Motif ID: RFX1..5_RFXANK_RFXAP.p2

Z-value: 1.678


Transcription factors associated with RFX1..5_RFXANK_RFXAP.p2:

Gene SymbolEntrez IDGene Name
RFX1 5989 regulatory factor X, 1 (influences HLA class II expression)
RFX2 5990 regulatory factor X, 2 (influences HLA class II expression)
RFX3 5991 regulatory factor X, 3 (influences HLA class II expression)
RFX4 5992 regulatory factor X, 4 (influences HLA class II expression)
RFX5 5993 regulatory factor X, 5 (influences HLA class II expression)
RFXANK 8625 regulatory factor X-associated ankyrin-containing protein
RFXAP 5994 regulatory factor X-associated protein



Activity profile for motif RFX1..5_RFXANK_RFXAP.p2.

activity profile for motif RFX1..5_RFXANK_RFXAP.p2


Sorted Z-values histogram for motif RFX1..5_RFXANK_RFXAP.p2

Sorted Z-values for motif RFX1..5_RFXANK_RFXAP.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RFX1..5_RFXANK_RFXAP.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr22_+_21817512 2.515 NM_004914
RAB36
RAB36, member RAS oncogene family
chr5_-_149649593 2.283 NM_015981
NM_171825
CAMK2A

calcium/calmodulin-dependent protein kinase II alpha

chr5_-_149649380 1.986 CAMK2A
calcium/calmodulin-dependent protein kinase II alpha
chr2_+_27046952 1.891 NM_012326
MAPRE3
microtubule-associated protein, RP/EB family, member 3
chr1_+_42701460 1.890 CCDC30
coiled-coil domain containing 30
chr17_-_53761119 1.710 NM_004758
NM_024418
BZRAP1

benzodiazapine receptor (peripheral) associated protein 1

chr1_-_158136521 1.709 NM_012337
CCDC19
coiled-coil domain containing 19
chr17_+_53761293 1.585 LOC100506779
hypothetical LOC100506779
chr17_-_959007 1.569 NM_001092
ABR
active BCR-related gene
chr7_-_139987044 1.529 DENND2A
DENN/MADD domain containing 2A
chr1_-_38097811 1.269 NM_005955
MTF1
metal-regulatory transcription factor 1
chr3_-_139315011 1.216 NM_001170538
DZIP1L
DAZ interacting protein 1-like
chr1_+_33319287 1.188 NM_052998
ADC
arginine decarboxylase
chr3_+_188397967 1.091 NM_153708
RTP1
receptor (chemosensory) transporter protein 1
chr1_-_152445432 1.080 NM_001010979
C1orf189
chromosome 1 open reading frame 189
chr11_+_61204392 1.074 NM_006133
DAGLA
diacylglycerol lipase, alpha
chr14_-_73250094 1.070 NM_006029
PNMA1
paraneoplastic antigen MA1
chr22_+_21742364 1.051 NM_002073
GNAZ
guanine nucleotide binding protein (G protein), alpha z polypeptide
chr14_+_20007377 0.982 NM_000270
PNP
purine nucleoside phosphorylase
chr7_+_101860958 0.963 NM_001126340
NM_032831
ORAI2

ORAI calcium release-activated calcium modulator 2

chr9_-_115101140 0.945 NM_145051
RNF183
ring finger protein 183
chr14_-_101841222 0.916 NM_014226
RAGE
renal tumor antigen
chr7_+_101861007 0.913 ORAI2
ORAI calcium release-activated calcium modulator 2
chr5_-_14064846 0.878 DNAH5
dynein, axonemal, heavy chain 5
chr5_+_34875025 0.872 NM_144725
TTC23L
tetratricopeptide repeat domain 23-like
chr19_-_51690989 0.860 NM_020709
PNMAL2
PNMA-like 2
chr17_-_39211706 0.859 NM_004090
DUSP3
dual specificity phosphatase 3
chr22_+_21742727 0.840 GNAZ
guanine nucleotide binding protein (G protein), alpha z polypeptide
chr1_+_158317967 0.824 NM_004983
KCNJ9
potassium inwardly-rectifying channel, subfamily J, member 9
chr12_+_46863632 0.820 NM_001013635
C12orf68
chromosome 12 open reading frame 68
chr1_+_111690717 0.804 NM_181643
C1orf88
chromosome 1 open reading frame 88
chr1_-_6468108 0.802 PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr1_-_6480058 0.783 NM_001042663
PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr1_-_36688556 0.778 NM_145047
NM_206837
OSCP1

organic solute carrier partner 1

chrX_-_99778340 0.765 NM_003270
TSPAN6
tetraspanin 6
chr19_+_40958206 0.757 NM_001172630
NM_052948
ARHGAP33

Rho GTPase activating protein 33

chr22_-_16887151 0.744 NM_001122731
NM_001136004
NM_015241
MICAL3


microtubule associated monoxygenase, calponin and LIM domain containing 3


chr1_-_35143570 0.740 NM_001080418
DLGAP3
discs, large (Drosophila) homolog-associated protein 3
chr7_-_140270749 0.734 NM_004333
BRAF
v-raf murine sarcoma viral oncogene homolog B1
chrX_-_71268475 0.733 NM_001024455
RGAG4
retrotransposon gag domain containing 4
chr6_+_43005214 0.728 CNPY3
canopy 3 homolog (zebrafish)
chr1_-_6480035 0.727 PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr9_-_134271985 0.723 NM_007344
TTF1
transcription termination factor, RNA polymerase I
chr5_+_157031138 0.719 NM_001145132
C5orf52
chromosome 5 open reading frame 52
chr21_-_43671355 0.705 NM_173354
SIK1
salt-inducible kinase 1
chr4_-_177353707 0.701 NM_144644
SPATA4
spermatogenesis associated 4
chr17_+_260408 0.687 NM_001013672
C17orf97
chromosome 17 open reading frame 97
chr5_-_157031022 0.682 SOX30
SRY (sex determining region Y)-box 30
chr10_+_127575097 0.677 NM_145235
FANK1
fibronectin type III and ankyrin repeat domains 1
chr7_-_129632452 0.664 NM_032842
TMEM209
transmembrane protein 209
chr9_-_125732005 0.659 NM_020946
NM_024820
DENND1A

DENN/MADD domain containing 1A

chrX_-_48653852 0.650 NM_005660
NM_001032289
SLC35A2

solute carrier family 35 (UDP-galactose transporter), member A2

chr19_-_15421761 0.646 NM_021241
WIZ
widely interspaced zinc finger motifs
chr10_-_127574957 0.642 DHX32
DEAH (Asp-Glu-Ala-His) box polypeptide 32
chr1_-_6162669 0.640 NM_015557
CHD5
chromodomain helicase DNA binding protein 5
chr1_-_51660328 0.640 NM_001159969
EPS15
epidermal growth factor receptor pathway substrate 15
chr19_-_6344005 0.624 NM_002096
GTF2F1
general transcription factor IIF, polypeptide 1, 74kDa
chr19_+_55571493 0.623 NM_007121
NR1H2
nuclear receptor subfamily 1, group H, member 2
chr12_-_108970658 0.620 C12orf76
chromosome 12 open reading frame 76
chr2_+_228444570 0.619 NM_178821
WDR69
WD repeat domain 69
chr1_-_39111422 0.613 NM_012333
MYCBP
c-myc binding protein
chr4_+_3220564 0.612 NM_001042690
C4orf44
chromosome 4 open reading frame 44
chr4_-_186362066 0.611 NM_020827
KIAA1430
KIAA1430
chr1_+_15609009 0.602 EFHD2
EF-hand domain family, member D2
chr9_+_123501186 0.600 DAB2IP
DAB2 interacting protein
chr10_-_69836912 0.592 NM_017987
NM_001042417
RUFY2

RUN and FYVE domain containing 2

chrX_-_13957879 0.584 NM_001042479
NM_001042480
NM_017856
GEMIN8


gem (nuclear organelle) associated protein 8


chr2_+_220170804 0.583 NM_052902
STK11IP
serine/threonine kinase 11 interacting protein
chr6_+_43005126 0.580 CNPY3
canopy 3 homolog (zebrafish)
chr12_+_8958397 0.579 NM_004426
PHC1
polyhomeotic homolog 1 (Drosophila)
chr11_+_46914804 0.578 NM_001003676
NM_001003677
NM_001003678
NM_024113
C11orf49



chromosome 11 open reading frame 49



chr19_-_63565890 0.575 NM_198458
ZNF497
zinc finger protein 497
chr3_+_184648089 0.570 LOC100505687
hypothetical LOC100505687
chrX_+_117841761 0.569 NM_173798
ZCCHC12
zinc finger, CCHC domain containing 12
chr3_-_50357994 0.567 NM_015896
ZMYND10
zinc finger, MYND-type containing 10
chr10_+_105243724 0.566 NM_004210
NEURL
neuralized homolog (Drosophila)
chr7_-_1144347 0.565 NM_001134395
NM_001134396
NM_032350
C7orf50


chromosome 7 open reading frame 50


chr1_+_15608974 0.563 NM_024329
EFHD2
EF-hand domain family, member D2
chr11_-_8911110 0.558 NM_020643
C11orf16
chromosome 11 open reading frame 16
chr15_+_88593765 0.553 NM_001029964
TTLL13
tubulin tyrosine ligase-like family, member 13
chr7_+_100584397 0.549 NM_001283
AP1S1
adaptor-related protein complex 1, sigma 1 subunit
chr6_+_88174408 0.548 NM_001031743
C6orf165
chromosome 6 open reading frame 165
chr2_+_55600220 0.544 NM_080667
CCDC104
coiled-coil domain containing 104
chr7_-_35044177 0.542 NM_015283
DPY19L1
dpy-19-like 1 (C. elegans)
chr7_-_36992221 0.538 NM_130442
ELMO1
engulfment and cell motility 1
chr19_-_63584194 0.538 NM_001129730
NM_138466
ZNF837

zinc finger protein 837

chr17_-_34235078 0.534 NM_017748
CWC25
CWC25 spliceosome-associated protein homolog (S. cerevisiae)
chr17_-_34234931 0.534 CWC25
CWC25 spliceosome-associated protein homolog (S. cerevisiae)
chrX_-_48654178 0.523 NM_001042498
SLC35A2
solute carrier family 35 (UDP-galactose transporter), member A2
chr6_-_41811323 0.517 TFEB
transcription factor EB
chr16_-_66007650 0.516 NM_013304
ZDHHC1
zinc finger, DHHC-type containing 1
chr17_-_55511056 0.512 NM_022070
HEATR6
HEAT repeat containing 6
chr3_-_10027770 0.509 NM_001008737
LOC401052
hypothetical LOC401052
chr3_+_42165740 0.508 TRAK1
trafficking protein, kinesin binding 1
chr14_-_105392671 0.506


chr2_-_64224948 0.504 NM_020651
PELI1
pellino homolog 1 (Drosophila)
chr1_-_203592538 0.503 NM_018203
KLHDC8A
kelch domain containing 8A
chr12_-_4624536 0.501 NM_006422
AKAP3
A kinase (PRKA) anchor protein 3
chr19_-_53706644 0.500


chr12_-_46786107 0.495 SENP1
SUMO1/sentrin specific peptidase 1
chr7_-_157054403 0.493 PTPRN2
protein tyrosine phosphatase, receptor type, N polypeptide 2
chr7_+_156126157 0.493 NM_030936
NM_001184996
RNF32

ring finger protein 32

chr15_-_41572660 0.492 TP53BP1
tumor protein p53 binding protein 1
chr5_-_16795336 0.491 MYO10
myosin X
chr11_+_66841885 0.485 LOC100130987
similar to hCG1815675
chr7_+_128861471 0.484 NM_001134336
NM_020704
FAM40B

family with sequence similarity 40, member B

chrX_+_15666312 0.480 NM_007220
CA5B
carbonic anhydrase VB, mitochondrial
chr6_-_121697305 0.480 NM_152730
C6orf170
chromosome 6 open reading frame 170
chr5_-_1165106 0.479 NM_006598
SLC12A7
solute carrier family 12 (potassium/chloride transporters), member 7
chr1_-_220829704 0.477 NM_005681
NM_139352
TAF1A

TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa

chr21_-_42789369 0.475 NM_080860
RSPH1
radial spoke head 1 homolog (Chlamydomonas)
chr3_+_47819631 0.473 DHX30
DEAH (Asp-Glu-Ala-His) box polypeptide 30
chr21_-_36354659 0.471 NM_017438
SETD4
SET domain containing 4
chr19_-_4408789 0.469 NM_025241
UBXN6
UBX domain protein 6
chr15_-_41572558 0.465 NM_001141979
NM_001141980
TP53BP1

tumor protein p53 binding protein 1

chr21_-_36354428 0.463 NM_001007259
SETD4
SET domain containing 4
chr4_+_123873306 0.461 NM_001178007
NM_152618
BBS12

Bardet-Biedl syndrome 12

chr1_+_37795101 0.460 NM_003462
DNALI1
dynein, axonemal, light intermediate chain 1
chr16_+_28893525 0.460 NM_001142448
NM_001142449
NM_001142450
NM_001142451
NM_032038
SPIN1
SPNS1




spindlin 1
spinster homolog 1 (Drosophila)




chr10_-_127361583 0.459 NM_001128202
C10orf122
chromosome 10 open reading frame 122
chr5_-_179712920 0.455 NM_005110
GFPT2
glutamine-fructose-6-phosphate transaminase 2
chr1_-_85497903 0.454 NM_198077
C1orf52
chromosome 1 open reading frame 52
chr9_-_139143980 0.454


chr1_-_199390215 0.451 NM_016456
TMEM9
transmembrane protein 9
chr13_+_30404809 0.451 NM_152325
C13orf26
chromosome 13 open reading frame 26
chr19_+_40325993 0.450 NM_022006
FXYD7
FXYD domain containing ion transport regulator 7
chrX_-_150893752 0.448 NM_004961
GABRE
gamma-aminobutyric acid (GABA) A receptor, epsilon
chrX_+_118913827 0.448 NM_001008534
NM_001008535
NM_178813
AKAP14


A kinase (PRKA) anchor protein 14


chr21_+_45532377 0.444 LOC642852
hypothetical LOC642852
chr22_-_29082880 0.440 NM_001005409
NM_005877
SF3A1

splicing factor 3a, subunit 1, 120kDa

chr7_+_48041632 0.440 NM_001100159
C7orf57
chromosome 7 open reading frame 57
chr16_-_82736186 0.440 NM_001146051
NM_031463
HSDL1

hydroxysteroid dehydrogenase like 1

chrX_-_49852397 0.437 NM_003886
AKAP4
A kinase (PRKA) anchor protein 4
chr1_-_24612742 0.437 NM_001199013
NM_001199014
NM_178122
C1orf201


chromosome 1 open reading frame 201


chr2_-_62586979 0.436 NM_198276
TMEM17
transmembrane protein 17
chrX_+_53095230 0.431 NM_018969
GPR173
G protein-coupled receptor 173
chr3_+_46717826 0.430 NM_147196
TMIE
transmembrane inner ear
chr11_-_67032675 0.429 NM_005851
CDK2AP2
cyclin-dependent kinase 2 associated protein 2
chr1_+_207926172 0.428 NM_181755
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr11_+_65469690 0.426 NM_152762
TSGA10IP
testis specific, 10 interacting protein
chr6_-_41811916 0.425 NM_001167827
TFEB
transcription factor EB
chr7_-_122985060 0.424 NM_005000
NDUFA5
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5, 13kDa
chr3_+_47819402 0.423 NM_014966
NM_138615
DHX30

DEAH (Asp-Glu-Ala-His) box polypeptide 30

chr4_+_1330957 0.421 NM_020894
KIAA1530
KIAA1530
chr1_-_154837855 0.419 NM_015590
NM_182679
GPATCH4

G patch domain containing 4

chr1_-_31883424 0.419 NM_012392
PEF1
penta-EF-hand domain containing 1
chr16_-_674318 0.417 JMJD8
jumonji domain containing 8
chr1_+_32443822 0.417 NM_001160042
NM_018134
IQCC

IQ motif containing C

chr19_+_4861339 0.416 NM_013282
UHRF1
ubiquitin-like with PHD and ring finger domains 1
chr19_-_45016587 0.410 NM_004714
NM_006483
NM_006484
DYRK1B


dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B


chr7_-_44195405 0.408 NM_000162
GCK
glucokinase (hexokinase 4)
chr12_+_124377114 0.408 NM_052907
TMEM132B
transmembrane protein 132B
chr7_+_31693155 0.404 NM_001145123
NM_006658
C7orf16

chromosome 7 open reading frame 16

chr10_-_11693535 0.402 NM_014688
USP6NL
USP6 N-terminal like
chr1_-_21982256 0.402 NM_001032730
NM_032236
USP48

ubiquitin specific peptidase 48

chr16_-_65984836 0.402 NM_015964
NM_016140
TPPP3

tubulin polymerization-promoting protein family member 3

chr12_-_46785682 0.400 NM_014554
SENP1
SUMO1/sentrin specific peptidase 1
chr11_-_64302777 0.400 NM_004630
NM_201995
NM_201997
NM_201998
SF1



splicing factor 1



chr8_-_37916803 0.398 NM_152413
GOT1L1
glutamic-oxaloacetic transaminase 1-like 1
chr10_+_15179187 0.395 NM_001097590
NM_006414
NM_183005
RPP38


ribonuclease P/MRP 38kDa subunit


chr4_-_123010918 0.393 NM_018190
NM_176824
BBS7

Bardet-Biedl syndrome 7

chr6_-_27548438 0.392 NM_007149
ZNF184
zinc finger protein 184
chr2_-_130619038 0.392 NM_207310
CCDC74B
coiled-coil domain containing 74B
chr10_+_124020810 0.392 NM_144587
BTBD16
BTB (POZ) domain containing 16
chr17_+_65612589 0.391 NM_170742
KCNJ16
potassium inwardly-rectifying channel, subfamily J, member 16
chr7_+_150356435 0.386 NM_007188
ABCB8
ATP-binding cassette, sub-family B (MDR/TAP), member 8
chr3_-_180467483 0.386 NM_001163677
NM_171828
KCNMB3

potassium large conductance calcium-activated channel, subfamily M beta member 3

chr16_-_56393871 0.385 KIFC3
kinesin family member C3
chr19_-_52045890 0.385 NM_004069
NM_021575
AP2S1

adaptor-related protein complex 2, sigma 1 subunit

chr15_+_53488014 0.385 NM_001198784
FLJ27352
hypothetical LOC145788
chr1_-_202647526 0.382 NM_032833
PPP1R15B
protein phosphatase 1, regulatory (inhibitor) subunit 15B
chr11_-_56859900 0.378 NM_003146
SSRP1
structure specific recognition protein 1
chr11_-_118716244 0.378 MFRP
membrane frizzled-related protein
chr1_+_109458247 0.377 KIAA1324
KIAA1324
chr19_-_19590438 0.376 NM_025245
PBX4
pre-B-cell leukemia homeobox 4
chrX_-_135941498 0.376 NM_054021
GPR101
G protein-coupled receptor 101
chr1_-_199390183 0.376 TMEM9
transmembrane protein 9
chr3_-_16281287 0.376 NM_001047434
NM_206831
DPH3

DPH3, KTI11 homolog (S. cerevisiae)

chr16_-_674357 0.375 NM_001005920
JMJD8
jumonji domain containing 8
chr7_-_156125876 0.373 C7orf13
chromosome 7 open reading frame 13
chr16_+_82736365 0.373 NM_178452
LRRC50
leucine rich repeat containing 50
chr9_+_135314907 0.371 NM_001135775
NM_017586
C9orf7

chromosome 9 open reading frame 7

chr12_+_120840829 0.371 NM_001178003
NM_144668
WDR66

WD repeat domain 66

chr1_-_209915443 0.368 NM_002497
NEK2
NIMA (never in mitosis gene a)-related kinase 2
chrX_-_48578878 0.368 NM_013271
PCSK1N
proprotein convertase subtilisin/kexin type 1 inhibitor
chr15_+_73803351 0.367 NM_175881
ODF3L1
outer dense fiber of sperm tails 3-like 1
chr11_+_8016755 0.366 NM_003320
TUB
tubby homolog (mouse)
chr7_+_30777512 0.366 NM_032222
FAM188B
family with sequence similarity 188, member B
chr1_-_21982192 0.366 USP48
ubiquitin specific peptidase 48
chr1_-_6502655 0.365 NM_198681
PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr1_+_149960636 0.364 NM_001144956
RIIAD1
regulatory subunit of type II PKA R-subunit (RIIa) domain containing 1
chr10_+_12211586 0.364 NM_001142627
NM_001142628
NM_018144
SEC61A2


Sec61 alpha 2 subunit (S. cerevisiae)


chr11_+_133444029 0.363 NM_032801
JAM3
junctional adhesion molecule 3
chr3_+_38055699 0.360 NM_007335
NM_007337
DLEC1

deleted in lung and esophageal cancer 1

chr17_-_19206475 0.360 NM_015681
B9D1
B9 protein domain 1
chrX_+_37429927 0.360 NM_021083
XK
X-linked Kx blood group (McLeod syndrome)
chr16_+_29971971 0.357 NM_000034
ALDOA
aldolase A, fructose-bisphosphate
chr4_-_76774594 0.350 NM_003948
CDKL2
cyclin-dependent kinase-like 2 (CDC2-related kinase)
chr11_+_45899747 0.350 NM_152312
GYLTL1B
glycosyltransferase-like 1B
chr17_-_40339919 0.349 GFAP
glial fibrillary acidic protein

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.93 1.30e-03 GO:0005929 cilium
1.88 1.38e-03 GO:0015630 microtubule cytoskeleton
9.81 4.69e-03 GO:0060170 cilium membrane
1.58 7.90e-03 GO:XXXXXXX unannotated
2.07 2.89e-02 GO:0005815 microtubule organizing center

Nothing significant found in function category.