Motif ID: GTF2A1,2.p2

Z-value: 2.048


Transcription factors associated with GTF2A1,2.p2:

Gene SymbolEntrez IDGene Name
GTF2A1 2957 general transcription factor IIA, 1, 19/37kDa
GTF2A2 2958 general transcription factor IIA, 2, 12kDa



Activity profile for motif GTF2A1,2.p2.

activity profile for motif GTF2A1,2.p2


Sorted Z-values histogram for motif GTF2A1,2.p2

Sorted Z-values for motif GTF2A1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of GTF2A1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_+_130620540 5.266 NM_004435
ENDOG
endonuclease G
chr1_+_148089251 4.086 NM_001040874
NM_003516
HIST2H2AA4
HIST2H2AA3
histone cluster 2, H2aa4
histone cluster 2, H2aa3
chr2_+_94900904 3.901 NM_144705
TEKT4
tektin 4
chr1_+_201541269 3.753 NM_006763
BTG2
BTG family, member 2
chr5_+_60969392 3.724 NM_173667
FLJ37543
hypothetical protein FLJ37543
chr1_+_201541241 3.380 BTG2
BTG family, member 2
chr19_-_1827133 3.336


chr22_+_20067662 2.927 NM_001128633
RIMBP3C
RIMS binding protein 3C
chr22_+_20068039 2.900 NM_001128635
RIMBP3B
RIMS binding protein 3B
chr22_+_21852911 2.859 BCR
breakpoint cluster region
chr22_+_21852699 2.764 BCR
breakpoint cluster region
chr11_+_60727559 2.761 NM_001079807
PGA3
PGA4
pepsinogen 3, group I (pepsinogen A)
pepsinogen 4, group I (pepsinogen A)
chr4_+_9094611 2.721 NM_001040071
LOC650293
seven transmembrane helix receptor
chr19_+_5082230 2.702 KDM4B
lysine (K)-specific demethylase 4B
chr6_-_32259974 2.645 NM_001136
NM_172197
AGER

advanced glycosylation end product-specific receptor

chr5_+_175041069 2.583 NM_022304
HRH2
histamine receptor H2
chr11_+_63864263 2.551 NM_032251
CCDC88B
coiled-coil domain containing 88B
chr19_+_10083196 2.533 NM_002566
P2RY11
purinergic receptor P2Y, G-protein coupled, 11
chr6_+_167504070 2.491 NM_001145121
TCP10L2
TCP10
t-complex 10-like 2 (mouse)
t-complex 10 homolog (mouse)
chrX_+_134383533 2.382 NCRNA00086
non-protein coding RNA 86
chr1_+_984935 2.374 LOC100288175
hypothetical LOC100288175
chr12_+_111980044 2.368 NM_004416
DTX1
deltex homolog 1 (Drosophila)
chr11_+_60765219 2.328 NM_014224
PGA5
pepsinogen 5, group I (pepsinogen A)
chr15_+_65245546 2.289 NM_001145104
SMAD3
SMAD family member 3
chr8_-_145119627 2.277 NM_201378
PLEC
plectin
chr1_+_203740391 2.170 CDK18
cyclin-dependent kinase 18
chr1_+_228949752 2.147 NM_006615
NM_016452
CAPN9

calpain 9

chr14_+_99859427 2.147 NM_207117
SLC25A47
solute carrier family 25, member 47
chr19_-_53868075 2.143 NM_145807
NTN5
netrin 5
chr15_-_81175542 2.136 NM_004644
AP3B2
adaptor-related protein complex 3, beta 2 subunit
chr11_+_60746396 2.123 NM_001079808
PGA5
PGA3
PGA4
pepsinogen 5, group I (pepsinogen A)
pepsinogen 3, group I (pepsinogen A)
pepsinogen 4, group I (pepsinogen A)
chr19_+_40895669 2.119 NM_014383
ZBTB32
zinc finger and BTB domain containing 32
chr6_+_43247179 2.064 SRF
serum response factor (c-fos serum response element-binding transcription factor)
chr1_+_203740306 2.054 NM_002596
NM_212502
NM_212503
CDK18


cyclin-dependent kinase 18


chr9_+_91409746 2.005 NM_006705
GADD45G
growth arrest and DNA-damage-inducible, gamma
chr20_+_61337679 1.978 NM_022161
NM_139317
BIRC7

baculoviral IAP repeat containing 7

chr3_+_42675841 1.970 ZBTB47
zinc finger and BTB domain containing 47
chr8_+_128817658 1.961 MYC
v-myc myelocytomatosis viral oncogene homolog (avian)
chr19_+_2173415 1.954 DOT1L
DOT1-like, histone H3 methyltransferase (S. cerevisiae)
chrX_-_118610880 1.949 NM_001173488
NKRF
NFKB repressing factor
chr2_+_242146791 1.925 NM_032515
BOK
BCL2-related ovarian killer
chr7_-_41709191 1.915 NM_002192
INHBA
inhibin, beta A
chr10_+_70745615 1.894 NM_033496
HK1
hexokinase 1
chr2_+_74914742 1.891 HK2
hexokinase 2
chr3_+_141879555 1.887 NM_152616
TRIM42
tripartite motif containing 42
chr17_+_76549658 1.866 RPTOR
regulatory associated protein of MTOR, complex 1
chr10_+_73703682 1.852 NM_019058
DDIT4
DNA-damage-inducible transcript 4
chr12_+_108452117 1.828 UBE3B
ubiquitin protein ligase E3B
chr22_+_21359175 1.819 IGLV3-25
immunoglobulin lambda variable 3-25
chr11_-_72063059 1.811 NM_002599
PDE2A
phosphodiesterase 2A, cGMP-stimulated
chr8_+_7663908 1.790 NM_001164447
FAM90A10
family with sequence similarity 90, member A10
chr6_+_43247168 1.790 SRF
serum response factor (c-fos serum response element-binding transcription factor)
chr2_-_96145614 1.783 NM_000682
ADRA2B
adrenergic, alpha-2B-, receptor
chr6_+_43246897 1.737 NM_003131
SRF
serum response factor (c-fos serum response element-binding transcription factor)
chr17_-_71404611 1.736 NM_173547
TRIM65
tripartite motif containing 65
chr1_-_20682541 1.701


chr21_-_42608531 1.691 TFF3
trefoil factor 3 (intestinal)
chr2_+_95326753 1.678 NM_013434
KCNIP3
Kv channel interacting protein 3, calsenilin
chr17_+_71141108 1.667 NM_001162995
LOC643008
hypothetical protein LOC643008
chr1_+_16566169 1.666 NM_001114600
NM_015609
C1orf144

chromosome 1 open reading frame 144

chr17_-_44006808 1.660 NM_002146
HOXB3
homeobox B3
chr1_+_984972 1.652 LOC100288175
hypothetical LOC100288175
chr7_+_72720093 1.643 NM_001077621
VPS37D
vacuolar protein sorting 37 homolog D (S. cerevisiae)
chr1_-_202432165 1.641 NM_002256
KISS1
KiSS-1 metastasis-suppressor
chr19_+_3958690 1.640 NM_015897
PIAS4
protein inhibitor of activated STAT, 4
chr10_-_44794146 1.634 NM_007021
C10orf10
chromosome 10 open reading frame 10
chr20_-_61356247 1.630 NM_152864
NKAIN4
Na+/K+ transporting ATPase interacting 4
chr22_-_20419975 1.613 NM_013313
YPEL1
yippee-like 1 (Drosophila)
chr17_+_58908152 1.609 NM_000789
ACE
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
chr20_+_62266270 1.602 NM_004535
MYT1
myelin transcription factor 1
chr11_+_118561375 1.577 NM_001168468
NM_024791
PDZD3

PDZ domain containing 3

chr8_-_11361594 1.566 NM_053279
FAM167A
family with sequence similarity 167, member A
chr22_+_28032950 1.564 NM_006478
NM_152236
NM_152237
GAS2L1


growth arrest-specific 2 like 1


chr16_-_727889 1.564 NARFL
nuclear prelamin A recognition factor-like
chr1_+_149520601 1.562 ZNF687
zinc finger protein 687
chr11_-_63292688 1.562 NM_001144936
C11orf95
chromosome 11 open reading frame 95
chr19_+_3523903 1.538 NM_006339
HMG20B
high-mobility group 20B
chr20_+_31334601 1.528 NM_033197
C20orf114
chromosome 20 open reading frame 114
chr16_+_751050 1.495 NM_013404
MSLN
mesothelin
chr2_-_198248828 1.481 NM_144629
RFTN2
raftlin family member 2
chr3_+_50217692 1.478 NM_006841
SLC38A3
solute carrier family 38, member 3
chr22_+_38246509 1.468 NM_001675
NM_182810
ATF4

activating transcription factor 4 (tax-responsive enhancer element B67)

chr7_+_72720256 1.458 VPS37D
vacuolar protein sorting 37 homolog D (S. cerevisiae)
chr16_+_68765428 1.451 NM_173619
CLEC18C
CLEC18A
CLEC18B
C-type lectin domain family 18, member C
C-type lectin domain family 18, member A
C-type lectin domain family 18, member B
chr4_-_26100986 1.426 NM_000730
CCKAR
cholecystokinin A receptor
chr22_+_21852743 1.423 BCR
breakpoint cluster region
chr8_-_22054939 1.419 NM_025232
REEP4
receptor accessory protein 4
chr11_-_64582568 1.408 NM_005468
NAALADL1
N-acetylated alpha-linked acidic dipeptidase-like 1
chr7_-_150702629 1.402


chr18_+_606671 1.398 NM_199167
CLUL1
clusterin-like 1 (retinal)
chr15_+_57696200 1.396 GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr17_-_6400470 1.380 NM_001165966
NM_031220
PITPNM3

PITPNM family member 3

chr19_+_3523950 1.375 HMG20B
high-mobility group 20B
chr16_+_82544327 1.365 NM_182981
OSGIN1
oxidative stress induced growth inhibitor 1
chr11_+_113280727 1.354 NM_006028
HTR3B
5-hydroxytryptamine (serotonin) receptor 3B
chr6_-_167717907 1.346 NM_004610
TCP10
t-complex 10 homolog (mouse)
chr6_-_41114905 1.341 NM_173561
UNC5CL
unc-5 homolog C (C. elegans)-like
chrX_+_49718954 1.337 NM_000084
CLCN5
chloride channel 5
chr1_-_110949867 1.335 NM_004974
KCNA2
potassium voltage-gated channel, shaker-related subfamily, member 2
chr4_+_1330957 1.313 NM_020894
KIAA1530
KIAA1530
chr1_-_154205675 1.310 ARHGEF2
Rho/Rac guanine nucleotide exchange factor (GEF) 2
chr1_+_200246370 1.292 ELF3
E74-like factor 3 (ets domain transcription factor, epithelial-specific )
chr17_-_59327602 1.286 NM_001317
NM_022640
NM_022641
CSH1


CSH2
chorionic somatomammotropin hormone 1 (placental lactogen)


chorionic somatomammotropin hormone 2
chr22_+_21484240 1.282


chr22_-_35829402 1.280 NM_153609
TMPRSS6
transmembrane protease, serine 6
chr16_+_25135783 1.278 NM_001169
AQP8
aquaporin 8
chr17_-_68769613 1.268 NM_001129885
CPSF4L
cleavage and polyadenylation specific factor 4-like
chr19_-_19175064 1.267 NM_176880
NR2C2AP
nuclear receptor 2C2-associated protein
chr3_-_13032130 1.259


chr1_+_201729893 1.259 NM_014359
OPTC
opticin
chr10_+_70517823 1.259 NM_002727
SRGN
serglycin
chr8_+_7656261 1.257 NM_001164448
FAM90A9
family with sequence similarity 90, member A9
chr15_-_87239745 1.257 NM_178232
HAPLN3
hyaluronan and proteoglycan link protein 3
chr22_-_29015452 1.246 NM_001037666
GATSL3
GATS protein-like 3
chr16_+_30843396 1.238 NM_001099784
FBXL19
F-box and leucine-rich repeat protein 19
chr21_-_32879617 1.237 NM_144659
TCP10L
t-complex 10 (mouse)-like
chr1_+_29086206 1.235 EPB41
erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)
chr19_-_59516155 1.229 NM_181879
NM_181985
NM_181986
NM_021250
LILRA5



leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5



chr22_+_21852551 1.223 NM_004327
NM_021574
BCR

breakpoint cluster region

chr19_-_53832381 1.219 NM_001352
DBP
D site of albumin promoter (albumin D-box) binding protein
chr6_+_28425666 1.218 NM_024493
ZKSCAN3
zinc finger with KRAB and SCAN domains 3
chr7_+_129807467 1.212 NM_001868
CPA1
carboxypeptidase A1 (pancreatic)
chr15_+_39008822 1.210 NM_019074
DLL4
delta-like 4 (Drosophila)
chr22_-_41685827 1.209 NM_001184971
PACSIN2
protein kinase C and casein kinase substrate in neurons 2
chr12_-_51047521 1.202 NM_002283
KRT85
keratin 85
chr7_+_68701704 1.202 NM_001127231
NM_001127232
NM_015570
AUTS2


autism susceptibility candidate 2


chr14_-_72430545 1.191 NM_012074
DPF3
D4, zinc and double PHD fingers, family 3
chr19_+_52214885 1.186 NPAS1
neuronal PAS domain protein 1
chr7_-_149631001 1.185 NM_001164459
ACTR3C
ARP3 actin-related protein 3 homolog C (yeast)
chr10_+_70517863 1.181 SRGN
serglycin
chr19_+_4353658 1.180 NM_005483
CHAF1A
chromatin assembly factor 1, subunit A (p150)
chr1_+_110683467 1.176 NM_022768
RBM15
RNA binding motif protein 15
chr19_+_44308224 1.175 NM_001014831
NM_001014832
NM_001014834
NM_001014835
NM_005884
PAK4




p21 protein (Cdc42/Rac)-activated kinase 4




chr3_-_50333859 1.174 HYAL2
hyaluronoglucosaminidase 2
chr1_+_45822246 1.169 NM_001195193
NM_002482
NM_152298
NASP


nuclear autoantigenic sperm protein (histone-binding)


chr21_+_44569537 1.158 PFKL
phosphofructokinase, liver
chr17_+_77603064 1.158 GPS1
G protein pathway suppressor 1
chr1_+_29086156 1.156 NM_001166005
NM_001166007
NM_004437
NM_203342
NM_203343
EPB41




erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)




chr21_+_44881700 1.153 NM_181688
KRTAP10-10
keratin associated protein 10-10
chr4_-_77176163 1.153 NM_005409
CXCL11
chemokine (C-X-C motif) ligand 11
chr11_-_1549719 1.151 NM_004420
DUSP8
dual specificity phosphatase 8
chr8_+_21956335 1.151 NM_003867
FGF17
fibroblast growth factor 17
chrX_-_43717864 1.144 NM_000266
NDP
Norrie disease (pseudoglioma)
chr1_-_24342158 1.139 NM_021258
IL22RA1
interleukin 22 receptor, alpha 1
chr6_-_31973434 1.135 NM_006709
NM_025256
EHMT2

euchromatic histone-lysine N-methyltransferase 2

chr22_+_36412277 1.132 NM_024313
NOL12
nucleolar protein 12
chr11_+_65781646 1.127 NM_001134776
NM_001134774
NM_022822
KLC2


kinesin light chain 2


chr20_+_34635362 1.127 NM_021809
TGIF2
TGFB-induced factor homeobox 2
chr22_+_21006814 1.127


chr11_+_65781322 1.127 NM_001134775
KLC2
kinesin light chain 2
chr1_+_2975590 1.126 NM_022114
NM_199454
PRDM16

PR domain containing 16

chr8_+_7618022 1.123 NM_001164451
NM_001164449
FAM90A18
FAM90A19
family with sequence similarity 90, member A18
family with sequence similarity 90, member A19
chr12_+_48219109 1.119 NM_012284
KCNH3
potassium voltage-gated channel, subfamily H (eag-related), member 3
chr1_-_205012348 1.118 NM_000572
IL10
interleukin 10
chr21_-_42608774 1.104 NM_003226
TFF3
trefoil factor 3 (intestinal)
chr11_+_119586879 1.102 NM_178507
OAF
OAF homolog (Drosophila)
chr3_+_42995762 1.101 NM_001129908
FAM198A
family with sequence similarity 198, member A
chr19_-_3930828 1.100 EEF2
eukaryotic translation elongation factor 2
chr22_-_25291268 1.099 NM_001008566
TPST2
tyrosylprotein sulfotransferase 2
chr12_+_51777715 1.097 IGFBP6
insulin-like growth factor binding protein 6
chr1_+_110795271 1.097 NM_032414
PROK1
prokineticin 1
chr16_-_48418418 1.095 NM_015069
ZNF423
zinc finger protein 423
chr6_-_24985432 1.092 NM_015864
FAM65B
family with sequence similarity 65, member B
chr1_+_95355415 1.091 NM_152487
TMEM56
transmembrane protein 56
chr17_+_8132539 1.089 NM_001177801
NM_001177802
NM_016492
RANGRF


RAN guanine nucleotide release factor


chr11_+_118269310 1.085 NM_032966
CXCR5
chemokine (C-X-C motif) receptor 5
chr6_+_32114060 1.085 NM_000500
NM_001128590
CYP21A2

cytochrome P450, family 21, subfamily A, polypeptide 2

chr19_+_17691283 1.081 MAP1S
microtubule-associated protein 1S
chr19_+_17691302 1.080 NM_018174
MAP1S
microtubule-associated protein 1S
chr8_+_7139945 1.079 NM_001164453
FAM90A20
family with sequence similarity 90, member A20
chr17_+_35075124 1.077 NM_003673
TCAP
titin-cap (telethonin)
chr6_-_31973418 1.072 EHMT2
euchromatic histone-lysine N-methyltransferase 2
chr1_+_46418786 1.071 TSPAN1
tetraspanin 1
chr1_-_109201228 1.068 NM_152763
AKNAD1
AKNA domain containing 1
chr19_+_991114 1.064 ABCA7
ATP-binding cassette, sub-family A (ABC1), member 7
chr12_-_108736983 1.062 NM_001177431
NM_001177428
NM_001177433
NM_147204
TRPV4



transient receptor potential cation channel, subfamily V, member 4



chr16_+_56616970 1.053 MMP15
matrix metallopeptidase 15 (membrane-inserted)
chr1_+_42391678 1.050 NM_007102
GUCA2B
guanylate cyclase activator 2B (uroguanylin)
chr11_-_70185592 1.048 SHANK2
SH3 and multiple ankyrin repeat domains 2
chr1_-_16812274 1.045 NM_017940
NBPF1
neuroblastoma breakpoint family, member 1
chr11_+_183079 1.039 NM_145651
SCGB1C1
secretoglobin, family 1C, member 1
chr19_+_63679563 1.039 NM_017908
ZNF446
zinc finger protein 446
chr6_-_46401174 1.038 RCAN2
regulator of calcineurin 2
chr2_+_113709553 1.030 LOC654433
hypothetical LOC654433
chr15_-_71448194 1.028 HCN4
hyperpolarization activated cyclic nucleotide-gated potassium channel 4
chr7_-_150605112 1.027 NM_003078
SMARCD3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
chr19_+_45799060 1.020 NM_001042545
LTBP4
latent transforming growth factor beta binding protein 4
chr5_+_40877053 1.017 NM_032587
CARD6
caspase recruitment domain family, member 6
chr17_+_7196151 1.017 KCTD11
potassium channel tetramerisation domain containing 11
chrX_-_114158388 1.015 NM_000640
IL13RA2
interleukin 13 receptor, alpha 2
chr8_+_7101835 0.999 NM_001164456
NM_001164452
FAM90A13
FAM90A14
family with sequence similarity 90, member A13
family with sequence similarity 90, member A14
chr8_+_7648613 0.998 NM_001164451
NM_001164449
FAM90A18
FAM90A19
family with sequence similarity 90, member A18
family with sequence similarity 90, member A19
chr12_+_56290229 0.997 NM_001111270
ARHGEF25
Rho guanine nucleotide exchange factor (GEF) 25
chr19_+_3523958 0.997 HMG20B
high-mobility group 20B
chr1_+_31655607 0.987 NM_001199037
SERINC2
serine incorporator 2
chr8_+_128817494 0.983 NM_002467
MYC
v-myc myelocytomatosis viral oncogene homolog (avian)
chr8_+_7633318 0.980 NM_001164450
FAM90A8
family with sequence similarity 90, member A8
chr20_-_42457717 0.973


chr1_+_212843205 0.972 CENPF
centromere protein F, 350/400kDa (mitosin)
chr6_-_31797434 0.970 NM_025261
LY6G6C
lymphocyte antigen 6 complex, locus G6C

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.89 8.84e-03 GO:0007015 actin filament organization

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.41 1.80e-07 GO:0005576 extracellular region
1.49 1.28e-04 GO:0044421 extracellular region part
1.44 1.78e-02 GO:0005615 extracellular space

Nothing significant found in function category.