Motif ID: GTF2I.p2

Z-value: 1.960


Transcription factors associated with GTF2I.p2:

Gene SymbolEntrez IDGene Name
GTF2I 2969 general transcription factor II, i



Activity profile for motif GTF2I.p2.

activity profile for motif GTF2I.p2


Sorted Z-values histogram for motif GTF2I.p2

Sorted Z-values for motif GTF2I.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of GTF2I.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_+_138060 3.237 NM_018390
PLCXD1
phosphatidylinositol-specific phospholipase C, X domain containing 1
chr9_+_132961683 2.299 NM_001185095
NM_001185096
NM_031426
AIF1L


allograft inflammatory factor 1-like


chr5_+_139008209 2.255 NM_016463
CXXC5
CXXC finger protein 5
chr9_+_132961723 2.209 AIF1L
allograft inflammatory factor 1-like
chr16_+_84202515 2.115 NM_001134473
KIAA0182
KIAA0182
chr5_+_139008667 1.812 CXXC5
CXXC finger protein 5
chr18_+_41659542 1.810 NM_213602
SIGLEC15
sialic acid binding Ig-like lectin 15
chr17_+_7682355 1.590


chr5_+_36912595 1.473 NM_015384
NM_133433
NIPBL

Nipped-B homolog (Drosophila)

chr16_-_71650034 1.451 NM_001164766
ZFHX3
zinc finger homeobox 3
chr5_+_139008052 1.400 CXXC5
CXXC finger protein 5
chr6_+_149680747 1.331 TAB2
TGF-beta activated kinase 1/MAP3K7 binding protein 2
chr7_+_5289079 1.310 NM_001040661
NM_153247
SLC29A4

solute carrier family 29 (nucleoside transporters), member 4

chr5_+_139008091 1.279 CXXC5
CXXC finger protein 5
chr5_-_36912487 1.210 LOC646719
hypothetical LOC646719
chr5_+_139008139 1.188 CXXC5
CXXC finger protein 5
chr17_-_34157962 1.185 NM_007144
PCGF2
polycomb group ring finger 2
chr5_+_36912656 1.175 NIPBL
Nipped-B homolog (Drosophila)
chr1_+_224317044 1.148 H3F3A
LOC440926
H3 histone, family 3A
H3 histone, family 3A pseudogene
chr1_+_224317030 1.145 H3F3A
H3 histone, family 3A
chr1_+_224317062 1.142 H3F3A
LOC440926
H3 histone, family 3A
H3 histone, family 3A pseudogene
chr1_+_224317056 1.116 H3F3A
LOC440926
H3 histone, family 3A
H3 histone, family 3A pseudogene
chr16_-_29817841 1.097 NM_001114099
NM_001114100
NM_012410
NM_201575
SEZ6L2



seizure related 6 homolog (mouse)-like 2



chr6_+_37245860 1.037 NM_002648
PIM1
pim-1 oncogene
chr6_+_43846735 0.970 VEGFA
vascular endothelial growth factor A
chr6_+_33046706 0.964 BRD2
bromodomain containing 2
chr20_+_30410447 0.955 ASXL1
additional sex combs like 1 (Drosophila)
chr1_+_224317036 0.950 NM_002107
H3F3A
H3 histone, family 3A
chr6_-_16869579 0.930 NM_000332
NM_001128164
ATXN1

ataxin 1

chr1_+_165866127 0.920 RCSD1
RCSD domain containing 1
chr16_+_73590739 0.904 ZNRF1
zinc and ring finger 1
chr20_+_60906605 0.893 NM_007346
OGFR
opioid growth factor receptor
chrX_+_122923279 0.853 STAG2
stromal antigen 2
chr6_-_32265489 0.853 NM_002586
PBX2
pre-B-cell leukemia homeobox 2
chr10_+_114699953 0.849 NM_001146274
NM_001146283
NM_001146284
NM_001146285
NM_001146286
NM_001198525
NM_001198526
NM_001198527
NM_001198528
NM_001198529
NM_001198530
NM_001198531
NM_030756
TCF7L2












transcription factor 7-like 2 (T-cell specific, HMG-box)












chr15_-_49174107 0.841 TNFAIP8L3
tumor necrosis factor, alpha-induced protein 8-like 3
chr1_-_20685314 0.830 NM_018584
CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr1_+_29113589 0.816 NM_001166006
EPB41
erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)
chr7_+_149707338 0.814 NM_173680
ZNF775
zinc finger protein 775
chr6_-_42527760 0.813 NM_033502
TRERF1
transcriptional regulating factor 1
chr15_-_73531082 0.813 NM_001145358
SIN3A
SIN3 homolog A, transcription regulator (yeast)
chr6_+_33046636 0.804 NM_001113182
BRD2
bromodomain containing 2
chr19_-_59676153 0.795 NM_145057
CDC42EP5
CDC42 effector protein (Rho GTPase binding) 5
chr11_-_56846246 0.794 TNKS1BP1
tankyrase 1 binding protein 1, 182kDa
chr2_-_19421852 0.783 NM_145260
OSR1
odd-skipped related 1 (Drosophila)
chr2_+_218972963 0.780 NM_182642
CTDSP1
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
chr2_+_218972721 0.780 NM_021198
CTDSP1
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
chr1_-_24307514 0.779 MYOM3
myomesin family, member 3
chr19_+_45797413 0.769 LTBP4
latent transforming growth factor beta binding protein 4
chr5_+_92944680 0.759 NM_005654
NR2F1
nuclear receptor subfamily 2, group F, member 1
chr22_-_19180075 0.758 NM_032775
KLHL22
kelch-like 22 (Drosophila)
chr20_-_30636535 0.758 LOC284804
hypothetical protein LOC284804
chr22_+_21852551 0.746 NM_004327
NM_021574
BCR

breakpoint cluster region

chr1_+_26895108 0.744 NM_006015
NM_139135
ARID1A

AT rich interactive domain 1A (SWI-like)

chr20_+_29870836 0.743 NM_033118
MYLK2
myosin light chain kinase 2
chr12_+_110328126 0.725 NM_005475
SH2B3
SH2B adaptor protein 3
chr15_-_73530829 0.725 NM_015477
SIN3A
SIN3 homolog A, transcription regulator (yeast)
chrX_+_122923236 0.723 NM_001042750
NM_001042751
NM_006603
STAG2


stromal antigen 2


chr1_+_945399 0.719


chr1_+_199884072 0.718 NM_020443
NAV1
neuron navigator 1
chr16_+_73590419 0.716 ZNRF1
zinc and ring finger 1
chr16_+_73590470 0.715 ZNRF1
zinc and ring finger 1
chr9_-_130006309 0.711 NM_001131015
NM_012127
CIZ1

CDKN1A interacting zinc finger protein 1

chr16_+_84204424 0.710 NM_014615
KIAA0182
KIAA0182
chr19_+_59061422 0.707 NM_001020820
MYADM
myeloid-associated differentiation marker
chr6_+_149681128 0.704 NM_015093
TAB2
TGF-beta activated kinase 1/MAP3K7 binding protein 2
chr11_-_72698050 0.703 LOC100287837
hypothetical protein LOC100287837
chr1_-_20684858 0.703 CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr10_+_22650145 0.702 BMI1
BMI1 polycomb ring finger oncogene
chr1_+_945331 0.698 NM_198576
AGRN
agrin
chr16_+_73590375 0.696 NM_032268
ZNRF1
zinc and ring finger 1
chr19_+_48549664 0.696 NM_020406
CD177
CD177 molecule
chr7_-_105304159 0.693 NM_020725
NM_152749
ATXN7L1

ataxin 7-like 1

chr6_+_33045070 0.691


chr2_+_54536780 0.681 NM_003128
SPTBN1
spectrin, beta, non-erythrocytic 1
chr17_-_7083321 0.677 NM_024297
PHF23
PHD finger protein 23
chr20_-_61574259 0.676 NM_004518
NM_172106
NM_172107
NM_172108
NM_172109
KCNQ2




potassium voltage-gated channel, KQT-like subfamily, member 2




chr16_+_29726962 0.676 MAZ
MYC-associated zinc finger protein (purine-binding transcription factor)
chr12_+_47495567 0.667 CACNB3
calcium channel, voltage-dependent, beta 3 subunit
chr1_+_110555433 0.666 KCNC4
potassium voltage-gated channel, Shaw-related subfamily, member 4
chr2_+_232281470 0.665 NM_001099285
NM_002823
PTMA

prothymosin, alpha

chr3_+_4996096 0.663 NM_003670
BHLHE40
basic helix-loop-helix family, member e40
chr6_+_33486750 0.659 NM_002636
NM_024165
PHF1

PHD finger protein 1

chr6_+_1335067 0.655 NM_001452
FOXF2
forkhead box F2
chr16_-_29949637 0.654 NM_031478
FAM57B
family with sequence similarity 57, member B
chr1_+_202308814 0.650 NM_005686
SOX13
SRY (sex determining region Y)-box 13
chr15_+_41597097 0.648 NM_002373
MAP1A
microtubule-associated protein 1A
chr12_-_52179462 0.645 NM_001193511
NM_006301
MAP3K12

mitogen-activated protein kinase kinase kinase 12

chr1_+_203740306 0.643 NM_002596
NM_212502
NM_212503
CDK18


cyclin-dependent kinase 18


chr7_+_73506333 0.642 NM_005685
GTF2IRD1
GTF2I repeat domain containing 1
chr5_-_81082614 0.639 SSBP2
single-stranded DNA binding protein 2
chr1_+_165865953 0.636 NM_052862
RCSD1
RCSD domain containing 1
chr1_-_8406288 0.635 NM_001042682
RERE
arginine-glutamic acid dipeptide (RE) repeats
chr7_+_105304445 0.631 LOC100506768
CDHR3
hypothetical LOC100506768
cadherin-related family member 3
chr19_-_55763091 0.629 NM_001080457
LRRC4B
leucine rich repeat containing 4B
chr2_+_149118791 0.628 EPC2
enhancer of polycomb homolog 2 (Drosophila)
chr2_+_127892459 0.627 NM_000312
PROC
protein C (inactivator of coagulation factors Va and VIIIa)
chr6_+_41622111 0.627 NM_001012426
NM_001012427
NM_138457
FOXP4


forkhead box P4


chr6_+_41622267 0.626 FOXP4
forkhead box P4
chr4_+_129950222 0.625 NM_024900
NM_199320
PHF17

PHD finger protein 17

chr18_+_44319365 0.623 NM_001142397
NM_014772
CTIF

CBP80/20-dependent translation initiation factor

chr17_+_34115383 0.621 NM_005937
MLLT6
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
chr16_+_24648446 0.618 NM_014494
TNRC6A
trinucleotide repeat containing 6A
chr2_+_127892489 0.617 PROC
protein C (inactivator of coagulation factors Va and VIIIa)
chr16_-_29818334 0.615 SEZ6L2
seizure related 6 homolog (mouse)-like 2
chr21_+_42946719 0.611 NM_001001567
NM_001001568
NM_001001569
NM_001001570
NM_001001571
NM_001001572
NM_001001573
NM_001001574
NM_001001575
NM_001001576
NM_001001577
NM_001001578
NM_001001579
NM_001001580
NM_001001581
NM_001001582
NM_001001583
NM_001001584
NM_001001585
NM_002606
PDE9A



















phosphodiesterase 9A



















chr7_+_73506172 0.610 GTF2IRD1
GTF2I repeat domain containing 1
chr15_+_88345612 0.609 NM_198526
ZNF710
zinc finger protein 710
chr16_-_20819061 0.604 NM_173475
DCUN1D3
DCN1, defective in cullin neddylation 1, domain containing 3 (S. cerevisiae)
chr17_+_53515725 0.603 NM_080677
DYNLL2
dynein, light chain, LC8-type 2
chr1_+_167342493 0.603 NM_001677
ATP1B1
ATPase, Na+/K+ transporting, beta 1 polypeptide
chr5_+_10406829 0.602 MARCH6
membrane-associated ring finger (C3HC4) 6
chr1_+_199884152 0.601 NAV1
neuron navigator 1
chr16_+_49139694 0.598 NM_033119
NKD1
naked cuticle homolog 1 (Drosophila)
chr6_+_43846155 0.596 VEGFA
vascular endothelial growth factor A
chr12_-_113606322 0.595 NM_005996
NM_016569
TBX3

T-box 3

chr16_+_29726931 0.593 MAZ
MYC-associated zinc finger protein (purine-binding transcription factor)
chr5_+_135392482 0.590 NM_000358
TGFBI
transforming growth factor, beta-induced, 68kDa
chr5_+_148766632 0.588 LOC728264
hypothetical LOC728264
chr17_-_43977273 0.586 NM_002145
HOXB2
homeobox B2
chr3_+_38470782 0.582 NM_001106
ACVR2B
activin A receptor, type IIB
chr20_+_51023159 0.582 TSHZ2
teashirt zinc finger homeobox 2
chr5_+_137701122 0.580 NM_001135647
FAM53C
family with sequence similarity 53, member C
chr2_+_8739563 0.577 NM_002166
ID2
inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
chr19_+_1226510 0.574 NM_017914
C19orf24
chromosome 19 open reading frame 24
chr19_-_55914837 0.566


chr17_+_19255083 0.565 NM_007148
RNF112
ring finger protein 112
chr2_+_220200530 0.562 NM_005070
NM_201574
SLC4A3

solute carrier family 4, anion exchanger, member 3

chr1_+_6596331 0.561 NM_153812
PHF13
PHD finger protein 13
chr1_+_201711505 0.560 NM_002725
NM_201348
PRELP

proline/arginine-rich end leucine-rich repeat protein

chr7_+_73506047 0.558 NM_016328
GTF2IRD1
GTF2I repeat domain containing 1
chr4_+_48038095 0.548 SLAIN2
SLAIN motif family, member 2
chr1_+_165456572 0.546 NM_001198786
NM_002697
POU2F1

POU class 2 homeobox 1

chr12_-_24606616 0.541 NM_152989
SOX5
SRY (sex determining region Y)-box 5
chr1_-_6468600 0.541 NM_001042665
PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr5_+_56505608 0.539 GPBP1
GC-rich promoter binding protein 1
chr20_-_61462960 0.537 NM_000744
CHRNA4
cholinergic receptor, nicotinic, alpha 4
chr2_-_148494732 0.535 NM_001190882
NM_001190879
NM_002552
NM_001190881
NM_181741
ORC4




origin recognition complex, subunit 4




chr4_-_185632610 0.532 NM_002199
IRF2
interferon regulatory factor 2
chr3_+_46898673 0.531 NM_001184744
PTH1R
parathyroid hormone 1 receptor
chr1_+_116718011 0.531 NM_001160233
ATP1A1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
chr15_+_91244563 0.530 CHD2
chromodomain helicase DNA binding protein 2
chr1_+_153241665 0.529 NM_015872
ZBTB7B
zinc finger and BTB domain containing 7B
chr1_+_87567136 0.529 LMO4
LIM domain only 4
chr6_-_143307976 0.526 NM_006734
HIVEP2
human immunodeficiency virus type I enhancer binding protein 2
chr1_-_166172901 0.526 NM_001143674
BRP44
brain protein 44
chr3_+_192529567 0.522 NM_174908
NM_178335
CCDC50

coiled-coil domain containing 50

chr3_+_38182120 0.520 OXSR1
oxidative-stress responsive 1
chr15_+_91244422 0.520 NM_001042572
NM_001271
CHD2

chromodomain helicase DNA binding protein 2

chr1_+_6226838 0.516 NM_001024598
HES3
hairy and enhancer of split 3 (Drosophila)
chr10_+_22649977 0.512 NM_005180
BMI1
BMI1 polycomb ring finger oncogene
chr7_+_104441730 0.512 NM_018682
NM_182931
MLL5

myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)

chr1_+_945472 0.511 AGRN
agrin
chr6_+_7053863 0.511 RREB1
ras responsive element binding protein 1
chr12_+_92295738 0.511 NM_019094
NM_199040
NUDT4

NUDT4P1
nudix (nucleoside diphosphate linked moiety X)-type motif 4

nudix (nucleoside diphosphate linked moiety X)-type motif 4 pseudogene 1
chr16_-_3008162 0.511 NM_021195
CLDN6
claudin 6
chr2_+_86521999 0.508 NM_001146688
KDM3A
lysine (K)-specific demethylase 3A
chr9_-_132804057 0.508 NM_032843
FIBCD1
fibrinogen C domain containing 1
chr7_+_7974941 0.507 NM_138426
GLCCI1
glucocorticoid induced transcript 1
chr5_-_10406690 0.504


chr2_+_86521781 0.503 NM_018433
KDM3A
lysine (K)-specific demethylase 3A
chr1_+_203740391 0.502 CDK18
cyclin-dependent kinase 18
chr8_+_27547379 0.501 NM_016240
NM_182826
SCARA3

scavenger receptor class A, member 3

chr3_+_9414290 0.498 NM_001080517
SETD5
SET domain containing 5
chr1_-_202595666 0.498 NM_014935
PLEKHA6
pleckstrin homology domain containing, family A member 6
chr19_+_3175734 0.497 CELF5
CUGBP, Elav-like family member 5
chr1_+_116717552 0.496 ATP1A1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
chr6_+_44352443 0.492 TMEM151B
transmembrane protein 151B
chr2_+_86521939 0.489 KDM3A
lysine (K)-specific demethylase 3A
chr1_+_167342149 0.487 ATP1B1
ATPase, Na+/K+ transporting, beta 1 polypeptide
chr7_-_150604752 0.486 NM_001003802
SMARCD3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
chr14_-_104507862 0.486 AHNAK2
AHNAK nucleoprotein 2
chr7_+_97748959 0.486 BRI3
brain protein I3
chr5_+_135392624 0.485 TGFBI
transforming growth factor, beta-induced, 68kDa
chr2_+_177785667 0.485 NM_194247
HNRNPA3P1
HNRNPA3
heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
heterogeneous nuclear ribonucleoprotein A3
chr3_+_23961739 0.484 NM_005126
NR1D2
nuclear receptor subfamily 1, group D, member 2
chr17_+_34279781 0.484 LASP1
LIM and SH3 protein 1
chr3_+_42675841 0.481 ZBTB47
zinc finger and BTB domain containing 47
chr6_+_43846372 0.479 VEGFA
vascular endothelial growth factor A
chr12_+_55769189 0.479 NAB2
NGFI-A binding protein 2 (EGR1 binding protein 2)
chr2_-_26395420 0.479 NM_001145168
NM_001145169
GPR113

G protein-coupled receptor 113

chr9_-_34579679 0.474 NM_001842
NM_147164
CNTFR

ciliary neurotrophic factor receptor

chr20_+_60558104 0.466 NM_178463
C20orf166
chromosome 20 open reading frame 166
chr22_-_44751671 0.464 NM_058238
WNT7B
wingless-type MMTV integration site family, member 7B
chr9_-_132803809 0.464 FIBCD1
fibrinogen C domain containing 1
chr14_-_23117833 0.462 NM_001146028
NM_032452
JPH4

junctophilin 4

chr17_-_70901303 0.461 GRB2
growth factor receptor-bound protein 2
chr6_+_89847019 0.461 NM_006813
PNRC1
proline-rich nuclear receptor coactivator 1
chr2_+_149119029 0.460 NM_015630
EPC2
enhancer of polycomb homolog 2 (Drosophila)
chrX_+_128942435 0.459


chr5_+_10406980 0.457


chr1_+_201711578 0.450 PRELP
proline/arginine-rich end leucine-rich repeat protein
chr14_+_20608179 0.450 NM_018071
ARHGEF40
Rho guanine nucleotide exchange factor (GEF) 40
chr1_+_153241858 0.448 ZBTB7B
zinc finger and BTB domain containing 7B
chr21_+_37661728 0.445 NM_101395
DYRK1A
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
chr15_+_38520594 0.445 NM_014952
BAHD1
bromo adjacent homology domain containing 1
chr1_-_27802947 0.444 AHDC1
AT hook, DNA binding motif, containing 1
chr20_-_61600834 0.444 NM_001958
EEF1A2
eukaryotic translation elongation factor 1 alpha 2
chr11_-_70350292 0.443 SHANK2
SH3 and multiple ankyrin repeat domains 2
chr2_-_227371698 0.443 NM_005544
IRS1
insulin receptor substrate 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.18 2.34e-27 GO:0050789 regulation of biological process
1.19 2.95e-27 GO:0050794 regulation of cellular process
1.17 3.24e-27 GO:0065007 biological regulation
1.30 1.99e-19 GO:0048518 positive regulation of biological process
1.31 1.61e-17 GO:0048522 positive regulation of cellular process
1.31 4.08e-17 GO:0048519 negative regulation of biological process
1.23 1.24e-16 GO:0023052 signaling
1.24 3.70e-16 GO:0060255 regulation of macromolecule metabolic process
1.32 5.76e-16 GO:0048523 negative regulation of cellular process
1.22 7.82e-16 GO:0019222 regulation of metabolic process
1.09 8.08e-16 GO:0009987 cellular process
1.23 1.51e-15 GO:0031323 regulation of cellular metabolic process
1.23 1.18e-14 GO:0080090 regulation of primary metabolic process
1.22 6.07e-13 GO:0007165 signal transduction
1.19 1.23e-12 GO:0051716 cellular response to stimulus
1.38 4.81e-12 GO:0009893 positive regulation of metabolic process
1.38 3.48e-11 GO:0010604 positive regulation of macromolecule metabolic process
1.20 8.22e-11 GO:0007275 multicellular organismal development
1.37 1.14e-10 GO:0031325 positive regulation of cellular metabolic process
1.31 1.28e-10 GO:0023051 regulation of signaling
1.39 1.43e-10 GO:0051246 regulation of protein metabolic process
1.50 1.46e-10 GO:0009719 response to endogenous stimulus
1.33 2.50e-10 GO:0009966 regulation of signal transduction
1.51 5.82e-10 GO:0009725 response to hormone stimulus
1.18 6.21e-10 GO:0032502 developmental process
1.39 9.89e-10 GO:0032268 regulation of cellular protein metabolic process
1.39 1.98e-09 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.22 1.17e-08 GO:0010468 regulation of gene expression
1.21 1.23e-08 GO:0048731 system development
1.16 1.41e-08 GO:0044260 cellular macromolecule metabolic process
1.26 2.41e-08 GO:0048583 regulation of response to stimulus
1.21 2.43e-08 GO:0031326 regulation of cellular biosynthetic process
1.32 2.55e-08 GO:0010033 response to organic substance
1.29 3.64e-08 GO:0009653 anatomical structure morphogenesis
1.22 4.56e-08 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.21 5.17e-08 GO:0009889 regulation of biosynthetic process
1.19 6.49e-08 GO:0048856 anatomical structure development
1.40 7.13e-08 GO:0031399 regulation of protein modification process
1.43 7.98e-08 GO:0019220 regulation of phosphate metabolic process
1.43 7.98e-08 GO:0051174 regulation of phosphorus metabolic process
1.39 1.05e-07 GO:0051128 regulation of cellular component organization
1.36 1.16e-07 GO:0009892 negative regulation of metabolic process
1.14 1.42e-07 GO:0043170 macromolecule metabolic process
1.43 2.34e-07 GO:0042325 regulation of phosphorylation
1.25 2.71e-07 GO:0048513 organ development
1.21 3.22e-07 GO:0010556 regulation of macromolecule biosynthetic process
1.36 4.75e-07 GO:0010605 negative regulation of macromolecule metabolic process
1.19 4.84e-07 GO:0051171 regulation of nitrogen compound metabolic process
1.43 7.62e-07 GO:0001932 regulation of protein phosphorylation
1.42 9.57e-07 GO:0071310 cellular response to organic substance
1.44 9.86e-07 GO:0010629 negative regulation of gene expression
1.29 1.00e-06 GO:0051239 regulation of multicellular organismal process
1.19 1.47e-06 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.35 1.76e-06 GO:0031324 negative regulation of cellular metabolic process
1.43 1.89e-06 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.41 2.17e-06 GO:0010628 positive regulation of gene expression
1.16 2.86e-06 GO:0071840 cellular component organization or biogenesis
1.41 2.96e-06 GO:0010558 negative regulation of macromolecule biosynthetic process
1.11 3.74e-06 GO:0044237 cellular metabolic process
1.37 3.87e-06 GO:0051173 positive regulation of nitrogen compound metabolic process
1.33 3.89e-06 GO:0042127 regulation of cell proliferation
1.47 3.90e-06 GO:0043549 regulation of kinase activity
1.39 4.53e-06 GO:0009890 negative regulation of biosynthetic process
1.16 4.74e-06 GO:0016043 cellular component organization
1.39 6.35e-06 GO:0031327 negative regulation of cellular biosynthetic process
1.47 6.42e-06 GO:0072358 cardiovascular system development
1.47 6.42e-06 GO:0072359 circulatory system development
1.39 7.57e-06 GO:0045595 regulation of cell differentiation
1.37 1.06e-05 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.31 1.08e-05 GO:0007154 cell communication
1.57 1.25e-05 GO:0033674 positive regulation of kinase activity
1.37 1.27e-05 GO:0006468 protein phosphorylation
1.23 1.36e-05 GO:0007166 cell surface receptor linked signaling pathway
1.38 1.52e-05 GO:0009790 embryo development
1.33 1.74e-05 GO:0050793 regulation of developmental process
1.43 1.96e-05 GO:0045892 negative regulation of transcription, DNA-dependent
1.46 2.13e-05 GO:0045859 regulation of protein kinase activity
1.26 2.74e-05 GO:0035556 intracellular signal transduction
1.55 3.00e-05 GO:0051347 positive regulation of transferase activity
1.44 3.16e-05 GO:0051338 regulation of transferase activity
1.54 3.31e-05 GO:0071495 cellular response to endogenous stimulus
1.31 3.37e-05 GO:0032879 regulation of localization
1.39 3.47e-05 GO:0045893 positive regulation of transcription, DNA-dependent
1.33 4.53e-05 GO:0016310 phosphorylation
1.51 5.16e-05 GO:0016568 chromatin modification
1.30 5.24e-05 GO:0006793 phosphorus metabolic process
1.30 5.24e-05 GO:0006796 phosphate metabolic process
1.24 5.93e-05 GO:0007399 nervous system development
1.55 7.10e-05 GO:0045860 positive regulation of protein kinase activity
1.34 7.28e-05 GO:0007267 cell-cell signaling
1.10 7.31e-05 GO:0044238 primary metabolic process
1.19 7.45e-05 GO:0051252 regulation of RNA metabolic process
1.35 7.50e-05 GO:0010557 positive regulation of macromolecule biosynthetic process
1.37 8.18e-05 GO:0051254 positive regulation of RNA metabolic process
1.32 9.55e-05 GO:0031328 positive regulation of cellular biosynthetic process
1.19 1.07e-04 GO:0065008 regulation of biological quality
1.21 1.15e-04 GO:0006464 protein modification process
1.19 1.22e-04 GO:0006355 regulation of transcription, DNA-dependent
1.40 1.28e-04 GO:0051253 negative regulation of RNA metabolic process
1.31 1.32e-04 GO:0006351 transcription, DNA-dependent
1.31 1.35e-04 GO:0022008 neurogenesis
1.55 1.44e-04 GO:0001944 vasculature development
1.19 1.45e-04 GO:0042221 response to chemical stimulus
1.28 1.83e-04 GO:0010646 regulation of cell communication
1.09 1.88e-04 GO:0008152 metabolic process
1.37 1.91e-04 GO:0051172 negative regulation of nitrogen compound metabolic process
1.31 2.53e-04 GO:0009891 positive regulation of biosynthetic process
1.33 2.56e-04 GO:2000026 regulation of multicellular organismal development
1.37 2.68e-04 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.29 2.80e-04 GO:0070887 cellular response to chemical stimulus
1.23 3.22e-04 GO:0065009 regulation of molecular function
1.52 3.76e-04 GO:0032870 cellular response to hormone stimulus
1.54 6.88e-04 GO:0001568 blood vessel development
1.63 7.05e-04 GO:0044087 regulation of cellular component biogenesis
1.19 7.80e-04 GO:0030154 cell differentiation
1.19 7.99e-04 GO:0043412 macromolecule modification
1.17 1.05e-03 GO:0006950 response to stress
1.29 1.10e-03 GO:0008219 cell death
1.68 1.20e-03 GO:0070482 response to oxygen levels
1.42 1.28e-03 GO:0032583 regulation of gene-specific transcription
1.55 1.33e-03 GO:0000165 MAPKKK cascade
1.29 1.49e-03 GO:0009888 tissue development
1.41 1.58e-03 GO:0051094 positive regulation of developmental process
1.33 1.72e-03 GO:0007167 enzyme linked receptor protein signaling pathway
1.29 1.85e-03 GO:0016265 death
1.52 1.90e-03 GO:0048545 response to steroid hormone stimulus
1.16 1.91e-03 GO:0071842 cellular component organization at cellular level
1.40 1.94e-03 GO:0048646 anatomical structure formation involved in morphogenesis
1.49 1.99e-03 GO:0051130 positive regulation of cellular component organization
1.18 2.28e-03 GO:0048869 cellular developmental process
1.48 2.30e-03 GO:0060284 regulation of cell development
1.38 2.37e-03 GO:0019226 transmission of nerve impulse
1.38 2.37e-03 GO:0035637 multicellular organismal signaling
1.16 2.55e-03 GO:0044267 cellular protein metabolic process
1.25 2.56e-03 GO:0010941 regulation of cell death
1.15 2.58e-03 GO:0071841 cellular component organization or biogenesis at cellular level
1.26 2.80e-03 GO:0043067 regulation of programmed cell death
1.40 3.15e-03 GO:0007268 synaptic transmission
1.39 3.23e-03 GO:0008283 cell proliferation
1.28 3.36e-03 GO:0048699 generation of neurons
1.41 3.54e-03 GO:0051247 positive regulation of protein metabolic process
1.28 4.55e-03 GO:0044093 positive regulation of molecular function
1.43 4.59e-03 GO:0048598 embryonic morphogenesis
1.25 4.75e-03 GO:0042981 regulation of apoptosis
1.18 4.75e-03 GO:0010467 gene expression
1.49 4.77e-03 GO:0010608 posttranscriptional regulation of gene expression
1.33 4.77e-03 GO:0009887 organ morphogenesis
1.19 4.86e-03 GO:0016070 RNA metabolic process
1.09 5.40e-03 GO:0050896 response to stimulus
1.54 5.44e-03 GO:0051129 negative regulation of cellular component organization
1.47 5.64e-03 GO:0048729 tissue morphogenesis
1.48 6.14e-03 GO:0071900 regulation of protein serine/threonine kinase activity
1.40 6.24e-03 GO:0007243 intracellular protein kinase cascade
1.40 6.24e-03 GO:0023014 signal transduction via phosphorylation event
1.45 6.70e-03 GO:0033043 regulation of organelle organization
1.44 7.06e-03 GO:0043434 response to peptide hormone stimulus
1.65 8.14e-03 GO:0001666 response to hypoxia
1.35 8.70e-03 GO:0008284 positive regulation of cell proliferation
1.30 9.65e-03 GO:0043085 positive regulation of catalytic activity
1.41 1.15e-02 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
1.29 1.16e-02 GO:0051049 regulation of transport
1.40 1.21e-02 GO:0010627 regulation of intracellular protein kinase cascade
1.61 1.24e-02 GO:0071902 positive regulation of protein serine/threonine kinase activity
1.75 1.48e-02 GO:0031098 stress-activated protein kinase signaling cascade
1.39 1.72e-02 GO:0007264 small GTPase mediated signal transduction
1.24 1.73e-02 GO:0032774 RNA biosynthetic process
1.36 1.73e-02 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.54 1.84e-02 GO:0043405 regulation of MAP kinase activity
1.91 1.90e-02 GO:0022612 gland morphogenesis
1.22 1.91e-02 GO:0050790 regulation of catalytic activity
1.41 1.96e-02 GO:0007420 brain development
1.35 2.03e-02 GO:0006325 chromatin organization
1.39 2.04e-02 GO:0032270 positive regulation of cellular protein metabolic process
1.39 2.06e-02 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.42 2.18e-02 GO:0045597 positive regulation of cell differentiation
1.40 2.38e-02 GO:0043009 chordate embryonic development
1.13 2.59e-02 GO:0019538 protein metabolic process
1.21 2.60e-02 GO:0002376 immune system process
1.49 2.73e-02 GO:0003002 regionalization
1.31 2.84e-02 GO:0042060 wound healing
1.39 2.86e-02 GO:0009792 embryo development ending in birth or egg hatching
1.51 3.00e-02 GO:0048011 nerve growth factor receptor signaling pathway
1.28 3.01e-02 GO:0006915 apoptosis
1.13 3.18e-02 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.73 3.26e-02 GO:0032970 regulation of actin filament-based process
1.59 3.27e-02 GO:0006936 muscle contraction
1.49 3.32e-02 GO:0048568 embryonic organ development
1.18 3.37e-02 GO:0006996 organelle organization
1.56 3.37e-02 GO:0003012 muscle system process
1.97 3.40e-02 GO:0051494 negative regulation of cytoskeleton organization
1.71 3.70e-02 GO:0000187 activation of MAPK activity
1.54 3.93e-02 GO:0048732 gland development
1.33 4.25e-02 GO:0007599 hemostasis
1.51 4.29e-02 GO:0048514 blood vessel morphogenesis
1.27 4.77e-02 GO:0012501 programmed cell death
1.29 5.00e-02 GO:0051726 regulation of cell cycle
1.09 5.00e-02 GO:0032501 multicellular organismal process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.06 1.09e-08 GO:0044424 intracellular part
1.23 1.41e-08 GO:0005829 cytosol
1.06 1.53e-08 GO:0005622 intracellular
1.80 3.22e-06 GO:0005912 adherens junction
1.11 4.58e-06 GO:0005634 nucleus
1.08 1.24e-05 GO:0005737 cytoplasm
1.71 2.42e-05 GO:0070161 anchoring junction
1.52 5.37e-05 GO:0015629 actin cytoskeleton
1.15 8.10e-05 GO:0043234 protein complex
1.89 8.82e-05 GO:0005925 focal adhesion
1.23 1.72e-04 GO:0005654 nucleoplasm
1.19 1.86e-04 GO:0031981 nuclear lumen
1.28 2.23e-04 GO:0042995 cell projection
1.17 3.59e-04 GO:0044428 nuclear part
1.61 4.38e-04 GO:0030424 axon
1.80 4.48e-04 GO:0030055 cell-substrate junction
1.33 6.34e-04 GO:0030054 cell junction
1.80 6.92e-04 GO:0005924 cell-substrate adherens junction
1.53 7.25e-04 GO:0016323 basolateral plasma membrane
1.38 2.51e-03 GO:0043005 neuron projection
1.05 3.02e-03 GO:0043226 organelle
1.11 3.84e-03 GO:0032991 macromolecular complex
1.15 4.92e-03 GO:0043233 organelle lumen
1.05 5.24e-03 GO:0043229 intracellular organelle
1.25 7.36e-03 GO:0031982 vesicle
1.14 8.41e-03 GO:0070013 intracellular organelle lumen
1.05 1.33e-02 GO:0043227 membrane-bounded organelle
1.52 1.36e-02 GO:0031252 cell leading edge
1.05 1.42e-02 GO:0043231 intracellular membrane-bounded organelle
1.25 1.44e-02 GO:0031988 membrane-bounded vesicle
1.14 1.67e-02 GO:0031974 membrane-enclosed lumen
1.23 3.38e-02 GO:0031410 cytoplasmic vesicle
1.48 3.60e-02 GO:0030425 dendrite
2.60 3.92e-02 GO:0031519 PcG protein complex
1.24 3.95e-02 GO:0016023 cytoplasmic membrane-bounded vesicle
1.16 4.80e-02 GO:0005856 cytoskeleton

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.19 8.56e-33 GO:0005515 protein binding
1.07 8.90e-15 GO:0005488 binding
1.38 5.20e-10 GO:0001071 nucleic acid binding transcription factor activity
1.38 5.20e-10 GO:0003700 sequence-specific DNA binding transcription factor activity
1.32 4.22e-07 GO:0030528 transcription regulator activity
1.37 3.99e-06 GO:0043565 sequence-specific DNA binding
1.35 4.43e-06 GO:0019899 enzyme binding
1.38 9.87e-05 GO:0008092 cytoskeletal protein binding
1.26 4.61e-04 GO:0005102 receptor binding
1.44 1.57e-03 GO:0003779 actin binding
1.37 2.81e-03 GO:0019904 protein domain specific binding
1.42 4.79e-03 GO:0016563 transcription activator activity
1.76 5.22e-03 GO:0005057 receptor signaling protein activity
1.28 2.78e-02 GO:0004672 protein kinase activity
1.79 3.21e-02 GO:0031625 ubiquitin protein ligase binding