Motif ID: FOXO1,3,4.p2

Z-value: 1.532


Transcription factors associated with FOXO1,3,4.p2:

Gene SymbolEntrez IDGene Name
FOXO1 2308 forkhead box O1
FOXO3 2309 forkhead box O3
FOXO4 4303 forkhead box O4



Activity profile for motif FOXO1,3,4.p2.

activity profile for motif FOXO1,3,4.p2


Sorted Z-values histogram for motif FOXO1,3,4.p2

Sorted Z-values for motif FOXO1,3,4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOXO1,3,4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_-_150569574 2.342 TM4SF1
transmembrane 4 L six family member 1
chr2_+_135526304 2.206 NM_001172435
NM_012233
RAB3GAP1

RAB3 GTPase activating protein subunit 1 (catalytic)

chr4_+_124540114 2.111 NM_005841
SPRY1
sprouty homolog 1, antagonist of FGF signaling (Drosophila)
chr7_+_134483305 2.013 NM_018295
TMEM140
transmembrane protein 140
chr3_+_23904086 1.756 UBE2E1
ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast)
chr6_+_127940011 1.666 NM_001010905
C6orf58
chromosome 6 open reading frame 58
chr2_+_191222077 1.436 NM_005966
NAB1
NGFI-A binding protein 1 (EGR1 binding protein 1)
chr15_+_22781292 1.425 PAR5
Prader-Willi/Angelman syndrome-5
chr13_+_23042722 1.425 NM_148957
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr6_+_131498540 1.320 AKAP7
A kinase (PRKA) anchor protein 7
chr2_-_215951161 1.289 FN1
fibronectin 1
chr2_-_210726539 1.257 C2orf67
chromosome 2 open reading frame 67
chr2_-_20390601 1.235 NM_015317
PUM2
pumilio homolog 2 (Drosophila)
chr17_-_36451189 1.218 NM_030967
KRTAP1-3
KRTAP1-1
keratin associated protein 1-3
keratin associated protein 1-1
chr17_-_36570508 1.211 NM_032524
KRTAP4-4
keratin associated protein 4-4
chr6_+_126319540 1.197 NM_138571
HINT3
histidine triad nucleotide binding protein 3
chr9_-_14769530 1.181 NM_001177704
FREM1
FRAS1 related extracellular matrix 1
chr2_-_21084911 1.179 APOB
apolipoprotein B (including Ag(x) antigen)
chr2_+_215885053 1.147 ATIC
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chr14_+_20226762 1.141 NM_001097577
NM_194431
ANG
RNASE4
angiogenin, ribonuclease, RNase A family, 5
ribonuclease, RNase A family, 4
chr4_+_86968069 1.137 ARHGAP24
Rho GTPase activating protein 24
chr17_+_36665161 1.112 NM_030975
KRTAP9-9
keratin associated protein 9-9
chr1_+_25537372 1.108 NM_014313
TMEM50A
transmembrane protein 50A
chr3_+_100840129 1.103 NM_001850
NM_020351
COL8A1

collagen, type VIII, alpha 1

chr3_-_52688768 1.085 NM_018165
NM_181042
PBRM1

polybromo 1

chr4_+_146623405 1.082 NM_001003688
SMAD1
SMAD family member 1
chr2_+_196229715 1.081 NM_001127257
SLC39A10
solute carrier family 39 (zinc transporter), member 10
chr2_-_40510923 1.079 NM_001112800
NM_001112801
NM_021097
SLC8A1


solute carrier family 8 (sodium/calcium exchanger), member 1


chr2_-_21079145 1.079 APOB
apolipoprotein B (including Ag(x) antigen)
chr5_+_27508139 1.072 LOC643401
hypothetical protein LOC643401
chr6_-_128281434 1.062 NM_001164687
THEMIS
thymocyte selection associated
chr2_+_196230096 1.056 NM_020342
SLC39A10
solute carrier family 39 (zinc transporter), member 10
chr10_-_113933457 1.050 NM_020918
GPAM
glycerol-3-phosphate acyltransferase, mitochondrial
chr8_+_79740813 1.039 NM_016010
FAM164A
family with sequence similarity 164, member A
chr13_-_44673174 1.029 NM_198404
KCTD4
potassium channel tetramerisation domain containing 4
chr5_-_58607673 1.023 NM_001197220
PDE4D
phosphodiesterase 4D, cAMP-specific
chr12_+_77963563 1.021 NM_001135806
SYT1
synaptotagmin I
chr3_+_173240983 1.018 NM_001135095
FNDC3B
fibronectin type III domain containing 3B
chr11_+_101488380 1.016 NM_001195045
YAP1
Yes-associated protein 1
chr17_-_51164443 1.013 NM_001099640
TMEM100
transmembrane protein 100
chr5_+_79739548 1.012 NM_001105251
NM_014733
ZFYVE16

zinc finger, FYVE domain containing 16

chr9_-_16717887 1.003 BNC2
basonuclin 2
chr16_-_66590856 0.999 NM_022355
DPEP2
dipeptidase 2
chr5_+_66160359 0.998 NM_015183
MAST4
microtubule associated serine/threonine kinase family member 4
chr6_+_153060722 0.993 NM_025107
MYCT1
myc target 1
chr19_-_57223329 0.988 NM_025040
ZNF614
zinc finger protein 614
chr10_-_75005421 0.981 NM_152586
USP54
ubiquitin specific peptidase 54
chr4_+_87070449 0.981 NM_031305
ARHGAP24
Rho GTPase activating protein 24
chr1_+_190811479 0.950 NM_002922
RGS1
regulator of G-protein signaling 1
chr3_+_189425886 0.949 NM_001167671
LPP
LIM domain containing preferred translocation partner in lipoma
chr17_+_36642240 0.937 NM_031962
KRTAP9-9
KRTAP9-3
keratin associated protein 9-9
keratin associated protein 9-3
chr3_+_109498082 0.931 HHLA2
HERV-H LTR-associating 2
chr9_+_102231616 0.920 NM_001198806
C9orf30
chromosome 9 open reading frame 30
chr13_+_20081940 0.913


chr14_+_101345878 0.908 NM_002719
NM_178586
NM_178587
PPP2R5C


protein phosphatase 2, regulatory subunit B', gamma


chr7_+_12217343 0.904 NM_001134232
NM_018374
TMEM106B

transmembrane protein 106B

chr7_-_83108682 0.900 NM_001178129
SEMA3E
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
chr10_+_82163568 0.888 C10orf58
chromosome 10 open reading frame 58
chr5_+_162865128 0.885 NM_013283
MAT2B
methionine adenosyltransferase II, beta
chr8_-_93144366 0.881 NM_004349
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr9_+_5500544 0.880 NM_025239
PDCD1LG2
programmed cell death 1 ligand 2
chr6_+_134315045 0.876 TBPL1
TBP-like 1
chr1_+_86662356 0.874 NM_006536
CLCA2
chloride channel accessory 2
chr9_+_66293049 0.872 MGC21881
hypothetical locus MGC21881
chr15_+_54444907 0.871 NM_198524
TEX9
testis expressed 9
chr6_-_117853710 0.868 NM_002944
ROS1
c-ros oncogene 1 , receptor tyrosine kinase
chr10_-_37931864 0.865 NM_001190489
MTRNR2L7
MT-RNR2-like 7
chr11_+_55899675 0.864 NM_001005204
NM_001013356
OR8U1
OR8U8
olfactory receptor, family 8, subfamily U, member 1
olfactory receptor, family 8, subfamily U, member 8
chr5_+_65258316 0.862 ERBB2IP
erbb2 interacting protein
chr7_+_20621769 0.855 NM_001163941
ABCB5
ATP-binding cassette, sub-family B (MDR/TAP), member 5
chr6_-_127822227 0.846 NM_014702
KIAA0408
KIAA0408
chr2_-_17563186 0.844 NM_001099218
RAD51AP2
RAD51 associated protein 2
chr1_-_7998265 0.836 ERRFI1
ERBB receptor feedback inhibitor 1
chr21_+_37377116 0.832 NM_003316
TTC3
tetratricopeptide repeat domain 3
chr11_+_114054409 0.825 NM_182495
FAM55B
family with sequence similarity 55, member B
chr15_+_38296920 0.825 NM_001128628
NM_001128629
PAK6

p21 protein (Cdc42/Rac)-activated kinase 6

chr20_-_45410033 0.824 ZMYND8
zinc finger, MYND-type containing 8
chr6_+_64414389 0.810 NM_015153
PHF3
PHD finger protein 3
chr6_-_88095714 0.806 NM_198568
GJB7
gap junction protein, beta 7, 25kDa
chr2_-_21084077 0.806 APOB
apolipoprotein B (including Ag(x) antigen)
chr4_+_91035025 0.805 NM_007351
MMRN1
multimerin 1
chr4_+_75242671 0.803 NM_001144978
MTHFD2L
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like
chr6_+_97117144 0.800 NM_001170807
NM_020482
FHL5

four and a half LIM domains 5

chr20_-_33783409 0.795 RBM39
RNA binding motif protein 39
chr4_-_70861301 0.788 NM_001891
CSN2
casein beta
chr1_+_149165438 0.784 NM_001145415
NM_012432
SETDB1

SET domain, bifurcated 1

chr8_-_62764839 0.773 NM_001164750
NM_001164751
NM_001164752
NM_001164753
NM_020164
NM_032467
NM_032468
ASPH






aspartate beta-hydroxylase






chr17_-_36403910 0.771 NM_033185
KRTAP3-3
keratin associated protein 3-3
chr11_-_27637771 0.757 NM_001143816
NM_170735
BDNF

brain-derived neurotrophic factor

chr14_-_30996348 0.756 NM_080664
C14orf126
HEATR5A
chromosome 14 open reading frame 126
HEAT repeat containing 5A
chr1_+_153366928 0.747 NM_004428
NM_182685
EFNA1

ephrin-A1

chr3_+_62280435 0.747 NM_020685
C3orf14
chromosome 3 open reading frame 14
chr18_-_28247193 0.745


chr18_-_56190980 0.745 NM_005912
MC4R
melanocortin 4 receptor
chr6_+_47732181 0.745 NM_153839
GPR111
G protein-coupled receptor 111
chr5_+_135496437 0.743 SMAD5
SMAD family member 5
chr9_+_71009746 0.742 NM_001170415
NM_001170416
TJP2

tight junction protein 2 (zona occludens 2)

chr4_+_184602778 0.739 NM_017632
CDKN2AIP
CDKN2A interacting protein
chr15_-_65601185 0.734 LOC100506686
hypothetical LOC100506686
chr5_+_135496421 0.733 NM_001001419
NM_001001420
NM_005903
SMAD5


SMAD family member 5


chr4_-_107508040 0.729 NM_001195138
LOC100507096
GTPase IMAP family member-like
chr9_+_112470871 0.728 NM_001166280
NM_001166281
NM_005592
MUSK


muscle, skeletal, receptor tyrosine kinase


chr6_+_62341966 0.726 NM_001190706
MTRNR2L9
MT-RNR2-like 9
chr2_-_138762909 0.725


chr6_+_118976134 0.725 NM_002667
PLN
phospholamban
chr13_+_40783340 0.725 NM_001110798
NM_024561
NM_018527
NAA16


N(alpha)-acetyltransferase 16, NatA auxiliary subunit


chr2_+_215885063 0.718 ATIC
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chr17_-_60439764 0.714 GNA13
guanine nucleotide binding protein (G protein), alpha 13
chr6_-_150099352 0.702 NUP43
nucleoporin 43kDa
chr8_+_144802972 0.701 NM_014789
ZNF623
zinc finger protein 623
chr2_+_234245243 0.700 NM_021027
UGT1A9
UDP glucuronosyltransferase 1 family, polypeptide A9
chr2_-_218865451 0.697 NM_022152
TMBIM1
transmembrane BAX inhibitor motif containing 1
chr18_-_59462469 0.697 NM_002974
SERPINB4
serpin peptidase inhibitor, clade B (ovalbumin), member 4
chr12_-_27126721 0.696 NM_001080406
C12orf71
chromosome 12 open reading frame 71
chr6_-_122807439 0.696 SERINC1
serine incorporator 1
chr6_-_138231006 0.692


chr8_-_130868315 0.691 NM_031415
GSDMC
gasdermin C
chr12_+_68923043 0.689 NM_014515
CNOT2
CCR4-NOT transcription complex, subunit 2
chr2_-_99412694 0.686 REV1
REV1 homolog (S. cerevisiae)
chr2_-_165133239 0.684 GRB14
growth factor receptor-bound protein 14
chr14_+_101346032 0.684 PPP2R5C
protein phosphatase 2, regulatory subunit B', gamma
chr6_+_64344307 0.683 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr15_+_97010219 0.682 NM_000875
IGF1R
insulin-like growth factor 1 receptor
chr2_+_215884923 0.681 NM_004044
ATIC
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chr2_+_211129567 0.681 NM_001875
CPS1
carbamoyl-phosphate synthase 1, mitochondrial
chr11_-_10630408 0.680 NM_001098579
MRVI1
murine retrovirus integration site 1 homolog
chr11_+_119862014 0.673 ARHGEF12
Rho guanine nucleotide exchange factor (GEF) 12
chr13_+_96672705 0.667 MBNL2
muscleblind-like 2 (Drosophila)
chr17_-_18469569 0.660 CCDC144B
coiled-coil domain containing 144B
chr2_+_54411574 0.658 NM_001100396
C2orf73
chromosome 2 open reading frame 73
chr4_+_73123712 0.658 NM_001144756
NM_053036
NPFFR2

neuropeptide FF receptor 2

chr12_+_123023521 0.653 NM_152437
ZNF664
zinc finger protein 664
chr6_+_131190237 0.653 NM_001195597
LOC285733
hypothetical LOC285733
chr2_+_86800940 0.651 RMND5A
required for meiotic nuclear division 5 homolog A (S. cerevisiae)
chr3_+_180348818 0.647 NM_006218
PIK3CA
phosphoinositide-3-kinase, catalytic, alpha polypeptide
chr2_-_191580567 0.646 STAT1
signal transducer and activator of transcription 1, 91kDa
chr13_+_96884316 0.644 NM_021033
RAP2A
RAP2A, member of RAS oncogene family
chr10_+_111959978 0.643 NM_001008541
MXI1
MAX interactor 1
chr5_-_86739683 0.642 CCNH
cyclin H
chr4_-_140443061 0.640 NM_001184987
NM_001184988
NM_001184989
NM_001184990
NDUFC1



NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa



chr8_+_50147455 0.637 NM_001007176
C8orf22
chromosome 8 open reading frame 22
chr4_+_91375204 0.635 NM_207491
FAM190A
family with sequence similarity 190, member A
chr2_+_182558795 0.635 NM_001080545
PPP1R1C
protein phosphatase 1, regulatory (inhibitor) subunit 1C
chr5_-_39400319 0.634 NM_001737
C9
complement component 9
chr8_+_19215279 0.629 NM_001174160
NM_022071
NM_001174159
SH2D4A


SH2 domain containing 4A


chr2_+_86801081 0.626 RMND5A
required for meiotic nuclear division 5 homolog A (S. cerevisiae)
chr19_+_59820413 0.625 NM_006669
LILRB1
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
chr6_+_142552320 0.624 VTA1
Vps20-associated 1 homolog (S. cerevisiae)
chr1_-_239869826 0.624 NM_014322
OPN3
opsin 3
chr11_+_33306652 0.623 HIPK3
homeodomain interacting protein kinase 3
chr2_+_120487076 0.623 NM_001184938
EPB41L5
erythrocyte membrane protein band 4.1 like 5
chr1_+_92318449 0.623 NM_183242
BTBD8
BTB (POZ) domain containing 8
chr1_+_100276238 0.623 HIAT1
hippocampus abundant transcript 1
chr1_+_100276242 0.619 NM_033055
HIAT1
hippocampus abundant transcript 1
chr13_-_85271329 0.618 NM_032229
SLITRK6
SLIT and NTRK-like family, member 6
chr17_-_36577949 0.618 NM_033187
KRTAP4-3
keratin associated protein 4-3
chr6_-_128263868 0.618 NM_001010923
NM_001164685
THEMIS

thymocyte selection associated

chr2_+_170392146 0.617 NM_172070
UBR3
ubiquitin protein ligase E3 component n-recognin 3 (putative)
chr9_+_4652285 0.616 NM_203453
PPAPDC2
phosphatidic acid phosphatase type 2 domain containing 2
chr6_+_154373323 0.613 NM_001145279
NM_001145280
NM_001145281
OPRM1


opioid receptor, mu 1


chr10_+_22580992 0.613


chr4_-_152368492 0.609 SH3D19
SH3 domain containing 19
chr11_+_123282307 0.609 NM_001005197
OR8D4
olfactory receptor, family 8, subfamily D, member 4
chr6_-_29081015 0.608 NM_001010877
ZNF311
zinc finger protein 311
chr10_+_92970302 0.607 NM_032373
PCGF5
polycomb group ring finger 5
chr1_+_161308318 0.606 NM_001113380
RGS4
regulator of G-protein signaling 4
chr16_-_10696285 0.605 NM_144674
TEKT5
tektin 5
chr5_+_73145098 0.604 RGNEF
190 kDa guanine nucleotide exchange factor
chr4_+_184602784 0.604 CDKN2AIP
CDKN2A interacting protein
chr7_-_95063738 0.604 NM_002612
PDK4
pyruvate dehydrogenase kinase, isozyme 4
chr20_+_56904042 0.603 GNAS
GNAS complex locus
chr20_+_56455866 0.602 VAPB
VAMP (vesicle-associated membrane protein)-associated protein B and C
chr7_-_148788799 0.597 NM_015694
ZNF777
zinc finger protein 777
chr2_+_166034402 0.595 NM_001172173
CSRNP3
cysteine-serine-rich nuclear protein 3
chr18_-_38949481 0.592 NM_002930
RIT2
Ras-like without CAAX 2
chr5_+_65475760 0.592 NM_001077199
SREK1
splicing regulatory glutamine/lysine-rich protein 1
chr14_+_34583863 0.589 NM_001079519
FAM177A1
family with sequence similarity 177, member A1
chr4_+_156349230 0.589 NM_000910
NPY2R
neuropeptide Y receptor Y2
chr4_+_172971149 0.587 NM_001034845
GALNTL6
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 6
chr18_+_64616296 0.587 NM_024781
CCDC102B
coiled-coil domain containing 102B
chr20_-_2589476 0.587 IDH3B
isocitrate dehydrogenase 3 (NAD+) beta
chr11_-_7804094 0.584 NM_153445
OR5P3
olfactory receptor, family 5, subfamily P, member 3
chr1_+_97033103 0.581


chr2_-_225086564 0.577 CUL3
cullin 3
chr6_-_66346417 0.576 NM_198283
EYS
eyes shut homolog (Drosophila)
chr22_-_15682555 0.576 NM_175878
XKR3
XK, Kell blood group complex subunit-related family, member 3
chr3_-_155630197 0.573 NM_001038705
GPR149
G protein-coupled receptor 149
chr2_+_190248955 0.573 NM_144708
ANKAR
ankyrin and armadillo repeat containing
chr13_+_75092570 0.572 NM_005358
LMO7
LIM domain 7
chr2_-_39310176 0.572 NM_001009565
CDKL4
cyclin-dependent kinase-like 4
chr20_+_35351473 0.570 MANBAL
mannosidase, beta A, lysosomal-like
chr11_-_102156531 0.565 NM_002425
MMP10
matrix metallopeptidase 10 (stromelysin 2)
chr5_-_58688428 0.563 NM_001197219
PDE4D
phosphodiesterase 4D, cAMP-specific
chr2_+_241193492 0.562 NM_001195381
NM_001195382
GPR35

G protein-coupled receptor 35

chr14_-_105589467 0.562 LOC100126583
IGHA1
IGHG1
IGHG2
IGHM
hypothetical LOC100126583
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 2 (G2m marker)
immunoglobulin heavy constant mu
chr1_+_111634996 0.557 NM_021797
NM_201653
CHIA

chitinase, acidic

chr6_-_58395610 0.556 GUSBP4
glucuronidase, beta pseudogene 4
chr12_-_23995109 0.556 SOX5
SRY (sex determining region Y)-box 5
chr2_+_113542017 0.554 NM_173161
IL1F10
interleukin 1 family, member 10 (theta)
chr20_+_42593849 0.553 NM_007066
NM_181804
NM_181805
PKIG


protein kinase (cAMP-dependent, catalytic) inhibitor gamma



Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.96 1.37e-05 GO:0007608 sensory perception of smell
1.82 2.13e-04 GO:0007606 sensory perception of chemical stimulus
1.50 1.54e-02 GO:0007600 sensory perception

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.95 1.05e-05 GO:0004984 olfactory receptor activity
1.42 4.93e-02 GO:0004930 G-protein coupled receptor activity