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• Activity deltas table
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Motif ID: bHLH_family.p2

Z-value: 1.420

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr22_+_38720881	3.054	NM_138435	FAM83F	family with sequence similarity 83, member F
chr8_+_120289735	2.610	NM_052886	MAL2	mal, T-cell differentiation protein 2 (gene/pseudogene)
chr6_+_138230045	2.232	NM_006290	TNFAIP3	tumor necrosis factor, alpha-induced protein 3
chr20_+_46971618	1.794	NM_006420	ARFGEF2	ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
chr8_+_32525269	1.509	NM_001160002 NM_001160004 NM_001160005 NM_001160007 NM_001160008 NM_004495 NM_013956 NM_013957 NM_013958 NM_013960 NM_013964	NRG1	neuregulin 1
chr2_+_28971007	1.308	NM_015131	WDR43	WD repeat domain 43
chr6_+_96570565	1.281	NM_006581	FUT9	fucosyltransferase 9 (alpha (1,3) fucosyltransferase)
chr17_+_44429748	1.180	NM_001160423 NM_006546	IGF2BP1	insulin-like growth factor 2 mRNA binding protein 1
chr2_+_46779553	1.165	NM_014011	SOCS5	suppressor of cytokine signaling 5
chr8_+_22281118	1.133		SLC39A14	solute carrier family 39 (zinc transporter), member 14
chr2_+_202838725	1.124	NM_015934	NOP58	NOP58 ribonucleoprotein homolog (yeast)
chr2_+_113119985	1.106	NM_005415	SLC20A1	solute carrier family 20 (phosphate transporter), member 1
chr2_+_46779827	1.065	NM_144949	SOCS5	suppressor of cytokine signaling 5
chr14_-_46190690	1.020	NM_080746	RPL10L	ribosomal protein L10-like
chr11_-_85457736	1.020		PICALM	phosphatidylinositol binding clathrin assembly protein
chr16_+_67236699	1.004		CDH3	cadherin 3, type 1, P-cadherin (placental)
chr8_+_22280942	1.004	NM_001135153	SLC39A14	solute carrier family 39 (zinc transporter), member 14
chr17_-_33043514	1.000	NM_001163544 NM_001163545 NM_001163546 NM_001163547 NM_007247 NM_080550 NM_198882	SYNRG	synergin, gamma
chr5_+_110455768	0.988	NM_139281	WDR36	WD repeat domain 36
chr2_+_206732859	0.971		EEF1B2	eukaryotic translation elongation factor 1 beta 2
chr14_-_34253473	0.971	NM_138638	CFL2	cofilin 2 (muscle)
chr14_-_93919305	0.970		SERPINA1	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr20_+_37024383	0.967	NM_001190809 NM_021931	DHX35	DEAH (Asp-Glu-Ala-His) box polypeptide 35
chr17_+_9489578	0.942	NM_153210	USP43	ubiquitin specific peptidase 43
chr17_+_52518098	0.938		AKAP1	A kinase (PRKA) anchor protein 1
chr2_+_202838680	0.933		NOP58	NOP58 ribonucleoprotein homolog (yeast)
chr11_-_85457753	0.888	NM_001008660 NM_007166	PICALM	phosphatidylinositol binding clathrin assembly protein
chr1_-_152459506	0.881		C1orf43	chromosome 1 open reading frame 43
chr13_+_112999462	0.866	NM_005561	LAMP1	lysosomal-associated membrane protein 1
chr2_-_50428395	0.864	NM_138735	NRXN1	neurexin 1
chr7_+_17304707	0.862	NM_001621	AHR	aryl hydrocarbon receptor
chr8_+_22280731	0.862		SLC39A14	solute carrier family 39 (zinc transporter), member 14
chr5_+_110455961	0.853		WDR36	WD repeat domain 36
chr2_+_169021001	0.852		LASS6	LAG1 homolog, ceramide synthase 6
chr1_-_152459667	0.850		C1orf43	chromosome 1 open reading frame 43
chr19_+_37528340	0.843	NM_001136156 NM_014910	ZNF507	zinc finger protein 507
chr11_+_384199	0.834	NM_007183	PKP3	plakophilin 3
chr8_+_22280703	0.832	NM_001128431 NM_001135154 NM_015359	SLC39A14	solute carrier family 39 (zinc transporter), member 14
chr2_+_169021039	0.827	NM_203463	LASS6	LAG1 homolog, ceramide synthase 6
chr16_-_23068010	0.825	NM_020718	USP31	ubiquitin specific peptidase 31
chr4_-_175986952	0.816	NM_001042543 NM_006529	GLRA3	glycine receptor, alpha 3
chr3_-_52694554	0.810	NM_018313	PBRM1	polybromo 1
chr17_-_37586716	0.809	NM_012285	KCNH4	potassium voltage-gated channel, subfamily H (eag-related), member 4
chr11_+_384238	0.796		PKP3	plakophilin 3
chr7_-_11838260	0.793	NM_015204	THSD7A	thrombospondin, type I, domain containing 7A
chr13_+_97426713	0.791		IPO5	importin 5
chr2_+_206732575	0.790		EEF1B2	eukaryotic translation elongation factor 1 beta 2
chr6_-_138231006	0.771
chrX_-_114703273	0.769
chr1_+_152459918	0.765	NM_014847	UBAP2L	ubiquitin associated protein 2-like
chr20_-_48980858	0.761	NM_015339 NM_181442	ADNP	activity-dependent neuroprotector homeobox
chr4_+_75529716	0.759	NM_001657	AREG	amphiregulin
chr2_-_11727705	0.747	NM_012344	NTSR2	neurotensin receptor 2
chr3_+_85090721	0.739	NM_001167674 NM_001167675	CADM2	cell adhesion molecule 2
chrX_+_16714452	0.737	NM_001168683 NM_018360	TXLNG	taxilin gamma
chr13_+_112999538	0.733		LAMP1	lysosomal-associated membrane protein 1
chr20_+_48781457	0.720	NM_032521	PARD6B	par-6 partitioning defective 6 homolog beta (C. elegans)
chr16_+_57106883	0.703	NM_001160305 NM_024860	SETD6	SET domain containing 6
chr2_+_241903395	0.702	NM_001008491 NM_006155	SEPT2	septin 2
chr18_+_54958095	0.689	NM_033280	SEC11C	SEC11 homolog C (S. cerevisiae)
chr13_+_112911927	0.686	NM_001008895	CUL4A	cullin 4A
chr11_-_85457469	0.683		PICALM	phosphatidylinositol binding clathrin assembly protein
chr20_-_604443	0.681
chr2_-_154043403	0.678	NM_019845	RPRM	reprimo, TP53 dependent G2 arrest mediator candidate
chr10_+_118340460	0.676	NM_006229	PNLIPRP1	pancreatic lipase-related protein 1
chr4_+_75242671	0.668	NM_001144978	MTHFD2L	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like
chr2_+_233270286	0.667		GIGYF2	GRB10 interacting GYF protein 2
chr2_-_241903657	0.667		HDLBP	high density lipoprotein binding protein
chr13_+_48582389	0.663	NM_014923	FNDC3A	fibronectin type III domain containing 3A
chr17_+_64020120	0.661	NM_002734 NM_212472	PRKAR1A	protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)
chr12_+_129922570	0.659		RAN	RAN, member RAS oncogene family
chr9_+_134535210	0.658		GTF3C4	general transcription factor IIIC, polypeptide 4, 90kDa
chr13_+_112911826	0.657		CUL4A	cullin 4A
chr14_-_19999475	0.656	NM_001100814 NM_144568	TMEM55B	transmembrane protein 55B
chr7_+_16759845	0.651	NM_014399	TSPAN13	tetraspanin 13
chr2_-_85683268	0.647	NM_001031738	TMEM150A	transmembrane protein 150A
chr2_-_74915722	0.642
chr12_-_56432385	0.640	NM_000075	CDK4	cyclin-dependent kinase 4
chr14_-_23981493	0.638	NM_020195	SDR39U1	short chain dehydrogenase/reductase family 39U, member 1
chr3_+_52694975	0.637	NM_014366 NM_206825 NM_206826	GNL3	guanine nucleotide binding protein-like 3 (nucleolar)
chr17_+_36636404	0.637	NM_031961	KRTAP9-2	keratin associated protein 9-2
chr14_-_38971370	0.636	NM_203301	FBXO33	F-box protein 33
chr17_+_70256518	0.635
chr10_+_94598204	0.632	NM_019053	EXOC6	exocyst complex component 6
chr19_+_43447262	0.627		SPINT2	serine peptidase inhibitor, Kunitz type, 2
chr20_+_18066473	0.626	NM_001164811	PET117	cytochrome c oxidase assembly factor-like
chr9_+_696744	0.625	NM_153186	KANK1	KN motif and ankyrin repeat domains 1
chr15_+_43102593	0.625	NM_003104	SORD	sorbitol dehydrogenase
chr16_+_67236730	0.624		CDH3	cadherin 3, type 1, P-cadherin (placental)
chr2_+_233270275	0.624		GIGYF2	GRB10 interacting GYF protein 2
chr1_+_181422016	0.624		LAMC2	laminin, gamma 2
chr2_+_176761552	0.619	NM_024501	HOXD1	homeobox D1
chr17_+_64020155	0.617		PRKAR1A	protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)
chr16_+_28893525	0.614	NM_001142448 NM_001142449 NM_001142450 NM_001142451 NM_032038	SPIN1 SPNS1	spindlin 1 spinster homolog 1 (Drosophila)
chr11_+_12088639	0.608	NM_014632	MICAL2	microtubule associated monoxygenase, calponin and LIM domain containing 2
chr2_-_241903787	0.607		HDLBP	high density lipoprotein binding protein
chr10_-_90332927	0.605	NM_001031709 NM_018363	RNLS	renalase, FAD-dependent amine oxidase
chr22_-_36212160	0.605	NM_001166343 NM_002405	MFNG	MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr2_+_173000590	0.604		ITGA6	integrin, alpha 6
chr20_+_33506322	0.603	NM_007186	CEP250	centrosomal protein 250kDa
chr12_-_56432375	0.602		CDK4	cyclin-dependent kinase 4
chr17_+_46692908	0.599		UTP18	UTP18, small subunit (SSU) processome component, homolog (yeast)
chr14_+_44622916	0.596	NM_017922	PRPF39	PRP39 pre-mRNA processing factor 39 homolog (S. cerevisiae)
chr14_+_23855291	0.587		LTB4R	leukotriene B4 receptor
chr1_-_152459697	0.587	NM_001098616 NM_015449 NM_138740	C1orf43	chromosome 1 open reading frame 43
chr12_-_56432377	0.586		CDK4	cyclin-dependent kinase 4
chr19_+_6690697	0.585	NM_004240	TRIP10	thyroid hormone receptor interactor 10
chr2_+_233270241	0.585	NM_001103146 NM_001103147 NM_001103148 NM_015575	GIGYF2	GRB10 interacting GYF protein 2
chr18_+_75967902	0.583	NM_014913	ADNP2	ADNP homeobox 2
chr9_-_134535148	0.582		DDX31	DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
chr4_+_75699652	0.582	NM_001657	AREG	amphiregulin
chr20_-_604822	0.581	NM_033129	SCRT2	scratch homolog 2, zinc finger protein (Drosophila)
chr7_+_43118721	0.576	NM_015052	HECW1	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
chr10_-_104463947	0.575	NM_004311	ARL3	ADP-ribosylation factor-like 3
chr17_+_64020159	0.575		PRKAR1A	protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)
chr5_+_41940216	0.575	NM_175921	C5orf51	chromosome 5 open reading frame 51
chr12_+_129922589	0.572		RAN	RAN, member RAS oncogene family
chrX_+_30581523	0.572		GK	glycerol kinase
chr17_+_64019693	0.563	NM_212471	PRKAR1A	protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)
chr13_+_112999590	0.561		LAMP1	lysosomal-associated membrane protein 1
chr12_-_131816604	0.559		ANKLE2	ankyrin repeat and LEM domain containing 2
chr20_+_39091026	0.559		TOP1	topoisomerase (DNA) I
chr14_+_23700261	0.555	NM_006084	IRF9	interferon regulatory factor 9
chr16_+_273118	0.554	NM_006849	PDIA2	protein disulfide isomerase family A, member 2
chr1_+_237616457	0.554		CHRM3	cholinergic receptor, muscarinic 3
chr19_+_43446937	0.553	NM_001166103 NM_021102	SPINT2	serine peptidase inhibitor, Kunitz type, 2
chr2_-_131567458	0.551	NM_001009993	FAM168B	family with sequence similarity 168, member B
chr20_-_41788975	0.550	NM_001008901 NM_176791	GTSF1L	gametocyte specific factor 1-like
chr18_-_45241014	0.549	NM_017653	DYM	dymeclin
chr12_+_32546243	0.548	NM_139241	FGD4	FYVE, RhoGEF and PH domain containing 4
chr19_+_43447078	0.547		SPINT2	serine peptidase inhibitor, Kunitz type, 2
chr16_+_55523526	0.546		HERPUD1	homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr17_+_64019748	0.543		PRKAR1A	protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)
chr7_+_94130673	0.540		PEG10	paternally expressed 10
chr13_-_49597776	0.535		DLEU2	deleted in lymphocytic leukemia 2 (non-protein coding)
chr10_-_32257693	0.530		ARHGAP12	Rho GTPase activating protein 12
chr14_-_23727826	0.530		IPO4	importin 4
chr2_+_227898163	0.530		MFF	mitochondrial fission factor
chr20_+_39090875	0.527	NM_003286	TOP1	topoisomerase (DNA) I
chr2_+_190014403	0.526	NM_032168	WDR75	WD repeat domain 75
chr12_-_119826073	0.525		SPPL3	signal peptide peptidase 3
chr17_+_32380287	0.525	NM_012138	AATF	apoptosis antagonizing transcription factor
chr17_-_54538816	0.521		TRIM37	tripartite motif containing 37
chr2_+_218992053	0.521	NM_007127	VIL1	villin 1
chr9_+_6747919	0.519		KDM4C	lysine (K)-specific demethylase 4C
chr2_-_217267742	0.519		IGFBP5	insulin-like growth factor binding protein 5
chr17_+_70256397	0.516		SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1
chr7_+_94374862	0.515	NM_001166160 NM_017650	PPP1R9A	protein phosphatase 1, regulatory (inhibitor) subunit 9A
chr17_-_54538898	0.515		TRIM37	tripartite motif containing 37
chr6_+_143423738	0.513		AIG1	androgen-induced 1
chr5_+_80292213	0.512		RASGRF2	Ras protein-specific guanine nucleotide-releasing factor 2
chr18_+_75968133	0.512		ADNP2	ADNP homeobox 2
chr6_+_143423723	0.511		AIG1	androgen-induced 1
chr17_-_54538956	0.510	NM_001005207 NM_015294	TRIM37	tripartite motif containing 37
chr7_-_86526880	0.510	NM_001142749	KIAA1324L	KIAA1324-like
chr10_+_103882776	0.510	NM_015062	PPRC1	peroxisome proliferator-activated receptor gamma, coactivator-related 1
chr1_+_42920946	0.508		YBX1	Y box binding protein 1
chr6_+_7052985	0.508	NM_001003698 NM_001003699 NM_001003700	RREB1	ras responsive element binding protein 1
chr17_+_70256341	0.504	NM_004252	SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1
chr1_+_181421984	0.504		LAMC2	laminin, gamma 2
chr10_+_69314347	0.503	NM_012238	SIRT1	sirtuin 1
chr9_+_71009746	0.501	NM_001170415 NM_001170416	TJP2	tight junction protein 2 (zona occludens 2)
chr17_+_70256389	0.499		SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1
chr20_+_5934761	0.498		CRLS1	cardiolipin synthase 1
chr17_+_70256370	0.494		SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1
chr21_+_33844793	0.491		SON	SON DNA binding protein
chr13_+_77170470	0.490	NM_001040153	SLAIN1	SLAIN motif family, member 1
chr9_-_124707314	0.489	NM_001100588 NM_018835	RC3H2	ring finger and CCCH-type domains 2
chrX_-_107866262	0.488	NM_003604	IRS4	insulin receptor substrate 4
chr12_+_6703686	0.487	NM_001164093	COPS7A	COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis)
chr20_+_32311831	0.484	NM_001672	ASIP	agouti signaling protein
chr12_+_70434920	0.482	NM_014999	RAB21	RAB21, member RAS oncogene family
chr11_+_32993973	0.482	NM_001077242	DEPDC7	DEP domain containing 7
chr2_+_42249896	0.480	NM_001145076 NM_019063	EML4	echinoderm microtubule associated protein like 4
chr3_-_172109119	0.476	NM_020390	EIF5A2	eukaryotic translation initiation factor 5A2
chr20_+_5934560	0.476	NM_019095	CRLS1	cardiolipin synthase 1
chr7_+_94130752	0.475		PEG10	paternally expressed 10
chr14_-_38971049	0.471		FBXO33	F-box protein 33
chr20_+_5934964	0.470		CRLS1	cardiolipin synthase 1
chr22_+_27609889	0.470	NM_032173	ZNRF3	zinc and ring finger 3
chr10_-_124758178	0.467	NM_022466	IKZF5	IKAROS family zinc finger 5 (Pegasus)
chr20_+_13924263	0.460		MACROD2	MACRO domain containing 2
chr16_+_85983447	0.459		MAP1LC3B	microtubule-associated protein 1 light chain 3 beta
chr14_+_38806280	0.457		CTAGE5	CTAGE family, member 5
chr17_-_71362971	0.456	NM_012478	WBP2	WW domain binding protein 2
chr5_-_65053630	0.455	NM_019072	SGTB	small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta
chr13_+_32488477	0.455	NM_004795	KL	klotho
chrX_+_55760774	0.455	NM_006064 NM_016656	RRAGB	Ras-related GTP binding B
chr2_+_215885063	0.454		ATIC	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chr6_+_7052798	0.453	NM_001168344	RREB1	ras responsive element binding protein 1
chr22_-_37425937	0.450	NM_014876	JOSD1	Josephin domain containing 1
chr22_+_40027529	0.450		ZC3H7B	zinc finger CCCH-type containing 7B
chr1_+_149779384	0.449	NM_001126337 NM_020127	TUFT1	tuftelin 1
chr13_-_27572646	0.449	NM_004119	FLT3	fms-related tyrosine kinase 3
chr10_+_75580914	0.445	NM_006721	ADK	adenosine kinase
chr2_+_208284484	0.442	NM_001142300 NM_152523	CCNYL1	cyclin Y-like 1
chr12_+_19173669	0.441	NM_001143821 NM_001190860 NM_019012	PLEKHA5	pleckstrin homology domain containing, family A member 5
chr9_+_70926205	0.440		TJP2	tight junction protein 2 (zona occludens 2)
chr2_+_55313434	0.438		RPS27A	ribosomal protein S27a
chr2_+_215885053	0.437		ATIC	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
1.09	1.19e-08	GO:0009987	cellular process
1.13	6.43e-05	GO:0044237	cellular metabolic process
1.13	1.31e-04	GO:0044238	primary metabolic process
1.11	5.86e-04	GO:0008152	metabolic process
1.15	2.59e-03	GO:0044260	cellular macromolecule metabolic process
1.13	7.01e-03	GO:0043170	macromolecule metabolic process
1.17	2.57e-02	GO:0048856	anatomical structure development
1.15	3.12e-02	GO:0032502	developmental process

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
1.09	1.12e-10	GO:0044424	intracellular part
1.09	2.41e-10	GO:0005622	intracellular
1.13	1.28e-09	GO:0005737	cytoplasm
1.09	8.23e-07	GO:0043226	organelle
1.09	1.81e-06	GO:0043229	intracellular organelle
1.15	3.07e-06	GO:0044422	organelle part
1.14	8.82e-06	GO:0044446	intracellular organelle part
1.13	9.35e-06	GO:0044444	cytoplasmic part
1.26	1.98e-05	GO:0044428	nuclear part
1.23	9.52e-05	GO:0043233	organelle lumen
1.09	1.18e-04	GO:0043227	membrane-bounded organelle
1.23	1.20e-04	GO:0031974	membrane-enclosed lumen
1.09	1.95e-04	GO:0043231	intracellular membrane-bounded organelle
1.52	2.32e-04	GO:0005730	nucleolus
1.26	2.39e-04	GO:0031981	nuclear lumen
1.23	3.08e-04	GO:0070013	intracellular organelle lumen
1.11	6.05e-03	GO:0005634	nucleus
1.20	8.26e-03	GO:0005829	cytosol
1.17	1.08e-02	GO:0043228	non-membrane-bounded organelle
1.17	1.08e-02	GO:0043232	intracellular non-membrane-bounded organelle
1.24	3.93e-02	GO:0005654	nucleoplasm
1.98	4.57e-02	GO:0042470	melanosome
1.98	4.57e-02	GO:0048770	pigment granule

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
1.14	2.12e-09	GO:0005515	protein binding
1.06	1.86e-04	GO:0005488	binding
1.72	1.91e-02	GO:0043566	structure-specific DNA binding