Motif ID: NFE2L2.p2

Z-value: 1.880


Transcription factors associated with NFE2L2.p2:

Gene SymbolEntrez IDGene Name
NFE2L2 4780 nuclear factor (erythroid-derived 2)-like 2



Activity profile for motif NFE2L2.p2.

activity profile for motif NFE2L2.p2


Sorted Z-values histogram for motif NFE2L2.p2

Sorted Z-values for motif NFE2L2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFE2L2.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr22_+_21484240 8.890


chr22_+_21340757 7.620


chr22_+_21359175 4.638 IGLV3-25
immunoglobulin lambda variable 3-25
chr22_+_21370394 4.509 IGL@
immunoglobulin lambda locus
chr22_+_21495273 3.803


chr22_+_21079355 3.350


chr22_+_21053972 3.345


chr22_+_21407066 3.246


chr22_+_21393107 3.134 IGLJ3
immunoglobulin lambda joining 3
chr22_+_20899155 3.037


chr1_-_24307514 2.755 MYOM3
myomesin family, member 3
chr9_+_129962292 2.568 NM_024112
C9orf16
chromosome 9 open reading frame 16
chr22_+_21094094 2.392


chr22_+_21116283 2.260


chr22_+_18388656 2.253 C22orf25
chromosome 22 open reading frame 25
chr22_+_21042091 2.252 IGLV1-44
IGL@
immunoglobulin lambda variable 1-44
immunoglobulin lambda locus
chr22_+_21559959 2.047 NM_001178126
IGLL5
IGLC1
immunoglobulin lambda-like polypeptide 5
immunoglobulin lambda constant 1 (Mcg marker)
chr22_+_20316968 2.042 NM_152612
CCDC116
coiled-coil domain containing 116
chr1_+_24522116 1.880 NM_021180
GRHL3
grainyhead-like 3 (Drosophila)
chr22_+_21065134 1.823 LOC100290481
immunoglobulin lambda light chain-like
chr22_+_21006814 1.774


chr1_-_6474346 1.743 NM_020631
PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr22_+_21552897 1.707 LOC100290481
immunoglobulin lambda light chain-like
chr22_+_21065207 1.703 IGLJ3
immunoglobulin lambda joining 3
chr22_-_17846711 1.659 UFD1L
ubiquitin fusion degradation 1 like (yeast)
chr22_-_17846621 1.654 UFD1L
ubiquitin fusion degradation 1 like (yeast)
chr22_+_21065202 1.651


chr22_+_19699441 1.589 NM_001159554
NM_005446
P2RX6

purinergic receptor P2X, ligand-gated ion channel, 6

chr6_+_34314545 1.582 NM_145905
HMGA1
high mobility group AT-hook 1
chr1_+_17571277 1.541 NM_207421
PADI6
peptidyl arginine deiminase, type VI
chr1_+_3378030 1.533 ARHGEF16
Rho guanine nucleotide exchange factor (GEF) 16
chr22_+_21011653 1.499


chr22_-_17846725 1.478 NM_001035247
NM_005659
UFD1L

ubiquitin fusion degradation 1 like (yeast)

chr11_+_118463906 1.462 NM_001024382
HMBS
hydroxymethylbilane synthase
chr22_+_20880159 1.454 IGLV6-57
immunoglobulin lambda variable 6-57
chr7_-_150561233 1.390


chr1_-_45760115 1.384 NM_002574
NM_181696
NM_181697
PRDX1


peroxiredoxin 1


chr21_+_45699830 1.374 NM_030582
NM_130444
COL18A1

collagen, type XVIII, alpha 1

chr7_+_1536847 1.369 NM_002360
MAFK
v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)
chr16_+_2023279 1.363 SLC9A3R2
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2
chr17_-_37022465 1.236 NM_005557
KRT16
keratin 16
chr2_+_87536174 1.235 NCRNA00152
non-protein coding RNA 152
chr6_-_31853027 1.224 NM_025258
C6orf27
chromosome 6 open reading frame 27
chr2_+_87536106 1.208 NCRNA00152
non-protein coding RNA 152
chr11_+_1812115 1.207 NM_138567
SYT8
synaptotagmin VIII
chr1_+_17404206 1.201 NM_013358
PADI1
peptidyl arginine deiminase, type I
chr7_+_150065594 1.184 GIMAP5
GTPase, IMAP family member 5
chr7_+_1543644 1.172 MAFK
v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)
chr10_+_85889164 1.091 NM_014394
GHITM
growth hormone inducible transmembrane protein
chr3_-_195571748 1.075 NM_001135057
NM_130830
LRRC15

leucine rich repeat containing 15

chr7_-_100667750 1.066 NM_014343
CLDN15
claudin 15
chr15_-_81037554 1.039 NM_001079533
NM_001079534
NM_001079535
CPEB1


cytoplasmic polyadenylation element binding protein 1


chr7_+_72883128 1.020 NM_001305
CLDN4
claudin 4
chr5_+_150000394 1.004 NM_001109974
NM_007286
SYNPO

synaptopodin

chr7_+_139175420 0.974 NM_001061
NM_001166253
NM_030984
TBXAS1


thromboxane A synthase 1 (platelet)


chr1_-_153209625 0.945 NM_001130040
NM_183001
SHC1

SHC (Src homology 2 domain containing) transforming protein 1

chr7_+_150065376 0.929 NM_018384
GIMAP5
GTPase, IMAP family member 5
chr16_+_56219802 0.914 NM_001145771
NM_001145772
NM_001145773
NM_201524
NM_201525
GPR56




G protein-coupled receptor 56




chr16_-_68843295 0.913 NM_058219
EXOSC6
exosome component 6
chr19_-_56279278 0.910 NM_022046
KLK14
kallikrein-related peptidase 14
chr6_-_29563657 0.909 NM_052967
MAS1L
MAS1 oncogene-like
chr1_-_45045543 0.902 NM_001013632
TCTEX1D4
Tctex1 domain containing 4
chr22_+_21027538 0.886


chr22_+_17273735 0.885 NM_005675
DGCR6
DiGeorge syndrome critical region gene 6
chr6_+_160462852 0.874 NM_003057
NM_153187
SLC22A1

solute carrier family 22 (organic cation transporter), member 1

chr15_+_38520594 0.853 NM_014952
BAHD1
bromo adjacent homology domain containing 1
chr1_-_115039614 0.852 NM_000036
NM_001172626
AMPD1

adenosine monophosphate deaminase 1

chr7_-_150352484 0.848 NM_173681
ATG9B
ATG9 autophagy related 9 homolog B (S. cerevisiae)
chr7_+_111850367 0.847 NM_001007245
NM_001197080
IFRD1

interferon-related developmental regulator 1

chr1_+_17507276 0.846 NM_012387
PADI4
peptidyl arginine deiminase, type IV
chrX_+_100361588 0.842 NM_001171184
NM_001939
DRP2

dystrophin related protein 2

chr6_-_35804337 0.830 NM_001145775
FKBP5
FK506 binding protein 5
chr22_+_20880112 0.828


chr6_+_41712907 0.819 MDFI
MyoD family inhibitor
chr17_+_45965076 0.781 EPN3
epsin 3
chr11_+_72660894 0.778 NM_004154
P2RY6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr7_+_133862883 0.774 NM_020299
AKR1B10
aldo-keto reductase family 1, member B10 (aldose reductase)
chr17_-_74433048 0.771 NM_003255
TIMP2
TIMP metallopeptidase inhibitor 2
chr13_+_112746908 0.769 MCF2L
MCF.2 cell line derived transforming sequence-like
chr1_-_7923464 0.768 NM_001561
TNFRSF9
tumor necrosis factor receptor superfamily, member 9
chr19_+_45564549 0.765 PLD3
phospholipase D family, member 3
chr8_-_38505331 0.756 NM_207412
C8orf86
chromosome 8 open reading frame 86
chr17_-_74432800 0.755 TIMP2
TIMP metallopeptidase inhibitor 2
chr19_-_59438411 0.750 NM_024318
LILRB3
LILRA6
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
chr19_+_55398680 0.741 NM_001077186
NM_001145809
NM_024729
MYH14


myosin, heavy chain 14, non-muscle


chrX_-_19598912 0.740 NM_001184960
SH3KBP1
SH3-domain kinase binding protein 1
chr20_+_61337679 0.738 NM_022161
NM_139317
BIRC7

baculoviral IAP repeat containing 7

chr11_+_10433241 0.726 NM_001025389
AMPD3
adenosine monophosphate deaminase 3
chr7_-_102772304 0.718 NM_001129887
NM_014377
DNAJC2

DnaJ (Hsp40) homolog, subfamily C, member 2

chr11_+_67107852 0.707 GSTP1
glutathione S-transferase pi 1
chr1_-_43168247 0.707 SLC2A1
solute carrier family 2 (facilitated glucose transporter), member 1
chr2_-_112907577 0.706 NM_001164463
RGPD8
RGPD5
RANBP2-like and GRIP domain containing 8
RANBP2-like and GRIP domain containing 5
chr6_-_24827265 0.700 NM_030939
C6orf62
chromosome 6 open reading frame 62
chr19_-_54212158 0.694 NM_000894
LHB
luteinizing hormone beta polypeptide
chr7_+_130445394 0.683 NM_001145354
MKLN1
muskelin 1, intracellular mediator containing kelch motifs
chr16_-_66075216 0.681 NM_001138
AGRP
agouti related protein homolog (mouse)
chr16_+_1230678 0.678 NM_003294
TPSB2
TPSAB1
tryptase beta 2 (gene/pseudogene)
tryptase alpha/beta 1
chr21_+_38566298 0.668 NM_170737
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr6_-_28429950 0.663 NM_145909
ZNF323
zinc finger protein 323
chr17_+_71109734 0.663 MYO15B
myosin XVB pseudogene
chr1_+_27591738 0.661 NM_005281
GPR3
G protein-coupled receptor 3
chr3_+_46894239 0.649 NM_000316
PTH1R
parathyroid hormone 1 receptor
chr19_+_3317589 0.646 NFIC
nuclear factor I/C (CCAAT-binding transcription factor)
chr7_+_150319076 0.643 NM_000603
NOS3
nitric oxide synthase 3 (endothelial cell)
chr12_-_46405477 0.635 NM_001172439
NM_001172440
NM_006025
ENDOU


endonuclease, polyU-specific


chr12_-_49897743 0.623 POU6F1
POU class 6 homeobox 1
chr11_+_67107641 0.620 NM_000852
GSTP1
glutathione S-transferase pi 1
chr6_+_43373986 0.618 SLC22A7
solute carrier family 22 (organic anion transporter), member 7
chrX_+_12903145 0.613 NM_021109
NM_183049
TMSB4X
TMSL3
thymosin beta 4, X-linked
thymosin-like 3
chr1_+_158426908 0.611 NM_001231
CASQ1
calsequestrin 1 (fast-twitch, skeletal muscle)
chrX_-_109570113 0.609 NM_001171689
AMMECR1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr10_-_76538859 0.598 NM_001007271
NM_001007272
NM_001007273
DUSP13


dual specificity phosphatase 13


chr7_+_129720209 0.597 NM_001163446
NM_016352
CPA4

carboxypeptidase A4

chr1_-_115682374 0.595 NM_002506
NGF
nerve growth factor (beta polypeptide)
chr11_+_62136788 0.592 NM_000327
ROM1
retinal outer segment membrane protein 1
chrX_-_48713194 0.583 NM_004979
KCND1
potassium voltage-gated channel, Shal-related subfamily, member 1
chr19_+_3317575 0.577 NFIC
nuclear factor I/C (CCAAT-binding transcription factor)
chr8_-_143820825 0.571 NM_020427
SLURP1
secreted LY6/PLAUR domain containing 1
chr16_-_27806978 0.570 NM_144675
GSG1L
GSG1-like
chr11_-_62136778 0.568 NM_153265
EML3
echinoderm microtubule associated protein like 3
chr6_+_31190505 0.558 NM_014068
PSORS1C1
psoriasis susceptibility 1 candidate 1
chr19_+_56319948 0.556 NM_001198558
NM_014441
SIGLEC9

sialic acid binding Ig-like lectin 9

chr11_-_6298284 0.554 NM_145040
PRKCDBP
protein kinase C, delta binding protein
chr1_+_36327039 0.550 NM_017825
ADPRHL2
ADP-ribosylhydrolase like 2
chr3_-_152403636 0.548 NM_013308
GPR171
G protein-coupled receptor 171
chr8_-_42742729 0.547 NM_004198
CHRNA6
cholinergic receptor, nicotinic, alpha 6
chr7_+_1050704 0.540


chr16_+_82544327 0.540 NM_182981
OSGIN1
oxidative stress induced growth inhibitor 1
chr1_+_19511326 0.534 NM_001040125
NM_001040126
NM_017765
PQLC2


PQ loop repeat containing 2


chr22_-_18687511 0.529 NM_033257
DGCR6L
DiGeorge syndrome critical region gene 6-like
chr7_+_106991638 0.526 NM_181581
DUS4L
dihydrouridine synthase 4-like (S. cerevisiae)
chr19_-_43955984 0.522 NM_002307
LGALS7
LGALS7B
lectin, galactoside-binding, soluble, 7
lectin, galactoside-binding, soluble, 7B
chr7_-_75280962 0.522 NM_002991
CCL24
chemokine (C-C motif) ligand 24
chr6_-_154719560 0.510 NM_001130700
NM_015553
IPCEF1

interaction protein for cytohesin exchange factors 1

chr11_-_116605761 0.507 PCSK7
proprotein convertase subtilisin/kexin type 7
chr19_+_56337368 0.505 NM_014385
NM_016543
SIGLEC7

sialic acid binding Ig-like lectin 7

chrX_+_153423652 0.505 NM_001099856
IKBKG
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
chr11_+_64079665 0.501 NM_018484
SLC22A11
solute carrier family 22 (organic anion/urate transporter), member 11
chr19_-_8118367 0.493 NM_032447
FBN3
fibrillin 3
chr3_+_130730171 0.491 NM_000539
RHO
rhodopsin
chr22_+_17498320 0.485 NM_053006
TSSK2
testis-specific serine kinase 2
chr4_-_38710376 0.484 NM_024943
TMEM156
transmembrane protein 156
chr6_-_170704251 0.482 PSMB1
proteasome (prosome, macropain) subunit, beta type, 1
chr7_+_157339985 0.482 LOC100506585
hypothetical LOC100506585
chr11_+_74548472 0.481 NM_001145211
SLCO2B1
solute carrier organic anion transporter family, member 2B1
chr7_+_142768916 0.478 ZYX
zyxin
chr15_+_32304477 0.469 NM_016454
TMEM85
transmembrane protein 85
chr21_+_31953803 0.468 NM_000454
SOD1
superoxide dismutase 1, soluble
chr22_+_18090118 0.463 SEPT5-GP1BB
SEPT5-GP1BB read-through transcript
chr1_+_153232685 0.461 NM_018655
LENEP
lens epithelial protein
chr5_-_75954807 0.460 NM_004101
F2RL2
coagulation factor II (thrombin) receptor-like 2
chr9_-_139042526 0.456 NM_001606
ABCA2
ATP-binding cassette, sub-family A (ABC1), member 2
chr1_-_45249603 0.456 NM_024602
HECTD3
HECT domain containing 3
chr10_-_73167586 0.452 NM_001168390
C10orf105
chromosome 10 open reading frame 105
chr12_+_63084317 0.448 NM_007235
XPOT
exportin, tRNA (nuclear export receptor for tRNAs)
chr15_-_71830868 0.448 NM_001039614
C15orf59
chromosome 15 open reading frame 59
chr19_-_40711034 0.448 NM_001166034
NM_001166035
NM_198538
SBSN


suprabasin


chr15_+_39638445 0.445 NM_006293
TYRO3
TYRO3 protein tyrosine kinase
chrX_+_133198742 0.435 NM_001101357
CCDC160
coiled-coil domain containing 160
chr1_-_33139425 0.433 NM_033504
TMEM54
transmembrane protein 54
chr19_+_3317536 0.432 NM_005597
NFIC
nuclear factor I/C (CCAAT-binding transcription factor)
chr9_-_139042416 0.432 ABCA2
ATP-binding cassette, sub-family A (ABC1), member 2
chr21_+_46367216 0.422 COL6A2
collagen, type VI, alpha 2
chr8_+_22266256 0.421 PIWIL2
piwi-like 2 (Drosophila)
chr9_+_139255559 0.420 TUBB2C
tubulin, beta 2C
chrX_-_100527799 0.417 NM_000061
BTK
Bruton agammaglobulinemia tyrosine kinase
chr2_+_173794692 0.417 ZAK
sterile alpha motif and leucine zipper containing kinase AZK
chr11_-_62539857 0.415 NM_001184732
NM_001184733
NM_001184736
NM_004254
SLC22A8



solute carrier family 22 (organic anion transporter), member 8



chr22_-_43040063 0.413 NM_001099294
KIAA1644
KIAA1644
chr1_+_46578976 0.413 NM_199044
NSUN4
NOP2/Sun domain family, member 4
chr19_-_40696393 0.406 NM_001126056
NM_001126057
NM_001126058
NM_001190347
NM_001190348
NM_001190349
NM_033317
DMKN






dermokine






chr6_-_3102690 0.403 NM_001069
TUBB2A
tubulin, beta 2A
chr19_+_991079 0.403 NM_019112
ABCA7
ATP-binding cassette, sub-family A (ABC1), member 7
chr2_+_113591940 0.403 NM_000577
NM_173841
NM_173843
IL1RN


interleukin 1 receptor antagonist


chr10_+_75202258 0.401 FUT11
fucosyltransferase 11 (alpha (1,3) fucosyltransferase)
chr1_-_84237316 0.398 NM_024686
TTLL7
tubulin tyrosine ligase-like family, member 7
chr6_-_30793436 0.397 NM_014641
MDC1
mediator of DNA-damage checkpoint 1
chr9_+_139255519 0.395 NM_006088
TUBB2C
tubulin, beta 2C
chr11_-_64906683 0.393 NM_001077241
NM_182556
SLC25A45

solute carrier family 25, member 45

chr1_-_153195219 0.388 PBXIP1
pre-B-cell leukemia homeobox interacting protein 1
chr10_+_75202071 0.388 FUT11
fucosyltransferase 11 (alpha (1,3) fucosyltransferase)
chr7_-_115458047 0.387 TFEC
transcription factor EC
chr7_-_33047042 0.386 NM_001166118
NM_016489
NT5C3

5'-nucleotidase, cytosolic III

chr6_-_2580296 0.383 NM_152554
C6orf195
chromosome 6 open reading frame 195
chr1_-_45249554 0.382 HECTD3
HECT domain containing 3
chr1_-_111908085 0.380 NM_001081976
ADORA3
adenosine A3 receptor
chr6_+_31782618 0.380 NM_001003693
LY6G6F
lymphocyte antigen 6 complex, locus G6F
chr9_+_94776538 0.377 NM_033086
FGD3
FYVE, RhoGEF and PH domain containing 3
chr9_+_131291224 0.377 LOC100506190
hypothetical LOC100506190
chr6_-_32929721 0.377 NM_000593
TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr16_+_28413421 0.377 NM_018690
APOBR
apolipoprotein B receptor
chr9_+_131291144 0.374


chr1_-_43523825 0.373 NM_182517
NM_001164829
C1orf210

chromosome 1 open reading frame 210

chr9_-_99974994 0.373 NM_003389
CORO2A
coronin, actin binding protein, 2A
chr16_+_87765661 0.372 NM_004933
CDH15
cadherin 15, type 1, M-cadherin (myotubule)
chr6_-_33655995 0.362 NM_001188
BAK1
BCL2-antagonist/killer 1
chr3_+_5204430 0.361 EDEM1
ER degradation enhancer, mannosidase alpha-like 1
chr7_-_76667045 0.361 NM_006682
FGL2
fibrinogen-like 2
chr2_+_74635019 0.358 NM_001381
DOK1
docking protein 1, 62kDa (downstream of tyrosine kinase 1)
chr1_-_240228987 0.358 NM_001004343
MAP1LC3C
microtubule-associated protein 1 light chain 3 gamma

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.13 5.77e-03 GO:0009987 cellular process
5.20 1.17e-02 GO:0006521 regulation of cellular amino acid metabolic process
1.67 2.49e-02 GO:0050790 regulation of catalytic activity
3.54 3.70e-02 GO:0000077 DNA damage checkpoint
3.97 3.84e-02 GO:0051351 positive regulation of ligase activity
4.23 4.10e-02 GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
5.01 4.36e-02 GO:0032313 regulation of Rab GTPase activity
5.01 4.36e-02 GO:0032483 regulation of Rab protein signal transduction
4.52 4.80e-02 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
4.52 4.80e-02 GO:0072395 signal transduction involved in cell cycle checkpoint
4.52 4.80e-02 GO:0072401 signal transduction involved in DNA integrity checkpoint
4.52 4.80e-02 GO:0072404 signal transduction involved in G1/S transition checkpoint
4.52 4.80e-02 GO:0072413 signal transduction involved in mitotic cell cycle checkpoint
4.52 4.80e-02 GO:0072422 signal transduction involved in DNA damage checkpoint
4.52 4.80e-02 GO:0072431 signal transduction involved in mitotic cell cycle G1/S transition DNA damage checkpoint
4.52 4.80e-02 GO:0072474 signal transduction involved in mitotic cell cycle G1/S checkpoint

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
4.37 1.01e-02 GO:0000502 proteasome complex
7.51 2.76e-02 GO:0005839 proteasome core complex
2.41 3.78e-02 GO:0016323 basolateral plasma membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
4.91 1.22e-02 GO:0005097 Rab GTPase activator activity