Motif ID: ZIC1..3.p2

Z-value: 1.273


Transcription factors associated with ZIC1..3.p2:

Gene SymbolEntrez IDGene Name
ZIC1 7545 Zic family member 1 (odd-paired homolog, Drosophila)
ZIC2 7546 Zic family member 2 (odd-paired homolog, Drosophila)
ZIC3 7547 Zic family member 3 (odd-paired homolog, Drosophila)



Activity profile for motif ZIC1..3.p2.

activity profile for motif ZIC1..3.p2


Sorted Z-values histogram for motif ZIC1..3.p2

Sorted Z-values for motif ZIC1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ZIC1..3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_+_37660568 2.568 NM_003246
THBS1
thrombospondin 1
chrX_-_107866262 1.106 NM_003604
IRS4
insulin receptor substrate 4
chr10_-_95350949 1.073 NM_006744
RBP4
retinol binding protein 4, plasma
chr9_+_111850698 1.070 NM_001004065
NM_001198656
AKAP2

A kinase (PRKA) anchor protein 2

chr4_-_174687104 1.037 HAND2
heart and neural crest derivatives expressed 2
chr1_+_234372454 1.000 NM_003272
GPR137B
G protein-coupled receptor 137B
chr19_-_13808101 0.991 LOC284454
hypothetical LOC284454
chr14_+_100362236 0.954 MEG3
maternally expressed 3 (non-protein coding)
chr14_+_100362204 0.951 MEG3
maternally expressed 3 (non-protein coding)
chr14_+_100270222 0.949 DLK1
delta-like 1 homolog (Drosophila)
chr12_+_6517600 0.938


chr12_+_6179736 0.884 NM_001769
CD9
CD9 molecule
chrX_+_106057984 0.847 CLDN2
claudin 2
chr4_-_174686918 0.822 HAND2
heart and neural crest derivatives expressed 2
chr3_+_171619346 0.810 NM_005602
CLDN11
claudin 11
chr3_-_88190737 0.805 NM_001008390
NM_003663
CGGBP1

CGG triplet repeat binding protein 1

chr9_+_99656013 0.764


chr6_+_31479340 0.753 NM_000247
NM_001177519
MICA

MHC class I polypeptide-related sequence A

chr17_-_25642962 0.733 NM_000386
BLMH
bleomycin hydrolase
chr1_+_36394044 0.728 MAP7D1
MAP7 domain containing 1
chr4_+_76077229 0.696 NM_015393
PARM1
prostate androgen-regulated mucin-like protein 1
chr17_+_4683280 0.679 NM_001024937
NM_015716
NM_153827
NM_170663
MINK1



misshapen-like kinase 1



chr5_+_150008030 0.661 SYNPO
synaptopodin
chrX_+_101792949 0.631 NM_001099410
NM_001099411
NM_014710
NM_001184727
GPRASP1



G protein-coupled receptor associated sorting protein 1



chr20_+_35583020 0.619 NM_005386
NM_181689
NNAT

neuronatin

chrX_+_51653348 0.616 NM_001005333
NM_006986
MAGED1

melanoma antigen family D, 1

chr1_-_90955365 0.615 NM_020063
BARHL2
BarH-like homeobox 2
chr1_+_154351082 0.605 NM_005572
NM_170707
NM_170708
LMNA


lamin A/C


chr19_+_16296632 0.602 NM_016270
KLF2
Kruppel-like factor 2 (lung)
chr21_-_26867138 0.598 NM_052954
CYYR1
cysteine/tyrosine-rich 1
chr22_+_35777561 0.594 NM_024681
KCTD17
potassium channel tetramerisation domain containing 17
chrX_+_153339814 0.590 NM_017514
PLXNA3
plexin A3
chr12_-_51734434 0.586 LOC283335
hypothetical LOC283335
chr9_+_111850770 0.582 AKAP2
A kinase (PRKA) anchor protein 2
chr15_+_38520594 0.582 NM_014952
BAHD1
bromo adjacent homology domain containing 1
chr11_+_43920385 0.543 NM_001145033
C11orf96
chromosome 11 open reading frame 96
chr18_+_19706979 0.541 NM_000227
NM_001127718
LAMA3

laminin, alpha 3

chrX_-_53367246 0.539 NM_001111125
IQSEC2
IQ motif and Sec7 domain 2
chr9_+_78824390 0.525 NM_001013735
FOXB2
forkhead box B2
chr19_+_60816770 0.521 NM_001195605
ZNF865
zinc finger protein 865
chr6_+_21701942 0.519 NM_003107
SOX4
SRY (sex determining region Y)-box 4
chr7_-_150737980 0.517 NM_198285
WDR86
WD repeat domain 86
chr12_+_5411534 0.513 NM_001102654
NTF3
neurotrophin 3
chr17_+_7252225 0.511 NM_020795
NLGN2
neuroligin 2
chr13_+_41520888 0.509 NM_152910
NM_178009
DGKH

diacylglycerol kinase, eta

chr12_-_131697109 0.509 NM_001195520
LOC645277
hypothetical LOC645277
chr7_-_27180398 0.506 NM_018951
HOXA10
homeobox A10
chrX_-_48743561 0.495 NM_020137
NM_207672
GRIPAP1

GRIP1 associated protein 1

chr11_-_56859900 0.491 NM_003146
SSRP1
structure specific recognition protein 1
chrX_-_135941498 0.479 NM_054021
GPR101
G protein-coupled receptor 101
chr10_-_103593529 0.477 NM_014591
NM_173191
NM_173192
NM_173193
NM_173195
NM_173197
KCNIP2





Kv channel interacting protein 2





chr17_-_75427644 0.472 NM_003655
CBX4
chromobox homolog 4
chr19_+_16296734 0.471 KLF2
Kruppel-like factor 2 (lung)
chr12_-_6668880 0.469 NM_001039917
NM_001039919
NM_001039920
NM_001135734
ZNF384



zinc finger protein 384



chrX_+_101887562 0.467 NM_001142529
NM_001142530
BHLHB9

basic helix-loop-helix domain containing, class B, 9

chr9_+_831689 0.466 NM_021951
DMRT1
doublesex and mab-3 related transcription factor 1
chr17_-_42250961 0.466 NM_030753
WNT3
wingless-type MMTV integration site family, member 3
chr16_-_66827449 0.455 NM_024939
ESRP2
epithelial splicing regulatory protein 2
chr2_+_172658453 0.454 NM_001038493
NM_178120
DLX1

distal-less homeobox 1

chr13_+_32488477 0.454 NM_004795
KL
klotho
chr8_-_144995007 0.451 NM_178564
NRBP2
nuclear receptor binding protein 2
chr10_+_75343352 0.449 PLAU
plasminogen activator, urokinase
chr9_+_123501186 0.448 DAB2IP
DAB2 interacting protein
chrX_+_133993984 0.444 NM_001078171
FAM127A
family with sequence similarity 127, member A
chr17_+_56884560 0.442 TBX4
T-box 4
chr5_+_167889123 0.441


chr14_+_105012106 0.440 NM_001312
CRIP2
cysteine-rich protein 2
chr11_+_44074322 0.440 NM_000401
EXT2
exostosin 2
chr16_+_85158357 0.437 NM_005251
FOXC2
forkhead box C2 (MFH-1, mesenchyme forkhead 1)
chr20_+_19903778 0.435 RIN2
Ras and Rab interactor 2
chr12_-_120389419 0.433 KDM2B
lysine (K)-specific demethylase 2B
chr13_+_75108450 0.431 LMO7
LIM domain 7
chr3_+_160964574 0.427 SCHIP1
schwannomin interacting protein 1
chr5_+_76047536 0.425 NM_001992
F2R
coagulation factor II (thrombin) receptor
chr16_+_54070302 0.422 NM_004530
MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chr3_-_137953876 0.421 NM_005862
STAG1
stromal antigen 1
chr14_-_70345485 0.421 NM_033141
MAP3K9
mitogen-activated protein kinase kinase kinase 9
chr19_-_13910167 0.420 NM_024825
PODNL1
podocan-like 1
chr12_+_6745835 0.420 PTMS
parathymosin
chr12_+_6915698 0.418


chr4_-_109308893 0.417 NM_001130713
NM_001130714
NM_016269
LEF1


lymphoid enhancer-binding factor 1


chr5_+_140835788 0.416 PCDHGC3
protocadherin gamma subfamily C, 3
chr9_-_139027435 0.416 ABCA2
ATP-binding cassette, sub-family A (ABC1), member 2
chr11_-_65396775 0.415 NM_016938
EFEMP2
EGF containing fibulin-like extracellular matrix protein 2
chr5_-_577444 0.415 NM_004174
SLC9A3
solute carrier family 9 (sodium/hydrogen exchanger), member 3
chr2_-_213111525 0.408 NM_001042599
NM_005235
ERBB4

v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)

chr16_-_1999760 0.406 NM_178167
ZNF598
zinc finger protein 598
chr8_+_1937711 0.405 KBTBD11
kelch repeat and BTB (POZ) domain containing 11
chr9_-_114858788 0.404 NM_003408
ZFP37
zinc finger protein 37 homolog (mouse)
chr2_+_202607554 0.401 NM_003507
FZD7
frizzled homolog 7 (Drosophila)
chr17_+_56832492 0.401 TBX2
T-box 2
chr17_-_1195096 0.400 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr9_-_34387786 0.400 NM_032596
C9orf24
chromosome 9 open reading frame 24
chr17_+_38088097 0.398 NM_003632
CNTNAP1
contactin associated protein 1
chr19_+_54786723 0.398 NM_020719
PRR12
proline rich 12
chr5_-_176760242 0.397 NM_001029886
PFN3
profilin 3
chr17_-_928960 0.396 ABR
active BCR-related gene
chr14_-_87859284 0.393 NM_138317
KCNK10
potassium channel, subfamily K, member 10
chr20_+_25176698 0.391 NM_002862
PYGB
phosphorylase, glycogen; brain
chr22_-_49063088 0.391 PLXNB2
plexin B2
chr16_-_73842884 0.386 NM_001170717
NM_014567
BCAR1

breast cancer anti-estrogen resistance 1

chr19_-_3820012 0.383 NM_001145640
NM_015174
ZFR2

zinc finger RNA binding protein 2

chr14_+_64040979 0.382 NM_001123329
NM_014950
ZBTB1

zinc finger and BTB domain containing 1

chr5_+_140835727 0.381 NM_002588
NM_032402
NM_032403
PCDHGC3


protocadherin gamma subfamily C, 3


chr1_-_114156387 0.380 RSBN1
round spermatid basic protein 1
chr10_-_127454379 0.380 NM_147191
MMP21
matrix metallopeptidase 21
chr12_+_6745729 0.379 NM_002824
PTMS
parathymosin
chr3_+_148610516 0.377 ZIC1
Zic family member 1 (odd-paired homolog, Drosophila)
chr3_+_142979639 0.377 NM_139209
GRK7
G protein-coupled receptor kinase 7
chr3_+_49566901 0.375 NM_003458
BSN
bassoon (presynaptic cytomatrix protein)
chrX_-_24941098 0.374 ARX
aristaless related homeobox
chr22_+_35290271 0.373


chr13_-_94162249 0.372 NM_007084
SOX21
SRY (sex determining region Y)-box 21
chr11_-_289518 0.371 NM_001025295
IFITM5
interferon induced transmembrane protein 5
chr6_-_107542328 0.371 NM_001080450
BEND3
BEN domain containing 3
chr19_-_19599973 0.366 NM_004720
LPAR2
lysophosphatidic acid receptor 2
chrX_+_90576252 0.365 NM_080832
PABPC5
poly(A) binding protein, cytoplasmic 5
chr3_-_107070400 0.362 NM_170662
CBLB
Cas-Br-M (murine) ecotropic retroviral transforming sequence b
chr1_-_114156429 0.362 NM_018364
RSBN1
round spermatid basic protein 1
chr19_-_5291700 0.361 NM_002850
NM_130853
NM_130854
NM_130855
PTPRS



protein tyrosine phosphatase, receptor type, S



chr17_-_59923547 0.359 NM_007215
POLG2
polymerase (DNA directed), gamma 2, accessory subunit
chr17_+_58058783 0.358 MRC2
mannose receptor, C type 2
chr3_-_130807865 0.356 NM_015103
PLXND1
plexin D1
chr16_-_34262262 0.355 UBE2MP1
ubiquitin-conjugating enzyme E2M pseudogene 1
chr14_+_64077171 0.353 HSPA2
heat shock 70kDa protein 2
chr17_+_6867138 0.352 BCL6B
B-cell CLL/lymphoma 6, member B
chr17_+_7264366 0.352 NM_199339
SPEM1
spermatid maturation 1
chr12_+_6745947 0.351 PTMS
parathymosin
chr17_+_6867090 0.350 NM_181844
BCL6B
B-cell CLL/lymphoma 6, member B
chr12_-_4425040 0.350 NM_020996
FGF6
fibroblast growth factor 6
chrX_-_70248022 0.348 NM_000206
IL2RG
interleukin 2 receptor, gamma
chr13_+_110565587 0.348 NM_001113511
NM_001113512
NM_145735
ARHGEF7


Rho guanine nucleotide exchange factor (GEF) 7


chr2_+_130846263 0.346 PTPN18
protein tyrosine phosphatase, non-receptor type 18 (brain-derived)
chr4_-_149582754 0.345 NR3C2
nuclear receptor subfamily 3, group C, member 2
chr2_+_159533329 0.344 NM_001145909
NM_033394
TANC1

tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1

chrX_-_134013644 0.344 NM_001078172
NM_001134321
FAM127B

family with sequence similarity 127, member B

chr19_-_51097694 0.343 NM_001012643
MYPOP
Myb-related transcription factor, partner of profilin
chr14_+_104261578 0.342 NM_152328
ADSSL1
adenylosuccinate synthase like 1
chr1_+_154351200 0.339 LMNA
lamin A/C
chr20_+_61622985 0.337 PPDPF
pancreatic progenitor cell differentiation and proliferation factor homolog (zebrafish)
chr11_-_61415429 0.337 NM_021727
FADS3
fatty acid desaturase 3
chr11_+_2355119 0.335 NM_004356
CD81
CD81 molecule
chr11_-_3035172 0.334 NM_001014437
NM_001194997
NM_001751
NM_139273
CARS



cysteinyl-tRNA synthetase



chrX_+_151991474 0.333 NM_001170944
NM_032882
LOC100287428
PNMA6A
paraneoplastic antigen-like protein 6A related gene
paraneoplastic antigen like 6A
chr16_+_1979959 0.332 NM_004209
SYNGR3
synaptogyrin 3
chr16_-_265868 0.330 NM_003834
NM_183337
RGS11

regulator of G-protein signaling 11

chr10_-_126706442 0.329 NM_022802
CTBP2
C-terminal binding protein 2
chr12_+_109536214 0.328 NM_001082537
NM_001082538
NM_001173976
NM_024549
NM_001173975
TCTN1




tectonic family member 1




chr12_+_52653176 0.327 NM_014212
HOXC11
homeobox C11
chrX_-_8729377 0.327 NM_001171186
NM_174951
FAM9A

family with sequence similarity 9, member A

chrX_+_101853912 0.324 NM_001004051
NM_001184874
NM_001184875
NM_001184876
NM_138437
GPRASP2




G protein-coupled receptor associated sorting protein 2




chr17_-_8020332 0.322 NM_032354
NM_183065
TMEM107

transmembrane protein 107

chr3_+_185377430 0.321 AP2M1
adaptor-related protein complex 2, mu 1 subunit
chr15_-_41669690 0.318 NM_001130858
NM_001130859
NM_001190214
PPIP5K1


diphosphoinositol pentakisphosphate kinase 1


chrX_-_111970662 0.317 NM_133265
AMOT
angiomotin
chr21_+_41461962 0.314 BACE2
beta-site APP-cleaving enzyme 2
chrX_-_114374860 0.314 NM_020871
LRCH2
leucine-rich repeats and calponin homology (CH) domain containing 2
chr7_+_119700924 0.313 NM_012281
KCND2
potassium voltage-gated channel, Shal-related subfamily, member 2
chr14_+_64076916 0.311 NM_021979
HSPA2
heat shock 70kDa protein 2
chr20_+_36786540 0.310 SLC32A1
solute carrier family 32 (GABA vesicular transporter), member 1
chr17_+_7549138 0.309 NM_001406
EFNB3
ephrin-B3
chrX_-_52700674 0.309 NM_173358
SSX7
synovial sarcoma, X breakpoint 7
chr16_+_30583278 0.307 NM_001105079
FBRS
fibrosin
chr11_+_122936145 0.306 GRAMD1B
GRAM domain containing 1B
chr8_-_134653194 0.306 NM_003033
NM_173344
ST3GAL1

ST3 beta-galactoside alpha-2,3-sialyltransferase 1

chrX_-_119329307 0.305 FAM70A
family with sequence similarity 70, member A
chr9_-_94566823 0.303 NM_001003800
NM_015250
BICD2

bicaudal D homolog 2 (Drosophila)

chr1_+_32251988 0.303 NM_006559
KHDRBS1
KH domain containing, RNA binding, signal transduction associated 1
chr17_+_7776197 0.303 NM_001037144
NM_053051
CNTROB

centrobin, centrosomal BRCA2 interacting protein

chr14_+_102662416 0.303 NM_006291
TNFAIP2
tumor necrosis factor, alpha-induced protein 2
chr22_+_40107878 0.302 NM_003216
TEF
thyrotrophic embryonic factor
chr12_+_11694172 0.302 ETV6
ets variant 6
chr19_+_60487345 0.301 NM_032430
BRSK1
BR serine/threonine kinase 1
chrX_+_48127911 0.300 NM_001034832
NM_001040612
NM_005636
NM_175729
SSX4B

SSX4

synovial sarcoma, X breakpoint 4B

synovial sarcoma, X breakpoint 4

chr14_-_60260211 0.298 NM_017420
SIX4
SIX homeobox 4
chr19_-_48976852 0.298 KCNN4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr11_-_106394039 0.298 NM_000855
GUCY1A2
guanylate cyclase 1, soluble, alpha 2
chr12_-_6668680 0.298 ZNF384
zinc finger protein 384
chr22_+_38090120 0.296 NM_145738
SYNGR1
synaptogyrin 1
chr19_+_12709281 0.295 NM_004317
ASNA1
arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)
chr1_+_154351162 0.295 LMNA
lamin A/C
chr19_-_48998365 0.294 NM_001031749
LYPD5
LY6/PLAUR domain containing 5
chr1_+_143304983 0.293 NBPF10
NBPF1
neuroblastoma breakpoint family, member 10
neuroblastoma breakpoint family, member 1
chr11_-_31796061 0.292 NM_001127612
PAX6
paired box 6
chr19_+_19510056 0.292 NM_153221
CILP2
cartilage intermediate layer protein 2
chrX_-_20044670 0.291 NM_001168467
MAP7D2
MAP7 domain containing 2
chr22_-_29231597 0.291 NM_001161368
NM_174977
SEC14L4

SEC14-like 4 (S. cerevisiae)

chr15_-_39195701 0.291 INO80
INO80 homolog (S. cerevisiae)
chr19_-_12858956 0.290 NM_006563
KLF1
Kruppel-like factor 1 (erythroid)
chr19_+_19510098 0.289 CILP2
cartilage intermediate layer protein 2
chr11_+_122936246 0.289 GRAMD1B
GRAM domain containing 1B
chrX_+_72140076 0.288 NM_001042506
PABPC1L2B
poly(A) binding protein, cytoplasmic 1-like 2B
chr20_+_36786518 0.288 NM_080552
SLC32A1
solute carrier family 32 (GABA vesicular transporter), member 1
chr1_-_29321599 0.288 NM_001171868
TMEM200B
transmembrane protein 200B
chr15_+_72209039 0.287 NM_001130137
ISLR2
immunoglobulin superfamily containing leucine-rich repeat 2
chr19_+_40795456 0.287 NM_015302
HAUS5
HAUS augmin-like complex, subunit 5
chr3_+_185377341 0.286 AP2M1
adaptor-related protein complex 2, mu 1 subunit
chr17_-_30838870 0.285 NM_001195790
SLFN12L
schlafen family member 12-like
chr19_+_2200112 0.285 NM_000479
AMH
anti-Mullerian hormone
chr12_-_53071285 0.283 NM_001130967
NM_001130968
ZNF385A

zinc finger protein 385A


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.52 1.22e-14 GO:0030154 cell differentiation
1.63 1.67e-14 GO:0007399 nervous system development
1.35 2.68e-14 GO:0032502 developmental process
1.50 4.44e-14 GO:0048869 cellular developmental process
1.38 1.48e-13 GO:0048856 anatomical structure development
1.41 3.59e-13 GO:0048731 system development
1.36 5.32e-13 GO:0007275 multicellular organismal development
1.72 5.60e-10 GO:0048699 generation of neurons
1.69 5.98e-10 GO:0022008 neurogenesis
1.17 7.43e-10 GO:0065007 biological regulation
1.52 1.14e-09 GO:0009653 anatomical structure morphogenesis
1.19 1.49e-09 GO:0050794 regulation of cellular process
1.74 2.98e-08 GO:0030182 neuron differentiation
1.17 6.50e-08 GO:0050789 regulation of biological process
1.90 2.92e-07 GO:0048667 cell morphogenesis involved in neuron differentiation
1.89 3.70e-07 GO:0048812 neuron projection morphogenesis
1.83 5.70e-07 GO:0000904 cell morphogenesis involved in differentiation
1.89 9.40e-07 GO:0007409 axonogenesis
2.00 1.35e-06 GO:0007411 axon guidance
1.55 2.11e-06 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.41 2.41e-06 GO:0023051 regulation of signaling
1.78 5.95e-06 GO:0031175 neuron projection development
1.71 8.22e-06 GO:0048666 neuron development
1.55 9.50e-06 GO:0048468 cell development
1.24 1.63e-05 GO:0023052 signaling
1.74 1.88e-05 GO:0048858 cell projection morphogenesis
1.73 3.08e-05 GO:0032990 cell part morphogenesis
1.32 3.41e-05 GO:0048523 negative regulation of cellular process
1.18 4.14e-05 GO:0032501 multicellular organismal process
1.58 5.82e-05 GO:0010557 positive regulation of macromolecule biosynthetic process
1.91 6.83e-05 GO:0060284 regulation of cell development
1.34 8.66e-05 GO:0048583 regulation of response to stimulus
1.23 8.67e-05 GO:0031323 regulation of cellular metabolic process
1.64 8.94e-05 GO:0000902 cell morphogenesis
1.28 9.34e-05 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.21 1.16e-04 GO:0019222 regulation of metabolic process
1.40 1.17e-04 GO:0009966 regulation of signal transduction
1.08 1.19e-04 GO:0009987 cellular process
1.41 2.58e-04 GO:0009893 positive regulation of metabolic process
1.51 2.89e-04 GO:0009891 positive regulation of biosynthetic process
1.29 2.97e-04 GO:0048519 negative regulation of biological process
1.29 3.03e-04 GO:0051252 regulation of RNA metabolic process
1.60 3.18e-04 GO:0032989 cellular component morphogenesis
1.49 3.50e-04 GO:0050793 regulation of developmental process
1.59 3.88e-04 GO:0030030 cell projection organization
1.44 4.38e-04 GO:0010646 regulation of cell communication
1.50 4.64e-04 GO:0031328 positive regulation of cellular biosynthetic process
1.42 4.77e-04 GO:0010604 positive regulation of macromolecule metabolic process
1.28 4.78e-04 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.49 5.22e-04 GO:0009888 tissue development
1.59 5.22e-04 GO:0045893 positive regulation of transcription, DNA-dependent
1.63 6.08e-04 GO:0051253 negative regulation of RNA metabolic process
1.25 6.12e-04 GO:0051171 regulation of nitrogen compound metabolic process
1.22 6.63e-04 GO:0080090 regulation of primary metabolic process
1.56 6.78e-04 GO:0045595 regulation of cell differentiation
1.63 7.37e-04 GO:0045892 negative regulation of transcription, DNA-dependent
1.56 8.23e-04 GO:0010628 positive regulation of gene expression
1.52 9.49e-04 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.73 1.05e-03 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.26 1.07e-03 GO:0010468 regulation of gene expression
1.40 1.09e-03 GO:0031325 positive regulation of cellular metabolic process
1.26 1.10e-03 GO:0010556 regulation of macromolecule biosynthetic process
1.25 1.13e-03 GO:0048518 positive regulation of biological process
1.28 1.14e-03 GO:0006355 regulation of transcription, DNA-dependent
1.22 1.16e-03 GO:0060255 regulation of macromolecule metabolic process
1.50 1.17e-03 GO:0051173 positive regulation of nitrogen compound metabolic process
1.45 1.23e-03 GO:0032879 regulation of localization
1.55 1.46e-03 GO:0051254 positive regulation of RNA metabolic process
1.51 1.51e-03 GO:2000026 regulation of multicellular organismal development
1.67 2.17e-03 GO:0032583 regulation of gene-specific transcription
1.83 2.38e-03 GO:0051270 regulation of cellular component movement
1.24 2.48e-03 GO:0031326 regulation of cellular biosynthetic process
1.55 2.70e-03 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.56 2.75e-03 GO:0010629 negative regulation of gene expression
1.24 3.27e-03 GO:0009889 regulation of biosynthetic process
1.61 3.38e-03 GO:0006935 chemotaxis
1.61 3.38e-03 GO:0042330 taxis
1.78 3.92e-03 GO:0001501 skeletal system development
1.55 4.02e-03 GO:0009887 organ morphogenesis
1.21 4.12e-03 GO:0016043 cellular component organization
2.01 4.17e-03 GO:0048732 gland development
1.25 4.20e-03 GO:0048522 positive regulation of cellular process
1.81 4.47e-03 GO:0040012 regulation of locomotion
1.54 5.26e-03 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.29 5.53e-03 GO:0048513 organ development
1.85 5.63e-03 GO:0030334 regulation of cell migration
1.54 5.70e-03 GO:0051172 negative regulation of nitrogen compound metabolic process
1.77 8.04e-03 GO:0048729 tissue morphogenesis
1.83 8.60e-03 GO:2000145 regulation of cell motility
2.45 8.74e-03 GO:0040013 negative regulation of locomotion
1.51 9.20e-03 GO:0010558 negative regulation of macromolecule biosynthetic process
1.49 1.07e-02 GO:0009790 embryo development
1.23 1.25e-02 GO:0071842 cellular component organization at cellular level
1.79 1.27e-02 GO:0051960 regulation of nervous system development
1.71 1.29e-02 GO:0007389 pattern specification process
1.49 1.57e-02 GO:0031327 negative regulation of cellular biosynthetic process
3.22 1.62e-02 GO:0051149 positive regulation of muscle cell differentiation
1.65 3.05e-02 GO:0048598 embryonic morphogenesis
1.54 3.46e-02 GO:0007417 central nervous system development
2.05 3.47e-02 GO:0034330 cell junction organization
1.68 3.83e-02 GO:0045597 positive regulation of cell differentiation
2.03 4.14e-02 GO:0045165 cell fate commitment
1.40 4.17e-02 GO:0031324 negative regulation of cellular metabolic process
1.45 4.40e-02 GO:0009890 negative regulation of biosynthetic process
2.09 4.53e-02 GO:0034329 cell junction assembly
1.18 4.62e-02 GO:0071840 cellular component organization or biogenesis
1.63 4.67e-02 GO:0009792 embryo development ending in birth or egg hatching
1.78 4.93e-02 GO:0050767 regulation of neurogenesis

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.36 3.58e-08 GO:0044459 plasma membrane part
1.59 7.68e-05 GO:0030054 cell junction
1.71 1.55e-04 GO:0045202 synapse
1.17 1.68e-03 GO:0071944 cell periphery
1.17 1.77e-03 GO:0005886 plasma membrane
1.75 1.81e-03 GO:0044456 synapse part
2.02 1.11e-02 GO:0034703 cation channel complex
1.03 2.58e-02 GO:0044464 cell part
1.03 2.67e-02 GO:0005623 cell
2.15 2.86e-02 GO:0005925 focal adhesion
1.75 3.36e-02 GO:0034702 ion channel complex
1.06 4.36e-02 GO:0005622 intracellular
1.85 4.58e-02 GO:0030136 clathrin-coated vesicle

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.51 1.31e-06 GO:0030528 transcription regulator activity
1.63 2.05e-06 GO:0043565 sequence-specific DNA binding
1.48 1.90e-05 GO:0001071 nucleic acid binding transcription factor activity
1.48 1.90e-05 GO:0003700 sequence-specific DNA binding transcription factor activity
2.14 1.50e-03 GO:0022843 voltage-gated cation channel activity
1.88 5.24e-03 GO:0000975 regulatory region DNA binding
1.88 5.24e-03 GO:0001067 regulatory region nucleic acid binding
1.88 5.24e-03 GO:0044212 transcription regulatory region DNA binding
1.58 6.48e-03 GO:0019904 protein domain specific binding
1.88 8.06e-03 GO:0010843 promoter binding
1.66 1.16e-02 GO:0016563 transcription activator activity
1.67 1.39e-02 GO:0016564 transcription repressor activity
1.70 2.36e-02 GO:0005261 cation channel activity
1.10 3.67e-02 GO:0005515 protein binding
1.45 4.55e-02 GO:0008324 cation transmembrane transporter activity