Motif ID: TFAP4.p2

Z-value: 1.287


Transcription factors associated with TFAP4.p2:

Gene SymbolEntrez IDGene Name
TFAP4 7023 transcription factor AP-4 (activating enhancer binding protein 4)



Activity profile for motif TFAP4.p2.

activity profile for motif TFAP4.p2


Sorted Z-values histogram for motif TFAP4.p2

Sorted Z-values for motif TFAP4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TFAP4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_13090101 4.627 NM_052876
NACC1
nucleus accumbens associated 1, BEN and BTB (POZ) domain containing
chr16_-_87405817 3.249 NM_000485
NM_001030018
APRT

adenine phosphoribosyltransferase

chr22_+_20068039 3.056 NM_001128635
RIMBP3B
RIMS binding protein 3B
chr19_+_1236766 2.939 NM_001405
EFNA2
ephrin-A2
chr19_+_530466 2.847 BSG
basigin (Ok blood group)
chr20_-_61669550 2.739 NM_033405
PRIC285
peroxisomal proliferator-activated receptor A interacting complex 285
chr9_+_139292094 2.666 NM_017723
C9orf167
chromosome 9 open reading frame 167
chr6_+_32114060 2.566 NM_000500
NM_001128590
CYP21A2

cytochrome P450, family 21, subfamily A, polypeptide 2

chr3_-_12983959 2.428 NM_014869
IQSEC1
IQ motif and Sec7 domain 1
chr19_+_10392128 2.363 NM_001111307
PDE4A
phosphodiesterase 4A, cAMP-specific
chr22_+_19649417 2.206 NM_001018060
NM_144704
AIFM3

apoptosis-inducing factor, mitochondrion-associated, 3

chr7_+_1239078 2.197 NM_001080461
UNCX
UNC homeobox
chr19_+_590878 2.187 NM_020637
FGF22
fibroblast growth factor 22
chr12_-_50871953 2.158 NM_001081492
NM_182507
KRT80

keratin 80

chr8_+_144711619 2.154 NM_024736
GSDMD
gasdermin D
chr2_+_128119908 2.089 NM_001161415
NM_001161416
NM_001161417
NM_005291
GPR17



G protein-coupled receptor 17



chr9_+_133154896 1.991 NM_032728
PPAPDC3
phosphatidic acid phosphatase type 2 domain containing 3
chr2_+_233029076 1.944 NM_001631
ALPI
alkaline phosphatase, intestinal
chr19_-_13808101 1.924 LOC284454
hypothetical LOC284454
chr1_+_200429740 1.902 NM_001017403
LGR6
leucine-rich repeat containing G protein-coupled receptor 6
chr19_+_2200112 1.897 NM_000479
AMH
anti-Mullerian hormone
chr11_+_43920385 1.880 NM_001145033
C11orf96
chromosome 11 open reading frame 96
chr1_-_6402467 1.843 NM_019089
HES2
hairy and enhancer of split 2 (Drosophila)
chr7_+_2525922 1.782 NM_001040167
NM_001040168
LFNG

LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

chr9_-_132804243 1.770 NM_001145106
FIBCD1
fibrinogen C domain containing 1
chr3_-_13032130 1.741


chr22_+_19248733 1.718 MED15
mediator complex subunit 15
chr9_-_139183675 1.717


chr4_+_8322358 1.688 NM_053044
HTRA3
HtrA serine peptidase 3
chr10_+_134060681 1.688 NM_001098637
NM_138499
PWWP2B

PWWP domain containing 2B

chr10_+_80498782 1.685 NM_020338
ZMIZ1
zinc finger, MIZ-type containing 1
chr16_+_2461500 1.645 NM_006181
NTN3
netrin 3
chr19_+_3473953 1.637 NM_001136197
NM_001136198
FZR1

fizzy/cell division cycle 20 related 1 (Drosophila)

chr1_-_226202210 1.636 NM_003395
WNT9A
wingless-type MMTV integration site family, member 9A
chr6_+_37245860 1.617 NM_002648
PIM1
pim-1 oncogene
chr19_+_55164668 1.602 SIGLEC16
sialic acid binding Ig-like lectin 16 (gene/pseudogene)
chr8_-_145085616 1.601 NM_201384
PLEC
plectin
chr1_+_1940605 1.584 NM_000815
GABRD
gamma-aminobutyric acid (GABA) A receptor, delta
chr5_+_176726918 1.579 RGS14
regulator of G-protein signaling 14
chr19_+_3045528 1.567 GNA11
guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
chr11_-_75595098 1.534 NM_004626
WNT11
wingless-type MMTV integration site family, member 11
chr17_+_77453363 1.529 NM_148896
NPB
neuropeptide B
chr1_-_21868380 1.523 NM_001145657
NM_002885
RAP1GAP

RAP1 GTPase activating protein

chr7_+_100515439 1.506 NM_030961
TRIM56
tripartite motif containing 56
chr1_-_37991160 1.497 EPHA10
EPH receptor A10
chr8_+_145705253 1.491 NM_138431
MFSD3
major facilitator superfamily domain containing 3
chr10_+_135343649 1.482 NM_012147
DUX2
double homeobox 2
chr10_+_72826656 1.477 NM_001171930
NM_001171931
NM_001171932
NM_022124
NM_052836
CDH23




cadherin-related 23




chr16_+_711139 1.475 NM_023933
FAM173A
family with sequence similarity 173, member A
chr1_+_3378030 1.454 ARHGEF16
Rho guanine nucleotide exchange factor (GEF) 16
chr11_-_75599433 1.422 WNT11
wingless-type MMTV integration site family, member 11
chrX_-_106846253 1.411 NM_001015881
TSC22D3
TSC22 domain family, member 3
chr19_+_44266784 1.409 NM_001004318
PAPL
iron/zinc purple acid phosphatase-like protein
chr11_+_2422747 1.402 NM_000218
KCNQ1
potassium voltage-gated channel, KQT-like subfamily, member 1
chr12_+_108636569 1.401 NM_032829
C12orf34
chromosome 12 open reading frame 34
chr7_-_127833231 1.400 NM_001142573
NM_001142574
NM_001142575
IMPDH1


IMP (inosine 5'-monophosphate) dehydrogenase 1


chr4_+_8633116 1.394 NM_080819
GPR78
G protein-coupled receptor 78
chr11_+_74629597 1.392 NM_001195528
LOC441617
hypothetical LOC441617
chr22_+_20101661 1.391 NM_015094
HIC2
hypermethylated in cancer 2
chr8_-_140784416 1.391 NM_016601
KCNK9
potassium channel, subfamily K, member 9
chr2_+_94900904 1.383 NM_144705
TEKT4
tektin 4
chr1_+_1256585 1.382 NM_152228
TAS1R3
taste receptor, type 1, member 3
chr19_-_54857003 1.379 IRF3
interferon regulatory factor 3
chr21_+_42946719 1.379 NM_001001567
NM_001001568
NM_001001569
NM_001001570
NM_001001571
NM_001001572
NM_001001573
NM_001001574
NM_001001575
NM_001001576
NM_001001577
NM_001001578
NM_001001579
NM_001001580
NM_001001581
NM_001001582
NM_001001583
NM_001001584
NM_001001585
NM_002606
PDE9A



















phosphodiesterase 9A



















chr2_+_3620296 1.378 NM_024027
NM_199235
COLEC11

collectin sub-family member 11

chr11_-_66877519 1.378 NM_021173
POLD4
polymerase (DNA-directed), delta 4
chr16_+_84204424 1.360 NM_014615
KIAA0182
KIAA0182
chr4_+_3413489 1.335 NM_001528
HGFAC
HGF activator
chr20_-_61933012 1.334 ZBTB46
zinc finger and BTB domain containing 46
chr15_-_75693309 1.332 LINGO1
leucine rich repeat and Ig domain containing 1
chr16_-_1215254 1.326 NM_012467
TPSG1
tryptase gamma 1
chr21_+_44844924 1.323 NM_198689
KRTAP10-7
keratin associated protein 10-7
chr7_+_154943466 1.321 NM_001427
EN2
engrailed homeobox 2
chr22_-_20235372 1.318 NM_001128635
RIMBP3B
RIMS binding protein 3B
chr19_+_46390916 1.308 NM_030622
CYP2S1
cytochrome P450, family 2, subfamily S, polypeptide 1
chr20_+_61838479 1.307 LIME1
Lck interacting transmembrane adaptor 1
chr3_+_135996990 1.302 EPHB1
EPH receptor B1
chr19_-_59438411 1.300 NM_024318
LILRB3
LILRA6
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
chr1_-_1171964 1.297 NM_001014980
FAM132A
family with sequence similarity 132, member A
chr3_+_151608673 1.289 TSC22D2
TSC22 domain family, member 2
chr12_+_50981915 1.288 NM_002284
KRT86
keratin 86
chr11_-_66945190 1.281 PPP1CA
protein phosphatase 1, catalytic subunit, alpha isozyme
chr1_-_6474346 1.276 NM_020631
PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr8_-_145090892 1.275 NM_201381
PLEC
plectin
chr22_+_17539198 1.272


chr17_+_7269658 1.272 NM_175734
C17orf74
chromosome 17 open reading frame 74
chr10_+_135333667 1.267 NM_033178
NM_012147
NM_001127387
NM_001127388
NM_001127389
NM_001164467
NM_001127386
DUX4
DUX2
DUX4L7
DUX4L6
DUX4L5
DUX4L3
DUX4L2
double homeobox 4
double homeobox 2
double homeobox 4 like 7
double homeobox 4 like 6
double homeobox 4 like 5
double homeobox 4 like 3
double homeobox 4 like 2
chr6_-_168219380 1.257 NM_001122841
FRMD1
FERM domain containing 1
chr19_-_3928516 1.252 EEF2
eukaryotic translation elongation factor 2
chr19_+_46390980 1.246 CYP2S1
cytochrome P450, family 2, subfamily S, polypeptide 1
chr19_+_54883732 1.243 NM_001101340
C19orf76
chromosome 19 open reading frame 76
chr3_-_50515857 1.237 NM_001005505
NM_001174051
NM_006030
CACNA2D2


calcium channel, voltage-dependent, alpha 2/delta subunit 2


chr8_-_142307854 1.235 NM_001080431
SLC45A4
solute carrier family 45, member 4
chr22_-_19122047 1.232 SCARF2
scavenger receptor class F, member 2
chr1_-_6585268 1.228 KLHL21
kelch-like 21 (Drosophila)
chr4_+_3737872 1.227 ADRA2C
adrenergic, alpha-2C-, receptor
chr2_-_233060774 1.226 NM_004826
ECEL1
endothelin converting enzyme-like 1
chr12_+_106236281 1.225 NM_001018072
BTBD11
BTB (POZ) domain containing 11
chr1_-_155095289 1.223 NM_014215
INSRR
insulin receptor-related receptor
chr14_+_104117100 1.217 NM_001008404
C14orf180
chromosome 14 open reading frame 180
chr8_-_145099963 1.216 NM_201379
PLEC
plectin
chr9_+_130620540 1.208 NM_004435
ENDOG
endonuclease G
chr5_-_525916 1.201 LOC25845
hypothetical LOC25845
chr1_-_925332 1.197 NM_001142467
NM_021170
HES4

hairy and enhancer of split 4 (Drosophila)

chr1_+_1360765 1.189 NM_022834
NM_199121
VWA1

von Willebrand factor A domain containing 1

chr20_+_61838389 1.188 NM_017806
LIME1
Lck interacting transmembrane adaptor 1
chr16_-_11270619 1.185 NM_005425
TNP2
transition protein 2 (during histone to protamine replacement)
chr2_+_241156776 1.183 NM_018226
RNPEPL1
arginyl aminopeptidase (aminopeptidase B)-like 1
chr14_+_99859427 1.170 NM_207117
SLC25A47
solute carrier family 25, member 47
chr21_+_44569537 1.169 PFKL
phosphofructokinase, liver
chr1_-_1525309 1.166 LOC643988
hypothetical LOC643988
chr22_+_19248810 1.160 MED15
mediator complex subunit 15
chr19_-_1062972 1.154 SBNO2
strawberry notch homolog 2 (Drosophila)
chr7_-_158073121 1.153 NM_002847
NM_130842
NM_130843
PTPRN2


protein tyrosine phosphatase, receptor type, N polypeptide 2


chr19_+_3045266 1.141 NM_002067
GNA11
guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
chr22_+_19649460 1.139 AIFM3
apoptosis-inducing factor, mitochondrion-associated, 3
chr7_+_73341640 1.134 NM_003388
NM_032421
CLIP2

CAP-GLY domain containing linker protein 2

chr9_-_139047112 1.129 NM_004479
FUT7
fucosyltransferase 7 (alpha (1,3) fucosyltransferase)
chr1_+_1099145 1.128 NM_001130045
TTLL10
tubulin tyrosine ligase-like family, member 10
chr4_+_191232653 1.127 NM_033178
NM_012147
NM_001177376
NM_001127387
NM_001127388
NM_001127389
NM_001164467
NM_001127386
DUX4
DUX2
DUX4L4
DUX4L7
DUX4L6
DUX4L5
DUX4L3
DUX4L2
double homeobox 4
double homeobox 2
double homeobox 4 like 4
double homeobox 4 like 7
double homeobox 4 like 6
double homeobox 4 like 5
double homeobox 4 like 3
double homeobox 4 like 2
chr17_+_75507750 1.124


chr10_+_88404285 1.114 NM_001030015
NM_033282
OPN4

opsin 4

chr4_+_191239247 1.114 NM_033178
NM_012147
NM_001177376
NM_001127388
NM_001127389
NM_001164467
NM_001127386
DUX4
DUX2
DUX4L4
DUX4L6
DUX4L5
DUX4L3
DUX4L2
double homeobox 4
double homeobox 2
double homeobox 4 like 4
double homeobox 4 like 6
double homeobox 4 like 5
double homeobox 4 like 3
double homeobox 4 like 2
chr8_+_145461356 1.109 NM_001008271
NM_001080514
SCXA
SCXB
scleraxis homolog A (mouse)
scleraxis homolog B (mouse)
chr9_-_128924782 1.094 ANGPTL2
angiopoietin-like 2
chr16_+_73810383 1.093 NM_001906
CTRB1
CTRB2
chymotrypsinogen B1
chymotrypsinogen B2
chr22_-_42619139 1.092 NM_001177675
NM_138814
PNPLA5

patatin-like phospholipase domain containing 5

chr22_-_19122107 1.091 NM_153334
NM_182895
SCARF2

scavenger receptor class F, member 2

chr19_+_482688 1.077 NM_004359
CDC34
cell division cycle 34 homolog (S. cerevisiae)
chr1_+_6226838 1.074 NM_001024598
HES3
hairy and enhancer of split 3 (Drosophila)
chr10_+_80740584 1.069 ZMIZ1
zinc finger, MIZ-type containing 1
chr22_+_49333327 1.060 NM_138433
KLHDC7B
kelch domain containing 7B
chr17_-_3447084 1.060 NM_018727
TRPV1
transient receptor potential cation channel, subfamily V, member 1
chr3_+_135996734 1.059 NM_004441
EPHB1
EPH receptor B1
chr1_+_1104939 1.057 NM_153254
TTLL10
tubulin tyrosine ligase-like family, member 10
chr19_+_55571493 1.055 NM_007121
NR1H2
nuclear receptor subfamily 1, group H, member 2
chr19_-_50355247 1.051 NM_198478
NKPD1
NTPase, KAP family P-loop domain containing 1
chr9_-_128924819 1.040 NM_012098
ANGPTL2
angiopoietin-like 2
chr21_+_43462209 1.033 NM_000394
CRYAA
crystallin, alpha A
chr3_-_10027770 1.031 NM_001008737
LOC401052
hypothetical LOC401052
chr22_-_30928497 1.031 NM_001159546
RFPL2
ret finger protein-like 2
chrX_-_55037235 1.028 NM_002625
PFKFB1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr1_+_152806874 1.014 NM_000748
CHRNB2
cholinergic receptor, nicotinic, beta 2 (neuronal)
chr10_+_135330357 1.012 NM_033178
NM_012147
NM_001127387
NM_001127388
NM_001127389
NM_001164467
NM_001127386
DUX4
DUX2
DUX4L7
DUX4L6
DUX4L5
DUX4L3
DUX4L2
double homeobox 4
double homeobox 2
double homeobox 4 like 7
double homeobox 4 like 6
double homeobox 4 like 5
double homeobox 4 like 3
double homeobox 4 like 2
chr19_-_2378874 1.008 NM_012458
TIMM13
translocase of inner mitochondrial membrane 13 homolog (yeast)
chr1_+_154878498 1.007 BCAN
brevican
chr11_-_785005 1.006 SLC25A22
solute carrier family 25 (mitochondrial carrier: glutamate), member 22
chr20_-_61639104 1.004 NM_005975
PTK6
PTK6 protein tyrosine kinase 6
chr8_-_41624030 1.004 NM_152568
NKX6-3
NK6 homeobox 3
chr17_-_36346240 1.003 KRT23
keratin 23 (histone deacetylase inducible)
chr17_-_29930431 1.002 NM_207454
C17orf102
chromosome 17 open reading frame 102
chr19_-_3922032 1.000 DAPK3
death-associated protein kinase 3
chr22_-_15982142 1.000 NM_031890
NM_001163079
CECR6

cat eye syndrome chromosome region, candidate 6

chr7_+_45163891 1.000 NM_005856
RAMP3
receptor (G protein-coupled) activity modifying protein 3
chr1_-_39871226 0.993 HEYL
hairy/enhancer-of-split related with YRPW motif-like
chr17_+_14145051 0.989 NM_006041
HS3ST3B1
heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1
chr16_-_790699 0.988 NM_016541
GNG13
guanine nucleotide binding protein (G protein), gamma 13
chr12_+_130878870 0.987 NM_016155
MMP17
matrix metallopeptidase 17 (membrane-inserted)
chr1_-_1840564 0.979 NM_178545
TMEM52
transmembrane protein 52
chr16_+_2226468 0.979 NM_001374
DNASE1L2
deoxyribonuclease I-like 2
chr19_+_482737 0.979 CDC34
cell division cycle 34 homolog (S. cerevisiae)
chr11_+_65100074 0.977 NM_001099409
EHBP1L1
EH domain binding protein 1-like 1
chr19_-_8118367 0.976 NM_032447
FBN3
fibrillin 3
chr4_+_191235959 0.973 NM_001177376
DUX4L4
double homeobox 4 like 4
chr7_+_128293699 0.971 NM_001195150
LOC100130705
hypothetical protein LOC100130705
chr9_+_139255559 0.966 TUBB2C
tubulin, beta 2C
chr15_-_66285427 0.964 NM_001031733
NM_033429
CALML4

calmodulin-like 4

chr1_+_152806924 0.959 CHRNB2
cholinergic receptor, nicotinic, beta 2 (neuronal)
chr11_+_67567022 0.959 NM_006053
TCIRG1
T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
chr1_-_20122638 0.958 NM_014589
PLA2G2E
phospholipase A2, group IIE
chr19_+_18543613 0.958 NM_001033930
NM_003333
UBA52

ubiquitin A-52 residue ribosomal protein fusion product 1

chr18_+_75724655 0.955 NM_012283
KCNG2
potassium voltage-gated channel, subfamily G, member 2
chr9_-_128924706 0.955 ANGPTL2
angiopoietin-like 2
chr1_-_6243621 0.954 NM_207370
GPR153
G protein-coupled receptor 153
chr3_-_195553297 0.942 NM_001080513
CPN2
carboxypeptidase N, polypeptide 2
chr3_-_48516486 0.940 NM_016479
SHISA5
shisa homolog 5 (Xenopus laevis)
chr19_-_3922089 0.935 DAPK3
death-associated protein kinase 3
chr9_-_138958889 0.927 FBXW5
F-box and WD repeat domain containing 5
chr20_+_1254033 0.925 LOC100507495
hypothetical LOC100507495
chr1_+_148788410 0.924 NM_019032
NM_025008
ADAMTSL4

ADAMTS-like 4

chr11_-_118693021 0.921 NM_006500
MCAM
melanoma cell adhesion molecule
chr6_+_108593907 0.907 NM_003269
NR2E1
nuclear receptor subfamily 2, group E, member 1
chr19_-_3931499 0.907 EEF2
eukaryotic translation elongation factor 2
chr7_-_127458231 0.907 NM_022143
LRRC4
leucine rich repeat containing 4
chr2_+_232165818 0.906 NM_152614
C2orf57
chromosome 2 open reading frame 57
chr1_+_44643513 0.904 NM_018150
RNF220
ring finger protein 220
chrX_+_67784235 0.903 NM_001142503
NM_014725
STARD8

StAR-related lipid transfer (START) domain containing 8

chr6_+_31538934 0.902 NM_006674
HCP5
HLA complex P5
chr20_-_61108831 0.900 NM_080606
BHLHE23
basic helix-loop-helix family, member e23
chr19_+_6415259 0.900 NM_139161
NM_174881
CRB3

crumbs homolog 3 (Drosophila)

chr8_-_145097031 0.897 NM_201380
PLEC
plectin
chr16_-_87460514 0.894 NM_001080487
PABPN1L
poly(A) binding protein, nuclear 1-like (cytoplasmic)
chr4_+_191226073 0.893 NM_012147
NM_001177376
NM_001127388
NM_001127389
NM_001164467
DUX2
DUX4L4
DUX4L6
DUX4L5
DUX4L3
double homeobox 2
double homeobox 4 like 4
double homeobox 4 like 6
double homeobox 4 like 5
double homeobox 4 like 3
chr16_+_2138608 0.893 NM_014353
RAB26
RAB26, member RAS oncogene family
chr11_-_46364681 0.886 NM_000741
CHRM4
cholinergic receptor, muscarinic 4
chr20_-_21442663 0.884 NM_002509
NKX2-2
NK2 homeobox 2
chr9_+_139255519 0.883 NM_006088
TUBB2C
tubulin, beta 2C
chr10_+_71908535 0.882 NM_014431
KIAA1274
KIAA1274
chr9_-_135213149 0.881 SURF1
surfeit 1
chr17_-_77462506 0.880 NM_001184917
NM_002861
PCYT2

phosphate cytidylyltransferase 2, ethanolamine


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.24 9.40e-08 GO:0023052 signaling
1.12 1.50e-05 GO:0065007 biological regulation
1.22 5.65e-05 GO:0007165 signal transduction
1.26 3.86e-04 GO:0042221 response to chemical stimulus
1.12 4.49e-04 GO:0050789 regulation of biological process
1.12 1.59e-03 GO:0050794 regulation of cellular process
1.19 1.71e-03 GO:0007275 multicellular organismal development
1.17 2.93e-03 GO:0051716 cellular response to stimulus
1.21 3.30e-03 GO:0048731 system development
2.52 6.44e-03 GO:0006937 regulation of muscle contraction
1.38 1.25e-02 GO:0006811 ion transport
1.36 1.33e-02 GO:0032879 regulation of localization
1.25 2.22e-02 GO:0007166 cell surface receptor linked signaling pathway
1.28 2.61e-02 GO:0007399 nervous system development
1.37 3.18e-02 GO:0040011 locomotion
1.15 4.79e-02 GO:0032502 developmental process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.27 1.32e-05 GO:0044459 plasma membrane part
1.85 4.44e-03 GO:0016324 apical plasma membrane
1.14 9.38e-03 GO:0005886 plasma membrane
1.95 9.86e-03 GO:0031225 anchored to membrane
1.53 1.23e-02 GO:0009986 cell surface
1.21 1.81e-02 GO:0005576 extracellular region
1.13 1.85e-02 GO:0071944 cell periphery
1.56 2.19e-02 GO:0005578 proteinaceous extracellular matrix

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.36 2.93e-02 GO:0015075 ion transmembrane transporter activity
1.46 3.99e-02 GO:0030695 GTPase regulator activity