Motif ID: PRRX1,2.p2

Z-value: 2.516


Transcription factors associated with PRRX1,2.p2:

Gene SymbolEntrez IDGene Name
PRRX1 5396 paired related homeobox 1
PRRX2 51450 paired related homeobox 2



Activity profile for motif PRRX1,2.p2.

activity profile for motif PRRX1,2.p2


Sorted Z-values histogram for motif PRRX1,2.p2

Sorted Z-values for motif PRRX1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PRRX1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_55053398 15.428


chr7_+_113853790 11.730 NM_001172767
NM_148899
FOXP2

forkhead box P2

chr6_+_64414389 10.829 NM_015153
PHF3
PHD finger protein 3
chr2_-_47969350 10.278 NM_025133
FBXO11
F-box protein 11
chr10_+_126620681 9.544 NM_017580
ZRANB1
zinc finger, RAN-binding domain containing 1
chr7_-_26202626 9.327 HNRNPA2B1
heterogeneous nuclear ribonucleoprotein A2/B1
chr2_-_55090759 9.166 NM_007008
RTN4
reticulon 4
chr10_-_98280299 9.024 TM9SF3
transmembrane 9 superfamily member 3
chr3_-_121065112 8.505


chr2_-_206790871 8.493 NM_001098199
NM_005279
GPR1

G protein-coupled receptor 1

chr2_-_210726539 8.464 C2orf67
chromosome 2 open reading frame 67
chr1_+_84402962 8.441 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr1_-_58920315 8.396


chr4_+_74520796 8.163 NM_001134
AFP
alpha-fetoprotein
chr9_-_14076901 8.090 NFIB
nuclear factor I/B
chr12_+_29267863 7.663 NM_018099
FAR2
fatty acyl CoA reductase 2
chr7_+_94135384 7.169 PEG10
paternally expressed 10
chr12_+_28301399 6.865 NM_018318
CCDC91
coiled-coil domain containing 91
chr9_-_85773899 6.761 HNRNPK
heterogeneous nuclear ribonucleoprotein K
chr4_-_70539922 6.733 NM_001105677
UGT2A2
UDP glucuronosyltransferase 2 family, polypeptide A2
chr11_-_85103438 6.468 NM_032379
SYTL2
synaptotagmin-like 2
chr7_-_83108682 6.399 NM_001178129
SEMA3E
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
chr12_-_11041740 6.347 NM_176889
TAS2R20
taste receptor, type 2, member 20
chr8_-_62764839 6.234 NM_001164750
NM_001164751
NM_001164752
NM_001164753
NM_020164
NM_032467
NM_032468
ASPH






aspartate beta-hydroxylase






chr9_+_5646582 6.232 NM_020829
KIAA1432
KIAA1432
chr9_+_102244005 6.213 NM_001198812
C9orf3-TMEFF1
C9orf30
C9orf3-TMEFF1 readthrough
chromosome 9 open reading frame 30
chr6_+_153060722 6.122 NM_025107
MYCT1
myc target 1
chr7_-_122627235 6.057 NM_022444
SLC13A1
solute carrier family 13 (sodium/sulfate symporters), member 1
chr20_+_5935897 6.042 NM_001127458
CRLS1
cardiolipin synthase 1
chr13_+_23042722 6.009 NM_148957
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr13_+_47948586 5.998 RB1
retinoblastoma 1
chr4_+_71054492 5.984 NM_214711
C4orf40
chromosome 4 open reading frame 40
chr6_+_55300225 5.978 NM_207410
GFRAL
GDNF family receptor alpha like
chr4_+_70831387 5.959 NM_001025104
NM_001890
CSN1S1

casein alpha s1

chr6_+_118976134 5.926 NM_002667
PLN
phospholamban
chr11_-_6005546 5.757 NM_001001917
OR56A1
olfactory receptor, family 56, subfamily A, member 1
chr1_+_74473672 5.714 NM_015978
TNNI3K
TNNI3 interacting kinase
chr20_+_56912146 5.710 GNAS
GNAS complex locus
chr1_-_120285753 5.686 NOTCH2
notch 2
chr9_-_13240313 5.666 NM_003829
MPDZ
multiple PDZ domain protein
chr15_+_47502666 5.659 NM_002009
FGF7
fibroblast growth factor 7
chr9_+_124072947 5.602 NM_199177
MRRF
mitochondrial ribosome recycling factor
chr12_+_9871343 5.581 NM_016523
KLRF1
killer cell lectin-like receptor subfamily F, member 1
chr14_-_94677807 5.572 NM_030621
DICER1
dicer 1, ribonuclease type III
chr3_-_102522093 5.477 NM_016247
IMPG2
interphotoreceptor matrix proteoglycan 2
chr12_-_16321885 5.443 NM_001170798
SLC15A5
solute carrier family 15, member 5
chr3_+_2528272 5.429 CNTN4
contactin 4
chr15_+_46285789 5.402 NM_000338
NM_001184832
SLC12A1

solute carrier family 12 (sodium/potassium/chloride transporters), member 1

chr17_-_10313600 5.397 NM_017533
MYH4
myosin, heavy chain 4, skeletal muscle
chr14_-_59264044 5.388 NM_206857
RTN1
reticulon 1
chr3_+_35697432 5.380 NM_198399
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr22_+_27998367 5.378 EWSR1
Ewing sarcoma breakpoint region 1
chr7_-_122126422 5.364 NM_139175
RNF133
ring finger protein 133
chr9_-_28709302 5.323 NM_152570
LINGO2
leucine rich repeat and Ig domain containing 2
chr6_-_127882192 5.317 NM_001012279
C6orf174
chromosome 6 open reading frame 174
chr8_+_9990471 5.257 NM_001135671
MSRA
methionine sulfoxide reductase A
chr5_+_67622242 5.160 NM_181504
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr10_-_98326435 5.133 TM9SF3
transmembrane 9 superfamily member 3
chr21_-_26345294 5.117


chr4_+_71096830 5.114 NM_017855
ODAM
odontogenic, ameloblast asssociated
chr22_+_29696662 5.053


chr3_+_35658852 5.047 NM_016300
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr15_+_97990705 5.034 NM_001130928
MEF2A
myocyte enhancer factor 2A
chr2_+_62787534 5.019 NM_001142614
EHBP1
EH domain binding protein 1
chr8_+_107807415 4.998 NM_001198534
NM_001198535
OXR1

oxidation resistance 1

chr11_-_55815113 4.976 NM_001005199
OR8H1
olfactory receptor, family 8, subfamily H, member 1
chr11_-_5110383 4.972 NM_001005160
OR52A5
olfactory receptor, family 52, subfamily A, member 5
chr2_+_182558795 4.962 NM_001080545
PPP1R1C
protein phosphatase 1, regulatory (inhibitor) subunit 1C
chr3_-_27473248 4.957 NM_003615
SLC4A7
solute carrier family 4, sodium bicarbonate cotransporter, member 7
chr7_+_17349425 4.940 AHR
aryl hydrocarbon receptor
chr2_+_187162969 4.929 NM_001145000
NM_002210
ITGAV

integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)

chr10_+_28918672 4.888 WAC
WW domain containing adaptor with coiled-coil
chr5_+_147775652 4.872 FBXO38
F-box protein 38
chr3_-_166278969 4.782 NM_001041
SI
sucrase-isomaltase (alpha-glucosidase)
chr14_+_69307914 4.747 SRSF5
serine/arginine-rich splicing factor 5
chr6_-_123999640 4.657 NM_006073
TRDN
triadin
chr12_-_10464308 4.613 NM_002261
NM_007333
KLRC3

killer cell lectin-like receptor subfamily C, member 3

chr4_+_86968069 4.558 ARHGAP24
Rho GTPase activating protein 24
chr3_-_121117647 4.554 GSK3B
glycogen synthase kinase 3 beta
chr20_+_9236446 4.543 NM_000933
PLCB4
phospholipase C, beta 4
chr17_-_36444626 4.537 NM_030966
KRTAP1-3
keratin associated protein 1-3
chr14_+_95915774 4.518 NM_016472
C14orf129
chromosome 14 open reading frame 129
chr15_+_32048380 4.511 NM_012125
CHRM5
cholinergic receptor, muscarinic 5
chr2_-_180135559 4.500 NM_001113398
ZNF385B
zinc finger protein 385B
chr4_-_116254381 4.488 NM_022569
NDST4
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4
chr15_+_55298908 4.478 NM_207040
TCF12
transcription factor 12
chr3_-_168580764 4.474 NM_024687
ZBBX
zinc finger, B-box domain containing
chr3_+_174598937 4.463 NM_014932
NLGN1
neuroligin 1
chr3_+_130014957 4.458 RAB7A
RAB7A, member RAS oncogene family
chr8_-_13018123 4.452 NM_001164271
DLC1
deleted in liver cancer 1
chr3_-_18455207 4.393 NM_001131010
SATB1
SATB homeobox 1
chr5_-_111340421 4.303 NM_001142474
NM_001142475
C5orf13

chromosome 5 open reading frame 13

chr3_-_99236520 4.270 NM_001105580
GABRR3
gamma-aminobutyric acid (GABA) receptor, rho 3
chr13_+_75232797 4.230 NM_015842
LMO7
LIM domain 7
chr14_+_100365390 4.215 MEG3
maternally expressed 3 (non-protein coding)
chr13_-_40491491 4.173 NM_172373
ELF1
E74-like factor 1 (ets domain transcription factor)
chr14_-_46882144 4.171 NM_182830
MDGA2
MAM domain containing glycosylphosphatidylinositol anchor 2
chr8_-_101384633 4.154 NM_015435
RNF19A
ring finger protein 19A
chr10_+_90414125 4.143 NM_001198828
NM_001198829
NM_001198830
NM_004190
LIPF



lipase, gastric



chr3_+_89239494 4.132 EPHA3
EPH receptor A3
chr15_+_100175888 4.123 NM_001001674
OR4F15
olfactory receptor, family 4, subfamily F, member 15
chr13_-_40491405 4.072 ELF1
E74-like factor 1 (ets domain transcription factor)
chr8_-_131483395 4.029 NM_018482
ASAP1
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
chr8_-_17599438 4.024 NM_020749
MTUS1
microtubule associated tumor suppressor 1
chr10_+_129237602 4.022 NM_001030013
NPS
neuropeptide S
chr3_-_115960807 3.996 NM_001164344
NM_001164345
ZBTB20

zinc finger and BTB domain containing 20

chr6_-_133008834 3.988 NM_138327
TAAR1
trace amine associated receptor 1
chr8_+_104900591 3.976 NM_014677
RIMS2
regulating synaptic membrane exocytosis 2
chr9_-_21156609 3.974 NM_002175
IFNA21
interferon, alpha 21
chr8_+_32698892 3.968 NM_001159996
NRG1
neuregulin 1
chr2_+_183316574 3.963 DNAJC10
DnaJ (Hsp40) homolog, subfamily C, member 10
chr4_+_146820805 3.942 NM_001080531
C4orf51
chromosome 4 open reading frame 51
chr22_-_39189369 3.921 MKL1
megakaryoblastic leukemia (translocation) 1
chr9_-_34719463 3.869 NM_001141917
C9orf144B
transmembrane protein C9orf144B
chr7_+_91762227 3.867


chr11_-_128567302 3.858 NM_001142685
ARHGAP32
Rho GTPase activating protein 32
chr6_-_66346417 3.856 NM_198283
EYS
eyes shut homolog (Drosophila)
chr17_-_60439764 3.812 GNA13
guanine nucleotide binding protein (G protein), alpha 13
chr12_-_10846435 3.791 NM_023919
TAS2R7
taste receptor, type 2, member 7
chr17_-_36403910 3.778 NM_033185
KRTAP3-3
keratin associated protein 3-3
chr16_-_3783475 3.769 CREBBP
CREB binding protein
chr18_-_35634247 3.741 LOC647946
hypothetical LOC647946
chr3_-_115380539 3.735 NM_000796
NM_033663
DRD3

dopamine receptor D3

chr11_-_77730573 3.719 NM_012296
GAB2
GRB2-associated binding protein 2
chr14_-_94669547 3.714 NM_001195573
DICER1
dicer 1, ribonuclease type III
chr14_+_100365162 3.669 MEG3
maternally expressed 3 (non-protein coding)
chr1_+_97033103 3.649


chr6_+_88026338 3.644 ZNF292
zinc finger protein 292
chr3_+_35696119 3.642 NM_001025068
NM_001025069
ARPP21

cAMP-regulated phosphoprotein, 21kDa

chr20_+_23293020 3.607 NM_022482
GZF1
GDNF-inducible zinc finger protein 1
chr2_+_211129567 3.605 NM_001875
CPS1
carbamoyl-phosphate synthase 1, mitochondrial
chr7_+_90177082 3.598 CDK14
cyclin-dependent kinase 14
chr11_-_100505667 3.591 NM_000926
PGR
progesterone receptor
chr22_-_37214480 3.576 NM_001098505
NM_030881
DDX17

DEAD (Asp-Glu-Ala-Asp) box polypeptide 17

chr10_+_83627422 3.570 NM_001165973
NRG3
neuregulin 3
chr11_+_86710076 3.566 TMEM135
transmembrane protein 135
chr1_+_62835759 3.562 NM_014495
ANGPTL3
angiopoietin-like 3
chr3_-_71860958 3.558 NM_001134650
EIF4E3
eukaryotic translation initiation factor 4E family member 3
chr2_+_166137091 3.555 NM_024969
CSRNP3
cysteine-serine-rich nuclear protein 3
chr12_+_15590811 3.545 PTPRO
protein tyrosine phosphatase, receptor type, O
chr4_-_46605980 3.539 NM_130902
COX7B2
cytochrome c oxidase subunit VIIb2
chr7_+_104539548 3.531 MLL5
myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)
chr10_+_63478974 3.525 ARID5B
AT rich interactive domain 5B (MRF1-like)
chr6_+_163904564 3.523 QKI
quaking homolog, KH domain RNA binding (mouse)
chr2_+_210152399 3.513 MAP2
microtubule-associated protein 2
chr9_+_12683385 3.513 NM_000550
TYRP1
tyrosinase-related protein 1
chr3_-_25658829 3.496 TOP2B
topoisomerase (DNA) II beta 180kDa
chr8_+_17440664 3.492 NM_001164771
NM_003046
SLC7A2

solute carrier family 7 (cationic amino acid transporter, y+ system), member 2

chr2_-_98646367 3.486 NM_001160154
MGAT4A
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr11_+_101488380 3.482 NM_001195045
YAP1
Yes-associated protein 1
chr12_-_88573949 3.481 NM_001001323
NM_001682
ATP2B1

ATPase, Ca++ transporting, plasma membrane 1

chr1_-_214663360 3.474 NM_007123
NM_206933
USH2A

Usher syndrome 2A (autosomal recessive, mild)

chr9_-_4656665 3.469 NM_001039395
C9orf68
chromosome 9 open reading frame 68
chr5_+_102493155 3.468 NM_015216
PPIP5K2
diphosphoinositol pentakisphosphate kinase 2
chr5_+_65408500 3.464 ERBB2IP
erbb2 interacting protein
chr2_+_54536780 3.464 NM_003128
SPTBN1
spectrin, beta, non-erythrocytic 1
chr13_-_25687062 3.447 RNF6
ring finger protein (C3H2C3 type) 6
chr14_+_66901237 3.446 EIF2S1
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
chr12_-_52281050 3.444 NM_001130059
ATF7
activating transcription factor 7
chr12_+_15590552 3.434 NM_030668
NM_030669
NM_030670
NM_030671
PTPRO



protein tyrosine phosphatase, receptor type, O



chr2_-_225086564 3.418 CUL3
cullin 3
chr12_+_18305740 3.411 NM_004570
PIK3C2G
phosphoinositide-3-kinase, class 2, gamma polypeptide
chr10_-_126706442 3.404 NM_022802
CTBP2
C-terminal binding protein 2
chr6_+_49575629 3.397 NM_001010904
GLYATL3
glycine-N-acyltransferase-like 3
chr10_-_108448990 3.357 SORCS1
sortilin-related VPS10 domain containing receptor 1
chr20_+_11846536 3.353 NM_014962
BTBD3
BTB (POZ) domain containing 3
chr18_+_59405513 3.352 NM_012397
SERPINB13
serpin peptidase inhibitor, clade B (ovalbumin), member 13
chr12_+_58369392 3.351 NM_004731
SLC16A7
solute carrier family 16, member 7 (monocarboxylic acid transporter 2)
chr20_+_56369012 3.345


chr6_+_72982865 3.331 NM_001168409
RIMS1
regulating synaptic membrane exocytosis 1
chr11_+_5024331 3.324 NM_001001916
OR52J3
olfactory receptor, family 52, subfamily J, member 3
chr5_+_166644420 3.322 NM_001122679
ODZ2
odz, odd Oz/ten-m homolog 2 (Drosophila)
chr6_+_64344307 3.321 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr15_-_23201740 3.304 NM_130838
UBE3A
ubiquitin protein ligase E3A
chr11_+_33306652 3.298 HIPK3
homeodomain interacting protein kinase 3
chr17_-_36877002 3.297 NM_002278
KRT32
keratin 32
chr3_-_166397142 3.289 NM_014926
SLITRK3
SLIT and NTRK-like family, member 3
chr13_-_59223074 3.264


chr9_-_21472311 3.261 NM_176891
IFNE
interferon, epsilon
chr20_+_56919233 3.251 GNAS
GNAS complex locus
chr17_-_1195096 3.249 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr8_-_17797127 3.249 NM_147203
NM_201553
NM_004467
NM_201552
FGL1



fibrinogen-like 1



chr21_+_30724442 3.248 NM_181600
KRTAP13-4
keratin associated protein 13-4
chr5_-_39430180 3.237 DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr3_-_52269467 3.234 WDR82
WD repeat domain 82
chr5_+_86712376 3.234


chr12_-_10853940 3.219 NM_023917
TAS2R9
taste receptor, type 2, member 9
chr9_-_21192201 3.202 NM_021057
IFNA7
interferon, alpha 7
chr1_-_156923111 3.195 NM_003126
SPTA1
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
chr4_+_160408447 3.180 NM_014247
RAPGEF2
Rap guanine nucleotide exchange factor (GEF) 2
chr12_-_9804682 3.178 NM_001781
CD69
CD69 molecule
chr4_-_105635499 3.166 CXXC4
CXXC finger protein 4
chr12_-_10479810 3.158 NM_002260
KLRC2
KLRC3
killer cell lectin-like receptor subfamily C, member 2
killer cell lectin-like receptor subfamily C, member 3
chr14_+_60271203 3.150 NM_001177963
NM_002431
MNAT1

menage a trois homolog 1, cyclin H assembly factor (Xenopus laevis)

chr11_-_121492010 3.140 NM_001001786
BLID
BH3-like motif containing, cell death inducer
chr3_-_79899748 3.127 NM_002941
ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr5_-_58331515 3.125 NM_001197223
PDE4D
phosphodiesterase 4D, cAMP-specific
chr10_+_118177371 3.102 NM_001011709
PNLIPRP3
pancreatic lipase-related protein 3
chr12_-_11106159 3.092 NM_176887
TAS2R46
taste receptor, type 2, member 46
chr1_+_213245507 3.092 NM_001017424
KCNK2
potassium channel, subfamily K, member 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.24 3.84e-31 GO:0007606 sensory perception of chemical stimulus
2.31 1.15e-30 GO:0007608 sensory perception of smell
1.77 2.36e-22 GO:0007600 sensory perception
1.47 4.88e-14 GO:0050877 neurological system process
1.39 2.48e-12 GO:0003008 system process
1.15 4.67e-07 GO:0032501 multicellular organismal process
1.13 2.21e-06 GO:0050896 response to stimulus

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.16 1.18e-06 GO:0071944 cell periphery
1.16 2.37e-06 GO:0005886 plasma membrane
1.69 6.40e-03 GO:0005882 intermediate filament
1.58 2.70e-02 GO:0045111 intermediate filament cytoskeleton

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.38 4.98e-33 GO:0004984 olfactory receptor activity
1.61 6.02e-15 GO:0004930 G-protein coupled receptor activity
1.43 1.59e-11 GO:0004888 transmembrane receptor activity
1.35 1.30e-10 GO:0004872 receptor activity
1.29 3.60e-09 GO:0004871 signal transducer activity
1.29 3.60e-09 GO:0060089 molecular transducer activity