Motif ID: HIC1.p2

Z-value: 1.606


Transcription factors associated with HIC1.p2:

Gene SymbolEntrez IDGene Name
HIC1 3090 hypermethylated in cancer 1



Activity profile for motif HIC1.p2.

activity profile for motif HIC1.p2


Sorted Z-values histogram for motif HIC1.p2

Sorted Z-values for motif HIC1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HIC1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_1704661 3.945 NM_001080488
ONECUT3
one cut homeobox 3
chr8_+_145461356 3.519 NM_001008271
NM_001080514
SCXA
SCXB
scleraxis homolog A (mouse)
scleraxis homolog B (mouse)
chr14_+_105012106 3.344 NM_001312
CRIP2
cysteine-rich protein 2
chr14_+_104226769 3.232 NM_001031714
NM_022489
NM_032714
INF2


inverted formin, FH2 and WH2 domain containing


chr11_+_359723 2.753 NM_178537
B4GALNT4
beta-1,4-N-acetyl-galactosaminyl transferase 4
chr16_+_162845 2.391 NM_000517
HBA1
HBA2
hemoglobin, alpha 1
hemoglobin, alpha 2
chr16_+_2510323 2.357 NM_001145815
NM_015944
AMDHD2

amidohydrolase domain containing 2

chr19_+_540849 2.339 NM_001194
HCN2
hyperpolarization activated cyclic nucleotide-gated potassium channel 2
chr2_+_241586927 2.304 NM_001080437
SNED1
sushi, nidogen and EGF-like domains 1
chr16_+_11669736 2.281 NM_003498
SNN
stannin
chr7_+_154943466 2.251 NM_001427
EN2
engrailed homeobox 2
chr7_-_44331544 2.121 NM_001220
NM_172078
NM_172079
NM_172080
NM_172081
NM_172082
NM_172083
NM_172084
CAMK2B







calcium/calmodulin-dependent protein kinase II beta







chr10_+_112247614 2.058 NM_004419
DUSP5
dual specificity phosphatase 5
chr1_+_2149993 2.057 NM_003036
SKI
v-ski sarcoma viral oncogene homolog (avian)
chr1_+_234372454 2.003 NM_003272
GPR137B
G protein-coupled receptor 137B
chr14_+_104402626 1.992 NM_001112726
NM_015005
KIAA0284

KIAA0284

chr19_+_1236766 1.979 NM_001405
EFNA2
ephrin-A2
chr2_+_238200922 1.965 NM_001137550
LRRFIP1
leucine rich repeat (in FLII) interacting protein 1
chr2_+_232281491 1.896 PTMA
prothymosin, alpha
chr9_+_17568952 1.892 NM_003026
SH3GL2
SH3-domain GRB2-like 2
chr4_+_3737872 1.891 ADRA2C
adrenergic, alpha-2C-, receptor
chr12_+_131705438 1.881 NM_012226
NM_016318
NM_170682
NM_170683
NM_174872
NM_174873
P2RX2





purinergic receptor P2X, ligand-gated ion channel, 2





chr19_+_748452 1.835 PTBP1
polypyrimidine tract binding protein 1
chr14_+_103621768 1.825 NM_001080464
ASPG
asparaginase homolog (S. cerevisiae)
chr13_-_94162249 1.813 NM_007084
SOX21
SRY (sex determining region Y)-box 21
chr4_+_2031036 1.812 NM_178557
NAT8L
N-acetyltransferase 8-like (GCN5-related, putative)
chr9_+_123501186 1.791 DAB2IP
DAB2 interacting protein
chr2_+_120820140 1.781 NM_002193
INHBB
inhibin, beta B
chr16_+_517834 1.754 NM_005632
SOLH
small optic lobes homolog (Drosophila)
chr15_+_39638445 1.720 NM_006293
TYRO3
TYRO3 protein tyrosine kinase
chr19_+_748448 1.706 PTBP1
polypyrimidine tract binding protein 1
chr19_+_748444 1.693 PTBP1
polypyrimidine tract binding protein 1
chr19_+_748390 1.638 NM_002819
NM_031990
NM_031991
NM_175847
PTBP1



polypyrimidine tract binding protein 1



chr14_+_72773957 1.629 NM_173462
NDRG2
PAPLN
NDRG family member 2
papilin, proteoglycan-like sulfated glycoprotein
chr12_+_3056781 1.568 NM_001168320
NM_006675
TSPAN9

tetraspanin 9

chr16_+_1299693 1.563 UBE2I
ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)
chr10_+_134060681 1.555 NM_001098637
NM_138499
PWWP2B

PWWP domain containing 2B

chr3_-_50515857 1.534 NM_001005505
NM_001174051
NM_006030
CACNA2D2


calcium channel, voltage-dependent, alpha 2/delta subunit 2


chr4_-_174687104 1.518 HAND2
heart and neural crest derivatives expressed 2
chr22_+_38183480 1.500 MGAT3
mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
chr9_+_131974506 1.500 NM_014286
NCS1
neuronal calcium sensor 1
chr17_+_24944605 1.479 NM_152345
ANKRD13B
ankyrin repeat domain 13B
chr11_+_69922236 1.465 NM_001184740
NM_005231
NM_138565
CTTN


cortactin


chr10_-_99521701 1.439 NM_003015
SFRP5
secreted frizzled-related protein 5
chr18_+_75540786 1.420 NM_004715
NM_048368
CTDP1

CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1

chr11_+_627268 1.412 NM_000797
DRD4
dopamine receptor D4
chr18_-_75540727 1.402 FLJ25715
hypothetical protein FLJ25715
chr22_+_38183262 1.400 NM_002409
MGAT3
mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
chr2_+_241023908 1.391 GPC1
glypican 1
chr4_-_174686918 1.384 HAND2
heart and neural crest derivatives expressed 2
chr16_+_705080 1.379 NM_024042
METRN
meteorin, glial cell differentiation regulator
chr11_-_525532 1.372 NM_001130442
NM_005343
NM_176795
HRAS


v-Ha-ras Harvey rat sarcoma viral oncogene homolog


chr18_+_53253775 1.352 NM_004852
ONECUT2
one cut homeobox 2
chr2_+_232281470 1.347 NM_001099285
NM_002823
PTMA

prothymosin, alpha

chr12_+_119562737 1.342 NM_001033677
CABP1
calcium binding protein 1
chr5_+_153550463 1.340 NM_198321
GALNT10
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10)
chr9_-_139060285 1.331 NPDC1
neural proliferation, differentiation and control, 1
chr10_-_103525646 1.329 NM_006119
NM_033163
NM_033164
NM_033165
FGF8



fibroblast growth factor 8 (androgen-induced)



chr16_+_2461500 1.325 NM_006181
NTN3
netrin 3
chr17_-_1560411 1.322 NM_001164407
TLCD2
TLC domain containing 2
chr17_-_4841628 1.317 NM_001167985
NM_001167986
NM_001167987
NM_213726
INCA1



inhibitor of CDK, cyclin A1 interacting protein 1



chr16_+_1299654 1.316 UBE2I
ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)
chr11_-_1549719 1.314 NM_004420
DUSP8
dual specificity phosphatase 8
chr9_-_139060377 1.291 NPDC1
neural proliferation, differentiation and control, 1
chr9_+_138726737 1.281 NM_152421
FAM69B
family with sequence similarity 69, member B
chr16_+_4361775 1.277 NM_138440
VASN
vasorin
chr15_+_94674849 1.267 NM_021005
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr16_+_88517187 1.260 NM_006086
TUBB3
tubulin, beta 3
chr1_+_226261374 1.249 NM_033131
WNT3A
wingless-type MMTV integration site family, member 3A
chr12_+_107047594 1.237 NM_014653
WSCD2
WSC domain containing 2
chrX_+_153339814 1.236 NM_017514
PLXNA3
plexin A3
chr8_+_145705253 1.235 NM_138431
MFSD3
major facilitator superfamily domain containing 3
chr20_+_20296744 1.235 NM_002196
INSM1
insulinoma-associated 1
chr1_-_1274618 1.233 DVL1
dishevelled, dsh homolog 1 (Drosophila)
chr17_+_4841923 1.216 NM_006612
KIF1C
kinesin family member 1C
chr9_+_139091759 1.211 NM_207309
UAP1L1
UDP-N-acteylglucosamine pyrophosphorylase 1-like 1
chr16_+_1299674 1.210 UBE2I
ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)
chr22_+_28446288 1.210 NM_182527
CABP7
calcium binding protein 7
chr19_+_659766 1.202 NM_001040134
NM_002579
PALM

paralemmin

chr17_+_8865547 1.191 NM_004822
NTN1
netrin 1
chr9_-_95757448 1.188 BARX1
BARX homeobox 1
chr3_+_51403760 1.147 NM_013286
RBM15B
RNA binding motif protein 15B
chr8_+_1937711 1.147 KBTBD11
kelch repeat and BTB (POZ) domain containing 11
chr22_+_48951286 1.143 NM_001160300
NM_052839
PANX2

pannexin 2

chr12_+_109956210 1.140 NM_015267
CUX2
cut-like homeobox 2
chr9_-_100510657 1.140 NM_005458
GABBR2
gamma-aminobutyric acid (GABA) B receptor, 2
chr9_-_95757365 1.137 NM_021570
BARX1
BARX homeobox 1
chr22_-_37180958 1.136 NM_152868
KCNJ4
potassium inwardly-rectifying channel, subfamily J, member 4
chr10_-_134449467 1.129 NM_177400
NKX6-2
NK6 homeobox 2
chr16_-_695719 1.120 NM_153350
FBXL16
F-box and leucine-rich repeat protein 16
chr1_+_36394044 1.114 MAP7D1
MAP7 domain containing 1
chr6_+_1335067 1.106 NM_001452
FOXF2
forkhead box F2
chr18_+_65219114 1.105 NM_152721
DOK6
docking protein 6
chr2_+_241023880 1.101


chr1_+_22762575 1.097 NM_001006943
NM_020526
EPHA8

EPH receptor A8

chr17_+_7152417 1.096 NM_001143762
EIF5A
eukaryotic translation initiation factor 5A
chr16_+_1299637 1.095 NM_003345
NM_194259
UBE2I

ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)

chr15_+_38923914 1.093 NM_001032367
SPINT1
serine peptidase inhibitor, Kunitz type 1
chr6_+_31479340 1.089 NM_000247
NM_001177519
MICA

MHC class I polypeptide-related sequence A

chr20_-_62151216 1.088 NM_018419
SOX18
SRY (sex determining region Y)-box 18
chr1_+_18306823 1.077 NM_032880
IGSF21
immunoglobin superfamily, member 21
chr22_+_31527678 1.074 TIMP3
TIMP metallopeptidase inhibitor 3
chr14_+_63389360 1.068 NM_015180
NM_182914
SYNE2

spectrin repeat containing, nuclear envelope 2

chr14_+_104337923 1.056 NM_001137601
ZBTB42
zinc finger and BTB domain containing 42
chr9_-_139060416 1.052 NM_015392
NPDC1
neural proliferation, differentiation and control, 1
chr22_+_36286350 1.050 NM_152243
CDC42EP1
CDC42 effector protein (Rho GTPase binding) 1
chr14_-_103251497 1.043 NM_001100118
NM_001100119
NM_005432
XRCC3


X-ray repair complementing defective repair in Chinese hamster cells 3


chr2_-_233501069 1.037 NM_001114090
NGEF
neuronal guanine nucleotide exchange factor
chr8_-_144583718 1.032 NM_201589
MAFA
v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)
chr2_+_109112428 1.032 NM_001099289
SH3RF3
SH3 domain containing ring finger 3
chr14_+_89934358 1.031 NM_001166106
CALM1
calmodulin 1 (phosphorylase kinase, delta)
chr1_-_11674264 1.031 NM_001127325
MAD2L2
MAD2 mitotic arrest deficient-like 2 (yeast)
chr22_+_47263919 1.027 NM_001082967
FAM19A5
family with sequence similarity 19 (chemokine (C-C motif)-like), member A5
chr11_-_69922112 1.023


chr17_+_26060617 1.023


chr22_-_37569679 1.023


chr20_-_61933012 1.008 ZBTB46
zinc finger and BTB domain containing 46
chr11_+_817584 1.007 NM_173584
EFCAB4A
EF-hand calcium binding domain 4A
chr4_+_3738093 1.003 NM_000683
ADRA2C
adrenergic, alpha-2C-, receptor
chr16_+_19032744 1.002 NM_001034841
ITPRIPL2
inositol 1,4,5-triphosphate receptor interacting protein-like 2
chrX_+_151991474 0.997 NM_001170944
NM_032882
LOC100287428
PNMA6A
paraneoplastic antigen-like protein 6A related gene
paraneoplastic antigen like 6A
chr19_-_411995 0.987 NM_012435
SHC2
SHC (Src homology 2 domain containing) transforming protein 2
chr18_+_75540831 0.979 CTDP1
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
chr15_+_29406335 0.970 NM_015995
KLF13
Kruppel-like factor 13
chr18_+_75724655 0.968 NM_012283
KCNG2
potassium voltage-gated channel, subfamily G, member 2
chr22_+_31527744 0.964 TIMP3
TIMP metallopeptidase inhibitor 3
chr16_+_67697622 0.963 NM_138612
HAS3
hyaluronan synthase 3
chr3_+_51680261 0.959 NM_001129884
NM_015926
TEX264

testis expressed 264

chr7_+_128257698 0.957 NM_001127487
NM_001458
FLNC

filamin C, gamma

chr9_-_138378061 0.955 NM_001080849
DNLZ
DNL-type zinc finger
chrX_+_73557809 0.955 NM_006517
SLC16A2
solute carrier family 16, member 2 (monocarboxylic acid transporter 8)
chr1_-_202921103 0.955 NM_006338
NM_201630
LRRN2

leucine rich repeat neuronal 2

chr7_+_45580704 0.953 ADCY1
adenylate cyclase 1 (brain)
chr17_-_6400470 0.952 NM_001165966
NM_031220
PITPNM3

PITPNM family member 3

chr17_+_11085464 0.947 NM_001173461
NM_001173462
NM_207386
SHISA6


shisa homolog 6 (Xenopus laevis)


chr17_-_29930431 0.944 NM_207454
C17orf102
chromosome 17 open reading frame 102
chr14_+_103251798 0.937 NM_001198953
NM_024071
ZFYVE21

zinc finger, FYVE domain containing 21

chr9_+_136673534 0.930 COL5A1
collagen, type V, alpha 1
chr16_-_73842884 0.926 NM_001170717
NM_014567
BCAR1

breast cancer anti-estrogen resistance 1

chr11_+_2355119 0.922 NM_004356
CD81
CD81 molecule
chr10_+_80672842 0.921 ZMIZ1
zinc finger, MIZ-type containing 1
chr19_+_2173415 0.919 DOT1L
DOT1-like, histone H3 methyltransferase (S. cerevisiae)
chr5_+_14196287 0.915 NM_007118
TRIO
triple functional domain (PTPRF interacting)
chr3_+_53503626 0.913 CACNA1D
calcium channel, voltage-dependent, L type, alpha 1D subunit
chr16_+_270606 0.910 NM_001176
ARHGDIG
Rho GDP dissociation inhibitor (GDI) gamma
chr9_+_139092016 0.908 UAP1L1
UDP-N-acteylglucosamine pyrophosphorylase 1-like 1
chr9_-_139183675 0.908


chr16_+_88169612 0.906 NM_014427
NM_153636
CPNE7

copine VII

chr15_-_38362078 0.895 NM_001190479
LOC100131244
hypothetical protein LOC100131244
chr20_-_60228665 0.895 NM_007232
HRH3
histamine receptor H3
chr16_+_559970 0.893 NM_004204
NM_148920
PIGQ

phosphatidylinositol glycan anchor biosynthesis, class Q

chr20_+_60810610 0.892 NM_002531
NTSR1
neurotensin receptor 1 (high affinity)
chr10_+_12211586 0.892 NM_001142627
NM_001142628
NM_018144
SEC61A2


Sec61 alpha 2 subunit (S. cerevisiae)


chr17_-_77512346 0.892 NM_178493
NOTUM
notum pectinacetylesterase homolog (Drosophila)
chr20_-_54013418 0.890 NM_080617
CBLN4
cerebellin 4 precursor
chr16_-_371823 0.886 NM_021259
TMEM8A
transmembrane protein 8A
chr7_+_45580606 0.883 NM_021116
ADCY1
adenylate cyclase 1 (brain)
chr11_+_64838882 0.883 NM_006779
CDC42EP2
CDC42 effector protein (Rho GTPase binding) 2
chr14_+_104338423 0.880 ZBTB42
zinc finger and BTB domain containing 42
chr16_+_1324505 0.879 NM_003933
BAIAP3
BAI1-associated protein 3
chr22_-_43784093 0.879 NM_138415
PHF21B
PHD finger protein 21B
chr8_-_41873401 0.877 NM_001142446
ANK1
ankyrin 1, erythrocytic
chr11_+_75056343 0.876


chr6_+_1556543 0.872 FOXC1
forkhead box C1
chr9_-_134986108 0.863 NM_006266
RALGDS
ral guanine nucleotide dissociation stimulator
chr3_+_61522310 0.863 PTPRG
protein tyrosine phosphatase, receptor type, G
chr19_+_10843369 0.860 CARM1
coactivator-associated arginine methyltransferase 1
chr4_+_1764802 0.858 NM_000142
NM_001163213
NM_022965
FGFR3


fibroblast growth factor receptor 3


chr15_+_99237527 0.856 NM_000693
ALDH1A3
aldehyde dehydrogenase 1 family, member A3
chr1_-_6162669 0.855 NM_015557
CHD5
chromodomain helicase DNA binding protein 5
chr1_-_62557559 0.853 KANK4
KN motif and ankyrin repeat domains 4
chr10_+_71908535 0.852 NM_014431
KIAA1274
KIAA1274
chr10_+_133850325 0.851 NM_006426
DPYSL4
dihydropyrimidinase-like 4
chr7_-_5429702 0.850 NM_001080495
TNRC18
trinucleotide repeat containing 18
chr1_+_22909916 0.845 NM_004442
NM_017449
EPHB2

EPH receptor B2

chr14_-_87859284 0.844 NM_138317
KCNK10
potassium channel, subfamily K, member 10
chr5_-_134397740 0.841 NM_002653
PITX1
paired-like homeodomain 1
chr10_+_124211353 0.837 HTRA1
HtrA serine peptidase 1
chr1_-_1274160 0.837 NM_004421
DVL1
dishevelled, dsh homolog 1 (Drosophila)
chr9_-_135847106 0.835 NM_001134398
NM_003371
VAV2

vav 2 guanine nucleotide exchange factor

chr1_+_11674365 0.831 NM_198545
C1orf187
chromosome 1 open reading frame 187
chr19_+_482688 0.831 NM_004359
CDC34
cell division cycle 34 homolog (S. cerevisiae)
chr15_-_91433165 0.826 NM_020211
RGMA
RGM domain family, member A
chr9_+_86473273 0.824 NM_001018064
NM_006180
NTRK2

neurotrophic tyrosine kinase, receptor, type 2

chr19_+_1358664 0.819 DAZAP1
DAZ associated protein 1
chr10_+_128583984 0.819 NM_001380
DOCK1
dedicator of cytokinesis 1
chr14_+_95575319 0.818 C14orf132
chromosome 14 open reading frame 132
chr16_+_166678 0.814 NM_000558
HBA1
HBA2
hemoglobin, alpha 1
hemoglobin, alpha 2
chr10_+_23521464 0.813 NM_178161
PTF1A
pancreas specific transcription factor, 1a
chr19_-_6230927 0.813 NM_005934
MLLT1
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1
chr5_+_76542461 0.806 NM_001029851
NM_001029852
NM_001029853
NM_001029854
NM_003719
PDE8B




phosphodiesterase 8B




chr22_-_49041786 0.804 MAPK12
mitogen-activated protein kinase 12
chr9_-_111122826 0.804 NM_018424
NM_019114
EPB41L4B

erythrocyte membrane protein band 4.1 like 4B

chr16_+_550394 0.804 NM_145270
C16orf11
chromosome 16 open reading frame 11
chr14_+_101097440 0.802 NM_001362
DIO3
deiodinase, iodothyronine, type III
chrX_+_21868635 0.802 NM_004595
SMS
spermine synthase
chr9_-_139184247 0.802 NM_001013653
LRRC26
leucine rich repeat containing 26
chr14_-_104706159 0.801 NM_002226
NM_145159
JAG2

jagged 2

chr21_-_45786709 0.799 NM_194255
SLC19A1
solute carrier family 19 (folate transporter), member 1
chr9_+_94898346 0.798 C9orf89
chromosome 9 open reading frame 89

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.49 5.87e-22 GO:0007399 nervous system development
1.40 1.38e-20 GO:0030154 cell differentiation
1.39 5.30e-20 GO:0048869 cellular developmental process
1.61 9.93e-20 GO:0022008 neurogenesis
1.61 3.26e-18 GO:0048699 generation of neurons
1.16 1.45e-17 GO:0050794 regulation of cellular process
1.57 3.22e-17 GO:0048468 cell development
1.41 4.02e-17 GO:0023051 regulation of signaling
1.43 1.47e-16 GO:0009653 anatomical structure morphogenesis
1.14 1.53e-16 GO:0065007 biological regulation
1.64 6.87e-16 GO:0030182 neuron differentiation
1.75 1.55e-15 GO:0000904 cell morphogenesis involved in differentiation
1.78 7.21e-15 GO:0048812 neuron projection morphogenesis
1.78 1.20e-14 GO:0048667 cell morphogenesis involved in neuron differentiation
1.80 1.33e-14 GO:0007409 axonogenesis
1.14 1.49e-14 GO:0050789 regulation of biological process
1.25 1.80e-14 GO:0007275 multicellular organismal development
1.28 3.49e-14 GO:0048731 system development
1.66 1.41e-13 GO:0048666 neuron development
1.71 1.52e-13 GO:0031175 neuron projection development
1.70 2.14e-13 GO:0032990 cell part morphogenesis
1.22 2.83e-13 GO:0032502 developmental process
1.69 3.65e-13 GO:0048858 cell projection morphogenesis
1.40 5.57e-13 GO:0009966 regulation of signal transduction
1.63 6.48e-13 GO:0000902 cell morphogenesis
1.60 1.24e-12 GO:0032989 cellular component morphogenesis
1.24 1.99e-12 GO:0048856 anatomical structure development
1.29 5.42e-12 GO:0048519 negative regulation of biological process
1.08 7.52e-12 GO:0009987 cellular process
1.44 1.01e-11 GO:0010646 regulation of cell communication
1.81 1.63e-11 GO:0007411 axon guidance
1.57 3.36e-11 GO:0030030 cell projection organization
1.29 4.32e-11 GO:0048523 negative regulation of cellular process
1.44 2.46e-10 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.57 1.23e-08 GO:0007417 central nervous system development
1.23 1.64e-08 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.73 5.01e-08 GO:0048729 tissue morphogenesis
1.19 5.10e-08 GO:0031323 regulation of cellular metabolic process
1.22 1.36e-07 GO:0051171 regulation of nitrogen compound metabolic process
1.54 1.45e-07 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.22 1.58e-07 GO:0010468 regulation of gene expression
1.18 1.64e-07 GO:0080090 regulation of primary metabolic process
1.49 2.40e-07 GO:0009887 organ morphogenesis
1.81 2.41e-07 GO:0002009 morphogenesis of an epithelium
1.27 2.52e-07 GO:0048583 regulation of response to stimulus
1.24 4.22e-07 GO:0051252 regulation of RNA metabolic process
1.46 5.37e-07 GO:0051254 positive regulation of RNA metabolic process
1.22 5.48e-07 GO:0048522 positive regulation of cellular process
1.47 6.21e-07 GO:0045893 positive regulation of transcription, DNA-dependent
1.62 6.29e-07 GO:0048598 embryonic morphogenesis
1.58 6.96e-07 GO:0009968 negative regulation of signal transduction
1.46 8.16e-07 GO:0007167 enzyme linked receptor protein signaling pathway
1.45 8.76e-07 GO:0010628 positive regulation of gene expression
1.56 9.19e-07 GO:0023057 negative regulation of signaling
1.97 9.39e-07 GO:0060562 epithelial tube morphogenesis
1.55 1.14e-06 GO:0010648 negative regulation of cell communication
1.86 1.32e-06 GO:0035239 tube morphogenesis
1.39 1.46e-06 GO:0009888 tissue development
1.16 3.32e-06 GO:0019222 regulation of metabolic process
1.16 4.23e-06 GO:0023052 signaling
1.68 5.01e-06 GO:0035295 tube development
1.20 7.08e-06 GO:0031326 regulation of cellular biosynthetic process
1.20 8.15e-06 GO:0009889 regulation of biosynthetic process
1.42 8.81e-06 GO:0009790 embryo development
1.24 9.80e-06 GO:0048513 organ development
1.20 1.01e-05 GO:0071842 cellular component organization at cellular level
1.22 1.03e-05 GO:0006355 regulation of transcription, DNA-dependent
1.44 1.17e-05 GO:0010629 negative regulation of gene expression
1.41 1.27e-05 GO:0009890 negative regulation of biosynthetic process
1.17 1.35e-05 GO:0060255 regulation of macromolecule metabolic process
1.19 1.51e-05 GO:0048518 positive regulation of biological process
1.46 2.17e-05 GO:0045892 negative regulation of transcription, DNA-dependent
1.49 2.21e-05 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.43 2.22e-05 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.46 2.31e-05 GO:0051253 negative regulation of RNA metabolic process
2.20 2.80e-05 GO:0021915 neural tube development
1.20 3.19e-05 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.56 3.66e-05 GO:0007420 brain development
1.40 3.67e-05 GO:0031327 negative regulation of cellular biosynthetic process
1.42 4.13e-05 GO:0051172 negative regulation of nitrogen compound metabolic process
1.41 4.50e-05 GO:0010558 negative regulation of macromolecule biosynthetic process
1.16 5.92e-05 GO:0016043 cellular component organization
1.46 6.54e-05 GO:0048585 negative regulation of response to stimulus
1.75 6.64e-05 GO:0032582 negative regulation of gene-specific transcription
2.71 6.74e-05 GO:0001843 neural tube closure
1.58 7.47e-05 GO:0060284 regulation of cell development
1.56 8.21e-05 GO:0007389 pattern specification process
1.34 9.85e-05 GO:0006351 transcription, DNA-dependent
1.36 9.90e-05 GO:0051173 positive regulation of nitrogen compound metabolic process
1.51 1.04e-04 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.19 1.04e-04 GO:0010556 regulation of macromolecule biosynthetic process
1.49 1.09e-04 GO:0032583 regulation of gene-specific transcription
1.41 1.33e-04 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.36 1.39e-04 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.52 1.53e-04 GO:0060429 epithelium development
2.64 1.57e-04 GO:0060606 tube closure
1.36 1.68e-04 GO:0010557 positive regulation of macromolecule biosynthetic process
1.16 2.08e-04 GO:0007165 signal transduction
1.27 2.14e-04 GO:0051239 regulation of multicellular organismal process
1.46 2.21e-04 GO:0048646 anatomical structure formation involved in morphogenesis
1.60 2.28e-04 GO:0051960 regulation of nervous system development
1.44 2.54e-04 GO:0006935 chemotaxis
1.44 2.54e-04 GO:0042330 taxis
1.52 2.57e-04 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
2.13 2.98e-04 GO:0021953 central nervous system neuron differentiation
2.57 3.46e-04 GO:0014020 primary neural tube formation
1.51 3.62e-04 GO:0009792 embryo development ending in birth or egg hatching
1.55 3.70e-04 GO:0001501 skeletal system development
1.32 4.35e-04 GO:0050793 regulation of developmental process
1.50 4.55e-04 GO:0051056 regulation of small GTPase mediated signal transduction
1.17 5.00e-04 GO:0071841 cellular component organization or biogenesis at cellular level
1.37 5.07e-04 GO:0045595 regulation of cell differentiation
1.65 5.30e-04 GO:0048011 nerve growth factor receptor signaling pathway
1.50 5.72e-04 GO:0043009 chordate embryonic development
1.94 5.97e-04 GO:0048736 appendage development
1.94 5.97e-04 GO:0060173 limb development
1.77 6.42e-04 GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter
2.05 7.03e-04 GO:0060828 regulation of canonical Wnt receptor signaling pathway
2.39 7.42e-04 GO:0001841 neural tube formation
1.32 7.76e-04 GO:0040011 locomotion
1.21 7.96e-04 GO:0007166 cell surface receptor linked signaling pathway
2.11 8.46e-04 GO:0016331 morphogenesis of embryonic epithelium
2.25 9.05e-04 GO:0001838 embryonic epithelial tube formation
1.32 9.71e-04 GO:0031328 positive regulation of cellular biosynthetic process
1.13 1.08e-03 GO:0051716 cellular response to stimulus
1.60 1.38e-03 GO:0050767 regulation of neurogenesis
1.29 1.55e-03 GO:0042127 regulation of cell proliferation
2.21 1.57e-03 GO:0072175 epithelial tube formation
1.19 1.70e-03 GO:0065008 regulation of biological quality
1.18 1.74e-03 GO:0042221 response to chemical stimulus
1.98 1.94e-03 GO:0030326 embryonic limb morphogenesis
1.98 1.94e-03 GO:0035113 embryonic appendage morphogenesis
1.31 2.07e-03 GO:0009891 positive regulation of biosynthetic process
1.30 2.63e-03 GO:0010605 negative regulation of macromolecule metabolic process
1.80 2.79e-03 GO:0030111 regulation of Wnt receptor signaling pathway
1.90 3.01e-03 GO:0035107 appendage morphogenesis
1.90 3.01e-03 GO:0035108 limb morphogenesis
1.33 3.12e-03 GO:2000026 regulation of multicellular organismal development
1.14 3.55e-03 GO:0071840 cellular component organization or biogenesis
1.28 4.53e-03 GO:0009892 negative regulation of metabolic process
1.70 6.58e-03 GO:0006813 potassium ion transport
1.23 7.15e-03 GO:0035556 intracellular signal transduction
2.11 7.33e-03 GO:0035148 tube formation
1.42 8.18e-03 GO:0008285 negative regulation of cell proliferation
1.86 8.28e-03 GO:0010720 positive regulation of cell development
1.27 8.91e-03 GO:0032774 RNA biosynthetic process
1.13 9.15e-03 GO:0051179 localization
1.56 9.19e-03 GO:0040007 growth
1.23 1.22e-02 GO:0009893 positive regulation of metabolic process
1.75 1.25e-02 GO:0048705 skeletal system morphogenesis
1.24 1.28e-02 GO:0031325 positive regulation of cellular metabolic process
1.26 1.75e-02 GO:0009605 response to external stimulus
1.27 1.84e-02 GO:0031324 negative regulation of cellular metabolic process
1.29 2.09e-02 GO:0051128 regulation of cellular component organization
2.01 2.18e-02 GO:0001657 ureteric bud development
1.98 2.51e-02 GO:0010721 negative regulation of cell development
1.24 2.63e-02 GO:0010604 positive regulation of macromolecule metabolic process
1.47 2.71e-02 GO:0022603 regulation of anatomical structure morphogenesis
2.09 2.75e-02 GO:0050768 negative regulation of neurogenesis
1.53 2.89e-02 GO:0003002 regionalization
1.73 2.91e-02 GO:0010769 regulation of cell morphogenesis involved in differentiation
1.36 3.45e-02 GO:0019226 transmission of nerve impulse
1.36 3.45e-02 GO:0035637 multicellular organismal signaling
1.72 3.91e-02 GO:0022604 regulation of cell morphogenesis
1.61 4.13e-02 GO:0030900 forebrain development
1.13 4.39e-02 GO:0051234 establishment of localization
1.56 4.63e-02 GO:0045664 regulation of neuron differentiation
1.90 4.68e-02 GO:0030178 negative regulation of Wnt receptor signaling pathway
1.47 4.88e-02 GO:0051270 regulation of cellular component movement

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.08 1.45e-13 GO:0044424 intracellular part
1.08 7.29e-13 GO:0005622 intracellular
1.58 8.79e-08 GO:0045202 synapse
1.09 1.47e-07 GO:0005737 cytoplasm
1.07 8.80e-07 GO:0043226 organelle
1.08 1.34e-06 GO:0043227 membrane-bounded organelle
1.07 1.65e-06 GO:0043229 intracellular organelle
1.08 1.92e-06 GO:0043231 intracellular membrane-bounded organelle
1.03 2.09e-06 GO:0044464 cell part
1.03 2.25e-06 GO:0005623 cell
1.11 1.79e-05 GO:0005634 nucleus
1.55 6.66e-05 GO:0044456 synapse part
1.35 9.00e-04 GO:0030054 cell junction
1.43 9.79e-04 GO:0043005 neuron projection
1.18 1.06e-03 GO:0005829 cytosol
1.09 1.76e-03 GO:0044444 cytoplasmic part
1.50 4.92e-03 GO:0005667 transcription factor complex
1.58 8.60e-03 GO:0044297 cell body
1.58 1.12e-02 GO:0043025 neuronal cell body
1.20 1.20e-02 GO:0005654 nucleoplasm
1.17 1.51e-02 GO:0031981 nuclear lumen
1.14 4.84e-02 GO:0044459 plasma membrane part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.48 1.12e-14 GO:0030528 transcription regulator activity
1.43 4.95e-11 GO:0001071 nucleic acid binding transcription factor activity
1.43 4.95e-11 GO:0003700 sequence-specific DNA binding transcription factor activity
1.46 2.03e-08 GO:0043565 sequence-specific DNA binding
1.66 6.03e-08 GO:0016563 transcription activator activity
1.06 1.80e-07 GO:0005488 binding
1.81 3.90e-07 GO:0010843 promoter binding
1.51 7.81e-07 GO:0030695 GTPase regulator activity
1.78 8.28e-07 GO:0000975 regulatory region DNA binding
1.78 8.28e-07 GO:0001067 regulatory region nucleic acid binding
1.78 8.28e-07 GO:0044212 transcription regulatory region DNA binding
1.10 1.73e-06 GO:0005515 protein binding
1.48 4.36e-06 GO:0060589 nucleoside-triphosphatase regulator activity
1.71 5.67e-05 GO:0005244 voltage-gated ion channel activity
1.71 5.67e-05 GO:0022832 voltage-gated channel activity
1.76 5.01e-04 GO:0022843 voltage-gated cation channel activity
1.17 8.06e-04 GO:0003677 DNA binding
1.93 8.53e-04 GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
1.41 1.08e-03 GO:0019904 protein domain specific binding
1.54 1.60e-03 GO:0005096 GTPase activator activity
1.95 1.79e-03 GO:0003705 sequence-specific enhancer binding RNA polymerase II transcription factor activity
1.47 3.28e-03 GO:0016564 transcription repressor activity
1.85 3.79e-03 GO:0016566 specific transcriptional repressor activity
1.87 6.19e-03 GO:0003704 specific RNA polymerase II transcription factor activity
1.71 1.04e-02 GO:0005267 potassium channel activity
1.49 1.12e-02 GO:0003702 RNA polymerase II transcription factor activity
1.44 1.23e-02 GO:0022836 gated channel activity
1.79 1.39e-02 GO:0005249 voltage-gated potassium channel activity
1.44 2.21e-02 GO:0005083 small GTPase regulator activity
1.45 2.92e-02 GO:0005261 cation channel activity
1.42 4.32e-02 GO:0008134 transcription factor binding
1.23 4.36e-02 GO:0022857 transmembrane transporter activity