_001194999
NM_001195000
NM_001195035
NM_001531
MR1



major histocompatibility complex, class I-related



chr16_-_3567354 0.065 NM_178844
NLRC3
NLR family, CARD domain containing 3
chr6_-_37575666 0.064 NM_138493
C6orf129
chromosome 6 open reading frame 129

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Nothing significant found in function category.