Motif ID: EN1,2.p2

Z-value: 2.023


Transcription factors associated with EN1,2.p2:

Gene SymbolEntrez IDGene Name
EN1 2019 engrailed homeobox 1
EN2 2020 engrailed homeobox 2



Activity profile for motif EN1,2.p2.

activity profile for motif EN1,2.p2


Sorted Z-values histogram for motif EN1,2.p2

Sorted Z-values for motif EN1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EN1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_246635918 2.526 NM_030904
OR2T1
olfactory receptor, family 2, subfamily T, member 1
chr17_-_60439764 2.104 GNA13
guanine nucleotide binding protein (G protein), alpha 13
chrX_+_106057984 1.887 CLDN2
claudin 2
chr1_+_157526127 1.750 NM_002001
FCER1A
Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
chr11_+_55776251 1.749 NM_001004747
OR5T3
olfactory receptor, family 5, subfamily T, member 3
chr10_+_114144512 1.720 ACSL5
acyl-CoA synthetase long-chain family member 5
chr3_-_38810504 1.595 NM_006514
SCN10A
sodium channel, voltage-gated, type X, alpha subunit
chr1_-_150353179 1.564 NM_007113
TCHH
trichohyalin
chr4_+_71126376 1.549 NM_152997
C4orf7
chromosome 4 open reading frame 7
chr3_-_58497913 1.524 NM_003500
ACOX2
acyl-CoA oxidase 2, branched chain
chr11_+_59979857 1.392 NM_021950
NM_152866
MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr17_+_22996461 1.380 LGALS9
lectin, galactoside-binding, soluble, 9
chr4_-_70539922 1.344 NM_001105677
UGT2A2
UDP glucuronosyltransferase 2 family, polypeptide A2
chrX_+_49480643 1.339 NM_007003
PAGE4
P antigen family, member 4 (prostate associated)
chr11_-_121492010 1.331 NM_001001786
BLID
BH3-like motif containing, cell death inducer
chr9_-_21218132 1.316 NM_021268
IFNA17
interferon, alpha 17
chr1_+_246718487 1.309 NM_001004697
OR2T5
olfactory receptor, family 2, subfamily T, member 5
chr11_+_123639909 1.302 NM_001005198
OR8G5
olfactory receptor, family 8, subfamily G, member 5
chr13_+_52114565 1.281 HNRNPA1L2
heterogeneous nuclear ribonucleoprotein A1-like 2
chr12_+_63510481 1.257


chr19_+_39402167 1.245 LSM14A
LSM14A, SCD6 homolog A (S. cerevisiae)
chrX_+_50670474 1.198 NM_005448
BMP15
bone morphogenetic protein 15
chr1_-_157950898 1.191 NM_000567
CRP
C-reactive protein, pentraxin-related
chrX_+_41433169 1.184 NM_001097579
NM_005300
GPR34

G protein-coupled receptor 34

chr5_-_77880731 1.176 LHFPL2
lipoma HMGIC fusion partner-like 2
chr6_-_119512035 1.145 NM_001100411
FAM184A
family with sequence similarity 184, member A
chrX_+_27674846 1.143 NM_001136533
DCAF8L2
DDB1 and CUL4 associated factor 8-like 2
chr14_+_69993969 1.130 NM_003813
ADAM21
ADAM metallopeptidase domain 21
chr2_+_96355661 1.126 NM_178495
NM_001163524
ITPRIPL1

inositol 1,4,5-triphosphate receptor interacting protein-like 1

chr1_+_69998445 1.119 NM_020794
LRRC7
leucine rich repeat containing 7
chr14_+_75907442 1.094 NM_004452
ESRRB
estrogen-related receptor beta
chr12_+_84792203 1.085 NM_006183
NTS
neurotensin
chr5_+_180514548 1.084 NM_206880
OR2V2
olfactory receptor, family 2, subfamily V, member 2
chr3_-_188903038 1.083 NM_001004312
RTP2
receptor (chemosensory) transporter protein 2
chr11_+_22316242 1.067 NM_020346
SLC17A6
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
chr6_-_32121784 1.064 NM_032470
TNXB
tenascin XB
chr10_-_104587069 1.054 NM_000102
CYP17A1
cytochrome P450, family 17, subfamily A, polypeptide 1
chr8_+_32698892 1.050 NM_001159996
NRG1
neuregulin 1
chr18_-_56190980 1.030 NM_005912
MC4R
melanocortin 4 receptor
chr3_+_50259329 1.014 NM_001166425
GNAI2
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
chr3_-_27473248 1.010 NM_003615
SLC4A7
solute carrier family 4, sodium bicarbonate cotransporter, member 7
chr8_+_32905027 1.005


chr4_+_70950747 0.988 NM_002159
HTN1
histatin 1
chr14_-_91111135 0.980 NM_001080113
C14orf184
chromosome 14 open reading frame 184
chr11_+_55078358 0.970 NM_001001920
OR4C15
olfactory receptor, family 4, subfamily C, member 15
chrX_-_100015783 0.969 NM_007052
NM_013955
NOX1

NADPH oxidase 1

chr1_+_159032551 0.956 NM_001033667
NM_002348
LY9

lymphocyte antigen 9

chr11_-_58947001 0.954 NM_001001954
OR5A2
olfactory receptor, family 5, subfamily A, member 2
chr6_+_129245978 0.952 NM_000426
NM_001079823
LAMA2

laminin, alpha 2

chr1_+_33710818 0.951 NM_145238
ZSCAN20
zinc finger and SCAN domain containing 20
chr11_-_83706027 0.935 DLG2
discs, large homolog 2 (Drosophila)
chr1_+_57093030 0.930 NM_000562
C8A
complement component 8, alpha polypeptide
chr10_+_104995633 0.928 NM_001143909
LOC729020
rcRPE
chr1_+_113038202 0.921 MOV10
Mov10, Moloney leukemia virus 10, homolog (mouse)
chr3_-_125192888 0.910 NM_017578
ROPN1
rhophilin associated tail protein 1
chr11_-_57947358 0.903 NM_001005566
OR5B2
olfactory receptor, family 5, subfamily B, member 2
chr9_-_74757735 0.893 NM_000689
ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr4_+_71096830 0.885 NM_017855
ODAM
odontogenic, ameloblast asssociated
chrX_-_139694248 0.876 NM_004065
CDR1
cerebellar degeneration-related protein 1, 34kDa
chr1_+_195010552 0.871 NM_001166624
NM_021023
CFHR3

complement factor H-related 3

chr4_-_80466177 0.868 NM_032693
NAA11
N(alpha)-acetyltransferase 11, NatA catalytic subunit
chr11_-_6870306 0.838 NM_003700
OR2D2
olfactory receptor, family 2, subfamily D, member 2
chrX_+_18618965 0.820 NM_006240
NM_152224
NM_152226
PPEF1


protein phosphatase, EF-hand calcium binding domain 1


chr6_+_97117144 0.807 NM_001170807
NM_020482
FHL5

four and a half LIM domains 5

chrX_+_55666557 0.806 NM_198451
FOXR2
forkhead box R2
chr13_+_110637173 0.802 NM_001113513
ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chr1_-_156784518 0.799 NM_001005189
OR6Y1
olfactory receptor, family 6, subfamily Y, member 1
chr10_-_108448990 0.795 SORCS1
sortilin-related VPS10 domain containing receptor 1
chr14_-_94053933 0.793 NM_173850
SERPINA12
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12
chr1_-_156567835 0.783 NM_001764
CD1B
CD1b molecule
chr11_-_55661769 0.783 NM_001004064
OR8J3
olfactory receptor, family 8, subfamily J, member 3
chr3_-_18455207 0.780 NM_001131010
SATB1
SATB homeobox 1
chrX_-_74921704 0.775 NM_138703
MAGEE2
melanoma antigen family E, 2
chr10_+_75343352 0.772 PLAU
plasminogen activator, urokinase
chr12_-_6313219 0.770 TNFRSF1A
tumor necrosis factor receptor superfamily, member 1A
chr10_+_5228756 0.767 NM_001818
AKR1C4
aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
chr9_-_21197141 0.753 NM_002171
IFNA10
interferon, alpha 10
chr1_+_144124547 0.744 NM_145277
NM_202004
NM_213652
NM_213653
HFE2



hemochromatosis type 2 (juvenile)



chr5_+_54491702 0.742 NM_001008397
GPX8
glutathione peroxidase 8 (putative)
chr11_+_66152309 0.738


chr12_+_10351683 0.737 NM_002262
NM_007334
KLRD1

killer cell lectin-like receptor subfamily D, member 1

chr4_+_71235259 0.737 NM_033122
CABS1
calcium-binding protein, spermatid-specific 1
chr12_-_54517241 0.736 MMP19
matrix metallopeptidase 19
chr1_+_31823097 0.718 TINAGL1
tubulointerstitial nephritis antigen-like 1
chr9_-_21340885 0.717 NM_021002
IFNA6
interferon, alpha 6
chr11_+_54891935 0.717 NM_001005275
OR4A15
olfactory receptor, family 4, subfamily A, member 15
chr11_+_48466844 0.705 NM_001005512
OR4A47
olfactory receptor, family 4, subfamily A, member 47
chr12_+_98565663 0.701 NM_153364
FAM71C
family with sequence similarity 71, member C
chr18_+_52575442 0.685 WDR7
WD repeat domain 7
chrX_-_53327473 0.680 NM_015075
IQSEC2
IQ motif and Sec7 domain 2
chr10_+_118370441 0.676 NM_005396
PNLIPRP2
pancreatic lipase-related protein 2
chrX_-_47374647 0.676 NM_002621
CFP
complement factor properdin
chr11_-_57792206 0.673 NM_207374
OR10W1
olfactory receptor, family 10, subfamily W, member 1
chrX_+_36163971 0.666 NM_001098843
CXorf30
chromosome X open reading frame 30
chr1_-_55103938 0.665 DHCR24
24-dehydrocholesterol reductase
chr11_+_55884266 0.659 NM_001005205
OR8J1
olfactory receptor, family 8, subfamily J, member 1
chr10_+_118295417 0.658 NM_000936
PNLIP
pancreatic lipase
chr18_-_39111243 0.653 NM_020783
SYT4
synaptotagmin IV
chr14_-_52689782 0.651 NM_001160147
NM_001160148
NM_030637
DDHD1


DDHD domain containing 1


chr4_+_157044296 0.650 NM_005651
TDO2
tryptophan 2,3-dioxygenase
chr8_+_11225904 0.648 NM_054028
AMAC1L2
acyl-malonyl condensing enzyme 1-like 2
chrX_-_102396704 0.648 NM_001006684
NM_153333
TCEAL8

transcription elongation factor A (SII)-like 8

chr1_-_156056456 0.641 NM_001159397
NM_001159398
NM_052938
FCRL1


Fc receptor-like 1


chr1_-_150328153 0.635 NM_001008536
TCHHL1
trichohyalin-like 1
chr4_-_104240413 0.632 NM_020139
BDH2
3-hydroxybutyrate dehydrogenase, type 2
chr4_-_20594645 0.631 KCNIP4
Kv channel interacting protein 4
chr2_+_231569082 0.628 NM_139073
SPATA3
spermatogenesis associated 3
chr10_+_95362334 0.626 NM_006204
PDE6C
phosphodiesterase 6C, cGMP-specific, cone, alpha prime
chr9_+_21430439 0.625 NM_024013
IFNA1
interferon, alpha 1
chrX_-_127014020 0.622 NM_138289
ACTRT1
actin-related protein T1
chrX_-_53646332 0.618 HUWE1
HECT, UBA and WWE domain containing 1
chr14_-_64479198 0.618 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr22_-_35011703 0.617 MYH9
myosin, heavy chain 9, non-muscle
chrX_-_10605726 0.611 NM_001098624
MID1
midline 1 (Opitz/BBB syndrome)
chr21_-_30893063 0.605 NM_181604
KRTAP6-2
keratin associated protein 6-2
chr19_-_46048033 0.604 NM_000762
CYP2A6
cytochrome P450, family 2, subfamily A, polypeptide 6
chr4_-_70547962 0.595 NM_006798
UGT2A1
UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus
chr14_-_94669547 0.593 NM_001195573
DICER1
dicer 1, ribonuclease type III
chr3_+_63613383 0.592 NM_001080537
SNTN
sentan, cilia apical structure protein
chrX_-_130792297 0.590 LOC286467
hypothetical LOC286467
chr12_-_21980894 0.586 NM_005691
NM_020297
NM_020298
ABCC9


ATP-binding cassette, sub-family C (CFTR/MRP), member 9


chrX_+_110252960 0.584 NM_001128168
NM_001128172
NM_001128173
PAK3


p21 protein (Cdc42/Rac)-activated kinase 3


chr2_+_108751033 0.583 RANBP2
RAN binding protein 2
chr12_+_1596482 0.578 NM_030775
WNT5B
wingless-type MMTV integration site family, member 5B
chr11_+_123600553 0.567 NM_001007249
OR8G2
olfactory receptor, family 8, subfamily G, member 2
chr5_-_135729062 0.566 NM_001167576
NM_001167577
NM_020389
TRPC7


transient receptor potential cation channel, subfamily C, member 7


chr5_-_86739683 0.556 CCNH
cyclin H
chr11_+_7463175 0.556 NM_198474
OLFML1
olfactomedin-like 1
chr1_+_246591505 0.555 NM_001004696
OR2T4
olfactory receptor, family 2, subfamily T, member 4
chrX_-_104352005 0.554 NM_031274
TEX13A
testis expressed 13A
chrX_-_27909486 0.554 NM_001017930
DCAF8L1
DDB1 and CUL4 associated factor 8-like 1
chr9_-_21067804 0.547 NM_002176
IFNB1
interferon, beta 1, fibroblast
chr5_+_180348450 0.542 NM_197975
BTNL3
butyrophilin-like 3
chr1_+_246125480 0.541 NM_001001957
OR2W3
olfactory receptor, family 2, subfamily W, member 3
chr4_+_91375204 0.539 NM_207491
FAM190A
family with sequence similarity 190, member A
chr18_+_29573152 0.531 ASXL3
additional sex combs like 3 (Drosophila)
chrX_-_50403412 0.527 SHROOM4
shroom family member 4
chr3_+_52788976 0.525 NM_001166435
NM_001166436
ITIH1

inter-alpha (globulin) inhibitor H1

chr18_-_29882555 0.518 NM_001198549
NOL4
nucleolar protein 4
chr7_+_50318801 0.517 IKZF1
IKAROS family zinc finger 1 (Ikaros)
chr9_-_139010805 0.516 NM_004669
CLIC3
chloride intracellular channel 3
chr12_-_9651748 0.515 NM_002258
KLRB1
killer cell lectin-like receptor subfamily B, member 1
chr3_+_99733432 0.512 NM_005290
GPR15
G protein-coupled receptor 15
chr3_-_185578621 0.511 NM_000460
NM_001177597
NM_001177598
THPO


thrombopoietin


chr11_-_56015421 0.510 NM_001005282
OR5M8
olfactory receptor, family 5, subfamily M, member 8
chr12_+_21417068 0.508 NM_000415
IAPP
islet amyloid polypeptide
chr21_-_18697829 0.506 NM_002772
TMPRSS15
transmembrane protease, serine 15
chr11_+_61389756 0.504 FADS2
fatty acid desaturase 2
chr12_-_51585004 0.504 NM_002273
KRT8
keratin 8
chr5_+_147562531 0.503 NM_001195290
NM_205841
SPINK6

serine peptidase inhibitor, Kazal type 6

chrX_+_139619589 0.503 RP1-177G6.2
hypothetical LOC286411
chr3_+_46423682 0.501 NM_003965
NM_001130910
CCRL2

chemokine (C-C motif) receptor-like 2

chr12_-_89922875 0.500 EPYC
epiphycan
chr15_-_50375143 0.499 NM_018728
MYO5C
myosin VC
chr11_-_89248832 0.498 NM_001164397
TRIM64B
tripartite motif containing 64B
chr17_+_35075124 0.497 NM_003673
TCAP
titin-cap (telethonin)
chr11_+_6762823 0.496 NM_001004489
OR2AG1
olfactory receptor, family 2, subfamily AG, member 1
chr11_-_7917642 0.495 NM_001003745
OR10A3
olfactory receptor, family 10, subfamily A, member 3
chr12_-_119172339 0.493 NM_025157
PXN
paxillin
chr9_-_21207303 0.487 NM_002173
IFNA16
interferon, alpha 16
chr11_-_123685871 0.485 NM_001002917
OR8D1
olfactory receptor, family 8, subfamily D, member 1
chr3_+_28406990 0.483 NM_001040432
ZCWPW2
zinc finger, CW type with PWWP domain 2
chr11_+_55096179 0.483 NM_001004701
OR4C16
olfactory receptor, family 4, subfamily C, member 16
chr5_+_140411144 0.482 NM_013340
PCDHB1
protocadherin beta 1
chrX_-_109570113 0.476 NM_001171689
AMMECR1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr2_+_191009265 0.475 MFSD6
major facilitator superfamily domain containing 6
chrX_-_110400406 0.473 NM_014289
CAPN6
calpain 6
chr6_+_132901119 0.472 NM_175057
TAAR9
trace amine associated receptor 9 (gene/pseudogene)
chr1_-_154484341 0.469 NM_198406
NM_024897
PAQR6

progestin and adipoQ receptor family member VI

chr8_+_144802972 0.468 NM_014789
ZNF623
zinc finger protein 623
chr6_-_30188845 0.464 NM_007028
TRIM31
tripartite motif containing 31
chr12_+_50342814 0.461 NM_001177984
SCN8A
sodium channel, voltage gated, type VIII, alpha subunit
chr12_-_89976261 0.461 NM_007035
KERA
keratocan
chr7_+_28418668 0.457 NM_182898
CREB5
cAMP responsive element binding protein 5
chr3_+_185377430 0.456 AP2M1
adaptor-related protein complex 2, mu 1 subunit
chrX_+_30171768 0.456 NM_002363
NM_177415
MAGEB1

melanoma antigen family B, 1

chr12_-_131816604 0.450 ANKLE2
ankyrin repeat and LEM domain containing 2
chr6_+_49575629 0.450 NM_001010904
GLYATL3
glycine-N-acyltransferase-like 3
chr5_-_180099663 0.450 NM_001001657
OR2Y1
olfactory receptor, family 2, subfamily Y, member 1
chr2_-_215967442 0.444 FN1
fibronectin 1
chr21_-_30836051 0.442 NM_181612
KRTAP19-6
keratin associated protein 19-6
chrX_-_110400321 0.442 CAPN6
calpain 6
chr9_-_103185621 0.442 NM_001127610
BAAT
bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)
chrX_-_6156655 0.439 NM_181332
NLGN4X
neuroligin 4, X-linked
chr6_-_76027286 0.439 TMEM30A
transmembrane protein 30A
chr8_-_66863841 0.438 NM_002603
PDE7A
phosphodiesterase 7A
chr1_-_154041393 0.437 GON4L
gon-4-like (C. elegans)
chr6_-_76838944 0.437 NM_001563
IMPG1
interphotoreceptor matrix proteoglycan 1
chr15_-_40173949 0.434 NM_178034
PLA2G4D
phospholipase A2, group IVD (cytosolic)
chr12_+_119617060 0.430


chr9_+_5646582 0.428 NM_020829
KIAA1432
KIAA1432
chr3_+_120375053 0.424 NM_006952
UPK1B
uroplakin 1B
chr3_+_185377341 0.422 AP2M1
adaptor-related protein complex 2, mu 1 subunit
chr14_+_51804180 0.419 NM_000953
PTGDR
prostaglandin D2 receptor (DP)
chr12_-_46883341 0.419 NM_001004134
OR10AD1
olfactory receptor, family 10, subfamily AD, member 1
chr1_-_152185764 0.413 NM_014856
DENND4B
DENN/MADD domain containing 4B
chr11_+_123315459 0.411 NM_001001965
OR4D5
olfactory receptor, family 4, subfamily D, member 5
chr10_+_105027431 0.406 INA
internexin neuronal intermediate filament protein, alpha
chr9_-_106401514 0.404 NM_001004482
OR13C5
olfactory receptor, family 13, subfamily C, member 5
chr3_+_129124591 0.403 NM_207335
KBTBD12
kelch repeat and BTB (POZ) domain containing 12

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
4.34 3.01e-43 GO:0007608 sensory perception of smell
4.11 6.29e-43 GO:0007606 sensory perception of chemical stimulus
2.90 2.04e-32 GO:0007600 sensory perception
2.09 9.01e-26 GO:0003008 system process
2.20 5.20e-24 GO:0050877 neurological system process
1.30 3.52e-11 GO:0050896 response to stimulus
1.33 5.44e-10 GO:0032501 multicellular organismal process
3.11 5.83e-03 GO:0007586 digestion
1.66 9.08e-03 GO:0006955 immune response

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.45 3.19e-15 GO:0071944 cell periphery
1.45 4.09e-15 GO:0005886 plasma membrane
1.30 7.12e-10 GO:0016021 integral to membrane
1.30 9.09e-10 GO:0031224 intrinsic to membrane
1.51 1.06e-07 GO:0005576 extracellular region
1.23 3.56e-07 GO:0044425 membrane part
1.18 8.14e-06 GO:0016020 membrane
1.54 1.23e-03 GO:0044421 extracellular region part
1.57 6.69e-03 GO:0005615 extracellular space
6.49 1.30e-02 GO:0034706 sodium channel complex
6.96 2.99e-02 GO:0001518 voltage-gated sodium channel complex

Gene overrepresentation in function category:

enrichment   p-value GO term description
4.48 1.08e-44 GO:0004984 olfactory receptor activity
2.76 5.52e-30 GO:0004930 G-protein coupled receptor activity
2.21 8.29e-24 GO:0004888 transmembrane receptor activity
1.91 1.68e-19 GO:0004872 receptor activity
1.76 2.65e-17 GO:0004871 signal transducer activity
1.76 2.65e-17 GO:0060089 molecular transducer activity
2.45 3.74e-04 GO:0005125 cytokine activity
10.43 1.87e-03 GO:0005132 interferon-alpha/beta receptor binding
1.62 1.51e-02 GO:0005509 calcium ion binding
7.59 2.55e-02 GO:0030553 cGMP binding
2.18 3.11e-02 GO:0005126 cytokine receptor binding
3.63 3.92e-02 GO:0008009 chemokine activity
6.96 4.80e-02 GO:0019002 GMP binding