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• Activity deltas table
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Motif ID: HIF1A.p2

Z-value: 0.819

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr2_-_97016027	1.633	NM_001122646	FAM178B	family with sequence similarity 178, member B
chr5_+_78568094	1.151
chr11_+_18372689	1.104		LDHA	lactate dehydrogenase A
chr17_+_77780177	1.094	NM_004207	SLC16A3	solute carrier family 16, member 3 (monocarboxylic acid transporter 4)
chr7_+_156624424	1.086		UBE3C	ubiquitin protein ligase E3C
chr20_+_30410447	1.075		ASXL1	additional sex combs like 1 (Drosophila)
chr13_-_43259032	1.036	NM_017993	ENOX1	ecto-NOX disulfide-thiol exchanger 1
chr7_+_156624392	1.034	NM_014671	UBE3C	ubiquitin protein ligase E3C
chr11_+_18372687	1.027		LDHA	lactate dehydrogenase A
chr11_+_18372493	1.024	NM_001135239 NM_001165415 NM_001165416 NM_005566	LDHA	lactate dehydrogenase A
chr11_+_18372708	0.997		LDHA	lactate dehydrogenase A
chr2_-_74915722	0.924
chr7_+_156624370	0.876		UBE3C	ubiquitin protein ligase E3C
chr20_+_41519947	0.847		SRSF6	serine/arginine-rich splicing factor 6
chr20_+_41519882	0.818	NM_006275	SRSF6	serine/arginine-rich splicing factor 6
chr10_+_104394185	0.809	NM_030912	TRIM8	tripartite motif containing 8
chr1_+_109963982	0.804		AMPD2	adenosine monophosphate deaminase 2
chr8_+_49083522	0.783	NM_003350	UBE2V2	ubiquitin-conjugating enzyme E2 variant 2
chr17_+_52517529	0.758	NM_003488	AKAP1	A kinase (PRKA) anchor protein 1
chr12_+_68923043	0.714	NM_014515	CNOT2	CCR4-NOT transcription complex, subunit 2
chr1_+_109963950	0.695	NM_139156	AMPD2	adenosine monophosphate deaminase 2
chr8_+_17398940	0.651	NM_001008539	SLC7A2	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
chr20_+_32414715	0.650	NM_031483	ITCH	itchy E3 ubiquitin protein ligase homolog (mouse)
chr16_+_14634324	0.630		BFAR	bifunctional apoptosis regulator
chr2_+_138975819	0.619	NM_001001664	SPOPL	speckle-type POZ protein-like
chr18_+_31963851	0.610		ELP2	elongation protein 2 homolog (S. cerevisiae)
chr3_+_184898234	0.600	NM_018023	YEATS2	YEATS domain containing 2
chr20_+_30409649	0.598	NM_001164603 NM_015338	ASXL1	additional sex combs like 1 (Drosophila)
chr12_+_105873803	0.586		C12orf23	chromosome 12 open reading frame 23
chr18_+_31963879	0.575	NM_018255	ELP2	elongation protein 2 homolog (S. cerevisiae)
chr2_+_32142083	0.574	NM_014946 NM_199436	SPAST	spastin
chr6_+_87921980	0.548	NM_015021	ZNF292	zinc finger protein 292
chr17_+_75366524	0.544	NM_005189 NM_032647	CBX2	chromobox homolog 2
chr6_+_43846735	0.525		VEGFA	vascular endothelial growth factor A
chr5_+_78567604	0.521	NM_152405	JMY	junction mediating and regulatory protein, p53 cofactor
chr17_+_42355482	0.515	NM_001012511 NM_004287 NM_054022	GOSR2	golgi SNAP receptor complex member 2
chr2_+_138975946	0.514
chr2_+_111594921	0.512	NM_006538 NM_138621 NM_207002	BCL2L11	BCL2-like 11 (apoptosis facilitator)
chr2_+_173129119	0.512		PDK1	pyruvate dehydrogenase kinase, isozyme 1
chr3_-_50311666	0.511	NM_012191 NM_003549	NAT6 HYAL3	N-acetyltransferase 6 (GCN5-related) hyaluronoglucosaminidase 3
chr16_-_23476138	0.508	NM_001083614	EARS2	glutamyl-tRNA synthetase 2, mitochondrial (putative)
chr2_-_241903787	0.504		HDLBP	high density lipoprotein binding protein
chr2_+_173129040	0.495		PDK1	pyruvate dehydrogenase kinase, isozyme 1
chr11_+_566482	0.494	NM_020901	PHRF1	PHD and ring finger domains 1
chr2_-_254037	0.485	NM_001159597 NM_015677	SH3YL1	SH3 domain containing, Ysc84-like 1 (S. cerevisiae)
chr2_-_253982	0.475		SH3YL1	SH3 domain containing, Ysc84-like 1 (S. cerevisiae)
chrX_+_152252738	0.475	NM_001080485	ZNF275	zinc finger protein 275
chr2_-_198073242	0.461	NM_199440	HSPD1	heat shock 60kDa protein 1 (chaperonin)
chr13_-_97627491	0.456	NM_178861	RNF113B	ring finger protein 113B
chr2_+_28828112	0.454	NM_206876 NM_002709	PPP1CB	protein phosphatase 1, catalytic subunit, beta isozyme
chr7_+_17304707	0.452	NM_001621	AHR	aryl hydrocarbon receptor
chr3_-_50311262	0.452		NAT6 HYAL3	N-acetyltransferase 6 (GCN5-related) hyaluronoglucosaminidase 3
chr2_-_198072767	0.451		HSPD1	heat shock 60kDa protein 1 (chaperonin)
chr2_-_170389669	0.447		METTL5	methyltransferase like 5
chr20_+_3399615	0.447	NM_139321 NM_139322	ATRN	attractin
chr2_+_122229590	0.446	NM_004622	TSN	translin
chr1_+_28717349	0.445		RCC1	regulator of chromosome condensation 1
chr3_-_57088332	0.442	NM_001128615	ARHGEF3	Rho guanine nucleotide exchange factor (GEF) 3
chr7_+_149696263	0.442		REPIN1	replication initiator 1
chr2_-_198072805	0.439		HSPD1	heat shock 60kDa protein 1 (chaperonin)
chr14_+_30098079	0.438	NM_017769	G2E3	G2/M-phase specific E3 ubiquitin protein ligase
chr19_+_1022208	0.436		HMHA1	histocompatibility (minor) HA-1
chr22_+_48740143	0.430	NM_001001852	PIM3	pim-3 oncogene
chr2_+_198072965	0.429	NM_002157	HSPE1	heat shock 10kDa protein 1 (chaperonin 10)
chr2_-_170389598	0.427	NM_014168	METTL5	methyltransferase like 5
chr7_+_97748959	0.424		BRI3	brain protein I3
chr17_+_42355492	0.423		GOSR2	golgi SNAP receptor complex member 2
chr10_-_60606195	0.423
chr20_+_48241334	0.421		CEBPB	CCAAT/enhancer binding protein (C/EBP), beta
chr2_+_241903395	0.416	NM_001008491 NM_006155	SEPT2	septin 2
chr11_+_18372682	0.412		LDHA	lactate dehydrogenase A
chr16_+_31098931	0.411	NM_001170634 NM_001170937 NM_004960	FUS	fused in sarcoma
chr12_+_6514228	0.408		GAPDH	glyceraldehyde-3-phosphate dehydrogenase
chr12_+_105873669	0.406	NM_152261	C12orf23	chromosome 12 open reading frame 23
chr20_-_17897067	0.395	NM_014426	SNX5	sorting nexin 5
chrX_+_77246321	0.390	NM_000291	PGK1	phosphoglycerate kinase 1
chrX_+_77246368	0.383		PGK1	phosphoglycerate kinase 1
chr2_-_198072868	0.383	NM_002156	HSPD1	heat shock 60kDa protein 1 (chaperonin)
chr20_+_3399727	0.382		ATRN	attractin
chr2_+_187059277	0.380		ZC3H15	zinc finger CCCH-type containing 15
chr7_+_97748914	0.380	NM_001159491 NM_015379	BRI3	brain protein I3
chr19_+_1358664	0.380		DAZAP1	DAZ associated protein 1
chr16_+_14634168	0.374	NM_016561	BFAR	bifunctional apoptosis regulator
chr12_+_6514160	0.372		GAPDH	glyceraldehyde-3-phosphate dehydrogenase
chr3_+_23962518	0.372	NM_001145425	NR1D2	nuclear receptor subfamily 1, group D, member 2
chr19_+_1358531	0.372	NM_018959 NM_170711	DAZAP1	DAZ associated protein 1
chr2_+_220007943	0.371	NM_005876	SPEG	SPEG complex locus
chr21_+_39099717	0.371	NM_005239	ETS2	v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)
chr6_-_153346283	0.370	NM_001142522	FBXO5	F-box protein 5
chr22_+_39818553	0.368	NM_001429	EP300	E1A binding protein p300
chr21_+_39099624	0.367		ETS2	v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)
chr17_+_32924110	0.365		DUSP14	dual specificity phosphatase 14
chr1_+_191357680	0.364	NM_024529	CDC73	cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
chr12_+_6893751	0.364	NM_001975	ENO2	enolase 2 (gamma, neuronal)
chrX_+_77246409	0.361		PGK1	phosphoglycerate kinase 1
chr2_-_138975682	0.361
chr5_+_126881207	0.361	NM_130809	PRRC1	proline-rich coiled-coil 1
chr10_+_73703682	0.360	NM_019058	DDIT4	DNA-damage-inducible transcript 4
chr6_-_35216981	0.359	NM_001093728 NM_018679	TCP11	t-complex 11 homolog (mouse)
chr11_+_65049552	0.356		SCYL1	SCY1-like 1 (S. cerevisiae)
chr1_+_65386359	0.355	NM_013410	AK4	adenylate kinase 4
chr2_+_46779827	0.352	NM_144949	SOCS5	suppressor of cytokine signaling 5
chr16_+_31098971	0.351		FUS	fused in sarcoma
chr11_-_565848	0.350		LOC143666	hypothetical LOC143666
chr6_+_7671267	0.350		BMP6	bone morphogenetic protein 6
chr9_+_131428225	0.349	NM_014064	METTL11A	methyltransferase like 11A
chr18_+_58341637	0.347	NM_017742	ZCCHC2	zinc finger, CCHC domain containing 2
chr9_+_131428272	0.346		METTL11A	methyltransferase like 11A
chr3_-_52694554	0.344	NM_018313	PBRM1	polybromo 1
chr9_+_137532294	0.344	NM_016034	MRPS2	mitochondrial ribosomal protein S2
chr16_+_31098959	0.343		FUS	fused in sarcoma
chr2_+_198073257	0.343		HSPE1	heat shock 10kDa protein 1 (chaperonin 10)
chr2_+_187059237	0.343		ZC3H15	zinc finger CCCH-type containing 15
chr20_+_48781457	0.342	NM_032521	PARD6B	par-6 partitioning defective 6 homolog beta (C. elegans)
chr1_+_65386559	0.342		AK4	adenylate kinase 4
chr2_-_108517028	0.341		FLJ38668	hypothetical LOC644903
chr6_+_16237300	0.339		MYLIP	myosin regulatory light chain interacting protein
chr6_+_46763570	0.336	NM_001010870 NM_001168359	TDRD6	tudor domain containing 6
chr22_+_39072448	0.336	NM_000026 NM_001123378	ADSL	adenylosuccinate lyase
chr4_+_56997205	0.336		PAICS	phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
chr16_+_3447957	0.332	NM_001083600 NM_024845	NAT15	N-acetyltransferase 15 (GCN5-related, putative)
chr2_+_62276764	0.329	NM_006577	B3GNT2	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
chr13_+_114098045	0.328	NM_001164144 NM_001164145 NM_032436	ZNF828	zinc finger protein 828
chr2_+_177785667	0.323	NM_194247	HNRNPA3P1 HNRNPA3	heterogeneous nuclear ribonucleoprotein A3 pseudogene 1 heterogeneous nuclear ribonucleoprotein A3
chr12_+_129922589	0.322		RAN	RAN, member RAS oncogene family
chr20_+_34635362	0.320	NM_021809	TGIF2	TGFB-induced factor homeobox 2
chr21_+_44544381	0.319		PFKL	phosphofructokinase, liver
chr6_+_30647148	0.319	NM_001025091 NM_001090	ABCF1	ATP-binding cassette, sub-family F (GCN20), member 1
chr9_-_139316523	0.318	NM_001004354	NRARP	NOTCH-regulated ankyrin repeat protein
chr2_-_241903657	0.315		HDLBP	high density lipoprotein binding protein
chr19_+_1358750	0.312		DAZAP1	DAZ associated protein 1
chr17_-_71815176	0.308	NM_032134	QRICH2	glutamine rich 2
chr7_+_127883117	0.307	NM_001098786 NM_013332	C7orf68	chromosome 7 open reading frame 68
chr2_+_187059115	0.306	NM_018471	ZC3H15	zinc finger CCCH-type containing 15
chr3_-_40473723	0.306
chr20_+_56989690	0.302	NM_198976	TH1L	TH1-like (Drosophila)
chr7_+_138695537	0.300		LUC7L2	LUC7-like 2 (S. cerevisiae)
chr3_+_157874898	0.300	NM_015508	TIPARP	TCDD-inducible poly(ADP-ribose) polymerase
chr7_+_6735911	0.299
chr17_-_72045218	0.299	NM_134268	CYGB	cytoglobin
chr2_+_131579355	0.298		PLEKHB2	pleckstrin homology domain containing, family B (evectins) member 2
chr2_-_219791638	0.298		ABCB6	ATP-binding cassette, sub-family B (MDR/TAP), member 6
chr6_+_2710675	0.297		WRNIP1	Werner helicase interacting protein 1
chr1_+_191357788	0.296		CDC73	cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
chr8_+_26296439	0.294	NM_004331	BNIP3L	BCL2/adenovirus E1B 19kDa interacting protein 3-like
chr20_-_60151835	0.293	NM_002792	PSMA7	proteasome (prosome, macropain) subunit, alpha type, 7
chr2_+_131579334	0.292		PLEKHB2	pleckstrin homology domain containing, family B (evectins) member 2
chr6_+_36206239	0.292	NM_002754	MAPK13	mitogen-activated protein kinase 13
chr20_-_60151753	0.291		PSMA7	proteasome (prosome, macropain) subunit, alpha type, 7
chr2_+_236067424	0.291	NM_001037131 NM_014914	AGAP1	ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
chr21_+_44544349	0.289	NM_002626	PFKL	phosphofructokinase, liver
chr22_+_34107051	0.287	NM_002133	HMOX1	heme oxygenase (decycling) 1
chrX_+_152608159	0.287	NM_001142806	SLC6A8	solute carrier family 6 (neurotransmitter transporter, creatine), member 8
chr6_+_160068531	0.287		WTAP	Wilms tumor 1 associated protein
chr10_+_93548119	0.285	NM_025235	TNKS2	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
chr16_+_23476334	0.285	NM_019116	UBFD1	ubiquitin family domain containing 1
chr2_+_203901160	0.285	NM_005759	ABI2	abl-interactor 2
chr4_+_186554958	0.283		ANKRD37	ankyrin repeat domain 37
chr10_-_43223226	0.283	NM_001098206	HNRNPF	heterogeneous nuclear ribonucleoprotein F
chr19_+_2736464	0.283	NM_003249	THOP1	thimet oligopeptidase 1
chr6_+_12120709	0.282	NM_002114	HIVEP1	human immunodeficiency virus type I enhancer binding protein 1
chr1_+_65385799	0.282	NM_203464 NM_001005353	AK4	adenylate kinase 4
chr2_-_219791902	0.281	NM_005689	ABCB6	ATP-binding cassette, sub-family B (MDR/TAP), member 6
chr1_+_191357843	0.278		CDC73	cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
chr3_+_52694975	0.277	NM_014366 NM_206825 NM_206826	GNL3	guanine nucleotide binding protein-like 3 (nucleolar)
chr3_+_124268545	0.277	NM_006810	PDIA5	protein disulfide isomerase family A, member 5
chr22_+_48633484	0.277	NM_014838	ZBED4	zinc finger, BED-type containing 4
chr17_+_44340719	0.276	NM_023079	UBE2Z	ubiquitin-conjugating enzyme E2Z
chr4_+_56997155	0.276		PAICS	phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
chr14_+_96038521	0.276		PAPOLA	poly(A) polymerase alpha
chr14_+_96038479	0.276		PAPOLA	poly(A) polymerase alpha
chr16_+_55523248	0.275	NM_001010989 NM_001010990 NM_014685	HERPUD1	homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr16_+_387176	0.274	NM_005009	NME4	non-metastatic cells 4, protein expressed in
chr20_+_17897529	0.274	NM_052865	C20orf72	chromosome 20 open reading frame 72
chr3_+_5204403	0.274		EDEM1	ER degradation enhancer, mannosidase alpha-like 1
chr20_+_56989717	0.271		TH1L	TH1-like (Drosophila)
chr13_+_97426713	0.270		IPO5	importin 5
chr17_+_44340828	0.270		UBE2Z	ubiquitin-conjugating enzyme E2Z
chr17_+_50697319	0.270	NM_002126	HLF	hepatic leukemia factor
chrX_+_77246430	0.270		PGK1	phosphoglycerate kinase 1
chr16_+_30113821	0.269	NM_001017389 NM_003166	SULT1A4 SULT1A3 SLX1B	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae)
chr6_+_2710560	0.268		WRNIP1	Werner helicase interacting protein 1
chr3_+_5204310	0.268		EDEM1	ER degradation enhancer, mannosidase alpha-like 1
chr2_+_236067687	0.268		AGAP1	ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
chr20_+_60246982	0.268		OSBPL2	oxysterol binding protein-like 2
chr4_+_186554831	0.268	NM_181726	ANKRD37	ankyrin repeat domain 37
chr3_+_40473785	0.267	NM_003973 NM_001034996	RPL14	ribosomal protein L14
chr3_+_5204430	0.267		EDEM1	ER degradation enhancer, mannosidase alpha-like 1
chr2_+_108517356	0.265		LIMS1	LIM and senescent cell antigen-like domains 1
chr20_-_60151802	0.265		PSMA7	proteasome (prosome, macropain) subunit, alpha type, 7
chr14_+_96038451	0.265	NM_032632	PAPOLA	poly(A) polymerase alpha
chr20_+_60246971	0.264		OSBPL2	oxysterol binding protein-like 2
chr2_+_74502364	0.264	NM_032118	WDR54	WD repeat domain 54
chr4_+_56997025	0.263	NM_001079524 NM_001079525	PAICS	phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
chr18_+_9904060	0.263		VAPA	VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa
chr2_+_108517239	0.262	NM_001193483	LIMS1	LIM and senescent cell antigen-like domains 1
chr12_+_68923477	0.262		CNOT2	CCR4-NOT transcription complex, subunit 2
chr5_+_138637339	0.262	NM_001194954 NM_199189	MATR3	matrin 3
chr11_+_113776582	0.261	NM_016090	RBM7	RNA binding motif protein 7
chr16_-_47201588	0.261	NM_153029	N4BP1	NEDD4 binding protein 1

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
1.30	1.64e-14	GO:0044237	cellular metabolic process
1.23	8.55e-11	GO:0008152	metabolic process
1.34	1.82e-10	GO:0044260	cellular macromolecule metabolic process
1.13	1.09e-09	GO:0009987	cellular process
1.25	1.18e-09	GO:0044238	primary metabolic process
1.27	2.07e-07	GO:0043170	macromolecule metabolic process
1.36	7.04e-05	GO:0044267	cellular protein metabolic process
1.31	7.48e-05	GO:0034641	cellular nitrogen compound metabolic process
1.37	7.85e-05	GO:0048519	negative regulation of biological process
1.33	8.43e-05	GO:0006139	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.30	1.06e-04	GO:0006807	nitrogen compound metabolic process
1.38	2.23e-04	GO:0048523	negative regulation of cellular process
1.35	2.36e-04	GO:0044249	cellular biosynthetic process
1.34	3.44e-04	GO:0009058	biosynthetic process
1.38	1.98e-03	GO:0010467	gene expression
1.34	2.48e-03	GO:0090304	nucleic acid metabolic process
1.36	6.19e-03	GO:0006464	protein modification process
1.27	7.22e-03	GO:0019538	protein metabolic process
1.53	9.43e-03	GO:0010605	negative regulation of macromolecule metabolic process
1.34	9.95e-03	GO:0043412	macromolecule modification
1.50	1.16e-02	GO:0009892	negative regulation of metabolic process
1.27	1.38e-02	GO:0071841	cellular component organization or biogenesis at cellular level
1.36	1.61e-02	GO:0016070	RNA metabolic process
1.35	2.64e-02	GO:0009059	macromolecule biosynthetic process
1.35	2.78e-02	GO:0034645	cellular macromolecule biosynthetic process
1.26	4.08e-02	GO:0071842	cellular component organization at cellular level

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
1.18	1.32e-21	GO:0044424	intracellular part
1.17	2.52e-20	GO:0005622	intracellular
1.22	4.93e-16	GO:0043231	intracellular membrane-bounded organelle
1.22	7.24e-16	GO:0043227	membrane-bounded organelle
1.17	2.44e-12	GO:0043226	organelle
1.17	3.16e-12	GO:0043229	intracellular organelle
1.20	1.41e-11	GO:0005737	cytoplasm
1.27	3.46e-10	GO:0005634	nucleus
1.27	3.52e-10	GO:0044446	intracellular organelle part
1.26	1.26e-09	GO:0044422	organelle part
1.45	4.32e-08	GO:0044428	nuclear part
1.22	1.44e-07	GO:0044444	cytoplasmic part
1.05	8.65e-06	GO:0044464	cell part
1.05	8.98e-06	GO:0005623	cell
1.37	1.04e-05	GO:0070013	intracellular organelle lumen
1.38	1.76e-05	GO:0031090	organelle membrane
1.36	1.84e-05	GO:0043233	organelle lumen
1.36	2.36e-05	GO:0031974	membrane-enclosed lumen
1.43	4.09e-05	GO:0012505	endomembrane system
2.16	1.51e-04	GO:0005635	nuclear envelope
1.35	2.40e-04	GO:0005829	cytosol
1.37	2.89e-04	GO:0031981	nuclear lumen
1.57	2.16e-03	GO:0031967	organelle envelope
1.56	2.62e-03	GO:0031975	envelope
2.20	1.80e-02	GO:0031965	nuclear membrane
2.04	2.65e-02	GO:0031252	cell leading edge
2.49	4.72e-02	GO:0001726	ruffle

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
1.22	1.49e-10	GO:0005515	protein binding
1.10	2.32e-07	GO:0005488	binding
1.18	1.82e-03	GO:0003824	catalytic activity
1.36	1.93e-03	GO:0016740	transferase activity
1.29	6.65e-03	GO:0000166	nucleotide binding
1.21	2.75e-02	GO:0003676	nucleic acid binding