Motif ID: NFE2L1.p2

Z-value: 2.137


Transcription factors associated with NFE2L1.p2:

Gene SymbolEntrez IDGene Name
NFE2L1 4779 nuclear factor (erythroid-derived 2)-like 1



Activity profile for motif NFE2L1.p2.

activity profile for motif NFE2L1.p2


Sorted Z-values histogram for motif NFE2L1.p2

Sorted Z-values for motif NFE2L1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFE2L1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_-_88573949 3.111 NM_001001323
NM_001682
ATP2B1

ATPase, Ca++ transporting, plasma membrane 1

chr21_+_33844793 2.427 SON
SON DNA binding protein
chr6_+_55147029 2.130 NM_001526
HCRTR2
hypocretin (orexin) receptor 2
chr10_+_129237602 2.036 NM_001030013
NPS
neuropeptide S
chr9_-_106420305 1.899 NM_001001956
OR13C9
olfactory receptor, family 13, subfamily C, member 9
chr7_+_113853790 1.698 NM_001172767
NM_148899
FOXP2

forkhead box P2

chr11_-_57752923 1.696 NM_001004471
OR10Q1
olfactory receptor, family 10, subfamily Q, member 1
chrX_+_142794838 1.536 NM_001012989
UBE2NL
ubiquitin-conjugating enzyme E2N-like
chr4_-_68678181 1.502 NM_207407
TMPRSS11F
transmembrane protease, serine 11F
chr11_+_5925152 1.498 NM_001003443
OR56A3
olfactory receptor, family 56, subfamily A, member 3
chr1_+_246635918 1.414 NM_030904
OR2T1
olfactory receptor, family 2, subfamily T, member 1
chr1_-_157551072 1.401 NM_001004467
OR10J3
olfactory receptor, family 10, subfamily J, member 3
chr9_-_72926333 1.400 NM_001007471
TRPM3
transient receptor potential cation channel, subfamily M, member 3
chr14_-_20969706 1.391 NM_001170629
CHD8
chromodomain helicase DNA binding protein 8
chr2_-_215967442 1.387 FN1
fibronectin 1
chr10_+_128583984 1.385 NM_001380
DOCK1
dedicator of cytokinesis 1
chr9_+_21399132 1.381 NM_002170
IFNA8
interferon, alpha 8
chr6_-_46155937 1.340 NM_001114086
CLIC5
chloride intracellular channel 5
chr2_+_191009265 1.329 MFSD6
major facilitator superfamily domain containing 6
chr2_+_228045121 1.327 NM_001135187
NM_001135188
NM_001135189
NM_004504
AGFG1



ArfGAP with FG repeats 1



chrX_-_32340291 1.322 NM_004011
NM_004012
DMD

dystrophin

chr12_-_44919818 1.310 SLC38A1
solute carrier family 38, member 1
chr2_+_228045053 1.293 AGFG1
ArfGAP with FG repeats 1
chr10_-_98315090 1.287 TM9SF3
transmembrane 9 superfamily member 3
chr9_-_21375258 1.287 NM_000605
IFNA2
interferon, alpha 2
chr9_-_21156609 1.283 NM_002175
IFNA21
interferon, alpha 21
chr11_-_13474101 1.272 NM_000315
PTH
parathyroid hormone
chr11_-_55815113 1.259 NM_001005199
OR8H1
olfactory receptor, family 8, subfamily H, member 1
chr17_+_36665161 1.253 NM_030975
KRTAP9-9
keratin associated protein 9-9
chr17_+_36642240 1.252 NM_031962
KRTAP9-9
KRTAP9-3
keratin associated protein 9-9
keratin associated protein 9-3
chr11_-_62753574 1.232 NM_199352
SLC22A25
solute carrier family 22, member 25
chr1_-_157772420 1.208 NM_001004469
OR10J5
olfactory receptor, family 10, subfamily J, member 5
chrX_-_33267646 1.182 NM_000109
DMD
dystrophin
chr12_+_84792203 1.175 NM_006183
NTS
neurotensin
chr10_-_108448990 1.165 SORCS1
sortilin-related VPS10 domain containing receptor 1
chr9_-_16717887 1.164 BNC2
basonuclin 2
chr11_-_6005546 1.140 NM_001001917
OR56A1
olfactory receptor, family 56, subfamily A, member 1
chr13_+_48692472 1.119 NM_001507
MLNR
motilin receptor
chr8_-_79880095 1.112 NM_000880
IL7
interleukin 7
chr3_+_171619346 1.096 NM_005602
CLDN11
claudin 11
chr9_-_21340885 1.090 NM_021002
IFNA6
interferon, alpha 6
chr2_+_88148413 1.087 NM_198274
SMYD1
SET and MYND domain containing 1
chr11_-_7917642 1.082 NM_001003745
OR10A3
olfactory receptor, family 10, subfamily A, member 3
chr11_+_55869996 1.080 NM_001002907
OR8K1
olfactory receptor, family 8, subfamily K, member 1
chr11_+_123945102 1.078 NM_001005194
OR8A1
olfactory receptor, family 8, subfamily A, member 1
chr22_+_27998367 1.065 EWSR1
Ewing sarcoma breakpoint region 1
chr9_-_85773899 1.063 HNRNPK
heterogeneous nuclear ribonucleoprotein K
chr1_-_156784518 1.060 NM_001005189
OR6Y1
olfactory receptor, family 6, subfamily Y, member 1
chr2_-_55053398 1.056


chr22_-_31732648 1.051 NM_003490
NM_133633
SYN3

synapsin III

chr2_+_211129567 1.046 NM_001875
CPS1
carbamoyl-phosphate synthase 1, mitochondrial
chr17_-_3248453 1.043 NM_003553
OR1E1
olfactory receptor, family 1, subfamily E, member 1
chr18_+_52575442 1.041 WDR7
WD repeat domain 7
chr22_-_37214480 1.006 NM_001098505
NM_030881
DDX17

DEAD (Asp-Glu-Ala-Asp) box polypeptide 17

chr1_-_157014048 1.000 NM_001005278
OR6N2
olfactory receptor, family 6, subfamily N, member 2
chr11_+_61352348 0.993 FADS2
fatty acid desaturase 2
chr11_-_27700180 0.988 NM_170731
BDNF
brain-derived neurotrophic factor
chr11_+_26310253 0.987 NM_031418
ANO3
anoctamin 3
chr5_+_132237253 0.987 NM_052971
LEAP2
liver expressed antimicrobial peptide 2
chr11_+_88550687 0.985 NM_000372
TYR
tyrosinase (oculocutaneous albinism IA)
chr12_-_18782184 0.979 NM_033123
PLCZ1
phospholipase C, zeta 1
chr4_+_99401543 0.976 NM_001100426
NM_001100427
NM_001100428
NM_001100429
NM_001100430
NM_021159
RAP1GDS1





RAP1, GTP-GDP dissociation stimulator 1





chr5_-_178977441 0.974 HNRNPH1
heterogeneous nuclear ribonucleoprotein H1 (H)
chr6_+_89847183 0.966 PNRC1
proline-rich nuclear receptor coactivator 1
chr1_-_157003095 0.951 NM_001005185
OR6N1
olfactory receptor, family 6, subfamily N, member 1
chr1_-_156635879 0.936 NM_001004475
OR10T2
olfactory receptor, family 10, subfamily T, member 2
chr1_+_93830106 0.935 LOC100129046
hypothetical LOC100129046
chr2_-_74455161 0.928 NM_001135041
NM_023019
DCTN1

dynactin 1

chr11_-_48330574 0.922 NM_001005513
OR4C45
olfactory receptor, family 4, subfamily C, member 45
chr12_+_18782307 0.917 NM_033328
CAPZA3
capping protein (actin filament) muscle Z-line, alpha 3
chr5_+_147562531 0.913 NM_001195290
NM_205841
SPINK6

serine peptidase inhibitor, Kazal type 6

chr1_+_93830169 0.913 LOC100129046
hypothetical LOC100129046
chr7_-_11838260 0.903 NM_015204
THSD7A
thrombospondin, type I, domain containing 7A
chr1_+_246718487 0.896 NM_001004697
OR2T5
olfactory receptor, family 2, subfamily T, member 5
chr8_+_32698892 0.894 NM_001159996
NRG1
neuregulin 1
chr17_-_8602601 0.893 NM_001128076
SPDYE4
speedy homolog E4 (Xenopus laevis)
chr17_+_15843832 0.891 TTC19
tetratricopeptide repeat domain 19
chr14_+_28306633 0.881 FOXG1
forkhead box G1
chr11_+_61352209 0.881 NM_004265
FADS2
fatty acid desaturase 2
chr8_+_118216517 0.880 NM_001172814
NM_173851
SLC30A8

solute carrier family 30 (zinc transporter), member 8

chr4_+_183302105 0.880 ODZ3
odz, odd Oz/ten-m homolog 3 (Drosophila)
chr1_-_71285847 0.880 NM_001126044
NM_198714
NM_198715
NM_198716
NM_198717
NM_198718
NM_198719
PTGER3






prostaglandin E receptor 3 (subtype EP3)






chr14_-_21108714 0.876 NM_001005465
OR10G3
olfactory receptor, family 10, subfamily G, member 3
chrX_-_127014020 0.875 NM_138289
ACTRT1
actin-related protein T1
chr9_-_21358005 0.872 NM_006900
IFNA1
IFNA13
interferon, alpha 1
interferon, alpha 13
chr3_-_187124290 0.868 TRA2B
transformer 2 beta homolog (Drosophila)
chr2_+_115635982 0.864 NM_001178034
NM_001004360
DPP10

dipeptidyl-peptidase 10 (non-functional)

chr11_+_6854431 0.862 NM_207186
OR10A4
olfactory receptor, family 10, subfamily A, member 4
chr14_+_74968589 0.861 NM_001135049
JDP2
Jun dimerization protein 2
chr14_-_94669547 0.858 NM_001195573
DICER1
dicer 1, ribonuclease type III
chr16_-_21439195 0.854 SLC7A5P2
solute carrier family 7 (cationic amino acid transporter, y+ system), member 5 pseudogene 2
chr3_-_181237210 0.849 NM_016559
PEX5L
peroxisomal biogenesis factor 5-like
chr4_-_39199527 0.848 UGDH
UDP-glucose 6-dehydrogenase
chr5_+_34720368 0.847 NM_001145521
NM_001145525
RAI14

retinoic acid induced 14

chr5_-_112798436 0.846 NM_032028
TSSK1B
testis-specific serine kinase 1B
chr8_-_30826074 0.845 NM_031271
TEX15
testis expressed 15
chr1_-_150328153 0.845 NM_001008536
TCHHL1
trichohyalin-like 1
chr22_+_29696662 0.840


chr17_-_25112393 0.837 SSH2
slingshot homolog 2 (Drosophila)
chr15_+_71953020 0.836 NM_153356
TBC1D21
TBC1 domain family, member 21
chr4_-_164754106 0.836 NM_017923
MARCH1
membrane-associated ring finger (C3HC4) 1
chr3_-_155630197 0.834 NM_001038705
GPR149
G protein-coupled receptor 149
chr17_-_36181927 0.832 NM_181539
KRT26
keratin 26
chr8_-_67253234 0.827 NM_000756
CRH
corticotropin releasing hormone
chrX_+_78313124 0.824 NM_032553
GPR174
G protein-coupled receptor 174
chr11_-_123695302 0.823 NM_001002918
OR8D2
olfactory receptor, family 8, subfamily D, member 2
chr20_+_9406460 0.811 PLCB4
phospholipase C, beta 4
chr9_-_21067804 0.806 NM_002176
IFNB1
interferon, beta 1, fibroblast
chr1_+_27972269 0.803 NM_177424
STX12
syntaxin 12
chr14_+_74353417 0.803 YLPM1
YLP motif containing 1
chr6_+_89847019 0.800 NM_006813
PNRC1
proline-rich nuclear receptor coactivator 1
chr14_-_46882144 0.796 NM_182830
MDGA2
MAM domain containing glycosylphosphatidylinositol anchor 2
chr14_-_93493519 0.793 NM_016150
ASB2
ankyrin repeat and SOCS box containing 2
chr15_+_92700167 0.784 NM_001159644
MCTP2
multiple C2 domains, transmembrane 2
chr6_+_72979234 0.775 NM_001168407
NM_001168408
RIMS1

regulating synaptic membrane exocytosis 1

chr10_+_115793795 0.770 NM_000684
ADRB1
adrenergic, beta-1-, receptor
chr14_-_35859545 0.769 NM_001144891
NM_016586
MBIP

MAP3K12 binding inhibitory protein 1

chr15_+_46271158 0.766 NM_001145668
CTXN2
SLC12A1
cortexin 2
solute carrier family 12 (sodium/potassium/chloride transporters), member 1
chr20_-_33705244 0.757 NM_003915
CPNE1
copine I
chr10_-_45350804 0.757 NM_001002266
MARCH8
membrane-associated ring finger (C3HC4) 8
chr1_-_156923111 0.755 NM_003126
SPTA1
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
chr2_-_240634161 0.751 NM_173351
OR6B3
olfactory receptor, family 6, subfamily B, member 3
chr4_-_123761615 0.748 NM_021803
IL21
interleukin 21
chr2_+_36436873 0.746 NM_016441
CRIM1
cysteine rich transmembrane BMP regulator 1 (chordin-like)
chr11_+_58967192 0.742 NM_001004728
OR5A1
olfactory receptor, family 5, subfamily A, member 1
chr1_+_156701895 0.740 NM_001004473
OR10K1
olfactory receptor, family 10, subfamily K, member 1
chr18_+_75760434 0.737


chrX_-_10495476 0.737 NM_001193278
NM_001193279
NM_001193280
NM_001193281
MID1



midline 1 (Opitz/BBB syndrome)



chr3_+_125296217 0.737 NM_001024660
NM_003947
KALRN

kalirin, RhoGEF kinase

chr8_+_94999167 0.735 NM_001161778
PDP1
pyruvate dehyrogenase phosphatase catalytic subunit 1
chr14_-_59264044 0.734 NM_206857
RTN1
reticulon 1
chr1_-_246525502 0.728 NM_001004692
OR2T12
olfactory receptor, family 2, subfamily T, member 12
chr3_+_103051015 0.727 NM_031419
NFKBIZ
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
chr1_-_156657279 0.724 NM_001004476
OR10K2
olfactory receptor, family 10, subfamily K, member 2
chr11_-_55661769 0.721 NM_001004064
OR8J3
olfactory receptor, family 8, subfamily J, member 3
chr14_-_19572756 0.719 NM_001004714
OR4K13
olfactory receptor, family 4, subfamily K, member 13
chr14_+_66901237 0.717 EIF2S1
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
chr11_+_77452550 0.716 NM_003251
THRSP
thyroid hormone responsive
chr15_+_61356801 0.716 NM_001145646
NM_031301
APH1B

anterior pharynx defective 1 homolog B (C. elegans)

chr17_-_36165050 0.715 NM_181534
KRT25
keratin 25
chr3_-_54937001 0.712 NM_020678
LRTM1
leucine-rich repeats and transmembrane domains 1
chr11_+_55629094 0.711 NM_001005200
OR8H2
olfactory receptor, family 8, subfamily H, member 2
chr11_+_55189189 0.710 NM_001004704
OR4C6
olfactory receptor, family 4, subfamily C, member 6
chr5_-_145464124 0.708 NM_001029869
PLAC8L1
PLAC8-like 1
chr3_-_110155237 0.708 NM_005459
GUCA1C
guanylate cyclase activator 1C
chr5_-_58688428 0.707 NM_001197219
PDE4D
phosphodiesterase 4D, cAMP-specific
chr15_+_89570333 0.703 SV2B
synaptic vesicle glycoprotein 2B
chr11_-_9243408 0.703 NM_015213
DENND5A
DENN/MADD domain containing 5A
chr8_+_104582151 0.702 NM_001100117
RIMS2
regulating synaptic membrane exocytosis 2
chr2_-_166638376 0.701 NM_001165963
NM_001165964
NM_006920
SCN1A


sodium channel, voltage-gated, type I, alpha subunit


chr1_+_168381811 0.701 NM_001136107
METTL11B
methyltransferase like 11B
chr10_+_86121526 0.698 FAM190B
family with sequence similarity 190, member B
chr14_+_100365162 0.682 MEG3
maternally expressed 3 (non-protein coding)
chr11_-_56166490 0.681 NM_001002925
OR5AP2
olfactory receptor, family 5, subfamily AP, member 2
chr3_+_160473784 0.680 SCHIP1
schwannomin interacting protein 1
chr9_+_106371269 0.674 NM_001004483
OR13C8
olfactory receptor, family 13, subfamily C, member 8
chr13_-_32658215 0.673 NM_178007
STARD13
StAR-related lipid transfer (START) domain containing 13
chr8_+_104900591 0.673 NM_014677
RIMS2
regulating synaptic membrane exocytosis 2
chr18_+_57308754 0.671 NM_031891
CDH20
cadherin 20, type 2
chr16_+_88467518 0.671 TCF25
transcription factor 25 (basic helix-loop-helix)
chr14_-_50631407 0.670 TRIM9
tripartite motif containing 9
chr12_-_10853940 0.669 NM_023917
TAS2R9
taste receptor, type 2, member 9
chr2_+_135392879 0.667 CCNT2
cyclin T2
chr20_+_155898 0.662 NM_080831
DEFB129
defensin, beta 129
chr12_-_3472245 0.661 LOC100129223
hypothetical LOC100129223
chr17_-_3283884 0.659 NM_003554
OR1E2
olfactory receptor, family 1, subfamily E, member 2
chr20_+_2892918 0.659 PTPRA
protein tyrosine phosphatase, receptor type, A
chr11_+_5714253 0.657 NM_001005180
OR56B1
olfactory receptor, family 56, subfamily B, member 1
chr1_+_158413824 0.656 NM_001001734
ATP1A4
ATPase, Na+/K+ transporting, alpha 4 polypeptide
chr16_-_88656092 0.654 NM_052996
PRDM7
PR domain containing 7
chr2_+_214984705 0.653 NM_001080500
VWC2L
von Willebrand factor C domain containing protein 2-like
chr11_-_83706027 0.650 DLG2
discs, large homolog 2 (Drosophila)
chr18_-_29882555 0.649 NM_001198549
NOL4
nucleolar protein 4
chr5_+_133735004 0.649 UBE2B
ubiquitin-conjugating enzyme E2B (RAD6 homolog)
chr1_-_246503738 0.648 NM_001004695
OR2T33
olfactory receptor, family 2, subfamily T, member 33
chr11_-_123353607 0.644 NM_001004474
OR10S1
olfactory receptor, family 10, subfamily S, member 1
chr1_+_69998445 0.643 NM_020794
LRRC7
leucine rich repeat containing 7
chr20_+_19903778 0.641 RIN2
Ras and Rab interactor 2
chr12_+_6517600 0.637


chr16_+_15503623 0.637 NM_001142469
C16orf45
chromosome 16 open reading frame 45
chr3_-_56784634 0.637 NM_001128616
ARHGEF3
Rho guanine nucleotide exchange factor (GEF) 3
chr9_-_21177529 0.636 NM_021068
IFNA4
interferon, alpha 4
chr11_+_48241988 0.632 NM_001004726
OR4X1
olfactory receptor, family 4, subfamily X, member 1
chr14_+_100270222 0.631 DLK1
delta-like 1 homolog (Drosophila)
chr4_+_158361185 0.630 NM_000826
NM_001083619
NM_001083620
GRIA2


glutamate receptor, ionotropic, AMPA 2


chr16_-_71549149 0.629 ZFHX3
zinc finger homeobox 3
chr11_-_57883117 0.628 NM_001005489
OR5B17
olfactory receptor, family 5, subfamily B, member 17
chr12_-_21649019 0.628 NM_021957
GYS2
glycogen synthase 2 (liver)
chr11_+_55776251 0.627 NM_001004747
OR5T3
olfactory receptor, family 5, subfamily T, member 3
chr3_+_160473729 0.626 NM_001197107
NM_001197108
NM_014575
SCHIP1


schwannomin interacting protein 1


chr5_-_34020445 0.626 NM_001012509
NM_016180
SLC45A2

solute carrier family 45, member 2

chr11_+_55362802 0.625 NM_001005496
OR5D16
olfactory receptor, family 5, subfamily D, member 16
chr19_+_39402167 0.625 LSM14A
LSM14A, SCD6 homolog A (S. cerevisiae)
chr6_+_52159143 0.623 NM_002190
IL17A
interleukin 17A
chr5_+_113726203 0.623 KCNN2
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
chr1_+_156991133 0.622 NM_001005184
OR6K6
olfactory receptor, family 6, subfamily K, member 6
chr2_+_135392857 0.622 NM_001241
NM_058241
CCNT2

cyclin T2

chr11_+_55884266 0.619 NM_001005205
OR8J1
olfactory receptor, family 8, subfamily J, member 1
chr14_+_19513442 0.617 NM_001005486
OR4K15
olfactory receptor, family 4, subfamily K, member 15
chr3_-_193609531 0.615 NM_021032
FGF12
fibroblast growth factor 12

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
3.47 5.23e-96 GO:0007608 sensory perception of smell
3.16 1.17e-82 GO:0007606 sensory perception of chemical stimulus
2.30 5.81e-57 GO:0007600 sensory perception
1.91 3.95e-49 GO:0050877 neurological system process
1.80 5.93e-49 GO:0003008 system process
1.26 2.13e-20 GO:0032501 multicellular organismal process
1.21 1.55e-17 GO:0050896 response to stimulus

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.31 1.00e-23 GO:0071944 cell periphery
1.31 2.34e-23 GO:0005886 plasma membrane
1.17 9.00e-10 GO:0016021 integral to membrane
1.15 3.61e-09 GO:0044425 membrane part
1.13 8.68e-09 GO:0016020 membrane
1.16 1.68e-08 GO:0031224 intrinsic to membrane
1.23 4.27e-03 GO:0005856 cytoskeleton
1.03 4.61e-03 GO:0044464 cell part
1.03 4.84e-03 GO:0005623 cell
1.28 4.88e-03 GO:0044430 cytoskeletal part

Gene overrepresentation in function category:

enrichment   p-value GO term description
3.59 2.77e-100 GO:0004984 olfactory receptor activity
2.28 9.35e-58 GO:0004930 G-protein coupled receptor activity
1.85 2.29e-41 GO:0004888 transmembrane receptor activity
1.60 1.26e-28 GO:0004872 receptor activity
1.49 1.47e-24 GO:0004871 signal transducer activity
1.49 1.47e-24 GO:0060089 molecular transducer activity