Motif ID: TP53.p2

Z-value: 0.315


Transcription factors associated with TP53.p2:

Gene SymbolEntrez IDGene Name
TP53 7157 tumor protein p53



Activity profile for motif TP53.p2.

activity profile for motif TP53.p2


Sorted Z-values histogram for motif TP53.p2

Sorted Z-values for motif TP53.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TP53.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_38185291 0.226 INPP5B
inositol polyphosphate-5-phosphatase, 75kDa
chr10_-_105202139 0.218 NM_015916
CALHM2
calcium homeostasis modulator 2
chr9_+_129962292 0.217 NM_024112
C9orf16
chromosome 9 open reading frame 16
chr1_+_117711575 0.214 NM_006699
MAN1A2
mannosidase, alpha, class 1A, member 2
chr3_-_13032130 0.209


chr1_-_38185312 0.207 NM_005540
INPP5B
inositol polyphosphate-5-phosphatase, 75kDa
chr10_+_133850325 0.197 NM_006426
DPYSL4
dihydropyrimidinase-like 4
chr10_-_105202012 0.195 CALHM2
calcium homeostasis modulator 2
chr2_+_197212522 0.195 NM_001080539
CCDC150
coiled-coil domain containing 150
chr2_+_113119985 0.193 NM_005415
SLC20A1
solute carrier family 20 (phosphate transporter), member 1
chr22_-_18687511 0.187 NM_033257
DGCR6L
DiGeorge syndrome critical region gene 6-like
chr4_+_6726699 0.185 LOC93622
hypothetical LOC93622
chr1_-_38185307 0.185 INPP5B
inositol polyphosphate-5-phosphatase, 75kDa
chr9_+_80101810 0.184 NM_021154
NM_058179
PSAT1

phosphoserine aminotransferase 1

chr1_-_38185254 0.176 INPP5B
inositol polyphosphate-5-phosphatase, 75kDa
chr16_-_66558197 0.163 NM_001145964
SLC12A4
solute carrier family 12 (potassium/chloride transporters), member 4
chr10_+_47216925 0.154 NM_001630
ANXA8L2
ANXA8
annexin A8-like 2
annexin A8
chr4_+_6726555 0.151 LOC93622
hypothetical LOC93622
chr1_-_10455100 0.145 DFFA
DNA fragmentation factor, 45kDa, alpha polypeptide
chr19_-_47438583 0.142 GSK3A
glycogen synthase kinase 3 alpha
chr19_-_47438518 0.142 GSK3A
glycogen synthase kinase 3 alpha
chr5_+_178419938 0.137 NM_014594
ZNF354C
zinc finger protein 354C
chr16_-_1410710 0.134 C16orf91
chromosome 16 open reading frame 91
chr19_+_458475 0.134 NM_033513
C19orf20
chromosome 19 open reading frame 20
chr20_+_4077409 0.133 NM_175839
NM_175840
NM_175841
NM_175842
SMOX



spermine oxidase



chr19_-_47438563 0.131 NM_019884
GSK3A
glycogen synthase kinase 3 alpha
chr17_+_73721924 0.131 BIRC5
baculoviral IAP repeat containing 5
chr1_-_10455190 0.130 NM_004401
NM_213566
DFFA

DNA fragmentation factor, 45kDa, alpha polypeptide

chr19_-_47438548 0.128 GSK3A
glycogen synthase kinase 3 alpha
chr4_+_52403922 0.125 NM_001040402
NM_015115
DCUN1D4

DCN1, defective in cullin neddylation 1, domain containing 4 (S. cerevisiae)

chr16_+_2593351 0.123 LOC652276
hypothetical LOC652276
chr19_+_55985483 0.122 NM_033068
ACPT
acid phosphatase, testicular
chr6_+_15353681 0.121 JARID2
jumonji, AT rich interactive domain 2
chr12_+_120055013 0.118 NM_002562
P2RX7
purinergic receptor P2X, ligand-gated ion channel, 7
chr1_+_54291847 0.117 NM_153035
TCEANC2
transcription elongation factor A (SII) N-terminal and central domain containing 2
chr14_+_96333434 0.114 NM_003384
VRK1
vaccinia related kinase 1
chr21_+_29593607 0.112 NM_206866
BACH1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
chr7_-_74291367 0.110 GTF2IP1
general transcription factor IIi, pseudogene 1
chr21_+_45649429 0.109 NM_130445
COL18A1
collagen, type XVIII, alpha 1
chr19_-_47438384 0.106 GSK3A
glycogen synthase kinase 3 alpha
chr6_+_36206239 0.105 NM_002754
MAPK13
mitogen-activated protein kinase 13
chr2_+_113546365 0.103 NM_032556
IL1F10
interleukin 1 family, member 10 (theta)
chr1_+_153799637 0.102 LOC645676
hypothetical LOC645676
chr20_+_4077466 0.102 SMOX
spermine oxidase
chr17_+_73721871 0.100 NM_001012270
NM_001012271
NM_001168
BIRC5


baculoviral IAP repeat containing 5


chr4_+_153676857 0.100 DKFZP434I0714
hypothetical protein DKFZP434I0714
chr16_-_69271428 0.098 MTSS1L
metastasis suppressor 1-like
chr22_+_18085990 0.098 SEPT5-GP1BB
SEPT5
SEPT5-GP1BB read-through transcript
septin 5
chr2_-_217267742 0.097 IGFBP5
insulin-like growth factor binding protein 5
chr1_+_84536636 0.094 NM_001010971
SAMD13
sterile alpha motif domain containing 13
chr3_-_44494108 0.091 ZNF445
zinc finger protein 445
chr7_-_156161130 0.090


chr14_-_30959487 0.089 HEATR5A
HEAT repeat containing 5A
chr3_-_46012303 0.087 NM_024513
FYCO1
FYVE and coiled-coil domain containing 1
chr19_+_49866563 0.087 NM_001127893
NM_020219
CEACAM19

carcinoembryonic antigen-related cell adhesion molecule 19

chr3_-_44494160 0.086 NM_181489
ZNF445
zinc finger protein 445
chr17_+_18027538 0.086 NM_017758
ALKBH5
alkB, alkylation repair homolog 5 (E. coli)
chr3_+_197951121 0.084 NM_002577
PAK2
p21 protein (Cdc42/Rac)-activated kinase 2
chr5_+_52320660 0.083 NM_002203
ITGA2
integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
chr20_-_60435983 0.083 NM_080833
C20orf151
chromosome 20 open reading frame 151
chr16_-_87244896 0.082 NM_000101
CYBA
cytochrome b-245, alpha polypeptide
chr15_-_63264698 0.081 CLPX
ClpX caseinolytic peptidase X homolog (E. coli)
chr19_+_15644885 0.080 NM_023944
CYP4F12
cytochrome P450, family 4, subfamily F, polypeptide 12
chr1_+_43084846 0.080 NM_015911
ZNF691
zinc finger protein 691
chr6_-_47030492 0.077 NM_015234
GPR116
G protein-coupled receptor 116
chr22_-_21231421 0.077 NM_206955
NM_206956
NM_006115
NM_206953
NM_206954
PRAME




preferentially expressed antigen in melanoma




chr12_+_52181643 0.076 NM_134324
TARBP2
TAR (HIV-1) RNA binding protein 2
chr1_-_52936602 0.076 C1orf163
chromosome 1 open reading frame 163
chr1_-_23376860 0.075 LUZP1
leucine zipper protein 1
chr10_-_46593923 0.075 NM_001040084
NM_001098845
ANXA8L2
LOC653110
ANXA8
ANXA8L1
annexin A8-like 2
hypothetical LOC653110
annexin A8
annexin A8-like 1
chr3_-_52454082 0.073 NM_020163
SEMA3G
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
chr2_+_169021001 0.073 LASS6
LAG1 homolog, ceramide synthase 6
chr1_-_52936573 0.072 C1orf163
chromosome 1 open reading frame 163
chr1_-_153799186 0.072 ASH1L
ash1 (absent, small, or homeotic)-like (Drosophila)
chr14_-_64040072 0.071 NM_006977
ZBTB25
zinc finger and BTB domain containing 25
chr19_+_1358664 0.070 DAZAP1
DAZ associated protein 1
chr2_+_169021039 0.070 NM_203463
LASS6
LAG1 homolog, ceramide synthase 6
chr1_+_226261374 0.070 NM_033131
WNT3A
wingless-type MMTV integration site family, member 3A
chr6_-_165643064 0.069 NM_144980
C6orf118
chromosome 6 open reading frame 118
chr20_-_5048443 0.069 NM_182649
PCNA
proliferating cell nuclear antigen
chr3_+_197951203 0.069 PAK2
p21 protein (Cdc42/Rac)-activated kinase 2
chr22_+_36632242 0.069 NM_033386
MICALL1
MICAL-like 1
chr17_-_59349867 0.069 NM_000515
NM_022559
NM_022560
NM_022561
NM_022562
GH1




growth hormone 1




chr6_+_117910472 0.068 NM_173674
DCBLD1
discoidin, CUB and LCCL domain containing 1
chr1_-_52936611 0.067 NM_023077
C1orf163
chromosome 1 open reading frame 163
chr21_-_42172476 0.067 NM_001040424
NM_022115
PRDM15

PR domain containing 15

chr20_+_34667566 0.067 NM_018840
NM_199483
C20orf24

chromosome 20 open reading frame 24

chr20_+_34667590 0.066 C20orf24
chromosome 20 open reading frame 24
chr19_-_52426055 0.066 NM_014417
BBC3
BCL2 binding component 3
chr6_+_37895570 0.066 ZFAND3
zinc finger, AN1-type domain 3
chr19_-_45623720 0.066 NM_013376
SERTAD1
SERTA domain containing 1
chr20_+_59260847 0.066 NM_001794
CDH4
cadherin 4, type 1, R-cadherin (retinal)
chr7_+_138675644 0.065 LUC7L2
LUC7-like 2 (S. cerevisiae)
chr11_-_3035172 0.065 NM_001014437
NM_001194997
NM_001751
NM_139273
CARS



cysteinyl-tRNA synthetase



chr11_+_118544625 0.065 NM_024618
NM_170722
NLRX1

NLR family member X1

chr6_+_36752244 0.065 NM_078467
CDKN1A
cyclin-dependent kinase inhibitor 1A (p21, Cip1)
chr15_+_73923439 0.065 NM_001145335
UBE2Q2
ubiquitin-conjugating enzyme E2Q family member 2
chr12_+_52180971 0.065 NM_004178
NM_134323
TARBP2

TAR (HIV-1) RNA binding protein 2

chr5_+_128458287 0.064 NM_016048
ISOC1
isochorismatase domain containing 1
chr20_-_23566325 0.064 NM_000099
CST3
cystatin C
chr9_-_94936319 0.064 NM_004148
NINJ1
ninjurin 1
chr1_+_221966835 0.063 CAPN2
calpain 2, (m/II) large subunit
chr1_-_27802947 0.063 AHDC1
AT hook, DNA binding motif, containing 1
chr22_+_21852551 0.063 NM_004327
NM_021574
BCR

breakpoint cluster region

chrX_+_129133234 0.063 NM_004794
RAB33A
RAB33A, member RAS oncogene family
chr11_-_107969554 0.062 NM_015065
EXPH5
exophilin 5
chr8_-_10734792 0.062 PINX1
PIN2/TERF1 interacting, telomerase inhibitor 1
chr16_+_28798735 0.060 ATP2A1
ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
chr17_-_70380663 0.060 NM_004110
NM_024417
FDXR

ferredoxin reductase

chr16_+_387176 0.060 NM_005009
NME4
non-metastatic cells 4, protein expressed in
chr9_+_37412645 0.059 NM_012203
GRHPR
glyoxylate reductase/hydroxypyruvate reductase
chr7_-_74705276 0.059 NM_001145064
GATSL2
GATS protein-like 2
chr4_-_6524910 0.058 PPP2R2C
protein phosphatase 2, regulatory subunit B, gamma
chr9_-_115077504 0.057 FKBP15
FK506 binding protein 15, 133kDa
chr14_+_77336172 0.057 NM_001142545
NM_020421
ADCK1

aarF domain containing kinase 1

chr3_-_8980070 0.057 NM_020165
RAD18
RAD18 homolog (S. cerevisiae)
chr17_+_18027816 0.056 ALKBH5
alkB, alkylation repair homolog 5 (E. coli)
chr7_-_72380020 0.055 NM_178125
TRIM50
tripartite motif containing 50
chr1_-_154977526 0.055 NM_024540
NM_145729
MRPL24

mitochondrial ribosomal protein L24

chr19_+_60691733 0.054 SSC5D
scavenger receptor cysteine rich domain containing (5 domains)
chr16_-_10943656 0.054 DEXI
Dexi homolog (mouse)
chr4_-_187881977 0.054 NM_005245
FAT1
FAT tumor suppressor homolog 1 (Drosophila)
chr1_-_154977479 0.054 MRPL24
mitochondrial ribosomal protein L24
chr1_+_41217555 0.053 NM_001905
CTPS
CTP synthase
chr1_+_149851289 0.053 SNX27
sorting nexin family member 27
chr22_+_18085891 0.053 SEPT5
septin 5
chr19_-_19110268 0.053 TMEM161A
transmembrane protein 161A
chr7_+_116099648 0.053 NM_000245
NM_001127500
MET

met proto-oncogene (hepatocyte growth factor receptor)

chr7_+_100557098 0.052 NM_000602
NM_001165413
SERPINE1

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

chr1_+_149851138 0.052 NM_030918
SNX27
sorting nexin family member 27
chr9_-_139235595 0.052 NM_031297
RNF208
ring finger protein 208
chr1_+_27025717 0.052 NM_032283
ZDHHC18
zinc finger, DHHC-type containing 18
chr9_+_131974506 0.052 NM_014286
NCS1
neuronal calcium sensor 1
chr9_+_137107222 0.052 OLFM1
olfactomedin 1
chr1_+_42619014 0.051 NM_173642
RIMKLA
ribosomal modification protein rimK-like family member A
chr1_-_207892420 0.051 NM_000228
LAMB3
laminin, beta 3
chr16_-_66555449 0.051 NM_001145963
SLC12A4
solute carrier family 12 (potassium/chloride transporters), member 4
chr19_-_6432765 0.051 NM_024898
DENND1C
DENN/MADD domain containing 1C
chr19_-_19110241 0.051 NM_017814
TMEM161A
transmembrane protein 161A
chr1_+_149851287 0.051 SNX27
sorting nexin family member 27
chr11_+_3833495 0.050 NM_003156
STIM1
stromal interaction molecule 1
chr3_+_52504410 0.050 STAB1
stabilin 1
chr9_+_137107187 0.050 OLFM1
olfactomedin 1
chr9_-_116307531 0.050 NM_001173425
NM_015404
DFNB31

deafness, autosomal recessive 31

chr2_-_242205556 0.050 NM_001164356
THAP4
THAP domain containing 4
chr19_+_60691671 0.050 NM_001144950
NM_001195267
SSC5D

scavenger receptor cysteine rich domain containing (5 domains)

chr15_+_72906003 0.049 NM_001030005
CPLX3
complexin 3
chr8_-_10734700 0.049 NM_017884
PINX1
PIN2/TERF1 interacting, telomerase inhibitor 1
chr18_-_75540255 0.048


chr7_+_23112441 0.047 NM_018846
KLHL7
kelch-like 7 (Drosophila)
chr16_-_10943716 0.047 NM_014015
DEXI
Dexi homolog (mouse)
chr19_-_5741913 0.047 DUS3L
dihydrouridine synthase 3-like (S. cerevisiae)
chr12_+_131577229 0.047 NM_001142641
FBRSL1
fibrosin-like 1
chr7_+_23111928 0.047 KLHL7
kelch-like 7 (Drosophila)
chr11_-_72986738 0.046 NM_015159
FAM168A
family with sequence similarity 168, member A
chr1_+_32443822 0.046 NM_001160042
NM_018134
IQCC

IQ motif containing C

chr1_+_232107170 0.046 NM_173508
SLC35F3
solute carrier family 35, member F3
chr1_-_201202956 0.046 NM_016243
CYB5R1
cytochrome b5 reductase 1
chr1_+_154318954 0.045 LMNA
lamin A/C
chr1_+_13782838 0.045 NM_006474
NM_198389
PDPN

podoplanin

chr19_-_8670054 0.045 NM_178525
ACTL9
actin-like 9
chr2_+_176761552 0.045 NM_024501
HOXD1
homeobox D1
chr1_-_54183833 0.045 NM_016126
HSPB11
heat shock protein family B (small), member 11
chr12_+_107480423 0.044 NM_014301
NM_213595
ISCU

iron-sulfur cluster scaffold homolog (E. coli)

chr4_+_3434830 0.044 NM_001164673
NM_173660
DOK7

docking protein 7

chr20_-_43022286 0.044 NM_006809
TOMM34
translocase of outer mitochondrial membrane 34
chr3_+_33293915 0.044 NM_012157
NM_001171713
FBXL2

F-box and leucine-rich repeat protein 2

chr1_-_54291634 0.044 NM_004872
TMEM59
transmembrane protein 59
chr7_-_150605112 0.044 NM_003078
SMARCD3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
chr5_-_175721320 0.044 NM_001079684
NM_001079685
NM_020444
KIAA1191


KIAA1191


chr7_+_142205266 0.043


chr12_-_14887648 0.043 NM_021071
ART4
ADP-ribosyltransferase 4 (Dombrock blood group)
chr12_+_42516118 0.043 NM_032256
TMEM117
transmembrane protein 117
chr6_-_114399005 0.042 NM_001527
HDAC2
histone deacetylase 2
chr6_+_21774624 0.041 FLJ22536
hypothetical locus LOC401237
chr16_-_74024750 0.041 NM_006324
CFDP1
craniofacial development protein 1
chr20_+_42007949 0.041 NM_001098798
TOX2
TOX high mobility group box family member 2
chr8_+_98950453 0.041 NM_002380
NM_030583
MATN2

matrilin 2

chr1_+_3679168 0.041 NM_001163724
LOC388588
hypothetical protein LOC388588
chr3_+_52504391 0.041 NM_015136
STAB1
stabilin 1
chr7_+_140042932 0.040 NM_004546
NDUFB2
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa
chr22_-_17546276 0.040 SLC25A1
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
chr22_-_17846711 0.040 UFD1L
ubiquitin fusion degradation 1 like (yeast)
chr9_+_138966588 0.039 NM_178536
LCN12
lipocalin 12
chr15_-_63264494 0.039 NM_006660
CLPX
ClpX caseinolytic peptidase X homolog (E. coli)
chr12_+_122652572 0.039 NM_020936
DDX55
DEAD (Asp-Glu-Ala-Asp) box polypeptide 55
chr18_+_75540786 0.038 NM_004715
NM_048368
CTDP1

CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1

chr10_+_72102563 0.038 NM_080722
NM_139155
ADAMTS14

ADAM metallopeptidase with thrombospondin type 1 motif, 14

chr3_+_185375341 0.038 AP2M1
adaptor-related protein complex 2, mu 1 subunit
chr19_-_13909877 0.038 PODNL1
podocan-like 1
chr3_+_127118130 0.038 LOC100125556
family with sequence similarity 86, member A pseudogene
chr1_+_25471470 0.037 NM_001127691
NM_016124
RHD

Rh blood group, D antigen

chr20_+_30409649 0.037 NM_001164603
NM_015338
ASXL1

additional sex combs like 1 (Drosophila)

chr22_-_17846621 0.037 UFD1L
ubiquitin fusion degradation 1 like (yeast)
chr7_-_1510533 0.036 NM_001080453
INTS1
integrator complex subunit 1
chr1_+_221966849 0.036 CAPN2
calpain 2, (m/II) large subunit
chr7_+_23111867 0.036 NM_001031710
NM_001172428
KLHL7

kelch-like 7 (Drosophila)

chr21_-_43671355 0.036 NM_173354
SIK1
salt-inducible kinase 1
chr11_-_128567302 0.036 NM_001142685
ARHGAP32
Rho GTPase activating protein 32
chr21_+_42807052 0.036 SLC37A1
solute carrier family 37 (glycerol-3-phosphate transporter), member 1

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.24 1.53e-02 GO:0044446 intracellular organelle part
1.45 1.57e-02 GO:0031090 organelle membrane
1.53 1.72e-02 GO:0012505 endomembrane system
1.23 2.16e-02 GO:0044422 organelle part
1.21 4.14e-02 GO:0044444 cytoplasmic part

Gene overrepresentation in function category:

enrichment   p-value GO term description
26.44 8.71e-04 GO:0004594 pantothenate kinase activity
1.24 3.78e-02 GO:0003824 catalytic activity