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• Activity deltas table
• Regulatory interactions
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Motif ID: LEF1_TCF7_TCF7L1,2.p2

Z-value: 1.106

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr9_-_21229975	2.841	NM_002172	IFNA14	interferon, alpha 14
chr6_-_127882192	2.011	NM_001012279	C6orf174	chromosome 6 open reading frame 174
chr8_+_32698892	1.909	NM_001159996	NRG1	neuregulin 1
chrX_-_105169370	1.625	NM_000354	SERPINA7	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr3_+_125296217	1.599	NM_001024660 NM_003947	KALRN	kalirin, RhoGEF kinase
chr8_-_6901661	1.466	NM_021010	DEFA5	defensin, alpha 5, Paneth cell-specific
chr12_+_19173669	1.229	NM_001143821 NM_001190860 NM_019012	PLEKHA5	pleckstrin homology domain containing, family A member 5
chr13_+_23042722	1.177	NM_148957	TNFRSF19	tumor necrosis factor receptor superfamily, member 19
chr6_-_128263868	1.165	NM_001010923 NM_001164685	THEMIS	thymocyte selection associated
chr13_+_75108450	1.156		LMO7	LIM domain 7
chr7_+_80069439	1.150	NM_001001547	CD36	CD36 molecule (thrombospondin receptor)
chr18_-_24011349	1.133	NM_001792	CDH2	cadherin 2, type 1, N-cadherin (neuronal)
chr9_-_35640852	1.125	NM_014450	SIT1	signaling threshold regulating transmembrane adaptor 1
chr8_-_16903911	1.118	NM_019851	FGF20	fibroblast growth factor 20
chr5_-_114543632	1.092	NM_001017397 NM_001017398 NM_018700	TRIM36	tripartite motif containing 36
chr13_-_71339313	1.086	NM_004392 NM_080759 NM_080760	DACH1	dachshund homolog 1 (Drosophila)
chr14_-_20572783	1.085	NM_001012264	RNASE13	ribonuclease, RNase A family, 13 (non-active)
chr8_-_120033240	1.055	NM_002546	TNFRSF11B	tumor necrosis factor receptor superfamily, member 11b
chr9_+_71009746	1.053	NM_001170415 NM_001170416	TJP2	tight junction protein 2 (zona occludens 2)
chr5_-_58370693	1.042	NM_001197221 NM_001197222	PDE4D	phosphodiesterase 4D, cAMP-specific
chr6_-_128883125	1.003	NM_002844 NM_001135648	PTPRK	protein tyrosine phosphatase, receptor type, K
chr17_+_24742068	0.999	NM_020791	TAOK1	TAO kinase 1
chr10_+_53744043	0.992	NM_012242	DKK1	dickkopf homolog 1 (Xenopus laevis)
chr12_+_8958397	0.978	NM_004426	PHC1	polyhomeotic homolog 1 (Drosophila)
chr17_+_16886491	0.974	NM_015134 NM_201274	MPRIP	myosin phosphatase Rho interacting protein
chr14_+_20306425	0.968	NM_022360	EDDM3B	epididymal protein 3B
chr12_+_15366712	0.964	NM_002848 NM_030667	PTPRO	protein tyrosine phosphatase, receptor type, O
chr4_+_42590038	0.954	NM_001080476	GRXCR1	glutaredoxin, cysteine rich 1
chr5_-_100266769	0.943	NM_175052 NM_005668	ST8SIA4	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
chr15_+_64481270	0.941		MAP2K1	mitogen-activated protein kinase kinase 1
chr17_-_35273947	0.931	NM_012481 NM_183228 NM_183229 NM_183230 NM_183231 NM_183232	IKZF3	IKAROS family zinc finger 3 (Aiolos)
chr2_-_231697999	0.928	NM_000867	HTR2B	5-hydroxytryptamine (serotonin) receptor 2B
chr3_-_191650291	0.925	NM_207316	TMEM207	transmembrane protein 207
chr14_+_74299748	0.913	NM_019589	YLPM1	YLP motif containing 1
chr4_+_113372287	0.900	NM_001128426 NM_018569	AP1AR	adaptor-related protein complex 1 associated regulatory protein
chr6_-_151754337	0.900	NM_020861	ZBTB2	zinc finger and BTB domain containing 2
chr1_+_93686154	0.898	NM_001024948 NM_001164473 NM_017737	FNBP1L	formin binding protein 1-like
chr9_-_21340885	0.897	NM_021002	IFNA6	interferon, alpha 6
chr21_-_26294332	0.896		APP	amyloid beta (A4) precursor protein
chr9_-_99746923	0.896	NM_018437	HEMGN	hemogen
chr1_+_221168388	0.887	NM_032890	DISP1	dispatched homolog 1 (Drosophila)
chr8_-_143958234	0.883	NM_000497 NM_001026213	CYP11B1	cytochrome P450, family 11, subfamily B, polypeptide 1
chr7_-_19778928	0.876	NM_152774	TMEM196	transmembrane protein 196
chr7_+_90176647	0.872	NM_012395	CDK14	cyclin-dependent kinase 14
chr9_+_17568952	0.865	NM_003026	SH3GL2	SH3-domain GRB2-like 2
chr18_-_55136673	0.842	NM_181654	CPLX4	complexin 4
chr17_-_61253122	0.822	NM_001037325	CCDC46	coiled-coil domain containing 46
chr3_-_87408301	0.813	NM_000306 NM_001122757	POU1F1	POU class 1 homeobox 1
chr18_-_24010944	0.796		CDH2	cadherin 2, type 1, N-cadherin (neuronal)
chr7_+_90177082	0.793		CDK14	cyclin-dependent kinase 14
chrX_-_108611940	0.788	NM_001522	GUCY2F	guanylate cyclase 2F, retinal
chr11_-_6633427	0.782	NM_003737	DCHS1	dachsous 1 (Drosophila)
chr9_+_90193058	0.780	NM_006717	SPIN1	spindlin 1
chr14_+_19655405	0.767	NM_001004715	OR4K17	olfactory receptor, family 4, subfamily K, member 17
chr17_-_36760581	0.763	NM_004138	KRT33A	keratin 33A
chr14_+_56927014	0.757	NM_001011713	NAA30	N(alpha)-acetyltransferase 30, NatC catalytic subunit
chr12_+_117067214	0.756		PEBP1	phosphatidylethanolamine binding protein 1
chr4_-_122213018	0.749	NM_024574	C4orf31	chromosome 4 open reading frame 31
chr11_+_101488380	0.749	NM_001195045	YAP1	Yes-associated protein 1
chr3_-_79899748	0.741	NM_002941	ROBO1	roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr3_-_181237210	0.741	NM_016559	PEX5L	peroxisomal biogenesis factor 5-like
chr3_-_166278969	0.739	NM_001041	SI	sucrase-isomaltase (alpha-glucosidase)
chr11_+_22646229	0.738	NM_177553	GAS2	growth arrest-specific 2
chr17_-_10313600	0.733	NM_017533	MYH4	myosin, heavy chain 4, skeletal muscle
chr10_+_114144512	0.723		ACSL5	acyl-CoA synthetase long-chain family member 5
chr12_+_26096757	0.719	NM_001164746	RASSF8	Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
chr14_+_56927066	0.718		NAA30	N(alpha)-acetyltransferase 30, NatC catalytic subunit
chr13_+_96884316	0.717	NM_021033	RAP2A	RAP2A, member of RAS oncogene family
chr2_+_104838177	0.716	NM_006236	POU3F3	POU class 3 homeobox 3
chr2_-_207739815	0.715		KLF7	Kruppel-like factor 7 (ubiquitous)
chr9_+_90193807	0.711		SPIN1	spindlin 1
chr4_+_78172966	0.711		SEPT11	septin 11
chr15_+_30694982	0.702	NM_014783 NM_199357	ARHGAP11A	Rho GTPase activating protein 11A
chr17_+_54997667	0.701	NM_001166301 NM_024612	DHX40	DEAH (Asp-Glu-Ala-His) box polypeptide 40
chr14_-_91111135	0.695	NM_001080113	C14orf184	chromosome 14 open reading frame 184
chr14_+_20283938	0.694	NM_006683	EDDM3A	epididymal protein 3A
chr12_+_7348194	0.680	NM_001080454	ACSM4	acyl-CoA synthetase medium-chain family member 4
chr12_-_88573949	0.677	NM_001001323 NM_001682	ATP2B1	ATPase, Ca++ transporting, plasma membrane 1
chr2_+_187163232	0.666		ITGAV	integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)
chr5_+_147775652	0.654		FBXO38	F-box protein 38
chr13_-_45087859	0.653	NM_182542	FAM194B	family with sequence similarity 194, member B
chr4_+_71330797	0.645	NM_001145006	MUC7	mucin 7, secreted
chr9_-_21295311	0.644	NM_002169	IFNA5	interferon, alpha 5
chr1_+_84402962	0.643		PRKACB	protein kinase, cAMP-dependent, catalytic, beta
chr1_+_195179533	0.635	NM_005666	CFHR2	complement factor H-related 2
chr20_-_43440290	0.626	NM_014477	TP53TG5	TP53 target 5
chr2_-_95846109	0.621		LOC150759	hypothetical LOC150759
chr3_+_99484421	0.620	NM_001005482	OR5H2	olfactory receptor, family 5, subfamily H, member 2
chr15_-_53667800	0.619		PYGO1	pygopus homolog 1 (Drosophila)
chr20_+_11846536	0.615	NM_014962	BTBD3	BTB (POZ) domain containing 3
chr5_+_34720368	0.602	NM_001145521 NM_001145525	RAI14	retinoic acid induced 14
chrX_+_69404879	0.597	NM_004312	ARR3	arrestin 3, retinal (X-arrestin)
chr4_+_15292363	0.595	NM_001145191	FAM200B	family with sequence similarity 200, member B
chr4_+_15292500	0.594		FAM200B	family with sequence similarity 200, member B
chr19_-_2901583	0.586
chr11_-_35235325	0.585		SLC1A2	solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr9_-_73715666	0.577		FAM108B1	family with sequence similarity 108, member B1
chr18_+_59521173	0.564	NM_080475	SERPINB11	serpin peptidase inhibitor, clade B (ovalbumin), member 11 (gene/pseudogene)
chr6_+_144649142	0.564		UTRN	utrophin
chr4_+_146622154	0.563	NM_005900	SMAD1	SMAD family member 1
chr14_-_57688560	0.563	NM_001001872	C14orf37	chromosome 14 open reading frame 37
chr11_+_58631190	0.560	NM_001142703 NM_001142704 NM_198947	FAM111B	family with sequence similarity 111, member B
chr11_-_89181390	0.559	NM_020358	TRIM49	tripartite motif containing 49
chr1_-_118529303	0.556	NM_206996	SPAG17	sperm associated antigen 17
chr4_-_40911212	0.554	NM_001166050 NM_004307 NM_173075	APBB2	amyloid beta (A4) precursor protein-binding, family B, member 2
chr13_+_75232797	0.553	NM_015842	LMO7	LIM domain 7
chr8_+_18072250	0.548	NM_001160179	NAT1	N-acetyltransferase 1 (arylamine N-acetyltransferase)
chr3_+_39346200	0.544	NM_005201	CCR8	chemokine (C-C motif) receptor 8
chr20_+_20296744	0.543	NM_002196	INSM1	insulinoma-associated 1
chr1_+_145479805	0.541	NM_004326	BCL9	B-cell CLL/lymphoma 9
chr18_+_59295123	0.541	NM_002639	SERPINB5	serpin peptidase inhibitor, clade B (ovalbumin), member 5
chr14_-_72563497	0.540	NM_021260	ZFYVE1	zinc finger, FYVE domain containing 1
chr14_-_22521544	0.529	NM_032876	JUB	jub, ajuba homolog (Xenopus laevis)
chr10_+_90552466	0.525	NM_001128215	LIPM	lipase, family member M
chr9_+_124551839	0.522	NM_001004453	OR1L6	olfactory receptor, family 1, subfamily L, member 6
chr7_-_122627235	0.522	NM_022444	SLC13A1	solute carrier family 13 (sodium/sulfate symporters), member 1
chr3_-_114643008	0.522	NM_001164496 NM_018338	WDR52	WD repeat domain 52
chr12_+_1608672	0.521	NM_032642	WNT5B	wingless-type MMTV integration site family, member 5B
chr6_+_134315940	0.520	NM_004865	TBPL1	TBP-like 1
chr2_+_185171682	0.519		ZNF804A	zinc finger protein 804A
chr6_-_52736231	0.512	NM_000846	GSTA2	glutathione S-transferase alpha 2
chr14_-_57688669	0.512		C14orf37	chromosome 14 open reading frame 37
chr2_-_165768798	0.510	NM_001081676 NM_001081677 NM_006922	SCN3A	sodium channel, voltage-gated, type III, alpha subunit
chr4_-_10295412	0.505	NM_052964	CLNK	cytokine-dependent hematopoietic cell linker
chr12_+_32151351	0.503	NM_001003398 NM_001714	BICD1	bicaudal D homolog 1 (Drosophila)
chr11_-_13474101	0.502	NM_000315	PTH	parathyroid hormone
chr5_+_149526533	0.498	NM_001804	CDX1	caudal type homeobox 1
chr9_-_14858974	0.497		FREM1	FRAS1 related extracellular matrix 1
chr4_+_69996780	0.496	NM_001074	UGT2B7	UDP glucuronosyltransferase 2 family, polypeptide B7
chr9_-_16717887	0.496		BNC2	basonuclin 2
chr11_-_121492010	0.496	NM_001001786	BLID	BH3-like motif containing, cell death inducer
chr6_-_11887265	0.495	NM_001143948 NM_032744	C6orf105	chromosome 6 open reading frame 105
chr4_-_85638410	0.495	NM_006168	NKX6-1	NK6 homeobox 1
chr3_+_134239860	0.492	NM_001136469 NM_023943	TMEM108	transmembrane protein 108
chr5_-_70621688	0.488		SMA4	glucuronidase, beta pseudogene
chr8_-_25338472	0.485	NM_000825 NM_001083111	GNRH1	gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
chr4_+_109761170	0.483	NM_000995 NM_033625	RPL34	ribosomal protein L34
chr9_-_106420305	0.480	NM_001001956	OR13C9	olfactory receptor, family 13, subfamily C, member 9
chr3_+_122109716	0.479	NM_014980	STXBP5L	syntaxin binding protein 5-like
chr18_-_29412148	0.478
chr12_-_47868563	0.474		TUBA1A	tubulin, alpha 1a
chr11_-_62753574	0.473	NM_199352	SLC22A25	solute carrier family 22, member 25
chr2_+_190981257	0.473	NM_017694	MFSD6	major facilitator superfamily domain containing 6
chr9_-_70345549	0.471	NM_153237	C9orf71	chromosome 9 open reading frame 71
chr2_+_54537842	0.468		SPTBN1	spectrin, beta, non-erythrocytic 1
chr5_-_39430180	0.467		DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr1_-_175400665	0.466		ASTN1	astrotactin 1
chr1_+_195055483	0.463	NM_002113	CFHR1	complement factor H-related 1
chrX_-_32083506	0.462	NM_004013 NM_004020 NM_004021 NM_004022 NM_004023	DMD	dystrophin
chr16_-_18720192	0.460	NM_015161	ARL6IP1	ADP-ribosylation factor-like 6 interacting protein 1
chr12_-_22378833	0.458	NM_003034	ST8SIA1	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
chr7_-_19151509	0.457	NM_152898	FERD3L	Fer3-like (Drosophila)
chr15_+_34659047	0.453	NM_001130010	C15orf41	chromosome 15 open reading frame 41
chr15_+_38923470	0.453	NM_003710 NM_181642	SPINT1	serine peptidase inhibitor, Kunitz type 1
chr1_+_156716290	0.452	NM_001004472	OR10R2	olfactory receptor, family 10, subfamily R, member 2
chr9_+_115265827	0.446	NM_017790	RGS3	regulator of G-protein signaling 3
chr2_-_136311219	0.445	NM_002299	LCT	lactase
chr5_+_140215778	0.444	NM_018901 NM_031859 NM_031860	PCDHA10	protocadherin alpha 10
chr19_-_58157832	0.441	NM_001031665	ZNF816-ZNF321 ZNF816	ZNF816-ZNF321 readthrough zinc finger protein 816
chr4_-_120462705	0.440	NM_000134	FABP2	fatty acid binding protein 2, intestinal
chrX_+_106050261	0.440	NM_020384	CLDN2	claudin 2
chr22_-_30885200	0.439	NM_001010859	C22orf42	chromosome 22 open reading frame 42
chr11_+_100367929	0.439	NM_032021	TMEM133	transmembrane protein 133
chr13_-_71338558	0.438		DACH1	dachshund homolog 1 (Drosophila)
chr11_+_62813947	0.438	NM_001039752	SLC22A10	solute carrier family 22, member 10
chrX_-_106248674	0.435		RBM41	RNA binding motif protein 41
chr5_-_159759620	0.432	NM_022090	C5orf54	chromosome 5 open reading frame 54
chr13_-_98708549	0.431	NM_001098200 NM_005292	GPR18	G protein-coupled receptor 18
chr7_+_110518297	0.431	NM_001099658 NM_001099660 NM_018334	LRRN3	leucine rich repeat neuronal 3
chrX_-_131918905	0.429		HS6ST2	heparan sulfate 6-O-sulfotransferase 2
chr11_-_88962426	0.424	NM_001143837	NOX4	NADPH oxidase 4
chr1_+_168381811	0.424	NM_001136107	METTL11B	methyltransferase like 11B
chr12_+_22669352	0.423		ETNK1	ethanolamine kinase 1
chr11_+_55899675	0.422	NM_001005204 NM_001013356	OR8U1 OR8U8	olfactory receptor, family 8, subfamily U, member 1 olfactory receptor, family 8, subfamily U, member 8
chr10_+_28918672	0.420		WAC	WW domain containing adaptor with coiled-coil
chr6_+_131190237	0.420	NM_001195597	LOC285733	hypothetical LOC285733
chr13_+_95541093	0.420	NM_153456	HS6ST3	heparan sulfate 6-O-sulfotransferase 3
chr15_+_45797977	0.419	NM_020858 NM_024966 NM_153616 NM_153617 NM_153618 NM_153619	SEMA6D	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
chr13_+_96884682	0.419		RAP2A	RAP2A, member of RAS oncogene family
chr15_-_80125514	0.419		MEX3B	mex-3 homolog B (C. elegans)
chr3_+_142569988	0.410		ZBTB38	zinc finger and BTB domain containing 38
chr3_-_188870799	0.409	NM_001048	SST	somatostatin
chr9_-_74169649	0.409	NM_001102420 NM_001102421 NM_006007	ZFAND5	zinc finger, AN1-type domain 5
chr1_+_195213289	0.409	NM_030787	CFHR5	complement factor H-related 5
chr8_+_94999167	0.408	NM_001161778	PDP1	pyruvate dehyrogenase phosphatase catalytic subunit 1
chr2_+_204509698	0.408	NM_012092	ICOS	inducible T-cell co-stimulator
chr6_+_83130673	0.408	NM_001166392	TPBG	trophoblast glycoprotein
chr2_+_101680594	0.408	NM_004834 NM_145686 NM_145687	MAP4K4	mitogen-activated protein kinase kinase kinase kinase 4
chr6_+_88111289	0.407	NM_001010868	C6orf163	chromosome 6 open reading frame 163
chrX_+_128867757	0.406	NM_001166221 NM_006649	UTP14A	UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
chrX_+_135057202	0.406	NM_001159702 NM_001159703 NM_001449	FHL1	four and a half LIM domains 1
chr1_-_156056456	0.405	NM_001159397 NM_001159398 NM_052938	FCRL1	Fc receptor-like 1
chr6_+_64339869	0.405	NM_003463	PTP4A1	protein tyrosine phosphatase type IVA, member 1
chr1_+_195010552	0.405	NM_001166624 NM_021023	CFHR3	complement factor H-related 3
chr2_+_112996053	0.404		TTL	tubulin tyrosine ligase
chr19_-_49523747	0.403		ZFP112	zinc finger protein 112 homolog (mouse)
chr5_-_34020445	0.399	NM_001012509 NM_016180	SLC45A2	solute carrier family 45, member 2
chr17_-_36376663	0.399	NM_213656	KRT39	keratin 39
chr7_+_29200636	0.398	NM_004067	CHN2	chimerin (chimaerin) 2
chr14_-_19553191	0.396	NM_001004712	OR4K14	olfactory receptor, family 4, subfamily K, member 14

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
1.75	2.83e-02	GO:0007608	sensory perception of smell
1.70	3.69e-02	GO:0007606	sensory perception of chemical stimulus

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
2.09	2.80e-02	GO:0005882	intermediate filament

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
1.84	1.51e-03	GO:0004984	olfactory receptor activity