Motif ID: LHX3,4.p2

Z-value: 0.869


Transcription factors associated with LHX3,4.p2:

Gene SymbolEntrez IDGene Name
LHX3 8022 LIM homeobox 3
LHX4 89884 LIM homeobox 4



Activity profile for motif LHX3,4.p2.

activity profile for motif LHX3,4.p2


Sorted Z-values histogram for motif LHX3,4.p2

Sorted Z-values for motif LHX3,4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of LHX3,4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_+_52697160 1.185 HOXC5
HOXC6
homeobox C5
homeobox C6
chr13_-_45323757 0.995 NM_198849
SIAH3
seven in absentia homolog 3 (Drosophila)
chr7_-_122627235 0.961 NM_022444
SLC13A1
solute carrier family 13 (sodium/sulfate symporters), member 1
chr8_-_62764839 0.956 NM_001164750
NM_001164751
NM_001164752
NM_001164753
NM_020164
NM_032467
NM_032468
ASPH






aspartate beta-hydroxylase






chr6_-_66346417 0.948 NM_198283
EYS
eyes shut homolog (Drosophila)
chr8_-_131483395 0.914 NM_018482
ASAP1
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
chr10_-_33264491 0.868 NM_033668
ITGB1
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
chr22_-_38619739 0.859 NM_152512
ENTHD1
ENTH domain containing 1
chr12_+_52696908 0.846 NM_014620
NM_153693
HOXC4
HOXC6
homeobox C4
homeobox C6
chr10_+_102212787 0.813 NM_003393
WNT8B
wingless-type MMTV integration site family, member 8B
chr8_+_32905027 0.728


chr1_+_157526127 0.712 NM_002001
FCER1A
Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
chr15_+_92700167 0.701 NM_001159644
MCTP2
multiple C2 domains, transmembrane 2
chr9_-_137671206 0.699 NM_182974
GLT6D1
glycosyltransferase 6 domain containing 1
chr9_+_4829763 0.696 RCL1
RNA terminal phosphate cyclase-like 1
chr15_+_46271158 0.675 NM_001145668
CTXN2
SLC12A1
cortexin 2
solute carrier family 12 (sodium/potassium/chloride transporters), member 1
chr12_-_88573949 0.663 NM_001001323
NM_001682
ATP2B1

ATPase, Ca++ transporting, plasma membrane 1

chr4_+_71054492 0.662 NM_214711
C4orf40
chromosome 4 open reading frame 40
chr18_+_59733724 0.662 NM_005024
SERPINB10
serpin peptidase inhibitor, clade B (ovalbumin), member 10
chr3_-_69212192 0.656 NM_003968
NM_198195
UBA3

ubiquitin-like modifier activating enzyme 3

chr12_-_10870134 0.638 NM_023921
TAS2R10
taste receptor, type 2, member 10
chr10_+_685887 0.636 C10orf108
chromosome 10 open reading frame 108
chr21_-_35153664 0.632 RUNX1
runt-related transcription factor 1
chr4_-_116254381 0.621 NM_022569
NDST4
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4
chr5_+_166644420 0.607 NM_001122679
ODZ2
odz, odd Oz/ten-m homolog 2 (Drosophila)
chr3_-_54937001 0.604 NM_020678
LRTM1
leucine-rich repeats and transmembrane domains 1
chr5_-_88155360 0.589 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr20_-_18425811 0.578 NM_006606
RBBP9
retinoblastoma binding protein 9
chr4_-_120462705 0.573 NM_000134
FABP2
fatty acid binding protein 2, intestinal
chr11_+_33306652 0.567 HIPK3
homeodomain interacting protein kinase 3
chr14_+_74968589 0.550 NM_001135049
JDP2
Jun dimerization protein 2
chr10_+_63478974 0.543 ARID5B
AT rich interactive domain 5B (MRF1-like)
chr11_+_22646229 0.538 NM_177553
GAS2
growth arrest-specific 2
chr5_-_160044844 0.537 ATP10B
ATPase, class V, type 10B
chr9_+_12683385 0.528 NM_000550
TYRP1
tyrosinase-related protein 1
chr11_-_117628211 0.526 NM_198275
MPZL3
myelin protein zero-like 3
chr3_-_166278969 0.522 NM_001041
SI
sucrase-isomaltase (alpha-glucosidase)
chr3_+_99334230 0.506 NM_001005338
OR5H1
olfactory receptor, family 5, subfamily H, member 1
chr11_+_26310253 0.503 NM_031418
ANO3
anoctamin 3
chr10_+_129237602 0.501 NM_001030013
NPS
neuropeptide S
chr11_-_30910074 0.499 NM_020869
DCDC5
doublecortin domain containing 5
chr14_+_100365390 0.491 MEG3
maternally expressed 3 (non-protein coding)
chr4_+_68995761 0.484 NM_014058
TMPRSS11E
transmembrane protease, serine 11E
chr16_-_3783475 0.478 CREBBP
CREB binding protein
chr7_-_87180499 0.466 NM_000927
ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr15_+_32048380 0.465 NM_012125
CHRM5
cholinergic receptor, muscarinic 5
chr21_-_26345294 0.460


chr12_-_9651748 0.456 NM_002258
KLRB1
killer cell lectin-like receptor subfamily B, member 1
chr4_+_78651929 0.455 NM_006419
CXCL13
chemokine (C-X-C motif) ligand 13
chr4_-_100492854 0.455 NM_000669
ADH1C
alcohol dehydrogenase 1C (class I), gamma polypeptide
chr3_-_114047479 0.449 NM_001008784
CD200R1L
CD200 receptor 1-like
chr7_-_86526880 0.446 NM_001142749
KIAA1324L
KIAA1324-like
chr4_+_119174947 0.438 NM_004784
NDST3
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
chr5_+_127012611 0.433 NM_001048252
CTXN3
cortexin 3
chr1_+_156991133 0.432 NM_001005184
OR6K6
olfactory receptor, family 6, subfamily K, member 6
chr7_+_18296569 0.429 HDAC9
histone deacetylase 9
chr14_-_60185659 0.427 NM_005982
SIX1
SIX homeobox 1
chr14_+_100365162 0.426 MEG3
maternally expressed 3 (non-protein coding)
chr3_-_121117647 0.421 GSK3B
glycogen synthase kinase 3 beta
chr5_-_16795336 0.419 MYO10
myosin X
chr1_-_92725017 0.418 NM_005263
GFI1
growth factor independent 1 transcription repressor
chr1_+_81544432 0.409 LPHN2
latrophilin 2
chr14_-_46882144 0.407 NM_182830
MDGA2
MAM domain containing glycosylphosphatidylinositol anchor 2
chr15_+_100175888 0.406 NM_001001674
OR4F15
olfactory receptor, family 4, subfamily F, member 15
chr5_+_147672181 0.398 NM_032566
SPINK7
serine peptidase inhibitor, Kazal type 7 (putative)
chr12_+_8557402 0.394 NM_080387
CLEC4D
C-type lectin domain family 4, member D
chr6_+_53043729 0.393 NM_012347
FBXO9
F-box protein 9
chr13_+_52500830 0.390 NM_006418
OLFM4
olfactomedin 4
chr3_-_99236520 0.385 NM_001105580
GABRR3
gamma-aminobutyric acid (GABA) receptor, rho 3
chr4_-_46605980 0.385 NM_130902
COX7B2
cytochrome c oxidase subunit VIIb2
chr17_-_38087366 0.384 NM_016602
CCR10
chemokine (C-C motif) receptor 10
chr12_-_15757114 0.378 EPS8
epidermal growth factor receptor pathway substrate 8
chr4_+_71330797 0.377 NM_001145006
MUC7
mucin 7, secreted
chr9_-_14076901 0.374 NFIB
nuclear factor I/B
chr1_+_144198658 0.371 LIX1L
Lix1 homolog (mouse)-like
chr3_+_73193499 0.368 NM_018029
EBLN2
endogenous Borna-like N element-2
chr10_-_45131061 0.366 NM_001004297
OR13A1
olfactory receptor, family 13, subfamily A, member 1
chr10_+_126620681 0.366 NM_017580
ZRANB1
zinc finger, RAN-binding domain containing 1
chr11_-_6005546 0.366 NM_001001917
OR56A1
olfactory receptor, family 56, subfamily A, member 1
chr19_-_21985560 0.365 NM_007153
ZNF208
zinc finger protein 208
chr13_+_47948586 0.363 RB1
retinoblastoma 1
chr11_-_20138445 0.362 NM_001029865
DBX1
developing brain homeobox 1
chr4_-_20594645 0.361 KCNIP4
Kv channel interacting protein 4
chr3_-_131081910 0.361 NM_001017395
TMCC1
transmembrane and coiled-coil domain family 1
chr11_-_102081654 0.360 NM_022122
MMP27
matrix metallopeptidase 27
chrX_-_102418329 0.357 NM_001012979
TCEAL5
transcription elongation factor A (SII)-like 5
chr3_-_101316038 0.356 NM_001042459
NM_182909
FILIP1L

filamin A interacting protein 1-like

chr4_+_88748704 0.356 NM_014208
DSPP
dentin sialophosphoprotein
chr2_+_216695062 0.356 XRCC5
X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
chr14_-_94669547 0.355 NM_001195573
DICER1
dicer 1, ribonuclease type III
chr1_-_245942679 0.354 NM_001005286
OR6F1
olfactory receptor, family 6, subfamily F, member 1
chr3_-_18455207 0.353 NM_001131010
SATB1
SATB homeobox 1
chr1_-_58920315 0.351


chr11_+_55351270 0.350 NM_001004739
OR5L2
olfactory receptor, family 5, subfamily L, member 2
chr17_-_1195096 0.349 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr6_+_55300225 0.348 NM_207410
GFRAL
GDNF family receptor alpha like
chr12_-_23628774 0.341 NM_178010
SOX5
SRY (sex determining region Y)-box 5
chr6_-_56615544 0.340 NM_001723
NM_015548
DST

dystonin

chr14_+_28311740 0.340 C14orf23
chromosome 14 open reading frame 23
chr14_+_66901237 0.333 EIF2S1
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
chr2_-_224574860 0.330 SERPINE2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr7_+_94135384 0.329 PEG10
paternally expressed 10
chr2_-_55053398 0.327


chr3_+_101316463 0.324 NM_001167924
C3orf26
chromosome 3 open reading frame 26
chr6_+_55147029 0.324 NM_001526
HCRTR2
hypocretin (orexin) receptor 2
chr6_-_152681171 0.321 NM_015293
SYNE1
spectrin repeat containing, nuclear envelope 1
chr10_+_57028755 0.319 NM_001190478
MTRNR2L5
MT-RNR2-like 5
chr8_+_9990471 0.313 NM_001135671
MSRA
methionine sulfoxide reductase A
chr12_+_52708460 0.312 NM_004503
HOXC6
homeobox C6
chr13_-_34948758 0.312 NM_005584
MAB21L1
mab-21-like 1 (C. elegans)
chr10_+_91142301 0.311 NM_001548
IFIT1
interferon-induced protein with tetratricopeptide repeats 1
chr11_-_57883117 0.307 NM_001005489
OR5B17
olfactory receptor, family 5, subfamily B, member 17
chr4_-_80548378 0.307 NM_033214
GK2
glycerol kinase 2
chr3_+_152934393 0.307 NM_207365
AADACL2
arylacetamide deacetylase-like 2
chr12_+_9871343 0.303 NM_016523
KLRF1
killer cell lectin-like receptor subfamily F, member 1
chr19_-_53841064 0.300 NM_001217
CA11
carbonic anhydrase XI
chr21_-_26294332 0.299 APP
amyloid beta (A4) precursor protein
chr14_+_69307914 0.299 SRSF5
serine/arginine-rich splicing factor 5
chr3_-_79899748 0.298 NM_002941
ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr10_+_17310475 0.294 VIM
vimentin
chrX_+_153186602 0.294 NM_001145934
TKTL1
transketolase-like 1
chr6_-_116799548 0.293 LOC100287467
hypothetical LOC100287467
chr18_-_49944986 0.291 MBD2
methyl-CpG binding domain protein 2
chr6_-_132952517 0.291 NM_003967
TAAR5
trace amine associated receptor 5
chr15_-_48345453 0.290 NM_002112
HDC
histidine decarboxylase
chr14_+_61532293 0.290 NM_031914
SYT16
synaptotagmin XVI
chr3_-_121065112 0.287


chr2_+_170074457 0.287 NM_006063
KBTBD10
kelch repeat and BTB (POZ) domain containing 10
chr11_-_124478414 0.287 NM_001080546
TMEM218
transmembrane protein 218
chr5_-_160211623 0.286 NM_025153
ATP10B
ATPase, class V, type 10B
chr11_-_26550243 0.285 NM_001135091
NM_001135092
NM_145650
MUC15


mucin 15, cell surface associated


chr6_-_109795925 0.284 CD164
CD164 molecule, sialomucin
chr1_+_62835759 0.280 NM_014495
ANGPTL3
angiopoietin-like 3
chrX_+_56772391 0.276 LOC550643
hypothetical LOC550643
chr2_+_225973845 0.276 NM_020864
KIAA1486
KIAA1486
chrX_-_62697473 0.274 LOC92249
hypothetical LOC92249
chr1_-_150398327 0.273 NM_001122965
RPTN
repetin
chr3_-_71860958 0.273 NM_001134650
EIF4E3
eukaryotic translation initiation factor 4E family member 3
chr11_+_63282639 0.273 RTN3
reticulon 3
chr22_+_42726423 0.271 NM_001003828
PARVB
parvin, beta
chr8_-_91164100 0.271 NM_004929
CALB1
calbindin 1, 28kDa
chr22_-_15682555 0.270 NM_175878
XKR3
XK, Kell blood group complex subunit-related family, member 3
chr9_-_21295311 0.269 NM_002169
IFNA5
interferon, alpha 5
chr5_-_58331515 0.269 NM_001197223
PDE4D
phosphodiesterase 4D, cAMP-specific
chr1_-_230717850 0.269 NM_020808
SIPA1L2
signal-induced proliferation-associated 1 like 2
chr2_+_183316574 0.268 DNAJC10
DnaJ (Hsp40) homolog, subfamily C, member 10
chr13_+_77007809 0.266 NM_001160706
NM_003843
NM_144777
SCEL


sciellin


chr1_-_188713324 0.265 NM_199051
FAM5C
family with sequence similarity 5, member C
chr3_-_159872960 0.265 NM_020169
LXN
latexin
chr10_-_48426868 0.264 NM_001042357
NM_001042389
PTPN20B
PTPN20A
protein tyrosine phosphatase, non-receptor type 20B
protein tyrosine phosphatase, non-receptor type 20A
chr1_-_214963279 0.263 NM_001438
ESRRG
estrogen-related receptor gamma
chr11_-_5766621 0.263 NM_001001913
OR52N1
olfactory receptor, family 52, subfamily N, member 1
chr10_-_50066386 0.262 NM_001010863
C10orf128
chromosome 10 open reading frame 128
chr14_+_28305922 0.262 NM_005249
FOXG1
forkhead box G1
chr5_-_145232723 0.261 NM_001080516
GRXCR2
glutaredoxin, cysteine rich 2
chr1_-_157014048 0.261 NM_001005278
OR6N2
olfactory receptor, family 6, subfamily N, member 2
chr9_-_74757735 0.261 NM_000689
ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr6_-_144427340 0.260 NM_001080951
NM_001080955
PLAGL1

pleiomorphic adenoma gene-like 1

chr18_+_64616296 0.260 NM_024781
CCDC102B
coiled-coil domain containing 102B
chr4_-_87593306 0.260 NM_002753
MAPK10
mitogen-activated protein kinase 10
chr3_+_103029523 0.258 NM_001005474
NFKBIZ
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
chr4_+_5577783 0.257 NM_005750
C4orf6
chromosome 4 open reading frame 6
chr7_+_129057152 0.256 NM_001040110
NRF1
nuclear respiratory factor 1
chr11_-_89181390 0.256 NM_020358
TRIM49
tripartite motif containing 49
chr16_+_68284252 0.253 NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr13_+_108046500 0.250 NM_015011
MYO16
myosin XVI
chr1_-_152394215 0.249 NM_001159484
NM_207308
NUP210L

nucleoporin 210kDa-like

chr9_-_21340885 0.246 NM_021002
IFNA6
interferon, alpha 6
chr3_-_52269467 0.246 WDR82
WD repeat domain 82
chr1_-_143708467 0.242 NM_001195260
PDE4DIP
phosphodiesterase 4D interacting protein
chr18_+_31488530 0.241 NM_020474
GALNT1
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1)
chr8_+_36760999 0.241 NM_001031836
KCNU1
potassium channel, subfamily U, member 1
chr17_-_60439764 0.241 GNA13
guanine nucleotide binding protein (G protein), alpha 13
chr9_-_28709302 0.238 NM_152570
LINGO2
leucine rich repeat and Ig domain containing 2
chr17_-_9635325 0.238 NM_001105571
DHRS7C
dehydrogenase/reductase (SDR family) member 7C
chr18_+_28023984 0.237 NM_005925
MEP1B
meprin A, beta
chr14_+_95915774 0.236 NM_016472
C14orf129
chromosome 14 open reading frame 129
chr11_+_91724909 0.236 NM_001008781
FAT3
FAT tumor suppressor homolog 3 (Drosophila)
chr5_+_132237253 0.235 NM_052971
LEAP2
liver expressed antimicrobial peptide 2
chrX_-_55074125 0.233 NM_000032
NM_001037967
NM_001037968
ALAS2


aminolevulinate, delta-, synthase 2


chr19_+_21056792 0.230 NM_182515
ZNF714
zinc finger protein 714
chr12_+_8499788 0.229 NM_001007033
CLEC6A
C-type lectin domain family 6, member A
chr16_+_2749934 0.229


chr20_+_2892918 0.229 PTPRA
protein tyrosine phosphatase, receptor type, A
chr16_+_24696069 0.227 TNRC6A
trinucleotide repeat containing 6A
chr3_-_64186151 0.226 NM_198859
PRICKLE2
prickle homolog 2 (Drosophila)
chrX_+_55951280 0.225


chrX_-_142432884 0.225 NM_001009609
SPANXN3
SPANX family, member N3
chr20_+_23293020 0.225 NM_022482
GZF1
GDNF-inducible zinc finger protein 1
chr8_-_82536312 0.224 NM_001080526
FABP9
fatty acid binding protein 9, testis
chr4_-_69116839 0.224 NM_001077
UGT2B17
UDP glucuronosyltransferase 2 family, polypeptide B17
chr9_-_21375258 0.223 NM_000605
IFNA2
interferon, alpha 2
chr3_+_99288706 0.223 NM_054106
OR5AC2
olfactory receptor, family 5, subfamily AC, member 2
chr14_+_55148488 0.223 KTN1
kinectin 1 (kinesin receptor)
chr12_-_52281050 0.222 NM_001130059
ATF7
activating transcription factor 7
chr8_+_70541631 0.218 SULF1
sulfatase 1
chr21_-_18697829 0.217 NM_002772
TMPRSS15
transmembrane protease, serine 15
chr3_+_174598937 0.216 NM_014932
NLGN1
neuroligin 1
chr19_+_9157269 0.215 NM_175883
OR7D2
olfactory receptor, family 7, subfamily D, member 2
chr7_+_90176647 0.215 NM_012395
CDK14
cyclin-dependent kinase 14

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
3.08 1.94e-12 GO:0007608 sensory perception of smell
2.89 1.03e-11 GO:0007606 sensory perception of chemical stimulus
1.77 1.20e-08 GO:0003008 system process
2.07 5.21e-07 GO:0007600 sensory perception
1.79 7.78e-07 GO:0050877 neurological system process
1.33 9.95e-07 GO:0032501 multicellular organismal process
1.22 3.68e-03 GO:0050896 response to stimulus

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.42 3.08e-09 GO:0005886 plasma membrane
1.41 6.03e-09 GO:0071944 cell periphery
1.23 1.15e-03 GO:0016021 integral to membrane
1.21 4.95e-03 GO:0031224 intrinsic to membrane
1.16 6.26e-03 GO:0016020 membrane
1.19 7.02e-03 GO:0044425 membrane part
1.52 3.25e-02 GO:0044430 cytoskeletal part
1.41 4.58e-02 GO:0005856 cytoskeleton

Gene overrepresentation in function category:

enrichment   p-value GO term description
3.18 1.72e-13 GO:0004984 olfactory receptor activity
2.29 1.47e-11 GO:0004930 G-protein coupled receptor activity
1.88 7.48e-09 GO:0004888 transmembrane receptor activity
1.64 2.09e-08 GO:0004871 signal transducer activity
1.64 2.09e-08 GO:0060089 molecular transducer activity
1.71 3.31e-08 GO:0004872 receptor activity