Motif ID: NR5A1,2.p2

Z-value: 1.912


Transcription factors associated with NR5A1,2.p2:

Gene SymbolEntrez IDGene Name
NR5A1 2516 nuclear receptor subfamily 5, group A, member 1
NR5A2 2494 nuclear receptor subfamily 5, group A, member 2



Activity profile for motif NR5A1,2.p2.

activity profile for motif NR5A1,2.p2


Sorted Z-values histogram for motif NR5A1,2.p2

Sorted Z-values for motif NR5A1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NR5A1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_540849 4.549 NM_001194
HCN2
hyperpolarization activated cyclic nucleotide-gated potassium channel 2
chr12_+_131577229 4.529 NM_001142641
FBRSL1
fibrosin-like 1
chr11_+_76491532 3.673 NM_006189
OMP
olfactory marker protein
chr19_-_54250808 3.619 NM_033142
CGB7
chorionic gonadotropin, beta polypeptide 7
chr19_+_1358604 3.117 DAZAP1
DAZ associated protein 1
chr19_+_1358531 3.006 NM_018959
NM_170711
DAZAP1

DAZ associated protein 1

chr3_+_50204026 2.987 NM_000172
NM_144499
GNAT1

guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1

chr1_+_15637521 2.727 NM_007272
CTRC
chymotrypsin C (caldecrin)
chr17_-_77092569 2.667 ACTG1
actin, gamma 1
chr19_-_54212158 2.664 NM_000894
LHB
luteinizing hormone beta polypeptide
chr10_+_44726635 2.651 NM_001123376
TMEM72
transmembrane protein 72
chr19_+_54238913 2.577 NM_033043
CGB
CGB5
chorionic gonadotropin, beta polypeptide
chorionic gonadotropin, beta polypeptide 5
chr1_+_31823097 2.519 TINAGL1
tubulointerstitial nephritis antigen-like 1
chr18_-_13905534 2.502 NM_000529
MC2R
melanocortin 2 receptor (adrenocorticotropic hormone)
chr1_+_29086206 2.440 EPB41
erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)
chr8_+_143758875 2.411 NM_005672
PSCA
prostate stem cell antigen
chr1_+_16242833 2.386 NM_000085
CLCNKB
chloride channel Kb
chr1_-_169888373 2.368 NM_000261
MYOC
myocilin, trabecular meshwork inducible glucocorticoid response
chr11_+_61005160 2.360 NM_001170753
NM_145017
C11orf66

chromosome 11 open reading frame 66

chr8_-_37576515 2.356 LOC157860
hypothetical protein LOC157860
chr1_+_29086156 2.284 NM_001166005
NM_001166007
NM_004437
NM_203342
NM_203343
EPB41




erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)




chrX_+_152608159 2.260 NM_001142806
SLC6A8
solute carrier family 6 (neurotransmitter transporter, creatine), member 8
chr16_+_10878539 2.257 NM_000246
CIITA
class II, major histocompatibility complex, transactivator
chr22_+_30340152 2.208 SFI1
Sfi1 homolog, spindle assembly associated (yeast)
chr16_+_2138608 2.195 NM_014353
RAB26
RAB26, member RAS oncogene family
chr8_+_145221973 2.173 CYC1
cytochrome c-1
chr11_+_63060848 2.138 NM_004585
RARRES3
retinoic acid receptor responder (tazarotene induced) 3
chr8_-_145090045 2.134 NM_201382
PLEC
plectin
chrX_+_46963107 2.128 CDK16
cyclin-dependent kinase 16
chr5_+_176807931 2.079 NM_001174102
PRR7
proline rich 7 (synaptic)
chr16_+_4325142 2.074 GLIS2
GLIS family zinc finger 2
chr16_-_65510230 2.073 NM_004062
CDH16
cadherin 16, KSP-cadherin
chr19_+_1358750 2.072 DAZAP1
DAZ associated protein 1
chr16_+_2138688 2.043 RAB26
RAB26, member RAS oncogene family
chr6_+_43846735 2.012 VEGFA
vascular endothelial growth factor A
chr7_+_149707338 1.964 NM_173680
ZNF775
zinc finger protein 775
chr19_+_1358664 1.957 DAZAP1
DAZ associated protein 1
chr10_+_73703682 1.941 NM_019058
DDIT4
DNA-damage-inducible transcript 4
chr9_+_132961723 1.933 AIF1L
allograft inflammatory factor 1-like
chr11_+_1897374 1.924 NM_001042780
NM_001042781
NM_001042782
NM_006757
TNNT3



troponin T type 3 (skeletal, fast)



chr3_-_124821868 1.889 MYLK
myosin light chain kinase
chr17_+_71975224 1.874 NM_001088
AANAT
aralkylamine N-acetyltransferase
chr11_+_1830763 1.866 NM_002339
LSP1
lymphocyte-specific protein 1
chr6_+_28425666 1.863 NM_024493
ZKSCAN3
zinc finger with KRAB and SCAN domains 3
chr19_+_7834124 1.836 EVI5L
ecotropic viral integration site 5-like
chr6_+_30964441 1.792 NM_013994
DDR1
discoidin domain receptor tyrosine kinase 1
chr19_+_750281 1.786 PTBP1
polypyrimidine tract binding protein 1
chr1_+_154478574 1.772 NM_199173
BGLAP
bone gamma-carboxyglutamate (gla) protein
chr12_+_6517600 1.756


chr19_-_7840806 1.707 FLJ22184
hypothetical protein FLJ22184
chr2_+_232281491 1.700 PTMA
prothymosin, alpha
chr19_+_5082230 1.679 KDM4B
lysine (K)-specific demethylase 4B
chr11_-_780103 1.668 NM_016564
CEND1
cell cycle exit and neuronal differentiation 1
chr19_-_1083109 1.663 NM_001100122
SBNO2
strawberry notch homolog 2 (Drosophila)
chr6_+_32114060 1.657 NM_000500
NM_001128590
CYP21A2

cytochrome P450, family 21, subfamily A, polypeptide 2

chr10_+_119292699 1.656


chr1_-_202726068 1.653 NM_002646
PIK3C2B
phosphoinositide-3-kinase, class 2, beta polypeptide
chr1_+_18680010 1.634 NM_152375
KLHDC7A
kelch domain containing 7A
chr19_-_40711034 1.624 NM_001166034
NM_001166035
NM_198538
SBSN


suprabasin


chr19_-_47261761 1.619 NM_002088
GRIK5
glutamate receptor, ionotropic, kainate 5
chr21_+_42946719 1.611 NM_001001567
NM_001001568
NM_001001569
NM_001001570
NM_001001571
NM_001001572
NM_001001573
NM_001001574
NM_001001575
NM_001001576
NM_001001577
NM_001001578
NM_001001579
NM_001001580
NM_001001581
NM_001001582
NM_001001583
NM_001001584
NM_001001585
NM_002606
PDE9A



















phosphodiesterase 9A



















chr7_+_27248688 1.606 NM_001989
EVX1
even-skipped homeobox 1
chr11_-_46364681 1.589 NM_000741
CHRM4
cholinergic receptor, muscarinic 4
chr1_+_2397613 1.589 NM_014638
PLCH2
phospholipase C, eta 2
chr22_+_19239221 1.586 MED15
mediator complex subunit 15
chr19_+_3136860 1.580 NM_020170
NCLN
nicalin
chr9_-_116190038 1.555 AKNA
AT-hook transcription factor
chr1_-_12599934 1.552 NM_004753
DHRS3
dehydrogenase/reductase (SDR family) member 3
chr20_+_30019465 1.548 NM_001011718
XKR7
XK, Kell blood group complex subunit-related family, member 7
chr19_+_482737 1.543 CDC34
cell division cycle 34 homolog (S. cerevisiae)
chr2_+_232281470 1.541 NM_001099285
NM_002823
PTMA

prothymosin, alpha

chr3_+_130730171 1.528 NM_000539
RHO
rhodopsin
chr22_+_21370394 1.519 IGL@
immunoglobulin lambda locus
chr1_+_148089251 1.514 NM_001040874
NM_003516
HIST2H2AA4
HIST2H2AA3
histone cluster 2, H2aa4
histone cluster 2, H2aa3
chr17_-_36928604 1.513 NM_002275
KRT15
keratin 15
chr22_+_19651446 1.511 NM_001146288
AIFM3
apoptosis-inducing factor, mitochondrion-associated, 3
chr13_+_112681626 1.511 NM_024979
MCF2L
MCF.2 cell line derived transforming sequence-like
chr8_+_145221966 1.506 CYC1
cytochrome c-1
chr16_-_29781842 1.504 NM_006319
CDIPT
CDP-diacylglycerol--inositol 3-phosphatidyltransferase
chr22_-_24088523 1.502 NM_182492
LRP5L
low density lipoprotein receptor-related protein 5-like
chr19_+_3136927 1.501 NCLN
nicalin
chr9_-_133574928 1.496 NM_198679
RAPGEF1
Rap guanine nucleotide exchange factor (GEF) 1
chr16_+_3642940 1.495 NM_005223
DNASE1
deoxyribonuclease I
chr19_+_3136965 1.490 NCLN
nicalin
chr12_+_131705438 1.490 NM_012226
NM_016318
NM_170682
NM_170683
NM_174872
NM_174873
P2RX2





purinergic receptor P2X, ligand-gated ion channel, 2





chr8_+_145221924 1.488 NM_001916
CYC1
cytochrome c-1
chr1_+_160618143 1.482 NM_001085375
C1orf226
chromosome 1 open reading frame 226
chr17_+_1586034 1.482 WDR81
WD repeat domain 81
chr19_-_54219039 1.470 NM_000737
CGB
CGB5
chorionic gonadotropin, beta polypeptide
chorionic gonadotropin, beta polypeptide 5
chr21_+_44544392 1.464 PFKL
phosphofructokinase, liver
chr14_-_104507862 1.464 AHNAK2
AHNAK nucleoprotein 2
chr20_+_57199469 1.452 NM_178457
ZNF831
zinc finger protein 831
chr19_+_38867273 1.446 NM_022467
CHST8
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
chr18_+_606671 1.445 NM_199167
CLUL1
clusterin-like 1 (retinal)
chr2_+_96790298 1.443 NM_020184
CNNM4
cyclin M4
chr11_+_71388310 1.441 NM_001145057
IL18BP
interleukin 18 binding protein
chr19_+_60543032 1.441 NM_032701
SUV420H2
suppressor of variegation 4-20 homolog 2 (Drosophila)
chr9_+_125813672 1.436 NM_004789
LHX2
LIM homeobox 2
chr1_+_17817397 1.423 ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr3_+_182900081 1.420 SOX2OT
SOX2 overlapping transcript (non-protein coding)
chr21_+_44544381 1.411 PFKL
phosphofructokinase, liver
chr21_+_44544349 1.410 NM_002626
PFKL
phosphofructokinase, liver
chr1_+_35104120 1.407


chr11_-_780065 1.404 CEND1
cell cycle exit and neuronal differentiation 1
chr10_+_85944383 1.403 NM_001171971
NM_033100
CDHR1

cadherin-related family member 1

chr19_+_5641270 1.399 NM_033643
RPL36
ribosomal protein L36
chr1_+_38032045 1.397 NM_001031740
NM_001113482
MANEAL

mannosidase, endo-alpha-like

chrX_+_67965517 1.393 NM_004429
EFNB1
ephrin-B1
chr17_+_7549138 1.392 NM_001406
EFNB3
ephrin-B3
chr2_+_111594921 1.387 NM_006538
NM_138621
NM_207002
BCL2L11


BCL2-like 11 (apoptosis facilitator)


chr11_+_71387572 1.386 NM_001039659
NM_001039660
NM_173042
IL18BP


interleukin 18 binding protein


chr7_-_27171673 1.365 NM_152739
HOXA9
homeobox A9
chr11_+_63498590 1.364 NM_004074
COX8A
cytochrome c oxidase subunit VIIIA (ubiquitous)
chr20_-_34921689 1.356 NM_199181
KIAA0889
KIAA0889
chr6_+_39124534 1.354 NM_002062
GLP1R
glucagon-like peptide 1 receptor
chr22_-_17891777 1.354 CLDN5
claudin 5
chr16_-_65984836 1.338 NM_015964
NM_016140
TPPP3

tubulin polymerization-promoting protein family member 3

chr1_+_109969571 1.338 NM_203404
AMPD2
adenosine monophosphate deaminase 2
chr2_-_32344192 1.334 NM_021209
NLRC4
NLR family, CARD domain containing 4
chr14_+_92459244 1.328 CHGA
chromogranin A (parathyroid secretory protein 1)
chr3_-_13359746 1.323 NUP210
nucleoporin 210kDa
chr17_-_45626364 1.314


chr9_+_125813849 1.313 LHX2
LIM homeobox 2
chr7_-_27171600 1.311 HOXA9
homeobox A9
chrX_+_48529905 1.309 NM_002049
GATA1
GATA binding protein 1 (globin transcription factor 1)
chr7_-_27171648 1.306 HOXA9
homeobox A9
chr3_-_42719322 1.299 NM_020707
HHATL
hedgehog acyltransferase-like
chr19_-_3928840 1.298 EEF2
eukaryotic translation elongation factor 2
chr11_+_817584 1.296 NM_173584
EFCAB4A
EF-hand calcium binding domain 4A
chr7_+_150319076 1.287 NM_000603
NOS3
nitric oxide synthase 3 (endothelial cell)
chr22_+_19458378 1.287 NM_000185
SERPIND1
serpin peptidase inhibitor, clade D (heparin cofactor), member 1
chr6_+_27883877 1.272 NM_003509
HIST1H2AI
HIST1H3F
histone cluster 1, H2ai
histone cluster 1, H3f
chr1_+_20489998 1.266 NM_001039500
VWA5B1
von Willebrand factor A domain containing 5B1
chr16_+_1230678 1.260 NM_003294
TPSB2
TPSAB1
tryptase beta 2 (gene/pseudogene)
tryptase alpha/beta 1
chr17_+_45900688 1.259 ACSF2
acyl-CoA synthetase family member 2
chr11_+_65414677 1.256 CCDC85B
coiled-coil domain containing 85B
chr17_-_45626967 1.256


chr1_-_114497994 1.252 NM_205848
SYT6
synaptotagmin VI
chr4_+_3434830 1.250 NM_001164673
NM_173660
DOK7

docking protein 7

chr19_+_59657440 1.246


chr19_-_5735775 1.238 NM_001134316
PRR22
proline rich 22
chr1_+_18306823 1.223 NM_032880
IGSF21
immunoglobin superfamily, member 21
chr9_-_131555111 1.223 NM_004878
PTGES
prostaglandin E synthase
chr1_+_6607511 1.220 NM_001195753
THAP3
THAP domain containing, apoptosis associated protein 3
chr6_-_2785682 1.219 SERPINB1
serpin peptidase inhibitor, clade B (ovalbumin), member 1
chr19_+_2200112 1.218 NM_000479
AMH
anti-Mullerian hormone
chr19_+_7734034 1.212 NM_001144904
NM_001144905
NM_001144906
NM_001144907
NM_001144908
NM_001144909
NM_001144910
NM_001144911
NM_014257
CLEC4M








C-type lectin domain family 4, member M








chr2_-_45090025 1.202 NM_016932
SIX2
SIX homeobox 2
chr19_+_3473953 1.202 NM_001136197
NM_001136198
FZR1

fizzy/cell division cycle 20 related 1 (Drosophila)

chr4_+_3220564 1.201 NM_001042690
C4orf44
chromosome 4 open reading frame 44
chr11_+_65945050 1.194 NM_178864
NPAS4
neuronal PAS domain protein 4
chr12_+_50981915 1.191 NM_002284
KRT86
keratin 86
chr5_+_169713458 1.190 NM_001034838
KCNIP1
Kv channel interacting protein 1
chr17_-_40695216 1.189 NM_152343
C17orf46
chromosome 17 open reading frame 46
chr1_+_22176004 1.189 NM_007352
CELA3A
CELA3B
chymotrypsin-like elastase family, member 3A
chymotrypsin-like elastase family, member 3B
chr6_+_101953389 1.188 GRIK2
glutamate receptor, ionotropic, kainate 2
chr17_-_36996611 1.184 NM_000526
KRT14
keratin 14
chr9_+_138997265 1.181 NM_207510
LCNL1
lipocalin-like 1
chr12_-_120725210 1.179 LOC338799
hypothetical LOC338799
chr3_-_197201497 1.178 SDHAP1
SDHAP2
succinate dehydrogenase complex, subunit A, flavoprotein pseudogene 1
succinate dehydrogenase complex, subunit A, flavoprotein pseudogene 2
chr3_+_52788976 1.161 NM_001166435
NM_001166436
ITIH1

inter-alpha (globulin) inhibitor H1

chr17_+_45706786 1.161 NM_153229
TMEM92
transmembrane protein 92
chr7_+_5598979 1.153 NM_003088
FSCN1
fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)
chr7_+_5598964 1.147 FSCN1
fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)
chr1_+_2026014 1.147 NM_001033582
PRKCZ
protein kinase C, zeta
chr19_+_59796858 1.145 NM_006863
LILRA1
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1
chr1_-_199608941 1.140 TNNT2
troponin T type 2 (cardiac)
chr19_+_10083196 1.139 NM_002566
P2RY11
purinergic receptor P2Y, G-protein coupled, 11
chr19_+_2279679 1.137 SPPL2B
signal peptide peptidase-like 2B
chr17_+_77110011 1.135 NM_001077182
NM_012418
FSCN2

fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus)

chr16_+_716936 1.133 NM_207112
NM_032304
HAGHL

hydroxyacylglutathione hydrolase-like

chr1_-_150065176 1.127 NM_001001523
RORC
RAR-related orphan receptor C
chrX_-_49851743 1.125 NM_139289
AKAP4
A kinase (PRKA) anchor protein 4
chrX_-_24600661 1.121 NM_001163264
PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr17_-_71017509 1.119 NM_001142643
CASKIN2
CASK interacting protein 2
chr20_-_60360789 1.118 LAMA5
laminin, alpha 5
chr8_+_144366442 1.113 NM_178172
GPIHBP1
glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1
chr19_-_60360768 1.110 NM_000363
TNNI3
troponin I type 3 (cardiac)
chr10_-_85991177 1.109 NM_015613
LRIT1
leucine-rich repeat, immunoglobulin-like and transmembrane domains 1
chr19_+_2279685 1.109 SPPL2B
signal peptide peptidase-like 2B
chr19_+_40541327 1.108 NM_005304
FFAR3
free fatty acid receptor 3
chr7_+_45580704 1.104 ADCY1
adenylate cyclase 1 (brain)
chr17_-_74361620 1.102 TIMP2
TIMP metallopeptidase inhibitor 2
chr10_+_80777248 1.098 PPIF
peptidylprolyl isomerase F
chr17_+_21249040 1.095 NM_001194958
KCNJ18
potassium inwardly-rectifying channel, subfamily J, member 18
chr2_+_233029076 1.088 NM_001631
ALPI
alkaline phosphatase, intestinal
chr19_+_482688 1.087 NM_004359
CDC34
cell division cycle 34 homolog (S. cerevisiae)
chr7_+_45580606 1.082 NM_021116
ADCY1
adenylate cyclase 1 (brain)
chr19_+_1199548 1.081 NM_177401
MIDN
midnolin
chr19_+_54996613 1.080


chr11_-_2400817 1.078 NM_014555
TRPM5
transient receptor potential cation channel, subfamily M, member 5
chr9_+_134927185 1.077 NM_001807
CEL
carboxyl ester lipase (bile salt-stimulated lipase)
chr2_+_119905812 1.076 NM_183240
TMEM37
transmembrane protein 37
chr12_+_6846844 1.074 NM_001159287
NM_000365
TPI1

triosephosphate isomerase 1

chr6_+_108593907 1.074 NM_003269
NR2E1
nuclear receptor subfamily 2, group E, member 1
chr4_+_3413489 1.073 NM_001528
HGFAC
HGF activator
chr17_-_45901173 1.059 NM_001267
CHAD
chondroadherin
chr12_+_52665196 1.050 NM_017409
HOXC10
homeobox C10
chr11_+_65140207 1.050 NM_032223
PCNXL3
pecanex-like 3 (Drosophila)
chrX_-_137649180 1.042 NM_033642
FGF13
fibroblast growth factor 13

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.08 2.75e-05 GO:0009987 cellular process
1.26 5.94e-05 GO:0048731 system development
1.17 1.77e-04 GO:0032501 multicellular organismal process
1.22 1.05e-03 GO:0048856 anatomical structure development
1.21 1.31e-03 GO:0007275 multicellular organismal development
1.18 8.98e-03 GO:0023052 signaling
1.94 1.37e-02 GO:0007517 muscle organ development
1.76 2.13e-02 GO:0010035 response to inorganic substance
1.24 2.14e-02 GO:0065008 regulation of biological quality
1.16 4.25e-02 GO:0032502 developmental process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
3.06 4.22e-05 GO:0000786 nucleosome
2.27 5.66e-03 GO:0032993 protein-DNA complex
1.76 8.49e-03 GO:0000785 chromatin

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.46 1.12e-02 GO:0005198 structural molecule activity
1.09 4.03e-02 GO:0005515 protein binding