Motif ID: STAT1,3.p3

Z-value: 0.674


Transcription factors associated with STAT1,3.p3:

Gene SymbolEntrez IDGene Name
STAT1 6772 signal transducer and activator of transcription 1, 91kDa
STAT3 6774 signal transducer and activator of transcription 3 (acute-phase response factor)



Activity profile for motif STAT1,3.p3.

activity profile for motif STAT1,3.p3


Sorted Z-values histogram for motif STAT1,3.p3

Sorted Z-values for motif STAT1,3.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of STAT1,3.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr16_+_54072969 1.808 NM_001127891
MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chr11_-_121492010 0.790 NM_001001786
BLID
BH3-like motif containing, cell death inducer
chr4_-_21155376 0.607 NM_001035004
KCNIP4
Kv channel interacting protein 4
chr22_-_29866339 0.603 NM_015715
PLA2G3
phospholipase A2, group III
chr11_+_113672378 0.592 NNMT
nicotinamide N-methyltransferase
chr11_+_113672407 0.565 NNMT
nicotinamide N-methyltransferase
chr1_-_157313179 0.525 NM_004833
AIM2
absent in melanoma 2
chr3_+_123882355 0.393 NM_017554
PARP14
poly (ADP-ribose) polymerase family, member 14
chr19_-_60566419 0.352 NM_001145402
FAM71E2
family with sequence similarity 71, member E2
chr20_-_42713663 0.349 ADA
adenosine deaminase
chr3_+_195786006 0.343


chr4_+_126457016 0.329 NM_024582
FAT4
FAT tumor suppressor homolog 4 (Drosophila)
chr12_+_11694172 0.314 ETV6
ets variant 6
chr1_+_154351200 0.298 LMNA
lamin A/C
chr2_+_165858586 0.294 NM_021007
SCN2A
sodium channel, voltage-gated, type II, alpha subunit
chr9_+_131937163 0.257 GPR107
G protein-coupled receptor 107
chr6_+_36754433 0.254 NM_000389
CDKN1A
cyclin-dependent kinase inhibitor 1A (p21, Cip1)
chr3_+_186483408 0.250 LOC100505749
MAP3K13
hypothetical LOC100505749
mitogen-activated protein kinase kinase kinase 13
chr5_+_133735004 0.245 UBE2B
ubiquitin-conjugating enzyme E2B (RAD6 homolog)
chr17_-_8020332 0.242 NM_032354
NM_183065
TMEM107

transmembrane protein 107

chr3_+_116824840 0.236 NM_001130064
NM_002045
GAP43

growth associated protein 43

chr14_+_66777578 0.232 NM_022474
MPP5
membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
chr3_-_121065112 0.231


chr6_+_36754467 0.227 CDKN1A
cyclin-dependent kinase inhibitor 1A (p21, Cip1)
chr11_+_32069183 0.223 RCN1
reticulocalbin 1, EF-hand calcium binding domain
chr16_-_24876357 0.220 ARHGAP17
Rho GTPase activating protein 17
chr3_-_172109119 0.220 NM_020390
EIF5A2
eukaryotic translation initiation factor 5A2
chr19_-_61596681 0.217 NM_144690
ZNF582
zinc finger protein 582
chr19_-_4782711 0.216 NM_182919
TICAM1
toll-like receptor adaptor molecule 1
chr17_+_57811645 0.216 NM_173503
EFCAB3
EF-hand calcium binding domain 3
chr2_-_70042900 0.215 NM_152792
ASPRV1
aspartic peptidase, retroviral-like 1
chr20_-_5982617 0.214 NM_152611
LRRN4
leucine rich repeat neuronal 4
chr5_-_138753443 0.212 NM_016459
MZB1
marginal zone B and B1 cell-specific protein
chr11_+_32068990 0.208 NM_002901
RCN1
reticulocalbin 1, EF-hand calcium binding domain
chr12_-_73889481 0.204 KCNC2
potassium voltage-gated channel, Shaw-related subfamily, member 2
chr20_+_34019942 0.201 NM_080834
C20orf152
chromosome 20 open reading frame 152
chr2_+_167468220 0.190 NM_001079810
NM_152381
XIRP2

xin actin-binding repeat containing 2

chr18_-_50777634 0.189 NM_025214
CCDC68
coiled-coil domain containing 68
chr19_-_4853878 0.185 NM_001080523
ARRDC5
arrestin domain containing 5
chr19_+_49023283 0.184 NM_181845
ZNF283
zinc finger protein 283
chr13_+_104916216 0.174 NM_001161814
NM_172370
DAOA

D-amino acid oxidase activator

chr19_-_39859997 0.174


chr14_+_99309688 0.169 EML1
echinoderm microtubule associated protein like 1
chr14_-_19951417 0.169 NM_007110
TEP1
telomerase-associated protein 1
chr9_+_87745922 0.168 NAA35
N(alpha)-acetyltransferase 35, NatC auxiliary subunit
chr11_-_128567302 0.167 NM_001142685
ARHGAP32
Rho GTPase activating protein 32
chr1_-_158883666 0.166 NM_003037
SLAMF1
signaling lymphocytic activation molecule family member 1
chr19_+_49198916 0.166 NM_006300
ZNF230
zinc finger protein 230
chr5_+_133734768 0.163 NM_003337
UBE2B
ubiquitin-conjugating enzyme E2B (RAD6 homolog)
chr19_-_49500966 0.162 NM_004234
ZNF235
zinc finger protein 235
chr9_-_85761472 0.158 NM_032307
C9orf64
chromosome 9 open reading frame 64
chr14_+_102313585 0.155 TRAF3
TNF receptor-associated factor 3
chr22_-_29833484 0.155 NM_080430
SELM
selenoprotein M
chr3_-_172109075 0.153 EIF5A2
eukaryotic translation initiation factor 5A2
chr19_-_11550576 0.152 NM_001111034
ACP5
acid phosphatase 5, tartrate resistant
chr9_+_124463665 0.150 NM_001005236
OR1L1
olfactory receptor, family 1, subfamily L, member 1
chr16_+_66129481 0.149 FAM65A
family with sequence similarity 65, member A
chr1_+_24944346 0.148 NM_013943
CLIC4
chloride intracellular channel 4
chr19_+_49290319 0.147 NM_013398
ZNF224
zinc finger protein 224
chr15_-_73719546 0.143 NM_018285
IMP3
IMP3, U3 small nucleolar ribonucleoprotein, homolog (yeast)
chr9_+_87745876 0.141 NM_024635
NAA35
N(alpha)-acetyltransferase 35, NatC auxiliary subunit
chr20_+_36534871 0.137 NM_020336
RALGAPB
Ral GTPase activating protein, beta subunit (non-catalytic)
chr4_+_52403922 0.126 NM_001040402
NM_015115
DCUN1D4

DCN1, defective in cullin neddylation 1, domain containing 4 (S. cerevisiae)

chr10_+_90741024 0.126 FAS
Fas (TNF receptor superfamily, member 6)
chr5_-_133734616 0.124 CDKL3
cyclin-dependent kinase-like 3
chr19_+_49337548 0.123 NM_001144824
NM_006630
ZNF234

zinc finger protein 234

chr9_-_85761353 0.123 C9orf64
chromosome 9 open reading frame 64
chr19_+_49221333 0.123 NM_001129996
NM_013360
ZNF284
ZNF222

zinc finger protein 284
zinc finger protein 222

chr3_-_130600931 0.122 RPL32P3
ribosomal protein L32 pseudogene 3
chr10_-_90740935 0.120 NM_001141945
ACTA2
actin, alpha 2, smooth muscle, aorta
chr6_-_28412130 0.115 NM_030899
ZNF323
zinc finger protein 323
chr5_+_73145098 0.112 RGNEF
190 kDa guanine nucleotide exchange factor
chr13_-_94751573 0.111 NM_001105515
NM_005845
ABCC4

ATP-binding cassette, sub-family C (CFTR/MRP), member 4

chr19_+_39860398 0.110 NM_001012320
NM_018443
ZNF302

zinc finger protein 302

chr3_-_15875932 0.108 NM_015199
ANKRD28
ankyrin repeat domain 28
chr9_-_85761451 0.107 C9orf64
chromosome 9 open reading frame 64
chr13_+_104916565 0.106 NM_001161812
DAOA
D-amino acid oxidase activator
chr1_-_145712107 0.106 NM_005266
GJA5
gap junction protein, alpha 5, 40kDa
chr4_-_77176163 0.104 NM_005409
CXCL11
chemokine (C-X-C motif) ligand 11
chr12_+_54011750 0.101 NM_054104
OR6C3
olfactory receptor, family 6, subfamily C, member 3
chr14_+_73027438 0.100 C14orf169
chromosome 14 open reading frame 169
chr10_+_90552466 0.097 NM_001128215
LIPM
lipase, family member M
chr19_+_49248003 0.097 NM_013361
ZNF223
zinc finger protein 223
chr14_+_73027410 0.097 C14orf169
chromosome 14 open reading frame 169
chr3_-_61212076 0.096 NM_001166243
NM_002012
FHIT

fragile histidine triad gene

chr14_+_73027423 0.095 C14orf169
chromosome 14 open reading frame 169
chr19_+_53559468 0.095 NM_012451
SYNGR4
synaptogyrin 4
chr22_+_34374358 0.094 NM_030641
APOL6
apolipoprotein L, 6
chr9_-_106705867 0.094 ABCA1
ATP-binding cassette, sub-family A (ABC1), member 1
chrX_-_154216929 0.094 NM_001289
CLIC2
chloride intracellular channel 2
chr9_-_74757735 0.092 NM_000689
ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr2_+_20510312 0.092 NM_004040
RHOB
ras homolog gene family, member B
chr14_+_73027361 0.091 NM_024644
C14orf169
chromosome 14 open reading frame 169
chr9_-_87546620 0.090 NM_015239
AGTPBP1
ATP/GTP binding protein 1
chr1_-_108536885 0.090 NM_213651
SLC25A24
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24
chr12_-_7153068 0.087 NM_016546
C1RL
complement component 1, r subcomponent-like
chr10_-_62882930 0.085 TMEM26
transmembrane protein 26
chr19_+_42651821 0.084 NM_144694
ZNF570
zinc finger protein 570
chr8_-_8276598 0.084 NM_001080826
SGK223
homolog of rat pragma of Rnd2
chr15_-_41409979 0.082 NM_014793
LCMT2
leucine carboxyl methyltransferase 2
chrX_+_505078 0.082 NM_000451
NM_006883
SHOX

short stature homeobox

chr6_-_86360279 0.081 NM_020468
NM_153816
SNX14

sorting nexin 14

chr14_-_36052727 0.080 NM_001101341
SFTA3
surfactant associated 3
chr2_-_200424140 0.078 LOC348751
hypothetical LOC348751
chr17_+_5264195 0.078 RPAIN
RPA interacting protein
chr14_+_102313566 0.076 NM_003300
NM_145725
NM_145726
TRAF3


TNF receptor-associated factor 3


chr15_+_41410163 0.076 NM_001012969
NM_001159280
ADAL

adenosine deaminase-like

chr19_+_61798434 0.075 NM_021216
ZNF71
zinc finger protein 71
chr16_+_66128843 0.074 NM_001193524
FAM65A
family with sequence similarity 65, member A
chr3_+_133798770 0.074 NM_016557
CCRL1
chemokine (C-C motif) receptor-like 1
chr9_+_22437064 0.074


chr2_+_235525355 0.072 NM_014521
SH3BP4
SH3-domain binding protein 4
chr20_+_35406497 0.072 NM_005417
SRC
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
chr11_-_128312922 0.071 NM_001195194
TP53AIP1
tumor protein p53 regulated apoptosis inducing protein 1
chr16_+_88696172 0.071 FAM157C
family with sequence similarity 157, member C
chr19_+_49337568 0.071 ZNF234
zinc finger protein 234
chr20_-_23566325 0.070 NM_000099
CST3
cystatin C
chr8_+_25372631 0.068 CDCA2
cell division cycle associated 2
chr5_+_179065282 0.068 CANX
calnexin
chr22_-_31732648 0.068 NM_003490
NM_133633
SYN3

synapsin III

chr11_-_64459910 0.067 NM_130769
GPHA2
glycoprotein hormone alpha 2
chr17_-_36294962 0.067 NM_019010
KRT20
keratin 20
chr17_+_5913149 0.065 WSCD1
WSC domain containing 1
chr5_+_55098469 0.064 NM_001166534
DDX4
DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
chr8_+_86344945 0.063 NM_198584
CA13
carbonic anhydrase XIII
chr15_-_40173949 0.063 NM_178034
PLA2G4D
phospholipase A2, group IVD (cytosolic)
chr5_+_134237325 0.062 NM_024715
TXNDC15
thioredoxin domain containing 15
chr8_+_25372653 0.061 CDCA2
cell division cycle associated 2
chr2_+_218698242 0.061 NM_001168298
CXCR2
chemokine (C-X-C motif) receptor 2
chr22_+_34374421 0.061 APOL6
apolipoprotein L, 6
chr11_+_57554977 0.061 NM_001005186
OR6Q1
olfactory receptor, family 6, subfamily Q, member 1
chr11_+_129823667 0.061 NM_139055
ADAMTS15
ADAM metallopeptidase with thrombospondin type 1 motif, 15
chr10_-_61139328 0.060 NM_194298
LOC100129721
SLC16A9
hypothetical protein LOC100129721
solute carrier family 16, member 9 (monocarboxylic acid transporter 9)
chr13_+_19105780 0.059 NM_017520
MPHOSPH8
M-phase phosphoprotein 8
chr19_+_49147219 0.059 NM_013359
ZNF221
zinc finger protein 221
chr9_+_22437353 0.059 DMRTA1
DMRT-like family A1
chr12_-_121404968 0.058 CLIP1
CAP-GLY domain containing linker protein 1
chr17_-_11841413 0.058 NM_144680
ZNF18
zinc finger protein 18
chr2_-_113310796 0.058 NM_000576
IL1B
interleukin 1, beta
chr12_-_41164052 0.058 NM_001144882
NM_001144883
PRICKLE1

prickle homolog 1 (Drosophila)

chr8_+_86344984 0.058 CA13
carbonic anhydrase XIII
chr3_-_189354510 0.058 LOC339929
hypothetical LOC339929
chr4_-_145281237 0.057 NM_002099
GYPA
glycophorin A (MNS blood group)
chr1_+_10457579 0.056 NM_004565
PEX14
peroxisomal biogenesis factor 14
chr5_-_180220881 0.055 NM_001172638
NM_152283
ZFP62

zinc finger protein 62 homolog (mouse)

chr16_-_3707450 0.055 NM_016292
TRAP1
TNF receptor-associated protein 1
chr8_-_18710575 0.053 NM_206909
PSD3
pleckstrin and Sec7 domain containing 3
chr3_-_48729593 0.053 NM_001005909
NM_001005910
NM_001005911
NM_001146178
NM_001146179
NM_001190316
NM_001190317
NM_016291
IP6K2







inositol hexakisphosphate kinase 2







chr12_+_15017222 0.052 NM_006205
PDE6H
phosphodiesterase 6H, cGMP-specific, cone, gamma
chr8_+_86345256 0.051 CA13
carbonic anhydrase XIII
chr14_-_103457590 0.050 C14orf2
chromosome 14 open reading frame 2
chr17_-_39822366 0.050 NM_000419
ITGA2B
integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
chr6_-_86360271 0.049 SNX14
sorting nexin 14
chr8_+_36760999 0.049 NM_001031836
KCNU1
potassium channel, subfamily U, member 1
chr7_-_87774130 0.046 NM_024636
STEAP4
STEAP family member 4
chr20_+_2743613 0.046 NM_080739
C20orf141
chromosome 20 open reading frame 141
chr6_+_97117144 0.045 NM_001170807
NM_020482
FHL5

four and a half LIM domains 5

chr3_-_171070314 0.044 NM_024727
LRRC31
leucine rich repeat containing 31
chr8_+_86345274 0.043


chr6_-_86360047 0.043 SNX14
sorting nexin 14
chr15_+_88609837 0.043 NM_001033088
NGRN
neugrin, neurite outgrowth associated
chr10_+_95838801 0.042 NM_001165979
PLCE1
phospholipase C, epsilon 1
chr19_+_10242763 0.042 ICAM1
intercellular adhesion molecule 1
chr19_+_49408523 0.041 NM_182490
ZNF227
zinc finger protein 227
chr12_+_100795213 0.041 NM_018370
DRAM1
DNA-damage regulated autophagy modulator 1
chr5_-_139993469 0.041 NM_001040021
NM_001174104
NM_001174105
CD14


CD14 molecule


chr19_-_49696322 0.040 NM_013256
ZNF180
zinc finger protein 180
chr13_+_24844084 0.040 NM_016529
ATP8A2
ATPase, aminophospholipid transporter, class I, type 8A, member 2
chr2_-_215605054 0.040 NM_015657
ABCA12
ATP-binding cassette, sub-family A (ABC1), member 12
chr19_-_62759536 0.040 NM_001039654
ZNF550
zinc finger protein 550
chr3_+_137224266 0.040 NM_181897
PPP2R3A
protein phosphatase 2, regulatory subunit B'', alpha
chrX_+_46318135 0.039 NM_019886
CHST7
carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7
chr8_+_1759502 0.039 NM_014629
ARHGEF10
Rho guanine nucleotide exchange factor (GEF) 10
chr22_-_49041786 0.037 MAPK12
mitogen-activated protein kinase 12
chr19_+_46992361 0.036 NM_001815
CEACAM3
carcinoembryonic antigen-related cell adhesion molecule 3
chr5_-_111340421 0.036 NM_001142474
NM_001142475
C5orf13

chromosome 5 open reading frame 13

chr9_-_23811477 0.035 NM_001171197
ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr10_+_93548162 0.034 TNKS2
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
chr11_+_118582231 0.034 CBL
Cas-Br-M (murine) ecotropic retroviral transforming sequence
chr9_-_106401514 0.033 NM_001004482
OR13C5
olfactory receptor, family 13, subfamily C, member 5
chr14_-_93988838 0.033 NM_001080451
SERPINA11
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11
chr15_+_89300995 0.033 RCCD1
RCC1 domain containing 1
chr12_-_47735373 0.032 NM_003482
MLL2
myeloid/lymphoid or mixed-lineage leukemia 2
chr7_-_44579787 0.031 DDX56
DEAD (Asp-Glu-Ala-Asp) box polypeptide 56
chr16_-_1410710 0.031 C16orf91
chromosome 16 open reading frame 91
chr6_-_132764257 0.031 NM_015529
MOXD1
monooxygenase, DBH-like 1
chr15_+_89300973 0.031 RCCD1
RCC1 domain containing 1
chr3_-_120442413 0.030 NM_003778
NM_212543
B4GALT4

UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4

chr19_+_49180171 0.030 NM_003445
NM_198089
ZNF155

zinc finger protein 155

chr19_+_44959073 0.029 NM_001143832
LEUTX
leucine twenty homeobox
chr2_+_95195260 0.029 ZNF2
zinc finger protein 2
chr11_-_55661769 0.029 NM_001004064
OR8J3
olfactory receptor, family 8, subfamily J, member 3
chr20_+_43470330 0.028 DBNDD2
dysbindin (dystrobrevin binding protein 1) domain containing 2
chr15_-_70863115 0.028 ADPGK
ADP-dependent glucokinase
chr1_-_201422436 0.028 CHI3L1
chitinase 3-like 1 (cartilage glycoprotein-39)
chr3_+_181802592 0.027 NM_001042601
NM_133462
TTC14

tetratricopeptide repeat domain 14

chr17_+_11405798 0.027 SHISA6
shisa homolog 6 (Xenopus laevis)
chrX_+_26066380 0.027 NM_173699
MAGEB18
melanoma antigen family B, 18
chr22_-_40856821 0.027 NM_000106
NM_001025161
CYP2D6

cytochrome P450, family 2, subfamily D, polypeptide 6

chr22_-_39966801 0.026 NM_138481
CHADL
chondroadherin-like

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.61 1.39e-04 GO:0043169 cation binding
1.61 1.55e-04 GO:0043167 ion binding
1.59 3.33e-04 GO:0046872 metal ion binding
1.71 8.56e-03 GO:0046914 transition metal ion binding
13.30 4.63e-02 GO:0001637 G-protein chemoattractant receptor activity
13.30 4.63e-02 GO:0004950 chemokine receptor activity