Motif ID: SPZ1.p2

Z-value: 1.104


Transcription factors associated with SPZ1.p2:

Gene SymbolEntrez IDGene Name
SPZ1 84654 spermatogenic leucine zipper 1



Activity profile for motif SPZ1.p2.

activity profile for motif SPZ1.p2


Sorted Z-values histogram for motif SPZ1.p2

Sorted Z-values for motif SPZ1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SPZ1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_-_88190737 1.411 NM_001008390
NM_003663
CGGBP1

CGG triplet repeat binding protein 1

chr9_-_5997891 0.928 NM_001017969
KIAA2026
KIAA2026
chr11_+_12987455 0.782 NM_001080521
RASSF10
Ras association (RalGDS/AF-6) domain family (N-terminal) member 10
chr12_+_50686990 0.782 NM_181711
GRASP
GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein
chr8_+_94998258 0.758 NM_018444
NM_001161780
NM_001161779
NM_001161781
PDP1



pyruvate dehyrogenase phosphatase catalytic subunit 1



chr17_+_31975611 0.735 GGNBP2
gametogenetin binding protein 2
chr12_+_52665196 0.713 NM_017409
HOXC10
homeobox C10
chr13_-_74953873 0.711 NM_014832
TBC1D4
TBC1 domain family, member 4
chr21_+_33844793 0.705 SON
SON DNA binding protein
chr1_-_86394695 0.689 NM_152890
COL24A1
collagen, type XXIV, alpha 1
chr10_-_104587069 0.639 NM_000102
CYP17A1
cytochrome P450, family 17, subfamily A, polypeptide 1
chr11_+_65594361 0.633 NM_018026
PACS1
phosphofurin acidic cluster sorting protein 1
chr12_+_63958949 0.622 NM_001193461
MSRB3
methionine sulfoxide reductase B3
chr13_+_34414390 0.621 NM_015678
NBEA
neurobeachin
chr17_+_35853177 0.571 NM_001552
IGFBP4
insulin-like growth factor binding protein 4
chr20_-_21326046 0.570 NM_033176
NKX2-4
NK2 homeobox 4
chr17_-_24973940 0.565 CORO6
coronin 6
chr17_+_2443983 0.561 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr20_+_20296744 0.555 NM_002196
INSM1
insulinoma-associated 1
chr3_-_18441763 0.541 NM_001195470
NM_002971
SATB1

SATB homeobox 1

chr10_-_103593529 0.534 NM_014591
NM_173191
NM_173192
NM_173193
NM_173195
NM_173197
KCNIP2





Kv channel interacting protein 2





chr7_-_103417198 0.530 NM_005045
NM_173054
RELN

reelin

chr1_-_148249152 0.529 NM_020205
OTUD7B
OTU domain containing 7B
chr3_+_171167243 0.513 NM_003262
SEC62
SEC62 homolog (S. cerevisiae)
chr12_-_22378833 0.508 NM_003034
ST8SIA1
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
chr10_+_89409332 0.506 NM_001015880
NM_004670
PAPSS2

3'-phosphoadenosine 5'-phosphosulfate synthase 2

chr22_-_29113301 0.505 NM_001017981
RNF215
ring finger protein 215
chrX_-_118870936 0.505 NM_023010
NM_080632
UPF3B

UPF3 regulator of nonsense transcripts homolog B (yeast)

chr1_-_21868380 0.495 NM_001145657
NM_002885
RAP1GAP

RAP1 GTPase activating protein

chr3_-_62835601 0.489


chr12_+_970613 0.487 NM_178039
NM_178040
ERC1

ELKS/RAB6-interacting/CAST family member 1

chr13_-_49597776 0.459 DLEU2
deleted in lymphocytic leukemia 2 (non-protein coding)
chr12_+_39372456 0.458 NM_001843
NM_175038
CNTN1

contactin 1

chr4_-_13155135 0.455 NM_001189
NKX3-2
NK3 homeobox 2
chr7_-_99219639 0.451 NM_017460
CYP3A4
cytochrome P450, family 3, subfamily A, polypeptide 4
chr5_+_67547357 0.448 PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr14_+_89934358 0.432 NM_001166106
CALM1
calmodulin 1 (phosphorylase kinase, delta)
chr6_+_96570565 0.430 NM_006581
FUT9
fucosyltransferase 9 (alpha (1,3) fucosyltransferase)
chr5_-_59225377 0.428 NM_001104631
PDE4D
phosphodiesterase 4D, cAMP-specific
chrX_+_46581418 0.426 RP2
retinitis pigmentosa 2 (X-linked recessive)
chr14_-_59407103 0.425 NM_021136
RTN1
reticulon 1
chr18_-_55091596 0.424 NM_013435
RAX
retina and anterior neural fold homeobox
chr4_-_57382584 0.421 NM_021114
SPINK2
serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
chr15_+_97462675 0.420 NM_015286
NM_145728
SYNM

synemin, intermediate filament protein

chr5_+_129268352 0.417 NM_175856
CHSY3
chondroitin sulfate synthase 3
chr14_+_85069217 0.414


chr18_+_50049846 0.414 NM_007195
POLI
polymerase (DNA directed) iota
chrX_-_106033202 0.413 NM_001171706
NM_138382
RIPPLY1

ripply1 homolog (zebrafish)

chr4_+_99401543 0.405 NM_001100426
NM_001100427
NM_001100428
NM_001100429
NM_001100430
NM_021159
RAP1GDS1





RAP1, GTP-GDP dissociation stimulator 1





chr18_-_50004458 0.401 MBD2
methyl-CpG binding domain protein 2
chr11_+_61352348 0.398 FADS2
fatty acid desaturase 2
chr10_-_44816265 0.396 NM_001039380
C10orf25
chromosome 10 open reading frame 25
chr15_+_36332258 0.395 NM_152594
SPRED1
sprouty-related, EVH1 domain containing 1
chr9_-_126945536 0.393 NM_001144877
NM_173690
SCAI

suppressor of cancer cell invasion

chr14_+_78815406 0.387 NM_001105250
NM_138970
NRXN3

neurexin 3

chrX_-_13866451 0.385 GPM6B
glycoprotein M6B
chr12_+_8741746 0.383 NM_020734
RIMKLB
ribosomal modification protein rimK-like family member B
chr17_+_24742068 0.382 NM_020791
TAOK1
TAO kinase 1
chr7_-_11838260 0.380 NM_015204
THSD7A
thrombospondin, type I, domain containing 7A
chr6_-_84994032 0.378 NM_014895
KIAA1009
KIAA1009
chr14_-_52689680 0.378 DDHD1
DDHD domain containing 1
chr12_+_77782719 0.377 SYT1
synaptotagmin I
chrX_-_13866565 0.376 NM_001001994
GPM6B
glycoprotein M6B
chr2_-_11402150 0.375 NM_004850
ROCK2
Rho-associated, coiled-coil containing protein kinase 2
chr22_+_38246509 0.375 NM_001675
NM_182810
ATF4

activating transcription factor 4 (tax-responsive enhancer element B67)

chr8_+_35212505 0.374 NM_080872
UNC5D
unc-5 homolog D (C. elegans)
chr9_-_79835970 0.373 NM_002072
GNAQ
guanine nucleotide binding protein (G protein), q polypeptide
chr8_-_144887876 0.372 NM_198488
FAM83H
family with sequence similarity 83, member H
chr5_+_140286485 0.372 NM_018898
NM_031882
PCDHAC1

protocadherin alpha subfamily C, 1

chr14_-_52689570 0.369 DDHD1
DDHD domain containing 1
chrX_-_107866262 0.363 NM_003604
IRS4
insulin receptor substrate 4
chr17_-_1195096 0.359 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr12_-_42486314 0.357 NM_002822
TWF1
twinfilin, actin-binding protein, homolog 1 (Drosophila)
chr18_-_50004770 0.355 MBD2
methyl-CpG binding domain protein 2
chr17_-_75385371 0.355 NM_020649
CBX8
chromobox homolog 8
chr17_-_1499849 0.355 NM_031430
RILP
Rab interacting lysosomal protein
chrX_-_68301974 0.354 NM_001032396
NM_022368
NM_145119
PJA1


praja ring finger 1


chr8_+_68418622 0.352


chr17_+_43082273 0.352 NM_002265
KPNB1
karyopherin (importin) beta 1
chr8_+_69405510 0.346 NM_001195639
NM_052958
C8orf34

chromosome 8 open reading frame 34

chr15_-_81113676 0.346 NM_030594
CPEB1
cytoplasmic polyadenylation element binding protein 1
chr12_+_60940404 0.343 NM_006313
USP15
ubiquitin specific peptidase 15
chr15_+_98960277 0.342 NM_024708
NM_198243
ASB7

ankyrin repeat and SOCS box containing 7

chrX_-_108754906 0.339 NM_012282
KCNE1L
KCNE1-like
chr4_+_113286001 0.337 NM_152400
C4orf32
chromosome 4 open reading frame 32
chr9_-_94566823 0.336 NM_001003800
NM_015250
BICD2

bicaudal D homolog 2 (Drosophila)

chr17_+_25828546 0.335 NM_001007024
NM_001007025
NM_004871
GOSR1


golgi SNAP receptor complex member 1


chr14_+_61231795 0.335 NM_001530
NM_181054
HIF1A

hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)

chr3_+_214668 0.333


chr4_-_118226119 0.330 NM_152402
TRAM1L1
translocation associated membrane protein 1-like 1
chr21_-_30720100 0.329 NM_181622
KRTAP13-3
keratin associated protein 13-3
chr3_-_187025438 0.329 IGF2BP2
insulin-like growth factor 2 mRNA binding protein 2
chrX_-_13866366 0.328


chr3_-_126576693 0.328 NM_021964
ZNF148
zinc finger protein 148
chr12_-_48017223 0.323 NM_001008223
C1QL4
complement component 1, q subcomponent-like 4
chr3_+_142688493 0.320 NM_006506
RASA2
RAS p21 protein activator 2
chr4_-_158111995 0.320 NM_016205
PDGFC
platelet derived growth factor C
chr14_+_70444191 0.319 PCNX
pecanex homolog (Drosophila)
chr3_+_35656012 0.317 ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr5_-_41546384 0.316 NM_001005473
PLCXD3
phosphatidylinositol-specific phospholipase C, X domain containing 3
chrX_+_46581368 0.315 RP2
retinitis pigmentosa 2 (X-linked recessive)
chr3_+_125786195 0.310 NM_007064
KALRN
kalirin, RhoGEF kinase
chr9_+_70509925 0.310 NM_003558
PIP5K1B
phosphatidylinositol-4-phosphate 5-kinase, type I, beta
chr14_-_70345485 0.309 NM_033141
MAP3K9
mitogen-activated protein kinase kinase kinase 9
chr3_-_151904408 0.306 NM_152394
FAM194A
family with sequence similarity 194, member A
chr11_+_12088639 0.305 NM_014632
MICAL2
microtubule associated monoxygenase, calponin and LIM domain containing 2
chr3_-_107070400 0.302 NM_170662
CBLB
Cas-Br-M (murine) ecotropic retroviral transforming sequence b
chr8_-_25371663 0.301 KCTD9
potassium channel tetramerisation domain containing 9
chr10_+_105243724 0.301 NM_004210
NEURL
neuralized homolog (Drosophila)
chr8_-_125454097 0.301 NM_194291
TMEM65
transmembrane protein 65
chr3_+_112273352 0.299 PVRL3
poliovirus receptor-related 3
chr11_+_45900731 0.298 GYLTL1B
glycosyltransferase-like 1B
chr7_-_37923040 0.295 NM_003014
SFRP4
secreted frizzled-related protein 4
chr14_+_69993969 0.294 NM_003813
ADAM21
ADAM metallopeptidase domain 21
chr20_+_17498507 0.289 NM_001011546
NM_006870
DSTN

destrin (actin depolymerizing factor)

chr11_+_27019084 0.288 NM_003986
BBOX1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr1_+_69806617 0.287 LRRC7
leucine rich repeat containing 7
chr13_-_45910325 0.286 C13orf18
chromosome 13 open reading frame 18
chr9_-_19778590 0.284 NM_001193288
NM_020344
SLC24A2

solute carrier family 24 (sodium/potassium/calcium exchanger), member 2

chrX_+_46581290 0.283 NM_006915
RP2
retinitis pigmentosa 2 (X-linked recessive)
chr2_-_51112743 0.283 NRXN1
neurexin 1
chrX_-_132947290 0.281 NM_001164617
NM_001164618
NM_001164619
NM_004484
GPC3



glypican 3



chr8_+_79740813 0.280 NM_016010
FAM164A
family with sequence similarity 164, member A
chr19_-_54350457 0.280 NM_002152
HRC
histidine rich calcium binding protein
chr12_+_7233536 0.279 NM_001131023
NM_001131024
NM_001131025
PEX5


peroxisomal biogenesis factor 5


chr12_-_6852709 0.278 NM_001146316
NM_032641
SPSB2

splA/ryanodine receptor domain and SOCS box containing 2

chr9_+_70107602 0.278 NM_199135
FOXD4L3
FOXD4L6
forkhead box D4-like 3
forkhead box D4-like 6
chr5_+_139473873 0.277 NM_005859
PURA
purine-rich element binding protein A
chr15_+_92575767 0.277 MCTP2
multiple C2 domains, transmembrane 2
chr14_+_89597860 0.276 NM_022054
KCNK13
potassium channel, subfamily K, member 13
chr11_+_33236435 0.275 HIPK3
homeodomain interacting protein kinase 3
chr3_+_162697289 0.275 NM_001080440
OTOL1
otolin 1 homolog (zebrafish)
chr5_+_113726203 0.274 KCNN2
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
chr12_-_129889569 0.274 NM_001980
NM_194356
STX2

syntaxin 2

chr5_-_111782637 0.273 NM_022140
EPB41L4A
erythrocyte membrane protein band 4.1 like 4A
chrX_-_132947141 0.272 GPC3
glypican 3
chr10_-_98263434 0.272 NM_012465
TLL2
tolloid-like 2
chr6_-_80713589 0.272 NM_022726
ELOVL4
elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4
chr12_-_55134692 0.272 NM_012064
MIP
major intrinsic protein of lens fiber
chr17_-_7036490 0.271


chr9_+_115678365 0.266 NM_133374
ZNF618
zinc finger protein 618
chr12_+_26003218 0.266 NM_001164748
NM_007211
RASSF8

Ras association (RalGDS/AF-6) domain family (N-terminal) member 8

chr6_-_110607496 0.266 WASF1
WAS protein family, member 1
chr9_-_35105844 0.266 NM_025182
KIAA1539
KIAA1539
chr10_+_76541351 0.265 NM_001174156
NM_144660
SAMD8

sterile alpha motif domain containing 8

chr10_+_121475583 0.265 NM_014937
INPP5F
inositol polyphosphate-5-phosphatase F
chr14_-_64416307 0.264 SPTB
spectrin, beta, erythrocytic
chr15_-_81412354 0.264 NM_004839
NM_199330
NM_199331
NM_199332
HOMER2



homer homolog 2 (Drosophila)



chr1_+_26896519 0.263 ARID1A
AT rich interactive domain 1A (SWI-like)
chr13_+_41520888 0.263 NM_152910
NM_178009
DGKH

diacylglycerol kinase, eta

chr5_-_93102952 0.262 NM_153216
POU5F2
POU domain class 5, transcription factor 2
chr9_-_85342868 0.261 NM_174938
FRMD3
FERM domain containing 3
chr12_-_52980914 0.258 NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr5_-_88016397 0.257 LOC645323
hypothetical LOC645323
chr18_-_38949481 0.256 NM_002930
RIT2
Ras-like without CAAX 2
chr1_+_166414839 0.256 TIPRL
TIP41, TOR signaling pathway regulator-like (S. cerevisiae)
chrX_+_23262905 0.255 NM_173495
PTCHD1
patched domain containing 1
chr1_-_11663762 0.255 NM_006341
MAD2L2
MAD2 mitotic arrest deficient-like 2 (yeast)
chr3_-_48204804 0.255 NM_001789
NM_201567
CDC25A

cell division cycle 25 homolog A (S. pombe)

chr9_-_34512972 0.255 NM_198573
ENHO
energy homeostasis associated
chr17_-_2153763 0.255 NM_017575
SMG6
Smg-6 homolog, nonsense mediated mRNA decay factor (C. elegans)
chr5_-_114543632 0.254 NM_001017397
NM_001017398
NM_018700
TRIM36


tripartite motif containing 36


chr10_+_98582648 0.254 NM_032440
LCOR
ligand dependent nuclear receptor corepressor
chr5_-_158569067 0.254 RNF145
ring finger protein 145
chr6_-_70563489 0.253 LMBRD1
LMBR1 domain containing 1
chr12_+_48303607 0.252 NM_012272
PRPF40B
PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae)
chr2_-_220144254 0.252 OBSL1
obscurin-like 1
chr12_-_78608154 0.252 PAWR
PRKC, apoptosis, WT1, regulator
chrX_-_83329562 0.252 NM_014496
RPS6KA6
ribosomal protein S6 kinase, 90kDa, polypeptide 6
chr4_-_44145266 0.250 KCTD8
potassium channel tetramerisation domain containing 8
chr14_+_64949447 0.249 FUT8
fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
chr8_+_22513043 0.249 NM_001013842
NM_001198827
NM_173686
C8orf58


chromosome 8 open reading frame 58


chr3_-_143350898 0.249 NM_001178138
NM_001178139
TFDP2

transcription factor Dp-2 (E2F dimerization partner 2)

chr15_-_72952648 0.248 NM_005697
SCAMP2
secretory carrier membrane protein 2
chr17_+_43082557 0.247 KPNB1
karyopherin (importin) beta 1
chr3_-_187025501 0.247 NM_001007225
NM_006548
IGF2BP2

insulin-like growth factor 2 mRNA binding protein 2

chr1_+_69806543 0.246


chr9_-_121171400 0.246 NM_014618
DBC1
deleted in bladder cancer 1
chr12_+_6907646 0.245 NM_001940
ATN1
atrophin 1
chr4_+_142777172 0.245 NM_000585
NM_172174
IL15

interleukin 15

chr15_+_83724743 0.245 NM_006738
NM_007200
AKAP13

A kinase (PRKA) anchor protein 13

chr18_-_22383066 0.244 NM_001136205
KCTD1
potassium channel tetramerisation domain containing 1
chr1_-_49014993 0.243 NM_024603
BEND5
BEN domain containing 5
chr5_+_17270781 0.242 BASP1
brain abundant, membrane attached signal protein 1
chr13_+_30089829 0.241 NM_005800
USPL1
ubiquitin specific peptidase like 1
chr6_+_124166767 0.240 NM_001040214
NM_153355
NKAIN2

Na+/K+ transporting ATPase interacting 2

chr11_-_94603857 0.240 NM_144665
SESN3
sestrin 3
chr1_-_32479785 0.239 MTMR9LP
myotubularin related protein 9-like, pseudogene
chr10_-_97040661 0.239 NM_020992
PDLIM1
PDZ and LIM domain 1
chr3_-_188870799 0.239 NM_001048
SST
somatostatin
chr14_+_70178126 0.237 NM_015351
TTC9
tetratricopeptide repeat domain 9
chr8_+_76482661 0.237 HNF4G
hepatocyte nuclear factor 4, gamma
chr11_-_10272256 0.236 NM_030962
SBF2
SET binding factor 2
chr6_+_72653420 0.236 RIMS1
regulating synaptic membrane exocytosis 1
chr10_-_104943000 0.236 NM_001134373
NM_012229
NT5C2

5'-nucleotidase, cytosolic II

chr6_-_70563564 0.236 NM_018368
LMBRD1
LMBR1 domain containing 1
chr5_+_96023926 0.236 CAST
calpastatin
chr3_+_113180517 0.235 NM_018394
ABHD10
abhydrolase domain containing 10
chr6_-_30151526 0.235 NM_170769
NM_025236
RNF39

ring finger protein 39

chr14_+_60858151 0.235 NM_006255
PRKCH
protein kinase C, eta

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.39 8.12e-12 GO:0007399 nervous system development
1.52 2.23e-11 GO:0048699 generation of neurons
1.50 6.07e-11 GO:0022008 neurogenesis
1.12 4.71e-09 GO:0065007 biological regulation
1.29 5.88e-09 GO:0048869 cellular developmental process
1.29 6.46e-09 GO:0030154 cell differentiation
1.12 1.71e-08 GO:0050789 regulation of biological process
1.13 3.75e-08 GO:0050794 regulation of cellular process
1.50 5.07e-08 GO:0030182 neuron differentiation
1.24 2.20e-07 GO:0048522 positive regulation of cellular process
1.53 3.67e-07 GO:0048666 neuron development
1.23 4.29e-07 GO:0048518 positive regulation of biological process
1.57 3.80e-06 GO:0048812 neuron projection morphogenesis
1.17 4.40e-06 GO:0023052 signaling
1.54 5.04e-06 GO:0031175 neuron projection development
1.53 6.77e-06 GO:0000904 cell morphogenesis involved in differentiation
1.52 7.54e-06 GO:0048858 cell projection morphogenesis
1.46 7.55e-06 GO:0030030 cell projection organization
1.48 7.98e-06 GO:0000902 cell morphogenesis
1.52 8.39e-06 GO:0032990 cell part morphogenesis
1.57 1.22e-05 GO:0007409 axonogenesis
1.55 1.35e-05 GO:0048667 cell morphogenesis involved in neuron differentiation
1.30 1.55e-05 GO:0009966 regulation of signal transduction
1.37 1.76e-05 GO:0048468 cell development
1.28 2.59e-05 GO:0009653 anatomical structure morphogenesis
1.25 2.63e-05 GO:0048583 regulation of response to stimulus
1.45 3.38e-05 GO:0032989 cellular component morphogenesis
1.18 3.40e-05 GO:0007165 signal transduction
1.26 5.30e-05 GO:0023051 regulation of signaling
1.39 1.13e-04 GO:2000026 regulation of multicellular organismal development
1.18 1.33e-04 GO:0048856 anatomical structure development
1.19 1.40e-04 GO:0048731 system development
1.34 1.61e-04 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.38 1.63e-04 GO:0051173 positive regulation of nitrogen compound metabolic process
1.15 2.67e-04 GO:0032502 developmental process
1.58 2.89e-04 GO:0007411 axon guidance
1.69 4.98e-04 GO:0048011 nerve growth factor receptor signaling pathway
1.39 5.90e-04 GO:0051254 positive regulation of RNA metabolic process
1.29 6.24e-04 GO:0031325 positive regulation of cellular metabolic process
1.06 6.91e-04 GO:0009987 cellular process
1.36 7.21e-04 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.29 8.23e-04 GO:0010604 positive regulation of macromolecule metabolic process
1.40 1.27e-03 GO:0045893 positive regulation of transcription, DNA-dependent
1.38 1.31e-03 GO:0010628 positive regulation of gene expression
1.34 1.53e-03 GO:0031328 positive regulation of cellular biosynthetic process
1.27 1.68e-03 GO:0009893 positive regulation of metabolic process
1.32 1.98e-03 GO:0050793 regulation of developmental process
1.63 2.01e-03 GO:0050767 regulation of neurogenesis
1.55 2.28e-03 GO:0060284 regulation of cell development
1.35 2.43e-03 GO:0010557 positive regulation of macromolecule biosynthetic process
1.15 2.51e-03 GO:0007275 multicellular organismal development
1.68 3.45e-03 GO:0045664 regulation of neuron differentiation
1.19 3.52e-03 GO:0048523 negative regulation of cellular process
1.32 4.37e-03 GO:0009891 positive regulation of biosynthetic process
1.93 4.84e-03 GO:0010720 positive regulation of cell development
1.13 5.12e-03 GO:0051716 cellular response to stimulus
1.41 6.01e-03 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.52 1.01e-02 GO:0022603 regulation of anatomical structure morphogenesis
1.32 1.06e-02 GO:0048584 positive regulation of response to stimulus
1.35 1.10e-02 GO:0007167 enzyme linked receptor protein signaling pathway
1.39 1.12e-02 GO:0051253 negative regulation of RNA metabolic process
1.24 1.20e-02 GO:0051239 regulation of multicellular organismal process
1.39 1.24e-02 GO:0045892 negative regulation of transcription, DNA-dependent
1.17 1.24e-02 GO:0048519 negative regulation of biological process
1.35 1.82e-02 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.36 1.87e-02 GO:0010629 negative regulation of gene expression
1.27 1.93e-02 GO:0010646 regulation of cell communication
1.34 2.00e-02 GO:0045595 regulation of cell differentiation
1.53 2.36e-02 GO:0051960 regulation of nervous system development
1.34 2.95e-02 GO:0010558 negative regulation of macromolecule biosynthetic process
1.27 3.33e-02 GO:0006793 phosphorus metabolic process
1.27 3.33e-02 GO:0006796 phosphate metabolic process
1.29 3.73e-02 GO:0051128 regulation of cellular component organization

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.40 1.55e-04 GO:0030054 cell junction
1.08 2.09e-04 GO:0005737 cytoplasm
1.05 9.57e-04 GO:0044424 intracellular part
1.22 1.35e-03 GO:0005856 cytoskeleton
1.05 2.32e-03 GO:0005622 intracellular
1.65 1.37e-02 GO:0005912 adherens junction
1.60 2.57e-02 GO:0070161 anchoring junction
1.73 3.68e-02 GO:0030055 cell-substrate junction
1.03 4.38e-02 GO:0044464 cell part
1.03 4.60e-02 GO:0005623 cell

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.13 1.65e-10 GO:0005515 protein binding
1.42 3.59e-03 GO:0019904 protein domain specific binding
1.44 6.63e-03 GO:0000988 protein binding transcription factor activity
1.44 6.63e-03 GO:0000989 transcription factor binding transcription factor activity
1.43 9.66e-03 GO:0003712 transcription cofactor activity
1.47 9.91e-03 GO:0016563 transcription activator activity
2.27 1.85e-02 GO:0046332 SMAD binding
1.04 2.37e-02 GO:0005488 binding
1.28 2.68e-02 GO:0016301 kinase activity