Motif ID: POU1F1.p2

Z-value: 1.838


Transcription factors associated with POU1F1.p2:

Gene SymbolEntrez IDGene Name
POU1F1 5449 POU class 1 homeobox 1



Activity profile for motif POU1F1.p2.

activity profile for motif POU1F1.p2


Sorted Z-values histogram for motif POU1F1.p2

Sorted Z-values for motif POU1F1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of POU1F1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_195123766 4.161 NM_006684
CFHR4
complement factor H-related 4
chr18_+_52575442 3.851 WDR7
WD repeat domain 7
chr9_-_21132143 3.260 NM_002177
IFNW1
interferon, omega 1
chr3_-_27473248 3.045 NM_003615
SLC4A7
solute carrier family 4, sodium bicarbonate cotransporter, member 7
chr12_-_43593977 3.008 NM_001145110
NELL2
NEL-like 2 (chicken)
chr15_+_64481270 2.995 MAP2K1
mitogen-activated protein kinase kinase 1
chr12_-_11041740 2.849 NM_176889
TAS2R20
taste receptor, type 2, member 20
chr1_+_195213289 2.787 NM_030787
CFHR5
complement factor H-related 5
chr4_+_70928718 2.786 NM_000200
HTN3
histatin 3
chr12_-_14740694 2.752 NM_004963
GUCY2C
guanylate cyclase 2C (heat stable enterotoxin receptor)
chr6_+_64344307 2.620 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr3_-_69381995 2.495 FRMD4B
FERM domain containing 4B
chr1_+_195010552 2.410 NM_001166624
NM_021023
CFHR3

complement factor H-related 3

chr21_-_26345294 2.383


chr5_-_93102952 2.297 NM_153216
POU5F2
POU domain class 5, transcription factor 2
chr6_+_153060722 2.296 NM_025107
MYCT1
myc target 1
chr6_-_109795925 2.263 CD164
CD164 molecule, sialomucin
chr4_+_95595419 2.212 PDLIM5
PDZ and LIM domain 5
chr11_+_101488380 2.193 NM_001195045
YAP1
Yes-associated protein 1
chr1_+_195179533 2.189 NM_005666
CFHR2
complement factor H-related 2
chr5_+_140200995 2.174 NM_018911
NM_031856
PCDHA8

protocadherin alpha 8

chr4_-_70115037 2.163 NM_001073
UGT2B11
UDP glucuronosyltransferase 2 family, polypeptide B11
chr9_-_21177529 2.144 NM_021068
IFNA4
interferon, alpha 4
chr2_+_211166323 2.116 NM_001122634
CPS1
carbamoyl-phosphate synthase 1, mitochondrial
chr15_-_23204887 2.071 NM_000462
UBE3A
ubiquitin protein ligase E3A
chr12_-_11106159 2.018 NM_176887
TAS2R46
taste receptor, type 2, member 46
chr9_-_21358005 2.008 NM_006900
IFNA1
IFNA13
interferon, alpha 1
interferon, alpha 13
chr2_+_234333653 2.001 NM_000463
UGT1A1
UDP glucuronosyltransferase 1 family, polypeptide A1
chrX_+_147608302 1.981 NM_001170628
AFF2
AF4/FMR2 family, member 2
chr9_+_21430439 1.978 NM_024013
IFNA1
interferon, alpha 1
chr5_-_58331515 1.932 NM_001197223
PDE4D
phosphodiesterase 4D, cAMP-specific
chr9_-_21207303 1.898 NM_002173
IFNA16
interferon, alpha 16
chr4_-_70547962 1.829 NM_006798
UGT2A1
UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus
chr1_-_157003095 1.806 NM_001005185
OR6N1
olfactory receptor, family 6, subfamily N, member 1
chr21_-_30614477 1.750 NM_203405
KRTAP26-1
keratin associated protein 26-1
chrX_+_66705407 1.746 NM_001011645
AR
androgen receptor
chr6_+_28217590 1.738 NM_006298
ZNF192
zinc finger protein 192
chr1_-_150599105 1.716 NM_001014342
FLG2
filaggrin family member 2
chr9_-_21340885 1.714 NM_021002
IFNA6
interferon, alpha 6
chr10_-_127559841 1.714 NM_018180
DHX32
DEAH (Asp-Glu-Ala-His) box polypeptide 32
chr6_-_52736231 1.714 NM_000846
GSTA2
glutathione S-transferase alpha 2
chr3_+_99592199 1.679 NM_001005516
OR5K3
olfactory receptor, family 5, subfamily K, member 3
chr17_-_36232366 1.663 NM_000421
KRT10
keratin 10
chr14_-_19553191 1.642 NM_001004712
OR4K14
olfactory receptor, family 4, subfamily K, member 14
chr5_-_41249270 1.636 NM_000065
C6
complement component 6
chr12_-_78831821 1.629 NM_001143886
PPP1R12A
protein phosphatase 1, regulatory (inhibitor) subunit 12A
chr11_-_48330574 1.610 NM_001005513
OR4C45
olfactory receptor, family 4, subfamily C, member 45
chr12_-_10953427 1.609 NM_023920
TAS2R13
taste receptor, type 2, member 13
chr18_-_62422195 1.602 NM_021153
CDH19
cadherin 19, type 2
chr18_-_38949481 1.578 NM_002930
RIT2
Ras-like without CAAX 2
chr11_+_59564323 1.569 NM_173801
PLAC1L
placenta-specific 1-like
chr12_-_60872814 1.534 NM_178539
FAM19A2
family with sequence similarity 19 (chemokine (C-C motif)-like), member A2
chr6_-_128263868 1.507 NM_001010923
NM_001164685
THEMIS

thymocyte selection associated

chr21_-_26294332 1.478 APP
amyloid beta (A4) precursor protein
chrX_-_8099307 1.460 NM_016378
VCX2
variable charge, X-linked 2
chr4_+_71298187 1.454 NM_021225
PROL1
proline rich, lacrimal 1
chr18_+_59295123 1.447 NM_002639
SERPINB5
serpin peptidase inhibitor, clade B (ovalbumin), member 5
chr4_-_70539922 1.445 NM_001105677
UGT2A2
UDP glucuronosyltransferase 2 family, polypeptide A2
chr8_-_102005697 1.436 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr3_+_109504021 1.436 NM_007072
HHLA2
HERV-H LTR-associating 2
chr9_-_21218132 1.378 NM_021268
IFNA17
interferon, alpha 17
chr12_-_11066436 1.374 NM_176888
TAS2R19
taste receptor, type 2, member 19
chr21_+_30886629 1.373 NM_181605
KRTAP6-3
keratin associated protein 6-3
chr3_-_61703850 1.371


chr4_+_71261066 1.367 NM_012390
SMR3B
SMR3A
submaxillary gland androgen regulated protein 3B
submaxillary gland androgen regulated protein 3A
chr9_+_106371269 1.361 NM_001004483
OR13C8
olfactory receptor, family 13, subfamily C, member 8
chr7_+_141265085 1.361 NM_001001656
OR9A4
olfactory receptor, family 9, subfamily A, member 4
chr20_+_71230 1.351 NM_030931
DEFB126
defensin, beta 126
chr4_+_73123712 1.350 NM_001144756
NM_053036
NPFFR2

neuropeptide FF receptor 2

chr11_+_30209138 1.346 NM_000510
NM_001018080
FSHB

follicle stimulating hormone, beta polypeptide

chr7_-_141604323 1.330 NM_001001317
TRYX3
trypsin X3
chr11_-_49960646 1.323 NM_001005270
OR4C12
olfactory receptor, family 4, subfamily C, member 12
chrX_-_57180782 1.317 NM_019003
SPIN2A
spindlin family, member 2A
chr12_-_54150188 1.302 NM_001005499
OR6C70
olfactory receptor, family 6, subfamily C, member 70
chr4_-_5762175 1.294 NM_001166136
EVC2
Ellis van Creveld syndrome 2
chr3_-_166278969 1.294 NM_001041
SI
sucrase-isomaltase (alpha-glucosidase)
chr3_+_99465777 1.292 NM_001005479
OR5H6
olfactory receptor, family 5, subfamily H, member 6
chr10_-_108448990 1.276 SORCS1
sortilin-related VPS10 domain containing receptor 1
chr3_-_17716515 1.275 NM_001134381
TBC1D5
TBC1 domain family, member 5
chr14_-_94669547 1.235 NM_001195573
DICER1
dicer 1, ribonuclease type III
chr11_+_89507465 1.230 NM_005467
NAALAD2
N-acetylated alpha-linked acidic dipeptidase 2
chr9_+_21399132 1.222 NM_002170
IFNA8
interferon, alpha 8
chr3_+_51870684 1.210 NM_203424
IQCF2
IQ motif containing F2
chr9_-_21067804 1.209 NM_002176
IFNB1
interferon, beta 1, fibroblast
chr7_-_83108682 1.199 NM_001178129
SEMA3E
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
chr3_+_12367993 1.190 NM_015869
PPARG
peroxisome proliferator-activated receptor gamma
chr6_-_116553918 1.188 NM_000493
COL10A1
collagen, type X, alpha 1
chr6_+_53043729 1.180 NM_012347
FBXO9
F-box protein 9
chr2_-_219906142 1.168 NM_001007089
RESP18
regulated endocrine-specific protein 18 homolog (rat)
chr3_+_181803649 1.168 TTC14
tetratricopeptide repeat domain 14
chrX_+_114734074 1.147 NM_001136025
NM_001172335
PLS3

plastin 3

chr18_+_57308754 1.142 NM_031891
CDH20
cadherin 20, type 2
chr11_-_35235325 1.139 SLC1A2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr6_-_101018271 1.137 NM_005068
SIM1
single-minded homolog 1 (Drosophila)
chr12_+_77963563 1.129 NM_001135806
SYT1
synaptotagmin I
chr3_+_99484421 1.125 NM_001005482
OR5H2
olfactory receptor, family 5, subfamily H, member 2
chr3_+_99370233 1.118 NM_001005515
OR5H15
olfactory receptor, family 5, subfamily H, member 15
chr12_+_70618892 1.094 NM_173353
TPH2
tryptophan hydroxylase 2
chr12_-_10870134 1.087 NM_023921
TAS2R10
taste receptor, type 2, member 10
chr13_+_45174446 1.082 NM_152719
SPERT
spermatid associated
chr12_-_21980894 1.067 NM_005691
NM_020297
NM_020298
ABCC9


ATP-binding cassette, sub-family C (CFTR/MRP), member 9


chrX_-_19898302 1.062 NM_198279
CXorf23
chromosome X open reading frame 23
chr13_+_110653407 1.060 ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chr15_+_92700167 1.056 NM_001159644
MCTP2
multiple C2 domains, transmembrane 2
chr5_+_57823017 1.050 NM_152687
GAPT
GRB2-binding adaptor protein, transmembrane
chr3_+_150065732 1.047 NM_001870
CPA3
carboxypeptidase A3 (mast cell)
chr18_-_35634247 1.042 LOC647946
hypothetical LOC647946
chr3_-_115380539 1.039 NM_000796
NM_033663
DRD3

dopamine receptor D3

chr5_-_39430180 1.037 DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr14_-_105785639 1.036


chr3_+_98641143 1.034 NM_173655
EPHA6
EPH receptor A6
chr15_-_75259714 1.024 PEAK1
NKF3 kinase family member
chrX_+_101910713 1.014 LOC100287765
hypothetical LOC100287765
chr20_+_86121 0.993 NM_139074
DEFB127
defensin, beta 127
chr12_+_58369392 0.991 NM_004731
SLC16A7
solute carrier family 16, member 7 (monocarboxylic acid transporter 2)
chr9_+_42707229 0.986 NM_001099279
NM_199244
FOXD4L2
FOXD4L4
forkhead box D4-like 2
forkhead box D4-like 4
chr3_+_88114415 0.984 NM_000866
HTR1F
5-hydroxytryptamine (serotonin) receptor 1F
chr9_+_5646582 0.981 NM_020829
KIAA1432
KIAA1432
chr11_-_127962662 0.971 NM_001143820
ETS1
v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)
chr4_-_100492854 0.971 NM_000669
ADH1C
alcohol dehydrogenase 1C (class I), gamma polypeptide
chr9_-_99746923 0.961 NM_018437
HEMGN
hemogen
chr4_+_74500748 0.955 ALB
albumin
chr12_+_43972732 0.954 NM_001142678
ANO6
anoctamin 6
chr9_-_69669550 0.949 NM_001099279
NM_199244
FOXD4L2
FOXD4L4
forkhead box D4-like 2
forkhead box D4-like 4
chr22_-_38619739 0.948 NM_152512
ENTHD1
ENTH domain containing 1
chr3_+_101910823 0.941 NM_001007565
NM_001195479
NM_006070
TFG


TRK-fused gene


chr14_-_105862080 0.938 IGHV4-31
IGHA1
IGHD
IGHG1
IGHG2
IGHG3
IGHM
SCFV
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant delta
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 2 (G2m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
immunoglobulin heavy constant mu
single-chain Fv fragment
chr3_+_192413015 0.934 NM_198184
OSTN
osteocrin
chr2_+_115538716 0.934 NM_001178037
DPP10
dipeptidyl-peptidase 10 (non-functional)
chr6_-_32742265 0.933 NM_002123
HLA-DQB1
major histocompatibility complex, class II, DQ beta 1
chr9_-_36365965 0.930 RNF38
ring finger protein 38
chr11_+_5862076 0.930 NM_001005165
OR52E4
olfactory receptor, family 52, subfamily E, member 4
chr5_-_146441184 0.922 NM_181677
NM_181678
PPP2R2B

protein phosphatase 2, regulatory subunit B, beta

chr21_-_14501114 0.916 NM_198996
LIPI
lipase, member I
chr1_+_169747788 0.916 PRRC2C
proline-rich coiled-coil 2C
chr1_+_246578699 0.908 NM_001001918
OR14C36
olfactory receptor, family 14, subfamily C, member 36
chr2_+_182558795 0.897 NM_001080545
PPP1R1C
protein phosphatase 1, regulatory (inhibitor) subunit 1C
chr20_+_56912146 0.877 GNAS
GNAS complex locus
chrX_-_127014020 0.873 NM_138289
ACTRT1
actin-related protein T1
chr11_-_4924905 0.872 NM_001005329
OR51A4
olfactory receptor, family 51, subfamily A, member 4
chr1_-_246869181 0.871 NM_001001827
OR2T35
olfactory receptor, family 2, subfamily T, member 35
chr15_+_22778233 0.866 SNRPN
small nuclear ribonucleoprotein polypeptide N
chr3_+_99350859 0.865 NM_001005514
OR5H14
olfactory receptor, family 5, subfamily H, member 14
chr6_+_72983183 0.863 NM_001168410
RIMS1
regulating synaptic membrane exocytosis 1
chr9_-_5294579 0.862 NM_005059
NM_134441
RLN2

relaxin 2

chr10_-_104587069 0.861 NM_000102
CYP17A1
cytochrome P450, family 17, subfamily A, polypeptide 1
chr9_-_5620070 0.857 C9orf46
chromosome 9 open reading frame 46
chr15_+_22652790 0.856 NM_022805
SNRPN
small nuclear ribonucleoprotein polypeptide N
chr5_-_37220702 0.851 C5orf42
chromosome 5 open reading frame 42
chrX_+_105298953 0.850 NM_001171020
NM_152423
MUM1L1

melanoma associated antigen (mutated) 1-like 1

chr2_+_165804157 0.849 NM_001040142
SCN2A
sodium channel, voltage-gated, type II, alpha subunit
chr11_+_122214415 0.843 NM_019604
CRTAM
cytotoxic and regulatory T cell molecule
chr11_-_5766621 0.828 NM_001001913
OR52N1
olfactory receptor, family 52, subfamily N, member 1
chr13_-_48008118 0.827 RCBTB2
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
chr5_+_147529488 0.826 NM_001001325
SPINK14
serine peptidase inhibitor, Kazal type 14 (putative)
chr2_-_27215781 0.823 NM_178553
C2orf53
chromosome 2 open reading frame 53
chr4_+_71054492 0.816 NM_214711
C4orf40
chromosome 4 open reading frame 40
chr7_+_143437539 0.809 NM_001005480
OR2A2
olfactory receptor, family 2, subfamily A, member 2
chr3_+_174598937 0.808 NM_014932
NLGN1
neuroligin 1
chr8_+_82807218 0.806 NM_152284
CHMP4C
chromatin modifying protein 4C
chr15_-_54175954 0.805 RFX7
regulatory factor X, 7
chr2_+_37282516 0.796 LOC100505876
hypothetical LOC100505876
chr12_-_85756766 0.793 NM_013244
MGAT4C
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr10_+_32896656 0.791 NM_024688
C10orf68
chromosome 10 open reading frame 68
chr4_-_100461530 0.790 NM_000668
ADH1B
alcohol dehydrogenase 1B (class I), beta polypeptide
chr6_-_88095714 0.786 NM_198568
GJB7
gap junction protein, beta 7, 25kDa
chr14_-_106170414 0.780 IGHG1
IGHG3
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
chr7_-_88262966 0.779 NM_152706
C7orf62
chromosome 7 open reading frame 62
chr1_-_246554492 0.778 NM_001004691
OR2M7
olfactory receptor, family 2, subfamily M, member 7
chr2_-_6924092 0.777 CMPK2
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr1_-_102235377 0.777 NM_058170
OLFM3
olfactomedin 3
chr4_-_75072683 0.771 NM_002704
PPBP
pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
chr1_-_120285753 0.768 NOTCH2
notch 2
chr2_+_216682251 0.764 NM_021141
XRCC5
X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
chr15_+_47502666 0.764 NM_002009
FGF7
fibroblast growth factor 7
chr4_-_87247829 0.760 NM_138981
MAPK10
mitogen-activated protein kinase 10
chr12_-_30721410 0.759 NM_001190995
IPO8
importin 8
chr4_-_153523113 0.758 NM_001013415
FBXW7
F-box and WD repeat domain containing 7
chr18_-_49944986 0.758 MBD2
methyl-CpG binding domain protein 2
chr2_-_215949566 0.758 FN1
fibronectin 1
chr12_-_10479810 0.750 NM_002260
KLRC2
KLRC3
killer cell lectin-like receptor subfamily C, member 2
killer cell lectin-like receptor subfamily C, member 3
chr4_+_71330797 0.741 NM_001145006
MUC7
mucin 7, secreted
chr12_+_76749199 0.737 NM_014903
NAV3
neuron navigator 3
chr15_-_75364387 0.734 NM_024776
PEAK1
NKF3 kinase family member
chrX_+_14813333 0.731 NM_001177475
MOSPD2
motile sperm domain containing 2
chr2_+_102456193 0.729 NM_001011552
SLC9A4
solute carrier family 9 (sodium/hydrogen exchanger), member 4
chr16_+_74901235 0.729 NM_138994
CNTNAP4
contactin associated protein-like 4
chr11_-_7804094 0.725 NM_153445
OR5P3
olfactory receptor, family 5, subfamily P, member 3
chr8_-_7207899 0.723 NM_001164457
ZNF705G
zinc finger protein 705G
chr11_+_26310253 0.723 NM_031418
ANO3
anoctamin 3
chr9_-_21156609 0.720 NM_002175
IFNA21
interferon, alpha 21
chr10_+_116687904 0.718 NM_139169
TRUB1
TruB pseudouridine (psi) synthase homolog 1 (E. coli)
chr15_+_43036194 0.717 NM_152448
C15orf43
chromosome 15 open reading frame 43
chr6_+_116939500 0.714 NM_153711
FAM26E
family with sequence similarity 26, member E
chrX_-_1291526 0.714 NM_001012288
NM_022148
CRLF2

cytokine receptor-like factor 2

chr12_+_9925354 0.712 NM_001190765
KLRF2
killer cell lectin-like receptor subfamily F, member 2
chr18_+_59705918 0.711 NM_001143818
NM_002575
SERPINB2

serpin peptidase inhibitor, clade B (ovalbumin), member 2

chr8_-_17797127 0.710 NM_147203
NM_201553
NM_004467
NM_201552
FGL1



fibrinogen-like 1



chr11_+_18150959 0.710 NM_054032
MRGPRX4
MAS-related GPR, member X4
chr4_+_9055357 0.710 NM_001040448
DEFB131
defensin, beta 131

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
4.99 8.79e-43 GO:0007606 sensory perception of chemical stimulus
5.16 1.03e-40 GO:0007608 sensory perception of smell
3.31 4.59e-30 GO:0007600 sensory perception
2.52 1.71e-24 GO:0050877 neurological system process
2.17 1.34e-19 GO:0003008 system process
1.37 2.51e-11 GO:0050896 response to stimulus
1.37 2.60e-08 GO:0032501 multicellular organismal process
1.81 2.96e-03 GO:0006952 defense response
3.22 3.18e-03 GO:0006805 xenobiotic metabolic process
3.22 3.18e-03 GO:0071466 cellular response to xenobiotic stimulus
3.20 3.60e-03 GO:0009410 response to xenobiotic stimulus

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.53 1.98e-14 GO:0071944 cell periphery
1.53 6.53e-14 GO:0005886 plasma membrane
1.36 3.52e-09 GO:0016021 integral to membrane
1.35 6.39e-09 GO:0031224 intrinsic to membrane
1.29 7.03e-08 GO:0044425 membrane part
1.22 3.14e-06 GO:0016020 membrane
8.74 8.07e-03 GO:0042613 MHC class II protein complex

Gene overrepresentation in function category:

enrichment   p-value GO term description
5.36 2.00e-42 GO:0004984 olfactory receptor activity
3.24 2.45e-30 GO:0004930 G-protein coupled receptor activity
2.57 1.86e-25 GO:0004888 transmembrane receptor activity
2.19 3.30e-21 GO:0004872 receptor activity
1.99 4.15e-19 GO:0004871 signal transducer activity
1.99 4.15e-19 GO:0060089 molecular transducer activity
12.74 5.75e-03 GO:0005132 interferon-alpha/beta receptor binding