Motif ID: NRF1.p2

Z-value: 3.239


Transcription factors associated with NRF1.p2:

Gene SymbolEntrez IDGene Name
NRF1 4899 nuclear respiratory factor 1



Activity profile for motif NRF1.p2.

activity profile for motif NRF1.p2


Sorted Z-values histogram for motif NRF1.p2

Sorted Z-values for motif NRF1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NRF1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_254742 6.373 SH3YL1
SH3 domain containing, Ysc84-like 1 (S. cerevisiae)
chr20_+_48781457 6.043 NM_032521
PARD6B
par-6 partitioning defective 6 homolog beta (C. elegans)
chr2_+_254843 5.374 NM_001040649
NM_004300
NM_007099
ACP1


acid phosphatase 1, soluble


chr2_+_118562499 5.080 NM_016133
INSIG2
insulin induced gene 2
chr12_+_105873803 4.864 C12orf23
chromosome 12 open reading frame 23
chr1_+_227473638 4.741 RAB4A
RAB4A, member RAS oncogene family
chr2_+_28828112 4.537 NM_206876
NM_002709
PPP1CB

protein phosphatase 1, catalytic subunit, beta isozyme

chr12_+_105873669 4.450 NM_152261
C12orf23
chromosome 12 open reading frame 23
chr6_+_41148869 4.266 NFYA
nuclear transcription factor Y, alpha
chr15_+_22751162 4.240 NM_003097
NM_022804
NM_005678
SNRPN
SNURF

small nuclear ribonucleoprotein polypeptide N
SNRPN upstream reading frame

chr5_+_52131686 4.131 PELO
pelota homolog (Drosophila)
chr9_+_109085337 4.129 NM_002874
RAD23B
RAD23 homolog B (S. cerevisiae)
chr14_+_22633728 4.108 C14orf119
chromosome 14 open reading frame 119
chr1_+_227473458 4.018 NM_004578
RAB4A
RAB4A, member RAS oncogene family
chr9_+_109085372 3.993 RAD23B
RAD23 homolog B (S. cerevisiae)
chr21_+_33619147 3.830 IFNAR1
interferon (alpha, beta and omega) receptor 1
chr9_+_109085386 3.810 RAD23B
RAD23 homolog B (S. cerevisiae)
chr2_+_71412348 3.717 NM_001014972
NM_014497
ZNF638

zinc finger protein 638

chr5_+_72287625 3.703


chr20_+_39091026 3.660 TOP1
topoisomerase (DNA) I
chr5_+_271355 3.621 NM_004168
SDHA
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
chr5_+_271447 3.616 SDHA
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
chr3_+_73128771 3.541 NM_174907
PPP4R2
protein phosphatase 4, regulatory subunit 2
chr20_+_11819364 3.514 NM_181443
BTBD3
BTB (POZ) domain containing 3
chr20_+_39090875 3.492 NM_003286
TOP1
topoisomerase (DNA) I
chr5_+_271428 3.490 SDHA
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
chr5_-_271235 3.489 NM_145265
CCDC127
coiled-coil domain containing 127
chr2_+_42249896 3.417 NM_001145076
NM_019063
EML4

echinoderm microtubule associated protein like 4

chr5_+_271441 3.403 SDHA
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
chr6_-_163754903 3.385 LOC100526820
hypothetical LOC100526820
chr4_+_6726555 3.368 LOC93622
hypothetical LOC93622
chr3_+_73128629 3.362 PPP4R2
protein phosphatase 4, regulatory subunit 2
chr3_+_43303005 3.361 NM_001100594
NM_017719
SNRK

SNF related kinase

chr1_+_165456572 3.309 NM_001198786
NM_002697
POU2F1

POU class 2 homeobox 1

chr3_+_73128667 3.238 PPP4R2
protein phosphatase 4, regulatory subunit 2
chr21_+_46880017 3.235 PRMT2
protein arginine methyltransferase 2
chr3_+_139388770 3.230 NM_014154
NM_015396
NM_213654
ARMC8


armadillo repeat containing 8


chr21_+_46879954 3.196 NM_001535
NM_206962
PRMT2

protein arginine methyltransferase 2

chr20_+_25124333 3.127 NM_001114089
NM_001247
ENTPD6

ectonucleoside triphosphate diphosphohydrolase 6 (putative)

chr2_+_86521781 3.107 NM_018433
KDM3A
lysine (K)-specific demethylase 3A
chr5_+_72287630 3.061 FCHO2
FCH domain only 2
chr6_+_44463265 3.049 NM_001253
CDC5L
CDC5 cell division cycle 5-like (S. pombe)
chr21_+_46880013 3.037 PRMT2
protein arginine methyltransferase 2
chr15_+_39739864 3.031 NM_001080541
NM_001164273
MGA

MAX gene associated

chr3_-_151803639 3.015 SERP1
stress-associated endoplasmic reticulum protein 1
chr11_+_66643311 3.001 NM_012308
KDM2A
lysine (K)-specific demethylase 2A
chr12_-_52960168 2.972 NM_012117
CBX5
chromobox homolog 5
chr6_+_44463418 2.960 CDC5L
CDC5 cell division cycle 5-like (S. pombe)
chr16_+_83291107 2.948 USP10
ubiquitin specific peptidase 10
chr3_+_151803755 2.938 NM_016275
SELT
selenoprotein T
chr16_+_83291055 2.900 NM_005153
USP10
ubiquitin specific peptidase 10
chr5_+_72287509 2.894 NM_001146032
NM_138782
FCHO2

FCH domain only 2

chr16_+_83291097 2.891 USP10
ubiquitin specific peptidase 10
chr21_+_37367432 2.864 NM_001001894
TTC3
tetratricopeptide repeat domain 3
chr12_-_52960146 2.807 CBX5
chromobox homolog 5
chr15_+_39739933 2.799 MGA
MAX gene associated
chr16_+_83291112 2.794 USP10
ubiquitin specific peptidase 10
chr2_+_196230096 2.770 NM_020342
SLC39A10
solute carrier family 39 (zinc transporter), member 10
chr10_+_59698891 2.770 NM_018464
CISD1
CDGSH iron sulfur domain 1
chr14_-_22634134 2.721 ACIN1
apoptotic chromatin condensation inducer 1
chr1_+_35507197 2.696 ZMYM4
zinc finger, MYM-type 4
chr6_+_41148691 2.695 NFYA
nuclear transcription factor Y, alpha
chr5_+_112340326 2.683 NM_152624
DCP2
DCP2 decapping enzyme homolog (S. cerevisiae)
chr21_+_33619067 2.683 NM_000629
IFNAR1
interferon (alpha, beta and omega) receptor 1
chr1_+_148603208 2.661 RPRD2
regulation of nuclear pre-mRNA domain containing 2
chr2_+_138975946 2.660


chr3_+_196870122 2.657 SDHAP2
succinate dehydrogenase complex, subunit A, flavoprotein pseudogene 2
chr8_+_28407613 2.636 NM_017412
FZD3
frizzled homolog 3 (Drosophila)
chr9_+_109085643 2.618 RAD23B
RAD23 homolog B (S. cerevisiae)
chr12_-_123023052 2.617 NM_025140
CCDC92
coiled-coil domain containing 92
chr12_-_52960206 2.587 CBX5
chromobox homolog 5
chr12_-_123023312 2.550 CCDC92
coiled-coil domain containing 92
chr5_+_138706029 2.533 NM_001033112
PAIP2
poly(A) binding protein interacting protein 2
chr2_+_86186815 2.486 NM_017952
PTCD3
Pentatricopeptide repeat domain 3
chr9_+_113433364 2.482 NM_001015882
NM_004125
DNAJC25
DNAJC25-GNG10
DnaJ (Hsp40) homolog, subfamily C , member 25
DNAJC25-GNG10 readthrough
chr2_+_69910424 2.476 GMCL1
germ cell-less homolog 1 (Drosophila)
chr16_+_73739890 2.472 NM_153688
ZFP1
zinc finger protein 1 homolog (mouse)
chr17_+_32924090 2.471 DUSP14
dual specificity phosphatase 14
chr20_+_55359706 2.469 RAE1
RAE1 RNA export 1 homolog (S. pombe)
chr12_+_129922510 2.443 NM_006325
RAN
RAN, member RAS oncogene family
chr2_+_98427737 2.443 NM_001134224
NM_001134225
NM_001566
NM_004027
INPP4A



inositol polyphosphate-4-phosphatase, type I, 107kDa



chr17_+_55325224 2.433 NM_003161
RPS6KB1
ribosomal protein S6 kinase, 70kDa, polypeptide 1
chr6_-_41148061 2.431 NM_145063
C6orf130
chromosome 6 open reading frame 130
chr9_+_70584739 2.427 NM_138333
FAM122A
family with sequence similarity 122A
chr16_+_14634168 2.404 NM_016561
BFAR
bifunctional apoptosis regulator
chr12_+_123023521 2.397 NM_152437
ZNF664
zinc finger protein 664
chr17_+_32924049 2.395 NM_007026
DUSP14
dual specificity phosphatase 14
chr2_-_86186788 2.378 NM_015425
POLR1A
polymerase (RNA) I polypeptide A, 194kDa
chr20_+_55359551 2.367 NM_003610
RAE1
RAE1 RNA export 1 homolog (S. pombe)
chr4_+_6726699 2.360 LOC93622
hypothetical LOC93622
chr17_+_55325268 2.343 RPS6KB1
ribosomal protein S6 kinase, 70kDa, polypeptide 1
chr6_+_237033 2.296 NM_020185
DUSP22
dual specificity phosphatase 22
chr3_+_113180517 2.294 NM_018394
ABHD10
abhydrolase domain containing 10
chr6_+_41148665 2.279 NM_002505
NM_021705
NFYA

nuclear transcription factor Y, alpha

chr2_+_131966970 2.269 LOC150776
sphingomyelin phosphodiesterase 4, neutral membrane pseudogene
chr17_+_32924110 2.253 DUSP14
dual specificity phosphatase 14
chr2_+_190234369 2.251 NM_019048
ASNSD1
asparagine synthetase domain containing 1
chr12_+_52960798 2.245 HNRNPA1L2
HNRNPA1
HNRNPA1P10
heterogeneous nuclear ribonucleoprotein A1-like 2
heterogeneous nuclear ribonucleoprotein A1
heterogeneous nuclear ribonucleoprotein A1 pseudogene 10
chr9_+_37069984 2.243 LOC100506710
hypothetical LOC100506710
chr10_-_127501683 2.232 UROS
uroporphyrinogen III synthase
chr12_+_129922570 2.223 RAN
RAN, member RAS oncogene family
chr17_-_55324859 2.216 NM_001193609
NM_001193610
NM_001193611
NM_001193612
NM_001193613
NM_016261
TUBD1





tubulin, delta 1





chr16_-_80761281 2.216 NM_005792
MPHOSPH6
M-phase phosphoprotein 6
chr9_+_114182216 2.188 HSDL2
hydroxysteroid dehydrogenase like 2
chr3_+_196870099 2.185 SDHAP2
succinate dehydrogenase complex, subunit A, flavoprotein pseudogene 2
chr19_-_5573725 2.174 SAFB2
scaffold attachment factor B2
chr16_+_14634324 2.166 BFAR
bifunctional apoptosis regulator
chr21_-_37367259 2.163 NM_153682
PIGP
phosphatidylinositol glycan anchor biosynthesis, class P
chr6_+_2710560 2.161 WRNIP1
Werner helicase interacting protein 1
chr20_+_25124457 2.144 ENTPD6
ectonucleoside triphosphate diphosphohydrolase 6 (putative)
chr20_+_55359992 2.139 NM_001015885
RAE1
RAE1 RNA export 1 homolog (S. pombe)
chr2_+_26110487 2.135 RAB10
RAB10, member RAS oncogene family
chr13_+_36291306 2.127 NM_000538
RFXAP
regulatory factor X-associated protein
chr2_+_26110232 2.107 NM_016131
RAB10
RAB10, member RAS oncogene family
chr3_+_180348818 2.086 NM_006218
PIK3CA
phosphoinositide-3-kinase, catalytic, alpha polypeptide
chr14_+_99507848 2.065 EVL
Enah/Vasp-like
chr4_+_146238936 2.063 ABCE1
ATP-binding cassette, sub-family E (OABP), member 1
chr3_+_37259684 2.040 NM_001172713
NM_002078
GOLGA4

golgin A4

chr19_-_5573794 2.036 NM_014649
SAFB2
scaffold attachment factor B2
chr3_+_15222747 2.036 CAPN7
calpain 7
chr2_+_54638957 2.035 NM_178313
SPTBN1
spectrin, beta, non-erythrocytic 1
chr7_+_107318852 2.028 DLD
dihydrolipoamide dehydrogenase
chr7_+_107318854 2.025 DLD
dihydrolipoamide dehydrogenase
chr2_-_207338247 2.024 NM_001039845
MDH1B
malate dehydrogenase 1B, NAD (soluble)
chr2_+_207338356 2.021 NM_001136193
NM_001136194
NM_014929
FASTKD2


FAST kinase domains 2


chr3_+_49702018 2.011 RNF123
ring finger protein 123
chr6_+_2710602 2.008 NM_020135
NM_130395
WRNIP1

Werner helicase interacting protein 1

chr21_+_39674112 1.999 WRB
tryptophan rich basic protein
chr16_+_31098931 1.998 NM_001170634
NM_001170937
NM_004960
FUS


fused in sarcoma


chr2_+_69910277 1.992 NM_178439
GMCL1
germ cell-less homolog 1 (Drosophila)
chr21_+_39674138 1.983 WRB
tryptophan rich basic protein
chr20_-_13713509 1.980 NM_016649
ESF1
ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)
chr9_+_114182009 1.979 NM_001195822
NM_032303
HSDL2

hydroxysteroid dehydrogenase like 2

chr2_+_28828332 1.953 PPP1CB
protein phosphatase 1, catalytic subunit, beta isozyme
chr7_+_107318821 1.949 NM_000108
DLD
dihydrolipoamide dehydrogenase
chr11_+_63205444 1.946 NM_006054
NM_201428
NM_201429
NM_201430
RTN3



reticulon 3



chr10_+_27833167 1.932 NM_021252
RAB18
RAB18, member RAS oncogene family
chr18_+_10516022 1.932 NAPG
N-ethylmaleimide-sensitive factor attachment protein, gamma
chr17_+_46692908 1.924 UTP18
UTP18, small subunit (SSU) processome component, homolog (yeast)
chr7_-_116854765 1.924 NM_130768
ASZ1
ankyrin repeat, SAM and basic leucine zipper domain containing 1
chr7_+_107171514 1.924 NM_024814
CBLL1
Cas-Br-M (murine) ecotropic retroviral transforming sequence-like 1
chr5_+_112071087 1.922 NM_001127511
APC
adenomatous polyposis coli
chr16_+_31098959 1.919 FUS
fused in sarcoma
chr10_+_133995587 1.918 NM_001143758
NM_001143759
NM_030626
LRRC27


leucine rich repeat containing 27


chr9_+_90193058 1.914 NM_006717
SPIN1
spindlin 1
chr5_+_79739548 1.906 NM_001105251
NM_014733
ZFYVE16

zinc finger, FYVE domain containing 16

chr4_+_141514187 1.903 SCOC
short coiled-coil protein
chr7_+_107997527 1.898 DNAJB9
DnaJ (Hsp40) homolog, subfamily B, member 9
chr5_+_154218389 1.897 NM_004779
CNOT8
CCR4-NOT transcription complex, subunit 8
chr10_-_127501822 1.891 NM_000375
UROS
uroporphyrinogen III synthase
chr3_+_49701978 1.891 NM_022064
RNF123
ring finger protein 123
chr2_+_241904013 1.889 SEPT2
septin 2
chr17_+_46692891 1.888 NM_016001
UTP18
UTP18, small subunit (SSU) processome component, homolog (yeast)
chr16_+_31098962 1.886 FUS
fused in sarcoma
chr21_+_39674082 1.885 NM_004627
WRB
tryptophan rich basic protein
chr22_-_26645150 1.885 PITPNB
phosphatidylinositol transfer protein, beta
chr22_-_26645202 1.883 PITPNB
phosphatidylinositol transfer protein, beta
chr7_+_107997544 1.878 NM_012328
DNAJB9
DnaJ (Hsp40) homolog, subfamily B, member 9
chr7_+_158341961 1.877 NM_018051
WDR60
WD repeat domain 60
chr22_-_26645214 1.875 NM_012399
PITPNB
phosphatidylinositol transfer protein, beta
chr9_+_45331898 1.870 LOC100132167
hypothetical LOC100132167
chr2_+_216682251 1.863 NM_021141
XRCC5
X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
chr6_+_13682628 1.853 NM_001193267
NM_031244
NM_012241
SIRT5


sirtuin 5


chr2_+_131579334 1.849 PLEKHB2
pleckstrin homology domain containing, family B (evectins) member 2
chr8_-_125555933 1.848


chr4_+_141514251 1.845 SCOC
short coiled-coil protein
chr3_+_43707362 1.832 NM_016006
ABHD5
abhydrolase domain containing 5
chr12_+_68418829 1.832 NM_022456
NM_175624
RAB3IP

RAB3A interacting protein (rabin3)

chr17_+_42963737 1.823 NPEPPS
aminopeptidase puromycin sensitive
chr18_+_46810598 1.816 SMAD4
SMAD family member 4
chr8_+_42368550 1.810 VDAC3
voltage-dependent anion channel 3
chr10_+_105716925 1.810 SLK
STE20-like kinase
chr20_+_41519947 1.806 SRSF6
serine/arginine-rich splicing factor 6
chr2_+_242679507 1.798 LOC728323
hypothetical LOC728323
chr2_+_241904024 1.793 SEPT2
septin 2
chr21_-_37366684 1.787 NM_153681
PIGP
phosphatidylinositol glycan anchor biosynthesis, class P
chr7_+_116289833 1.785 CAPZA2
capping protein (actin filament) muscle Z-line, alpha 2
chr16_+_8622974 1.777 NM_024109
METTL22
methyltransferase like 22
chr2_+_241903943 1.769 NM_001008492
NM_004404
SEPT2

septin 2

chr2_+_241904038 1.762 SEPT2
septin 2
chr16_+_31098963 1.748 FUS
fused in sarcoma
chr22_-_21814208 1.748 NM_014433
RTDR1
rhabdoid tumor deletion region gene 1
chr8_-_125555989 1.740


chr3_+_49701965 1.737 RNF123
ring finger protein 123
chr17_+_30331579 1.736 NM_002311
NM_013975
LIG3

ligase III, DNA, ATP-dependent

chr8_+_42368533 1.731 VDAC3
voltage-dependent anion channel 3
chr2_+_196229715 1.724 NM_001127257
SLC39A10
solute carrier family 39 (zinc transporter), member 10
chr17_+_42963636 1.724 NPEPPS
aminopeptidase puromycin sensitive
chr11_+_64857921 1.714 NM_006268
DPF2
D4, zinc and double PHD fingers family 2
chr16_+_31098971 1.708 FUS
fused in sarcoma
chr9_+_99214000 1.707 NM_014290
TDRD7
tudor domain containing 7
chr2_-_241903787 1.703 HDLBP
high density lipoprotein binding protein
chr12_+_52960745 1.702 NM_002136
NM_031157
HNRNPA1

heterogeneous nuclear ribonucleoprotein A1

chr15_-_66900266 1.701 ANP32A
acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
chr18_+_10515861 1.701 NM_003826
NAPG
N-ethylmaleimide-sensitive factor attachment protein, gamma
chr11_+_75833707 1.697 NM_020193
C11orf30
chromosome 11 open reading frame 30
chr18_+_10516044 1.694 NAPG
N-ethylmaleimide-sensitive factor attachment protein, gamma
chr7_+_116289827 1.693 CAPZA2
capping protein (actin filament) muscle Z-line, alpha 2
chr4_+_25931745 1.685 RBPJ
recombination signal binding protein for immunoglobulin kappa J region
chr4_+_146238818 1.685 ABCE1
ATP-binding cassette, sub-family E (OABP), member 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.48 1.08e-28 GO:0044260 cellular macromolecule metabolic process
1.33 2.57e-23 GO:0044237 cellular metabolic process
1.38 4.81e-21 GO:0043170 macromolecule metabolic process
1.60 4.49e-18 GO:0090304 nucleic acid metabolic process
1.51 1.60e-17 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.28 3.30e-17 GO:0044238 primary metabolic process
1.25 1.23e-16 GO:0008152 metabolic process
1.43 1.55e-14 GO:0034641 cellular nitrogen compound metabolic process
1.41 1.09e-13 GO:0006807 nitrogen compound metabolic process
1.58 9.09e-12 GO:0006996 organelle organization
1.54 1.28e-11 GO:0010467 gene expression
1.45 1.50e-11 GO:0044267 cellular protein metabolic process
2.00 1.58e-11 GO:0051276 chromosome organization
1.97 3.94e-11 GO:0006396 RNA processing
1.54 1.09e-10 GO:0016070 RNA metabolic process
1.39 1.97e-09 GO:0071841 cellular component organization or biogenesis at cellular level
1.98 2.81e-09 GO:0016071 mRNA metabolic process
1.38 1.10e-08 GO:0071842 cellular component organization at cellular level
1.97 1.72e-08 GO:0006974 response to DNA damage stimulus
2.26 4.22e-08 GO:0008380 RNA splicing
1.99 4.30e-08 GO:0006325 chromatin organization
1.87 6.10e-08 GO:0006259 DNA metabolic process
2.08 8.46e-08 GO:0006397 mRNA processing
2.16 9.66e-08 GO:0006281 DNA repair
1.70 1.51e-07 GO:0033554 cellular response to stress
2.50 2.74e-07 GO:0000375 RNA splicing, via transesterification reactions
1.32 7.23e-07 GO:0019538 protein metabolic process
2.47 9.51e-07 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
2.47 9.51e-07 GO:0000398 nuclear mRNA splicing, via spliceosome
1.10 1.01e-06 GO:0009987 cellular process
1.44 3.47e-06 GO:0034645 cellular macromolecule biosynthetic process
1.43 6.70e-06 GO:0009059 macromolecule biosynthetic process
1.26 6.37e-05 GO:0071840 cellular component organization or biogenesis
1.82 1.35e-04 GO:0000279 M phase
1.25 1.57e-04 GO:0016043 cellular component organization
1.58 2.29e-04 GO:0046907 intracellular transport
1.88 2.36e-04 GO:0034622 cellular macromolecular complex assembly
1.88 2.48e-04 GO:0044419 interspecies interaction between organisms
1.75 2.53e-04 GO:0034621 cellular macromolecular complex subunit organization
1.72 2.84e-04 GO:0044265 cellular macromolecule catabolic process
1.94 4.55e-04 GO:0006412 translation
1.48 4.57e-04 GO:0008104 protein localization
2.43 4.87e-04 GO:0006310 DNA recombination
1.34 6.20e-04 GO:0043412 macromolecule modification
3.05 8.27e-04 GO:0006302 double-strand break repair
1.29 8.40e-04 GO:0044249 cellular biosynthetic process
1.62 1.19e-03 GO:0009057 macromolecule catabolic process
1.55 1.54e-03 GO:0071844 cellular component assembly at cellular level
1.58 1.65e-03 GO:0022403 cell cycle phase
1.80 2.07e-03 GO:0016568 chromatin modification
2.33 2.18e-03 GO:0006333 chromatin assembly or disassembly
1.81 2.34e-03 GO:0051301 cell division
1.50 2.40e-03 GO:0045184 establishment of protein localization
1.33 2.47e-03 GO:0006464 protein modification process
1.27 2.48e-03 GO:0009058 biosynthetic process
1.41 5.02e-03 GO:0044248 cellular catabolic process
1.40 6.11e-03 GO:0044085 cellular component biogenesis
1.48 6.91e-03 GO:0015031 protein transport
1.38 7.65e-03 GO:0033036 macromolecule localization
2.87 7.77e-03 GO:0006200 ATP catabolic process
1.71 8.46e-03 GO:0016032 viral reproduction
1.90 9.49e-03 GO:0016567 protein ubiquitination
1.37 1.43e-02 GO:0051641 cellular localization
1.84 1.78e-02 GO:0032446 protein modification by small protein conjugation
1.72 2.07e-02 GO:0030163 protein catabolic process
2.24 2.28e-02 GO:0046034 ATP metabolic process
1.41 2.46e-02 GO:0007049 cell cycle
2.12 2.48e-02 GO:0000226 microtubule cytoskeleton organization
1.46 2.59e-02 GO:0022402 cell cycle process
1.40 3.16e-02 GO:0022607 cellular component assembly
1.73 3.39e-02 GO:0044257 cellular protein catabolic process
1.82 3.58e-02 GO:0034660 ncRNA metabolic process
1.49 3.80e-02 GO:0065003 macromolecular complex assembly
1.77 4.62e-02 GO:0009199 ribonucleoside triphosphate metabolic process
2.09 4.63e-02 GO:0071103 DNA conformation change

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.23 2.40e-51 GO:0005622 intracellular
1.23 4.95e-48 GO:0044424 intracellular part
1.32 5.91e-45 GO:0043231 intracellular membrane-bounded organelle
1.31 1.20e-44 GO:0043227 membrane-bounded organelle
1.28 3.39e-44 GO:0043229 intracellular organelle
1.27 1.17e-43 GO:0043226 organelle
1.43 4.91e-35 GO:0005634 nucleus
1.37 2.17e-26 GO:0044446 intracellular organelle part
1.36 3.85e-25 GO:0044422 organelle part
1.64 3.80e-22 GO:0044428 nuclear part
1.57 2.81e-18 GO:0070013 intracellular organelle lumen
1.56 3.94e-18 GO:0031974 membrane-enclosed lumen
1.55 1.54e-17 GO:0043233 organelle lumen
1.21 1.79e-17 GO:0005737 cytoplasm
1.62 5.01e-17 GO:0031981 nuclear lumen
1.38 9.93e-15 GO:0032991 macromolecular complex
1.69 4.33e-14 GO:0005654 nucleoplasm
2.02 9.66e-12 GO:0005694 chromosome
1.99 2.89e-10 GO:0030529 ribonucleoprotein complex
1.36 2.78e-09 GO:0043228 non-membrane-bounded organelle
1.36 2.78e-09 GO:0043232 intracellular non-membrane-bounded organelle
1.21 7.54e-09 GO:0044444 cytoplasmic part
1.97 1.34e-08 GO:0044427 chromosomal part
1.05 2.33e-08 GO:0044464 cell part
1.05 2.45e-08 GO:0005623 cell
1.28 5.91e-06 GO:0043234 protein complex
1.34 1.59e-05 GO:0005829 cytosol
1.92 1.90e-05 GO:0005815 microtubule organizing center
2.13 3.19e-05 GO:0005813 centrosome
2.55 5.67e-05 GO:0044455 mitochondrial membrane part
2.06 8.05e-05 GO:0000785 chromatin
1.60 9.42e-05 GO:0015630 microtubule cytoskeleton
1.40 1.40e-04 GO:0005739 mitochondrion
2.40 1.85e-04 GO:0005681 spliceosomal complex
1.53 5.76e-04 GO:0044451 nucleoplasm part
2.11 7.14e-04 GO:0005819 spindle
1.51 1.79e-03 GO:0031967 organelle envelope
1.48 4.14e-03 GO:0031975 envelope
1.50 4.45e-03 GO:0044429 mitochondrial part
2.11 1.17e-02 GO:0000151 ubiquitin ligase complex
2.49 2.83e-02 GO:0016591 DNA-directed RNA polymerase II, holoenzyme
1.93 2.96e-02 GO:0044454 nuclear chromosome part
3.03 4.76e-02 GO:0008287 protein serine/threonine phosphatase complex

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.25 4.99e-18 GO:0005515 protein binding
1.40 1.11e-14 GO:0003676 nucleic acid binding
1.12 6.18e-13 GO:0005488 binding
1.79 5.15e-11 GO:0003723 RNA binding
1.20 2.35e-06 GO:0003824 catalytic activity
1.34 4.08e-06 GO:0000166 nucleotide binding
1.31 6.11e-05 GO:0003677 DNA binding
1.30 1.48e-03 GO:0017076 purine nucleotide binding
1.31 1.51e-03 GO:0035639 purine ribonucleoside triphosphate binding
1.83 1.68e-03 GO:0016879 ligase activity, forming carbon-nitrogen bonds
1.65 2.18e-03 GO:0016874 ligase activity
1.29 2.73e-03 GO:0032553 ribonucleotide binding
1.29 2.73e-03 GO:0032555 purine ribonucleotide binding
1.83 5.37e-03 GO:0016881 acid-amino acid ligase activity
2.13 5.67e-03 GO:0004518 nuclease activity
2.96 6.02e-03 GO:0003697 single-stranded DNA binding
1.46 6.21e-03 GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
1.46 7.54e-03 GO:0016817 hydrolase activity, acting on acid anhydrides
1.31 7.91e-03 GO:0030554 adenyl nucleotide binding
1.45 8.25e-03 GO:0016462 pyrophosphatase activity
1.31 1.21e-02 GO:0005524 ATP binding
1.45 1.57e-02 GO:0017111 nucleoside-triphosphatase activity
1.30 1.60e-02 GO:0032559 adenyl ribonucleotide binding
2.18 4.95e-02 GO:0016779 nucleotidyltransferase activity