Motif ID: SOX5.p2

Z-value: 1.525


Transcription factors associated with SOX5.p2:

Gene SymbolEntrez IDGene Name
SOX5 6660 SRY (sex determining region Y)-box 5



Activity profile for motif SOX5.p2.

activity profile for motif SOX5.p2


Sorted Z-values histogram for motif SOX5.p2

Sorted Z-values for motif SOX5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SOX5.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_-_16380967 3.627 NM_001145819
NM_017508
SOX6

SRY (sex determining region Y)-box 6

chr7_-_11838260 3.244 NM_015204
THSD7A
thrombospondin, type I, domain containing 7A
chr4_+_42590038 3.005 NM_001080476
GRXCR1
glutaredoxin, cysteine rich 1
chr3_+_174598937 2.124 NM_014932
NLGN1
neuroligin 1
chr4_-_101658094 2.099 NM_001159694
NM_016242
EMCN

endomucin

chr3_+_88270951 1.944 NM_018293
ZNF654
zinc finger protein 654
chr11_-_51269023 1.924 NM_001005272
OR4A5
olfactory receptor, family 4, subfamily A, member 5
chr2_+_166137091 1.897 NM_024969
CSRNP3
cysteine-serine-rich nuclear protein 3
chr4_-_105635499 1.806 CXXC4
CXXC finger protein 4
chr12_-_11399776 1.805 NM_005039
NM_199353
NM_199354
PRB1


proline-rich protein BstNI subfamily 1


chr15_+_47502666 1.783 NM_002009
FGF7
fibroblast growth factor 7
chr3_-_121065112 1.778


chr10_+_96433240 1.713 NM_000772
NM_001128925
CYP2C18

cytochrome P450, family 2, subfamily C, polypeptide 18

chrX_-_151370325 1.709 NM_000808
GABRA3
gamma-aminobutyric acid (GABA) A receptor, alpha 3
chr2_-_225073357 1.646 CUL3
cullin 3
chr1_-_51660328 1.616 NM_001159969
EPS15
epidermal growth factor receptor pathway substrate 15
chr20_-_21326046 1.614 NM_033176
NKX2-4
NK2 homeobox 4
chr11_-_121492010 1.602 NM_001001786
BLID
BH3-like motif containing, cell death inducer
chr9_-_85773899 1.584 HNRNPK
heterogeneous nuclear ribonucleoprotein K
chr10_+_49184658 1.576 MAPK8
mitogen-activated protein kinase 8
chr11_-_48330574 1.571 NM_001005513
OR4C45
olfactory receptor, family 4, subfamily C, member 45
chr11_+_101488380 1.557 NM_001195045
YAP1
Yes-associated protein 1
chr4_+_71096830 1.544 NM_017855
ODAM
odontogenic, ameloblast asssociated
chr12_-_11354620 1.527 NM_002723
PRB4
proline-rich protein BstNI subfamily 4
chr18_-_29412148 1.512


chr11_-_7684516 1.501 NM_198185
OVCH2
ovochymase 2 (gene/pseudogene)
chr1_+_198975227 1.497 NM_203459
CAMSAP1L1
calmodulin regulated spectrin-associated protein 1-like 1
chr2_-_55053398 1.446


chr15_+_22751162 1.412 NM_003097
NM_022804
NM_005678
SNRPN
SNURF

small nuclear ribonucleoprotein polypeptide N
SNRPN upstream reading frame

chr14_-_105862080 1.383 IGHV4-31
IGHA1
IGHD
IGHG1
IGHG2
IGHG3
IGHM
SCFV
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant delta
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 2 (G2m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
immunoglobulin heavy constant mu
single-chain Fv fragment
chr4_+_110968594 1.365 NM_006583
RRH
retinal pigment epithelium-derived rhodopsin homolog
chr8_+_104900591 1.354 NM_014677
RIMS2
regulating synaptic membrane exocytosis 2
chr3_+_89239494 1.354 EPHA3
EPH receptor A3
chr10_+_104525877 1.349 NM_017787
C10orf26
chromosome 10 open reading frame 26
chr1_-_150564302 1.334 NM_002016
FLG
filaggrin
chr9_-_21375258 1.330 NM_000605
IFNA2
interferon, alpha 2
chr17_-_44058612 1.283 NM_024017
HOXB9
homeobox B9
chr17_+_3065661 1.274 NM_014565
OR1A1
olfactory receptor, family 1, subfamily A, member 1
chr15_-_23204887 1.249 NM_000462
UBE3A
ubiquitin protein ligase E3A
chr9_+_108665168 1.248 NM_021224
ZNF462
zinc finger protein 462
chr11_-_55460451 1.206 NM_006637
OR5I1
olfactory receptor, family 5, subfamily I, member 1
chr9_+_102244005 1.201 NM_001198812
C9orf3-TMEFF1
C9orf30
C9orf3-TMEFF1 readthrough
chromosome 9 open reading frame 30
chr21_-_30583702 1.199 NM_001128598
KRTAP25-1
keratin associated protein 25-1
chr3_+_89239363 1.198 NM_005233
NM_182644
EPHA3

EPH receptor A3

chr5_-_111340421 1.188 NM_001142474
NM_001142475
C5orf13

chromosome 5 open reading frame 13

chr1_-_7998265 1.173 ERRFI1
ERBB receptor feedback inhibitor 1
chr10_-_98311813 1.172 TM9SF3
transmembrane 9 superfamily member 3
chr2_-_63518589 1.166 NM_001042692
WDPCP
WD repeat containing planar cell polarity effector
chrX_+_55951280 1.164


chr12_-_23995109 1.162 SOX5
SRY (sex determining region Y)-box 5
chr6_+_105511615 1.157 NM_001004317
LIN28B
lin-28 homolog B (C. elegans)
chr12_-_23995220 1.153 SOX5
SRY (sex determining region Y)-box 5
chr10_-_98280299 1.141 TM9SF3
transmembrane 9 superfamily member 3
chr7_-_86526880 1.136 NM_001142749
KIAA1324L
KIAA1324-like
chr2_-_39310176 1.093 NM_001009565
CDKL4
cyclin-dependent kinase-like 4
chr12_-_89976261 1.093 NM_007035
KERA
keratocan
chr5_-_147266257 1.090 NM_206966
C5orf46
chromosome 5 open reading frame 46
chr3_+_99350859 1.082 NM_001005514
OR5H14
olfactory receptor, family 5, subfamily H, member 14
chr7_-_22518200 1.081 EEF1A1
eukaryotic translation elongation factor 1 alpha 1
chr6_+_88026338 1.081 ZNF292
zinc finger protein 292
chr3_-_18455207 1.074 NM_001131010
SATB1
SATB homeobox 1
chr12_-_97812633 1.073 ANKS1B
ankyrin repeat and sterile alpha motif domain containing 1B
chr10_-_108914277 1.044 NM_001013031
NM_052918
SORCS1

sortilin-related VPS10 domain containing receptor 1

chr3_-_56673113 1.042 NM_015224
C3orf63
chromosome 3 open reading frame 63
chr3_+_85858321 1.041 NM_153184
CADM2
cell adhesion molecule 2
chr1_+_116727514 1.040 NM_001160234
ATP1A1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
chrX_-_39921525 1.035 NM_001123383
NM_001123384
BCOR

BCL6 corepressor

chr15_+_100175888 1.030 NM_001001674
OR4F15
olfactory receptor, family 4, subfamily F, member 15
chr3_+_173954940 1.020 NM_018098
ECT2
epithelial cell transforming sequence 2 oncogene
chr21_-_31049566 1.020 NM_181619
KRTAP21-1
keratin associated protein 21-1
chr2_+_211166323 1.018 NM_001122634
CPS1
carbamoyl-phosphate synthase 1, mitochondrial
chr14_-_106184988 1.016 IGHA1
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr9_-_28709302 1.012 NM_152570
LINGO2
leucine rich repeat and Ig domain containing 2
chr12_+_68028397 1.007 NM_000239
LYZ
lysozyme
chr1_+_145479805 1.000 NM_004326
BCL9
B-cell CLL/lymphoma 9
chr16_+_65938753 0.994 NM_001161575
LRRC36
leucine rich repeat containing 36
chr6_-_46155937 0.992 NM_001114086
CLIC5
chloride intracellular channel 5
chr4_-_113656762 0.980 NM_024019
NEUROG2
neurogenin 2
chr14_-_54948290 0.980 NM_014924
ATG14
ATG14 autophagy related 14 homolog (S. cerevisiae)
chr6_+_154373323 0.974 NM_001145279
NM_001145280
NM_001145281
OPRM1


opioid receptor, mu 1


chr1_-_150353179 0.972 NM_007113
TCHH
trichohyalin
chr2_-_55090759 0.970 NM_007008
RTN4
reticulon 4
chr1_-_49014993 0.967 NM_024603
BEND5
BEN domain containing 5
chr2_+_167468220 0.958 NM_001079810
NM_152381
XIRP2

xin actin-binding repeat containing 2

chr1_-_214963279 0.957 NM_001438
ESRRG
estrogen-related receptor gamma
chr8_-_125785611 0.948 MTSS1
metastasis suppressor 1
chr6_-_128263868 0.948 NM_001010923
NM_001164685
THEMIS

thymocyte selection associated

chr10_-_62002672 0.922 ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr12_+_26017954 0.921 NM_001164747
RASSF8
Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
chr1_+_183281173 0.920 NM_007212
RNF2
ring finger protein 2
chr14_-_22974707 0.916 NM_000257
MYH7
myosin, heavy chain 7, cardiac muscle, beta
chr3_-_113701073 0.903 NM_001085357
NM_181780
BTLA

B and T lymphocyte associated

chr20_+_20296744 0.897 NM_002196
INSM1
insulinoma-associated 1
chr11_+_5925152 0.894 NM_001003443
OR56A3
olfactory receptor, family 56, subfamily A, member 3
chr5_+_147754467 0.893 FBXO38
F-box protein 38
chr11_+_54891935 0.891 NM_001005275
OR4A15
olfactory receptor, family 4, subfamily A, member 15
chr20_+_23293020 0.889 NM_022482
GZF1
GDNF-inducible zinc finger protein 1
chr10_+_24537725 0.889 NM_001098501
NM_019590
KIAA1217

KIAA1217

chr17_-_36451189 0.885 NM_030967
KRTAP1-3
KRTAP1-1
keratin associated protein 1-3
keratin associated protein 1-1
chr11_+_55799604 0.884 NM_001004745
OR5T1
olfactory receptor, family 5, subfamily T, member 1
chr2_+_62787534 0.878 NM_001142614
EHBP1
EH domain binding protein 1
chr4_+_114190233 0.877 NM_001148
NM_020977
ANK2

ankyrin 2, neuronal

chr11_+_33236435 0.874 HIPK3
homeodomain interacting protein kinase 3
chrX_-_83644054 0.871 NM_001177478
NM_001177479
NM_144657
HDX


highly divergent homeobox


chr12_+_68028407 0.859 LYZ
lysozyme
chr20_+_71230 0.857 NM_030931
DEFB126
defensin, beta 126
chr16_+_68284252 0.854 NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr12_-_11066436 0.854 NM_176888
TAS2R19
taste receptor, type 2, member 19
chr11_+_55842358 0.852 NM_001005202
OR8K3
olfactory receptor, family 8, subfamily K, member 3
chr11_-_123353607 0.848 NM_001004474
OR10S1
olfactory receptor, family 10, subfamily S, member 1
chr16_+_55373241 0.845 NUP93
nucleoporin 93kDa
chr4_-_20594645 0.844 KCNIP4
Kv channel interacting protein 4
chr3_-_130373241 0.840 CNBP
CCHC-type zinc finger, nucleic acid binding protein
chr7_+_93373755 0.839 NM_021955
GNGT1
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1
chr3_+_150028130 0.837 NM_001871
CPB1
carboxypeptidase B1 (tissue)
chr8_+_103633023 0.833 NM_024410
ODF1
outer dense fiber of sperm tails 1
chr10_-_98263434 0.829 NM_012465
TLL2
tolloid-like 2
chr8_-_72437020 0.823 NM_000503
EYA1
eyes absent homolog 1 (Drosophila)
chr11_+_5862076 0.823 NM_001005165
OR52E4
olfactory receptor, family 52, subfamily E, member 4
chr10_+_97749837 0.822 NM_001001732
NM_001159747
CC2D2B

coiled-coil and C2 domain containing 2B

chr20_+_2892918 0.819 PTPRA
protein tyrosine phosphatase, receptor type, A
chr4_-_83566045 0.808


chr3_-_69212192 0.799 NM_003968
NM_198195
UBA3

ubiquitin-like modifier activating enzyme 3

chr8_-_93144366 0.798 NM_004349
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr5_-_178977441 0.795 HNRNPH1
heterogeneous nuclear ribonucleoprotein H1 (H)
chr22_-_39189369 0.794 MKL1
megakaryoblastic leukemia (translocation) 1
chr2_-_128138435 0.784 NM_017980
LIMS2
LIM and senescent cell antigen-like domains 2
chr10_-_56230953 0.773 NM_001142763
NM_001142764
NM_001142765
NM_001142766
NM_001142767
NM_001142768
NM_001142769
NM_001142770
NM_001142771
NM_001142772
NM_001142773
NM_033056
PCDH15











protocadherin-related 15











chr3_-_62835601 0.771


chr1_+_81544432 0.770 LPHN2
latrophilin 2
chr9_-_72673753 0.770 NM_001007470
NM_020952
NM_024971
NM_206944
NM_206945
NM_206946
NM_206947
NM_206948
TRPM3







transient receptor potential cation channel, subfamily M, member 3







chr12_-_66905802 0.762 NM_018402
IL26
interleukin 26
chr8_+_74369647 0.761 NM_172037
RDH10
retinol dehydrogenase 10 (all-trans)
chr12_-_11041740 0.760 NM_176889
TAS2R20
taste receptor, type 2, member 20
chr15_+_71953020 0.751 NM_153356
TBC1D21
TBC1 domain family, member 21
chr11_+_22652957 0.749 GAS2
growth arrest-specific 2
chr10_-_74863303 0.748 NM_001024593
ZMYND17
zinc finger, MYND-type containing 17
chr11_-_92570626 0.745


chr3_-_47909001 0.741 MAP4
microtubule-associated protein 4
chr10_+_86121526 0.741 FAM190B
family with sequence similarity 190, member B
chr1_-_246804680 0.741 NM_001001821
OR2T34
olfactory receptor, family 2, subfamily T, member 34
chr2_+_228386800 0.740 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr3_+_162697289 0.740 NM_001080440
OTOL1
otolin 1 homolog (zebrafish)
chr2_-_208697441 0.738 NM_006891
CRYGD
crystallin, gamma D
chr4_+_53975597 0.737 FIP1L1
FIP1 like 1 (S. cerevisiae)
chr7_-_82630063 0.735 NM_014510
NM_033026
PCLO

piccolo (presynaptic cytomatrix protein)

chr6_+_89847183 0.734 PNRC1
proline-rich nuclear receptor coactivator 1
chr6_-_128883125 0.733 NM_002844
NM_001135648
PTPRK

protein tyrosine phosphatase, receptor type, K

chr12_-_18134319 0.732 NM_024730
RERGL
RERG/RAS-like
chr5_+_102493155 0.731 NM_015216
PPIP5K2
diphosphoinositol pentakisphosphate kinase 2
chr2_-_164300758 0.729 NM_018086
FIGN
fidgetin
chr10_+_118295417 0.727 NM_000936
PNLIP
pancreatic lipase
chr11_+_36274300 0.723 NM_001160167
PRR5L
proline rich 5 like
chr17_-_3248453 0.721 NM_003553
OR1E1
olfactory receptor, family 1, subfamily E, member 1
chr5_-_146441184 0.721 NM_181677
NM_181678
PPP2R2B

protein phosphatase 2, regulatory subunit B, beta

chr2_+_191009265 0.720 MFSD6
major facilitator superfamily domain containing 6
chr14_-_94669547 0.715 NM_001195573
DICER1
dicer 1, ribonuclease type III
chr15_+_37660568 0.712 NM_003246
THBS1
thrombospondin 1
chr8_+_87947788 0.712 NM_173538
CNBD1
cyclic nucleotide binding domain containing 1
chr14_-_91483757 0.711 NM_006329
FBLN5
fibulin 5
chrX_-_32340291 0.705 NM_004011
NM_004012
DMD

dystrophin

chr15_+_36331411 0.705 SPRED1
sprouty-related, EVH1 domain containing 1
chr10_+_129237602 0.702 NM_001030013
NPS
neuropeptide S
chr11_-_27637771 0.695 NM_001143816
NM_170735
BDNF

brain-derived neurotrophic factor

chr14_+_19414230 0.694 NM_001005501
OR4K2
olfactory receptor, family 4, subfamily K, member 2
chr12_+_21417068 0.688 NM_000415
IAPP
islet amyloid polypeptide
chr18_-_55136673 0.686 NM_181654
CPLX4
complexin 4
chr3_-_66634031 0.683 LRIG1
leucine-rich repeats and immunoglobulin-like domains 1
chrX_-_111970662 0.681 NM_133265
AMOT
angiomotin
chr18_+_29412538 0.680 NM_030632
ASXL3
additional sex combs like 3 (Drosophila)
chr12_-_85756766 0.679 NM_013244
MGAT4C
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr13_+_81162030 0.679


chr16_+_21518633 0.678 METTL9
methyltransferase like 9
chr14_-_70345485 0.678 NM_033141
MAP3K9
mitogen-activated protein kinase kinase kinase 9
chr1_+_148603769 0.677 RPRD2
regulation of nuclear pre-mRNA domain containing 2
chr12_+_54132264 0.677 NM_054105
OR6C2
olfactory receptor, family 6, subfamily C, member 2
chr9_-_4142182 0.676 NM_152629
GLIS3
GLIS family zinc finger 3
chr2_+_108230082 0.674 NM_001008743
SULT1C3
sulfotransferase family, cytosolic, 1C, member 3
chr3_-_101077605 0.673 NM_014890
FILIP1L
filamin A interacting protein 1-like
chr3_+_112743615 0.672 NM_005816
NM_198196
CD96

CD96 molecule

chr7_-_116854765 0.671 NM_130768
ASZ1
ankyrin repeat, SAM and basic leucine zipper domain containing 1
chr13_+_51933228 0.670 CKAP2
cytoskeleton associated protein 2
chr4_+_71235259 0.668 NM_033122
CABS1
calcium-binding protein, spermatid-specific 1
chr2_-_215953818 0.667 FN1
fibronectin 1
chr1_-_90955365 0.665 NM_020063
BARHL2
BarH-like homeobox 2
chr17_+_59244363 0.662 DDX42
DEAD (Asp-Glu-Ala-Asp) box polypeptide 42
chr17_-_36074812 0.658 NM_152349
KRT222
keratin 222
chr2_-_180319013 0.657 NM_001113397
ZNF385B
zinc finger protein 385B
chr3_-_121117647 0.656 GSK3B
glycogen synthase kinase 3 beta
chr4_-_64957595 0.655 NM_001010874
TECRL
trans-2,3-enoyl-CoA reductase-like
chr3_+_189425886 0.654 NM_001167671
LPP
LIM domain containing preferred translocation partner in lipoma
chr1_+_74473672 0.653 NM_015978
TNNI3K
TNNI3 interacting kinase
chr6_-_127882192 0.651 NM_001012279
C6orf174
chromosome 6 open reading frame 174
chr12_-_98072602 0.646 NM_020140
NM_181670
ANKS1B

ankyrin repeat and sterile alpha motif domain containing 1B

chr9_+_106371269 0.645 NM_001004483
OR13C8
olfactory receptor, family 13, subfamily C, member 8
chr1_-_202730135 0.638 PIK3C2B
phosphoinositide-3-kinase, class 2, beta polypeptide
chr10_+_115514567 0.636 NM_182601
C10orf81
chromosome 10 open reading frame 81
chr7_-_122126422 0.635 NM_139175
RNF133
ring finger protein 133
chr3_+_112743729 0.632 CD96
CD96 molecule
chr9_-_40782062 0.630 NM_033160
ZNF658
zinc finger protein 658

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.55 3.76e-16 GO:0007608 sensory perception of smell
2.40 7.42e-15 GO:0007606 sensory perception of chemical stimulus
1.83 9.34e-10 GO:0007600 sensory perception
1.56 1.14e-07 GO:0050877 neurological system process
1.47 6.47e-07 GO:0003008 system process
1.16 1.03e-03 GO:0050896 response to stimulus

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.29 3.97e-02 GO:0005856 cytoskeleton

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.60 8.23e-17 GO:0004984 olfactory receptor activity
1.69 2.29e-07 GO:0004930 G-protein coupled receptor activity
1.42 4.91e-04 GO:0004888 transmembrane receptor activity
1.31 9.62e-03 GO:0004872 receptor activity
1.26 2.86e-02 GO:0004871 signal transducer activity
1.26 2.86e-02 GO:0060089 molecular transducer activity