Motif ID: NKX3-1.p2

Z-value: 2.625


Transcription factors associated with NKX3-1.p2:

Gene SymbolEntrez IDGene Name
NKX3-1 4824 NK3 homeobox 1



Activity profile for motif NKX3-1.p2.

activity profile for motif NKX3-1.p2


Sorted Z-values histogram for motif NKX3-1.p2

Sorted Z-values for motif NKX3-1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX3-1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_228064531 5.244 AGFG1
ArfGAP with FG repeats 1
chr9_+_21399132 4.351 NM_002170
IFNA8
interferon, alpha 8
chr11_+_33319680 3.252 HIPK3
homeodomain interacting protein kinase 3
chr3_-_121117647 3.241 GSK3B
glycogen synthase kinase 3 beta
chr14_-_74669864 2.917 TMED10
transmembrane emp24-like trafficking protein 10 (yeast)
chr14_+_66901237 2.788 EIF2S1
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
chr3_+_174598937 2.744 NM_014932
NLGN1
neuroligin 1
chr2_+_114390975 2.707 ACTR3
ARP3 actin-related protein 3 homolog (yeast)
chr10_+_90336489 2.685 NM_001010939
LIPJ
lipase, family member J
chr3_-_121445831 2.636 NM_001168271
NM_153002
GPR156

G protein-coupled receptor 156

chr20_+_12937616 2.565 NM_018327
SPTLC3
serine palmitoyltransferase, long chain base subunit 3
chr11_-_104332631 2.493 NM_033306
CASP4
caspase 4, apoptosis-related cysteine peptidase
chr9_-_13240313 2.294 NM_003829
MPDZ
multiple PDZ domain protein
chr3_-_99236520 2.281 NM_001105580
GABRR3
gamma-aminobutyric acid (GABA) receptor, rho 3
chrX_+_114734074 2.262 NM_001136025
NM_001172335
PLS3

plastin 3

chr4_+_119174947 2.131 NM_004784
NDST3
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
chr6_+_64344307 2.102 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr14_-_24115268 2.048 NM_001911
CTSG
cathepsin G
chr10_-_98280299 2.003 TM9SF3
transmembrane 9 superfamily member 3
chr6_+_153060722 1.999 NM_025107
MYCT1
myc target 1
chr9_-_21218132 1.945 NM_021268
IFNA17
interferon, alpha 17
chr12_-_5925658 1.881 NM_020373
ANO2
anoctamin 2
chr3_-_115380539 1.851 NM_000796
NM_033663
DRD3

dopamine receptor D3

chr6_+_53043729 1.843 NM_012347
FBXO9
F-box protein 9
chr11_-_13474101 1.805 NM_000315
PTH
parathyroid hormone
chr4_+_152417774 1.788 NM_183375
PRSS48
protease, serine, 48
chr14_-_19553191 1.734 NM_001004712
OR4K14
olfactory receptor, family 4, subfamily K, member 14
chr2_+_37282516 1.723 LOC100505876
hypothetical LOC100505876
chr11_-_100505667 1.720 NM_000926
PGR
progesterone receptor
chr3_+_99350859 1.713 NM_001005514
OR5H14
olfactory receptor, family 5, subfamily H, member 14
chr7_+_94377145 1.702 NM_001166161
NM_001166162
NM_001166163
PPP1R9A


protein phosphatase 1, regulatory (inhibitor) subunit 9A


chrX_+_56772391 1.695 LOC550643
hypothetical LOC550643
chr9_-_25668855 1.658 NM_001004125
TUSC1
tumor suppressor candidate 1
chr20_+_9236446 1.651 NM_000933
PLCB4
phospholipase C, beta 4
chr1_-_246823691 1.623 NM_001004693
OR2T10
olfactory receptor, family 2, subfamily T, member 10
chrX_+_66705407 1.554 NM_001011645
AR
androgen receptor
chr7_+_80069439 1.538 NM_001001547
CD36
CD36 molecule (thrombospondin receptor)
chr17_+_58440629 1.522 NM_025185
TANC2
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
chr13_+_51496679 1.504 NM_021645
ALG11
UTP14C
asparagine-linked glycosylation 11, alpha-1,2-mannosyltransferase homolog (yeast)
UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast)
chr20_-_1298493 1.487 FKBP1A
FK506 binding protein 1A, 12kDa
chr19_+_62844143 1.463 ZNF211
zinc finger protein 211
chr1_-_103269356 1.457 COL11A1
collagen, type XI, alpha 1
chrX_-_1291526 1.455 NM_001012288
NM_022148
CRLF2

cytokine receptor-like factor 2

chr10_+_90552466 1.452 NM_001128215
LIPM
lipase, family member M
chrX_+_115215985 1.450 NM_000686
AGTR2
angiotensin II receptor, type 2
chr12_+_8167494 1.449 NM_016184
NM_194447
NM_194448
NM_194450
CLEC4A



C-type lectin domain family 4, member A



chr9_-_21375258 1.440 NM_000605
IFNA2
interferon, alpha 2
chr11_-_7775064 1.435 NM_153444
OR5P2
olfactory receptor, family 5, subfamily P, member 2
chr2_+_207512522 1.409 NM_173077
CPO
carboxypeptidase O
chr7_-_123460722 1.403 NM_001136002
TMEM229A
transmembrane protein 229A
chr5_+_147238466 1.397 NM_054023
SCGB3A2
secretoglobin, family 3A, member 2
chr1_+_246578699 1.394 NM_001001918
OR14C36
olfactory receptor, family 14, subfamily C, member 36
chr14_+_44436176 1.389 NM_001017923
C14orf28
chromosome 14 open reading frame 28
chr10_+_118340460 1.386 NM_006229
PNLIPRP1
pancreatic lipase-related protein 1
chr3_+_50119261 1.385 RBM5
RNA binding motif protein 5
chr2_+_115538716 1.382 NM_001178037
DPP10
dipeptidyl-peptidase 10 (non-functional)
chr2_-_233349469 1.365 NM_001172416
NM_001172417
NM_002242
KCNJ13


potassium inwardly-rectifying channel, subfamily J, member 13


chr11_+_89507465 1.362 NM_005467
NAALAD2
N-acetylated alpha-linked acidic dipeptidase 2
chr6_+_153113624 1.352 NM_003381
NM_194435
VIP

vasoactive intestinal peptide

chr13_+_110637173 1.350 NM_001113513
ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chrX_-_32340291 1.337 NM_004011
NM_004012
DMD

dystrophin

chr5_-_58331515 1.332 NM_001197223
PDE4D
phosphodiesterase 4D, cAMP-specific
chr14_+_19655405 1.331 NM_001004715
OR4K17
olfactory receptor, family 4, subfamily K, member 17
chr10_+_116687904 1.321 NM_139169
TRUB1
TruB pseudouridine (psi) synthase homolog 1 (E. coli)
chr2_-_18634257 1.316 NM_001002006
NM_033253
NT5C1B-RDH14
NT5C1B

NT5C1B-RDH14 readthrough
5'-nucleotidase, cytosolic IB

chr5_-_160044844 1.295 ATP10B
ATPase, class V, type 10B
chr4_-_163304567 1.295 NM_001128427
NM_001128428
NM_020116
FSTL5


follistatin-like 5


chr10_-_126706442 1.278 NM_022802
CTBP2
C-terminal binding protein 2
chr12_+_79362256 1.264 NM_001145026
PTPRQ
protein tyrosine phosphatase, receptor type, Q
chr1_+_69998445 1.252 NM_020794
LRRC7
leucine rich repeat containing 7
chr21_-_26345294 1.251


chr15_+_92700167 1.250 NM_001159644
MCTP2
multiple C2 domains, transmembrane 2
chr14_-_106084085 1.225 IGHV4-31
IGHG1
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant gamma 1 (G1m marker)
chr22_+_29696662 1.224


chr3_-_174341653 1.202 NM_031955
SPATA16
spermatogenesis associated 16
chr14_-_105681377 1.197 IGHV4-31
IGHG1
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant gamma 1 (G1m marker)
chr11_+_55362802 1.192 NM_001005496
OR5D16
olfactory receptor, family 5, subfamily D, member 16
chr5_+_147423727 1.189 NM_001127698
NM_001127699
NM_006846
SPINK5


serine peptidase inhibitor, Kazal type 5


chr9_-_21177529 1.188 NM_021068
IFNA4
interferon, alpha 4
chr11_-_30910074 1.180 NM_020869
DCDC5
doublecortin domain containing 5
chr14_-_20098929 1.151 NM_001001673
NM_001110356
NM_001110357
NM_001110358
NM_001110359
NM_001110360
NM_001110361
RNASE9






ribonuclease, RNase A family, 9 (non-active)






chr9_+_4829763 1.147 RCL1
RNA terminal phosphate cyclase-like 1
chrX_+_89063595 1.142 NM_138960
TGIF2LX
TGFB-induced factor homeobox 2-like, X-linked
chr15_+_22781292 1.137 PAR5
Prader-Willi/Angelman syndrome-5
chr7_-_108311872 1.134 NM_001024607
C7orf66
chromosome 7 open reading frame 66
chr4_-_157006827 1.126 NM_017419
ACCN5
amiloride-sensitive cation channel 5, intestinal
chr1_+_74473672 1.126 NM_015978
TNNI3K
TNNI3 interacting kinase
chr14_+_74353417 1.123 YLPM1
YLP motif containing 1
chr9_-_41944687 1.113 MGC21881
hypothetical locus MGC21881
chr7_-_38915306 1.109 NM_014396
NM_080631
VPS41

vacuolar protein sorting 41 homolog (S. cerevisiae)

chr11_-_48330574 1.103 NM_001005513
OR4C45
olfactory receptor, family 4, subfamily C, member 45
chr9_-_21192201 1.095 NM_021057
IFNA7
interferon, alpha 7
chr16_+_82540172 1.083 NM_013370
NM_182980
OSGIN1

oxidative stress induced growth inhibitor 1

chr4_-_153523113 1.069 NM_001013415
FBXW7
F-box and WD repeat domain containing 7
chr3_+_99484421 1.069 NM_001005482
OR5H2
olfactory receptor, family 5, subfamily H, member 2
chr6_+_88021644 1.066 ZNF292
zinc finger protein 292
chr20_-_52120710 1.065 NM_003657
BCAS1
breast carcinoma amplified sequence 1
chr18_-_62422195 1.065 NM_021153
CDH19
cadherin 19, type 2
chr15_+_100163424 1.063 NM_001005326
OR4F6
olfactory receptor, family 4, subfamily F, member 6
chr3_+_99288706 1.058 NM_054106
OR5AC2
olfactory receptor, family 5, subfamily AC, member 2
chr2_+_203763649 1.046 RPL12
ribosomal protein L12
chr3_-_153541468 1.037 NM_001123228
TMEM14E
transmembrane protein 14E
chr9_+_95273241 1.028 FAM120A
family with sequence similarity 120A
chr16_-_70339666 1.012 AP1G1
adaptor-related protein complex 1, gamma 1 subunit
chr11_+_88550687 1.008 NM_000372
TYR
tyrosinase (oculocutaneous albinism IA)
chr2_+_211166323 1.004 NM_001122634
CPS1
carbamoyl-phosphate synthase 1, mitochondrial
chr11_-_57883117 1.004 NM_001005489
OR5B17
olfactory receptor, family 5, subfamily B, member 17
chr4_+_74520796 0.997 NM_001134
AFP
alpha-fetoprotein
chr22_-_39587944 0.993 NM_145174
DNAJB7
DnaJ (Hsp40) homolog, subfamily B, member 7
chr14_-_46882144 0.990 NM_182830
MDGA2
MAM domain containing glycosylphosphatidylinositol anchor 2
chr5_+_140235114 0.985 NM_018903
NM_031864
PCDHA12

protocadherin alpha 12

chr15_+_64481270 0.979 MAP2K1
mitogen-activated protein kinase kinase 1
chr8_-_18710575 0.978 NM_206909
PSD3
pleckstrin and Sec7 domain containing 3
chr5_+_54491702 0.973 NM_001008397
GPX8
glutathione peroxidase 8 (putative)
chr1_-_246869181 0.939 NM_001001827
OR2T35
olfactory receptor, family 2, subfamily T, member 35
chr6_-_52060327 0.931 NM_138694
NM_170724
PKHD1

polycystic kidney and hepatic disease 1 (autosomal recessive)

chr14_+_88130482 0.927 NM_207662
ZC3H14
zinc finger CCCH-type containing 14
chr2_-_165259334 0.926 COBLL1
COBL-like 1
chr3_+_171183203 0.924 SEC62
SEC62 homolog (S. cerevisiae)
chr15_-_100280784 0.922 NM_001004195
OR4F4
OR4F17
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 17
chr12_-_78608873 0.919 NM_002583
PAWR
PRKC, apoptosis, WT1, regulator
chr18_+_59705918 0.918 NM_001143818
NM_002575
SERPINB2

serpin peptidase inhibitor, clade B (ovalbumin), member 2

chr20_+_29309127 0.916 NM_001037730
DEFB115
defensin, beta 115
chr12_-_80676562 0.913 PPFIA2
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
chr10_+_90474280 0.896 NM_001080518
LIPK
lipase, family member K
chr7_+_141457977 0.896 LOC93432
maltase-glucoamylase-like pseudogene
chr2_-_215956429 0.894 FN1
fibronectin 1
chr2_+_102744921 0.894 NM_144632
TMEM182
transmembrane protein 182
chr8_+_24354387 0.888 NM_003817
ADAM7
ADAM metallopeptidase domain 7
chr5_+_139869819 0.881


chr14_-_101617680 0.869 HSP90AA1
heat shock protein 90kDa alpha (cytosolic), class A member 1
chr11_-_77730573 0.865 NM_012296
GAB2
GRB2-associated binding protein 2
chr1_+_84402962 0.865 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr21_-_30836051 0.846 NM_181612
KRTAP19-6
keratin associated protein 19-6
chr5_-_150663519 0.827 NM_001145017
NM_181774
SLC36A3

solute carrier family 36 (proton/amino acid symporter), member 3

chr4_-_279943 0.826 NM_001137608
ZNF732
zinc finger protein 732
chr11_-_55128424 0.824 NM_001004700
OR4C11
olfactory receptor, family 4, subfamily C, member 11
chr9_-_35860316 0.823 NM_001004487
OR13J1
olfactory receptor, family 13, subfamily J, member 1
chr3_+_129124591 0.821 NM_207335
KBTBD12
kelch repeat and BTB (POZ) domain containing 12
chr17_-_15914485 0.820 NCOR1
nuclear receptor corepressor 1
chr6_-_122807439 0.813 SERINC1
serine incorporator 1
chr12_-_14982708 0.807 NM_152321
ERP27
endoplasmic reticulum protein 27
chr13_+_52500830 0.799 NM_006418
OLFM4
olfactomedin 4
chr9_-_74757735 0.798 NM_000689
ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr5_+_76470829 0.797


chr3_-_127760447 0.793 NM_152533
C3orf22
chromosome 3 open reading frame 22
chr3_+_85858321 0.791 NM_153184
CADM2
cell adhesion molecule 2
chr11_-_62668268 0.789 NM_001136506
SLC22A24
solute carrier family 22, member 24
chr10_+_97749837 0.787 NM_001001732
NM_001159747
CC2D2B

coiled-coil and C2 domain containing 2B

chr12_+_32578513 0.784 FGD4
FYVE, RhoGEF and PH domain containing 4
chr4_-_187764213 0.776


chr6_+_97117144 0.773 NM_001170807
NM_020482
FHL5

four and a half LIM domains 5

chr18_+_74957475 0.769


chr1_-_156954528 0.762 NM_001005327
OR6K3
olfactory receptor, family 6, subfamily K, member 3
chr12_-_83954185 0.759 NM_001100917
TSPAN19
tetraspanin 19
chr5_+_179065282 0.757 CANX
calnexin
chr9_+_80134302 0.756 PSAT1
phosphoserine aminotransferase 1
chr2_+_114935623 0.754 NM_001178036
DPP10
dipeptidyl-peptidase 10 (non-functional)
chr11_+_56224436 0.753 NM_001005213
NM_001013358
OR9G1
OR9G9
olfactory receptor, family 9, subfamily G, member 1
olfactory receptor, family 9, subfamily G, member 9
chr9_+_71009746 0.751 NM_001170415
NM_001170416
TJP2

tight junction protein 2 (zona occludens 2)

chr1_+_149165438 0.751 NM_001145415
NM_012432
SETDB1

SET domain, bifurcated 1

chr9_-_85773899 0.749 HNRNPK
heterogeneous nuclear ribonucleoprotein K
chr8_+_110168828 0.747 NM_003301
TRHR
thyrotropin-releasing hormone receptor
chr2_-_207291364 0.742 NM_001093730
DYTN
dystrotelin
chr3_-_56673113 0.742 NM_015224
C3orf63
chromosome 3 open reading frame 63
chr8_-_25338472 0.739 NM_000825
NM_001083111
GNRH1

gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)

chr4_-_10295412 0.739 NM_052964
CLNK
cytokine-dependent hematopoietic cell linker
chr11_+_89032112 0.733 NM_153696
FOLH1B
folate hydrolase 1B
chr4_-_21155376 0.730 NM_001035004
KCNIP4
Kv channel interacting protein 4
chr3_+_160473784 0.730 SCHIP1
schwannomin interacting protein 1
chr1_+_169747788 0.730 PRRC2C
proline-rich coiled-coil 2C
chr12_-_18134319 0.719 NM_024730
RERGL
RERG/RAS-like
chr9_-_21358005 0.718 NM_006900
IFNA1
IFNA13
interferon, alpha 1
interferon, alpha 13
chr4_+_71283383 0.717 NM_006685
SMR3B
submaxillary gland androgen regulated protein 3B
chr11_+_55799604 0.716 NM_001004745
OR5T1
olfactory receptor, family 5, subfamily T, member 1
chr4_+_146250978 0.715 ABCE1
ATP-binding cassette, sub-family E (OABP), member 1
chr2_+_48661229 0.714 NM_001198594
STON1
STON1-GTF2A1L
stonin 1
STON1-GTF2A1L readthrough
chr12_+_63510481 0.713


chr11_-_83661878 0.712 NM_001142700
DLG2
discs, large homolog 2 (Drosophila)
chr6_-_64087806 0.710 NM_001143940
NM_016571
LGSN

lengsin, lens protein with glutamine synthetase domain

chr21_-_26175068 0.708 APP
amyloid beta (A4) precursor protein
chr10_+_112334066 0.707 SMC3
structural maintenance of chromosomes 3
chr14_-_24148658 0.705 NM_033423
GZMH
granzyme H (cathepsin G-like 2, protein h-CCPX)
chr13_+_28131140 0.704 NM_015932
POMP
proteasome maturation protein
chr1_+_190871868 0.704 NM_002927
NM_144766
RGS13

regulator of G-protein signaling 13

chr5_+_147672181 0.697 NM_032566
SPINK7
serine peptidase inhibitor, Kazal type 7 (putative)
chr11_-_55942283 0.695 NM_001004744
OR5R1
olfactory receptor, family 5, subfamily R, member 1
chr19_+_21371724 0.694 NM_001076678
NM_145326
NM_175910
ZNF493


zinc finger protein 493


chrX_+_57329834 0.690 NM_174912
FAAH2
fatty acid amide hydrolase 2
chr14_+_60271203 0.688 NM_001177963
NM_002431
MNAT1

menage a trois homolog 1, cyclin H assembly factor (Xenopus laevis)

chr15_+_46285789 0.688 NM_000338
NM_001184832
SLC12A1

solute carrier family 12 (sodium/potassium/chloride transporters), member 1

chr5_+_126887056 0.683 PRRC1
proline-rich coiled-coil 1
chrX_-_131401319 0.678 NM_018388
NM_133486
MBNL3

muscleblind-like 3 (Drosophila)

chr16_+_74868676 0.671 NM_033401
CNTNAP4
contactin associated protein-like 4
chr9_+_124416768 0.669 NM_012364
OR1Q1
olfactory receptor, family 1, subfamily Q, member 1
chr2_-_39310176 0.668 NM_001009565
CDKL4
cyclin-dependent kinase-like 4
chr5_-_58607673 0.660 NM_001197220
PDE4D
phosphodiesterase 4D, cAMP-specific
chr14_+_44622916 0.659 NM_017922
PRPF39
PRP39 pre-mRNA processing factor 39 homolog (S. cerevisiae)
chr1_-_102234959 0.658 OLFM3
olfactomedin 3
chr19_+_9157269 0.655 NM_175883
OR7D2
olfactory receptor, family 7, subfamily D, member 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
4.11 1.89e-31 GO:0007606 sensory perception of chemical stimulus
4.32 3.67e-31 GO:0007608 sensory perception of smell
2.75 2.04e-20 GO:0007600 sensory perception
1.99 6.50e-12 GO:0050877 neurological system process
1.82 1.53e-10 GO:0003008 system process
1.33 9.12e-07 GO:0032501 multicellular organismal process
1.26 2.06e-05 GO:0050896 response to stimulus

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.40 1.60e-08 GO:0005886 plasma membrane
1.39 3.27e-08 GO:0071944 cell periphery
1.25 6.49e-06 GO:0044425 membrane part
1.25 2.05e-04 GO:0016021 integral to membrane
1.24 3.77e-04 GO:0031224 intrinsic to membrane
1.41 2.12e-03 GO:0005576 extracellular region
1.16 3.76e-03 GO:0016020 membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
4.48 8.78e-33 GO:0004984 olfactory receptor activity
2.77 2.52e-22 GO:0004930 G-protein coupled receptor activity
2.21 1.37e-17 GO:0004888 transmembrane receptor activity
1.97 4.22e-16 GO:0004872 receptor activity
1.75 1.96e-12 GO:0004871 signal transducer activity
1.75 1.96e-12 GO:0060089 molecular transducer activity
13.61 3.32e-04 GO:0005132 interferon-alpha/beta receptor binding
3.30 1.04e-02 GO:0004867 serine-type endopeptidase inhibitor activity
8.38 1.60e-02 GO:0004522 pancreatic ribonuclease activity