Motif ID: PAX6.p2

Z-value: 0.713


Transcription factors associated with PAX6.p2:

Gene SymbolEntrez IDGene Name
PAX6 5080 paired box 6



Activity profile for motif PAX6.p2.

activity profile for motif PAX6.p2


Sorted Z-values histogram for motif PAX6.p2

Sorted Z-values for motif PAX6.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PAX6.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_72761367 1.342 STX1A
syntaxin 1A (brain)
chr1_+_93830106 1.056 LOC100129046
hypothetical LOC100129046
chr7_+_154943466 0.943 NM_001427
EN2
engrailed homeobox 2
chr1_+_93830169 0.828 LOC100129046
hypothetical LOC100129046
chrX_-_123925343 0.706 NM_001163278
NM_001163279
NM_014253
ODZ1


odz, odd Oz/ten-m homolog 1(Drosophila)


chr16_+_70646008 0.651 NM_001126102
NM_005143
HP

haptoglobin

chr22_+_38075703 0.564 NM_004711
NM_145731
SYNGR1

synaptogyrin 1

chr15_+_49760841 0.460 NM_001165257
NM_013243
SCG3

secretogranin III

chr10_+_118340460 0.425 NM_006229
PNLIPRP1
pancreatic lipase-related protein 1
chr4_+_70896236 0.399 NM_001009181
NM_003154
STATH

statherin

chr5_-_135259403 0.391 NM_000590
IL9
interleukin 9
chr1_+_113038202 0.373 MOV10
Mov10, Moloney leukemia virus 10, homolog (mouse)
chrX_-_53478016 0.322 NM_001037811
NM_004493
HSD17B10

hydroxysteroid (17-beta) dehydrogenase 10

chr3_+_52212969 0.315 ALAS1
aminolevulinate, delta-, synthase 1
chr10_-_82039158 0.288 NM_000429
MAT1A
methionine adenosyltransferase I, alpha
chrX_-_65176564 0.277 NM_001100431
NM_001184830
NM_001184831
NM_007268
VSIG4



V-set and immunoglobulin domain containing 4



chr9_+_102380156 0.254 NM_001018116
MURC
muscle-related coiled-coil protein
chr17_-_1195096 0.241 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr2_+_39000007 0.239 NM_001145451
ARHGEF33
Rho guanine nucleotide exchange factor (GEF) 33
chr3_-_120861959 0.211 NM_022135
POPDC2
popeye domain containing 2
chr4_+_187385618 0.183 NM_000892
KLKB1
kallikrein B, plasma (Fletcher factor) 1
chr5_-_142057692 0.177 NM_001144934
NM_001144935
FGF1

fibroblast growth factor 1 (acidic)

chr3_-_15538164 0.164 NM_005677
NM_080539
COLQ

collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase

chr6_+_101953389 0.160 GRIK2
glutamate receptor, ionotropic, kainate 2
chr18_+_17076166 0.160 NM_001142966
GREB1L
growth regulation by estrogen in breast cancer-like
chr4_-_26100986 0.159 NM_000730
CCKAR
cholecystokinin A receptor
chr18_+_59571256 0.155 NM_001040147
SERPINB7
serpin peptidase inhibitor, clade B (ovalbumin), member 7
chr11_-_117253354 0.153 NM_001164831
FXYD6
FXYD domain containing ion transport regulator 6
chr16_+_70654625 0.152 NM_020995
HPR
haptoglobin-related protein
chr4_+_114190233 0.149 NM_001148
NM_020977
ANK2

ankyrin 2, neuronal

chr5_+_57823017 0.149 NM_152687
GAPT
GRB2-binding adaptor protein, transmembrane
chr11_+_14883118 0.141 CALCB
calcitonin-related polypeptide beta
chr3_-_147805715 0.141 PLSCR5
phospholipid scramblase family, member 5
chrX_+_52797004 0.140 NM_003147
NM_175698
NM_001164417
SSX2

SSX2B
synovial sarcoma, X breakpoint 2

synovial sarcoma, X breakpoint 2B
chrX_-_13745134 0.138 GPM6B
glycoprotein M6B
chr15_-_23204887 0.136 NM_000462
UBE3A
ubiquitin protein ligase E3A
chr11_+_55776251 0.133 NM_001004747
OR5T3
olfactory receptor, family 5, subfamily T, member 3
chr6_+_25760352 0.133 NM_006998
SCGN
secretagogin, EF-hand calcium binding protein
chr16_-_11282595 0.131 NM_002761
PRM1
protamine 1
chr1_-_6502655 0.130 NM_198681
PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chrX_+_48127911 0.130 NM_001034832
NM_001040612
NM_005636
NM_175729
SSX4B

SSX4

synovial sarcoma, X breakpoint 4B

synovial sarcoma, X breakpoint 4

chrX_+_49718954 0.127 NM_000084
CLCN5
chloride channel 5
chr5_+_79651545 0.126 NM_032567
SPZ1
spermatogenic leucine zipper 1
chr19_-_56825400 0.122 NM_003830
SIGLEC5
sialic acid binding Ig-like lectin 5
chr1_+_108794426 0.120 NM_001143987
NM_001143988
NBPF4
NBPF6

neuroblastoma breakpoint family, member 4
neuroblastoma breakpoint family, member 6

chr12_-_131725848 0.120 POLE
polymerase (DNA directed), epsilon
chrX_-_15242589 0.119 NM_001012428
ASB11
ankyrin repeat and SOCS box containing 11
chrX_+_50670474 0.116 NM_005448
BMP15
bone morphogenetic protein 15
chr6_-_10520264 0.114 TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr10_+_129735796 0.114 NM_130435
PTPRE
protein tyrosine phosphatase, receptor type, E
chrX_-_6156655 0.113 NM_181332
NLGN4X
neuroligin 4, X-linked
chrX_-_130251068 0.113 NM_001170961
NM_001170962
NM_001555
NM_205833
IGSF1



immunoglobulin superfamily, member 1



chr17_-_33602374 0.112 NM_032258
TBC1D3C
TBC1D3G
TBC1D3
TBC1D3F
TBC1 domain family, member 3C
TBC1 domain family, member 3G
TBC1 domain family, member 3
TBC1 domain family, member 3F
chr5_-_22248630 0.107 CDH12
cadherin 12, type 2 (N-cadherin 2)
chr13_+_52500830 0.104 NM_006418
OLFM4
olfactomedin 4
chrX_-_130250880 0.102 IGSF1
immunoglobulin superfamily, member 1
chr10_+_114033403 0.101 NM_058222
TECTB
tectorin beta
chrX_-_106336199 0.101 NM_017681
NUP62CL
nucleoporin 62kDa C-terminal like
chr3_-_129668780 0.100 NM_153330
DNAJB8
DnaJ (Hsp40) homolog, subfamily B, member 8
chr5_-_141318810 0.099 NM_016580
PCDH12
protocadherin 12
chrX_+_103243762 0.099 NM_001143978
ZCCHC18
zinc finger, CCHC domain containing 18
chrX_-_76823813 0.094


chr11_+_76561471 0.093 MYO7A
myosin VIIA
chrX_-_148604506 0.090 NM_001011544
MAGEA11
melanoma antigen family A, 11
chr11_+_834445 0.090 NM_001025237
TSPAN4
tetraspanin 4
chr9_-_94206648 0.089 NM_014057
NM_033014
OGN

osteoglycin

chrX_-_138742050 0.089 NM_001010986
NM_173694
ATP11C

ATPase, class VI, type 11C

chr17_+_4776371 0.088 NM_000173
GP1BA
glycoprotein Ib (platelet), alpha polypeptide
chr13_-_109600709 0.088 COL4A1
collagen, type IV, alpha 1
chr19_+_54299686 0.084 SNRNP70
small nuclear ribonucleoprotein 70kDa (U1)
chr8_+_18123456 0.083 NM_001160174
NAT1
N-acetyltransferase 1 (arylamine N-acetyltransferase)
chr12_+_10351683 0.082 NM_002262
NM_007334
KLRD1

killer cell lectin-like receptor subfamily D, member 1

chr1_-_246804680 0.080 NM_001001821
OR2T34
olfactory receptor, family 2, subfamily T, member 34
chr2_-_133256097 0.079 NCKAP5
NCK-associated protein 5
chr6_-_64087806 0.078 NM_001143940
NM_016571
LGSN

lengsin, lens protein with glutamine synthetase domain

chr15_+_43331719 0.078 NM_004212
SLC28A2
solute carrier family 28 (sodium-coupled nucleoside transporter), member 2
chr16_-_46823682 0.077 NM_033151
ABCC11
ATP-binding cassette, sub-family C (CFTR/MRP), member 11
chr10_+_35934343 0.076 NM_153368
GJD4
gap junction protein, delta 4, 40.1kDa
chr6_+_101953581 0.076 NM_001166247
NM_021956
NM_175768
GRIK2


glutamate receptor, ionotropic, kainate 2


chr12_+_108035424 0.074


chr16_-_29514140 0.073


chr8_-_87824996 0.073 NM_019098
CNGB3
cyclic nucleotide gated channel beta 3
chr2_+_214984705 0.069 NM_001080500
VWC2L
von Willebrand factor C domain containing protein 2-like
chr12_-_18134319 0.068 NM_024730
RERGL
RERG/RAS-like
chr11_-_117252541 0.067 FXYD6
FXYD domain containing ion transport regulator 6
chr3_-_58627509 0.065 NM_138805
FAM3D
family with sequence similarity 3, member D
chrX_-_52700674 0.065 NM_173358
SSX7
synovial sarcoma, X breakpoint 7
chr19_+_9064854 0.064 NM_001004456
OR1M1
olfactory receptor, family 1, subfamily M, member 1
chr11_+_19328846 0.063 NM_001111018
NAV2
neuron navigator 2
chr3_-_152585226 0.062 NM_022788
P2RY12
purinergic receptor P2Y, G-protein coupled, 12
chr16_-_18845223 0.061 NM_015092
SMG1
SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans)
chr4_-_64957595 0.057 NM_001010874
TECRL
trans-2,3-enoyl-CoA reductase-like
chr14_+_28311740 0.055 C14orf23
chromosome 14 open reading frame 23
chr1_-_12830728 0.055 NM_001146181
HNRNPCL1
LOC649330
heterogeneous nuclear ribonucleoprotein C-like 1
heterogeneous nuclear ribonucleoprotein C-like
chr8_-_93181091 0.055 NM_001198628
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chrX_+_92815667 0.054 NM_001171109
NM_001171110
NM_001171111
NM_173698
FAM133A



family with sequence similarity 133, member A



chr10_+_83627422 0.054 NM_001165973
NRG3
neuregulin 3
chrX_-_13745108 0.046 GPM6B
glycoprotein M6B
chr9_-_139262009 0.046 NM_001001710
FAM166A
family with sequence similarity 166, member A
chr3_+_115495522 0.045 NM_173799
TIGIT
T cell immunoreceptor with Ig and ITIM domains
chr3_-_150533948 0.045 NM_001184723
NM_138786
TM4SF18

transmembrane 4 L six family member 18

chr6_-_10520592 0.045 NM_001032280
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr3_-_155630197 0.044 NM_001038705
GPR149
G protein-coupled receptor 149
chr1_-_54861656 0.043 NM_176782
FAM151A
family with sequence similarity 151, member A
chrX_-_13745234 0.043 NM_001001995
NM_001001996
NM_005278
GPM6B


glycoprotein M6B


chr2_+_178893216 0.042 NM_145739
OSBPL6
oxysterol binding protein-like 6
chr3_-_109730858 0.042 NM_014981
MYH15
myosin, heavy chain 15
chr12_+_97513644 0.041 SLC25A3
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3
chr1_-_89230844 0.041 RBMXL1
CCBL2
RNA binding motif protein, X-linked-like 1
cysteine conjugate-beta lyase 2
chr9_-_115901157 0.041 NM_138424
KIF12
kinesin family member 12
chr1_+_246703249 0.040 NM_001005495
OR2T3
olfactory receptor, family 2, subfamily T, member 3
chr10_+_102212787 0.040 NM_003393
WNT8B
wingless-type MMTV integration site family, member 8B
chr1_+_145841569 0.038 NM_005267
GJA8
gap junction protein, alpha 8, 50kDa
chrX_+_36163971 0.037 NM_001098843
CXorf30
chromosome X open reading frame 30
chr1_+_207944807 0.037 NM_005525
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr11_-_57054756 0.037 NM_012456
TIMM10
translocase of inner mitochondrial membrane 10 homolog (yeast)
chr1_-_245902965 0.036 NM_001005487
OR13G1
olfactory receptor, family 13, subfamily G, member 1
chr4_-_170314382 0.036 SH3RF1
SH3 domain containing ring finger 1
chr10_-_79298876 0.036 DLG5
discs, large homolog 5 (Drosophila)
chr16_-_49742008 0.035 NM_001127892
SALL1
sal-like 1 (Drosophila)
chr21_-_30855478 0.034 NM_181614
KRTAP19-7
keratin associated protein 19-7
chr17_-_31831093 0.033 NM_001123392
NM_032258
TBC1D3C
TBC1D3G
TBC1D3
TBC1D3H
TBC1D3F
TBC1 domain family, member 3C
TBC1 domain family, member 3G
TBC1 domain family, member 3
TBC1 domain family, member 3H
TBC1 domain family, member 3F
chr4_-_10295412 0.033 NM_052964
CLNK
cytokine-dependent hematopoietic cell linker
chrX_-_48156287 0.032 NM_001034832
NM_001040612
NM_005636
NM_175729
SSX4B

SSX4

synovial sarcoma, X breakpoint 4B

synovial sarcoma, X breakpoint 4

chr5_-_58918031 0.032 NM_006203
PDE4D
phosphodiesterase 4D, cAMP-specific
chr11_-_123130435 0.030 NM_001005188
OR6X1
olfactory receptor, family 6, subfamily X, member 1
chr7_-_26198673 0.030 HNRNPA2B1
heterogeneous nuclear ribonucleoprotein A2/B1
chr8_+_124264054 0.030 FAM83A
family with sequence similarity 83, member A
chrX_-_84250629 0.029 NM_001012980
SATL1
spermidine/spermine N1-acetyl transferase-like 1
chr1_+_148747208 0.029 ECM1
extracellular matrix protein 1
chr1_+_97033103 0.027


chr12_+_8557402 0.027 NM_080387
CLEC4D
C-type lectin domain family 4, member D
chr1_-_108588186 0.026 NM_001143989
NBPF4
NBPF6
neuroblastoma breakpoint family, member 4
neuroblastoma breakpoint family, member 6
chr6_-_28591542 0.026 NM_182701
GPX6
glutathione peroxidase 6 (olfactory)
chr22_+_24468168 0.025 MYO18B
myosin XVIIIB
chr12_-_78853365 0.024 NM_001143885
PPP1R12A
protein phosphatase 1, regulatory (inhibitor) subunit 12A
chr12_-_43555607 0.024 NM_001145109
NELL2
NEL-like 2 (chicken)
chrX_+_144716619 0.023 NM_004709
CXorf1
chromosome X open reading frame 1
chrX_-_13744933 0.022 GPM6B
glycoprotein M6B
chr3_-_14558591 0.022 NM_001080423
GRIP2
glutamate receptor interacting protein 2
chr6_-_50097606 0.021 NM_001037497
NM_001037728
DEFB110

defensin, beta 110 locus

chr9_-_16860664 0.020 BNC2
basonuclin 2
chr3_-_121117647 0.020 GSK3B
glycogen synthase kinase 3 beta
chr17_-_8602601 0.020 NM_001128076
SPDYE4
speedy homolog E4 (Xenopus laevis)
chr7_+_80105718 0.019 NM_000072
NM_001001548
CD36

CD36 molecule (thrombospondin receptor)

chr2_-_200033445 0.019 SATB2
SATB homeobox 2
chr9_+_130485754 0.017 NM_001122821
SET
SET nuclear oncogene
chr4_-_174557191 0.017 NM_007281
SCRG1
stimulator of chondrogenesis 1
chr19_+_56990222 0.016 NM_002030
FPR3
formyl peptide receptor 3
chr11_-_11331411 0.016 CSNK2A1P
casein kinase 2, alpha 1 polypeptide pseudogene
chr19_+_15713200 0.015 NM_013938
OR10H3
olfactory receptor, family 10, subfamily H, member 3
chr6_-_152681171 0.014 NM_015293
SYNE1
spectrin repeat containing, nuclear envelope 1
chr1_-_31117948 0.013 SDC3
syndecan 3
chr3_+_134601479 0.012 NM_003571
BFSP2
beaded filament structural protein 2, phakinin
chr15_+_63124760 0.012 NM_178859
OSTBETA
organic solute transporter beta
chr4_-_91979113 0.012 NM_183049
TMSL3
thymosin-like 3
chr5_-_142795269 0.012 NM_001018074
NM_001018075
NM_001018077
NR3C1


nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)


chr14_-_20694023 0.011 NM_001004731
OR5AU1
olfactory receptor, family 5, subfamily AU, member 1
chr4_+_77829634 0.011 SHROOM3
shroom family member 3
chr8_-_102029997 0.011 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chrX_-_135783496 0.010


chr8_-_59575249 0.010 NM_000780
CYP7A1
cytochrome P450, family 7, subfamily A, polypeptide 1
chr3_+_122769467 0.010 NM_001012659
ARGFX
arginine-fifty homeobox
chr1_+_35623688 0.010 ZMYM4
zinc finger, MYM-type 4
chr5_-_169657312 0.010 LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr11_-_49960646 0.009 NM_001005270
OR4C12
olfactory receptor, family 4, subfamily C, member 12
chr10_-_7699192 0.008 ITIH5
inter-alpha (globulin) inhibitor H5
chr11_+_117680504 0.008 NM_000733
CD3E
CD3e molecule, epsilon (CD3-TCR complex)
chr12_-_43556220 0.007 NELL2
NEL-like 2 (chicken)
chr17_+_22982372 0.006 LGALS9
lectin, galactoside-binding, soluble, 9
chr3_-_196792059 0.006 APOD
apolipoprotein D
chr21_-_30510113 0.005 NM_199328
CLDN8
claudin 8
chr7_+_80105907 0.005 CD36
CD36 molecule (thrombospondin receptor)
chr10_+_91082218 0.004 NM_001031683
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr6_-_48186868 0.004 C6orf138
chromosome 6 open reading frame 138
chr11_+_111294810 0.004 NM_080659
C11orf52
chromosome 11 open reading frame 52
chr17_+_55854636 0.003 NM_181707
C17orf64
chromosome 17 open reading frame 64
chr17_-_34209671 0.003 NM_003559
PIP4K2B
phosphatidylinositol-5-phosphate 4-kinase, type II, beta
chr4_-_185963859 0.003 ACSL1
acyl-CoA synthetase long-chain family member 1
chr2_+_119416214 0.003 NM_006770
MARCO
macrophage receptor with collagenous structure
chr2_-_18634257 0.002 NM_001002006
NM_033253
NT5C1B-RDH14
NT5C1B

NT5C1B-RDH14 readthrough
5'-nucleotidase, cytosolic IB

chr1_+_148747110 0.002 NM_004425
NM_022664
ECM1

extracellular matrix protein 1

chr6_-_155818728 0.002 NM_015718
NOX3
NADPH oxidase 3
chr12_+_55201854 0.002 NM_002898
RBMS2
RNA binding motif, single stranded interacting protein 2
chr12_-_55790355 0.001 NM_001178079
STAT6
signal transducer and activator of transcription 6, interleukin-4 induced
chr12_+_119224506 0.001 NM_012240
SIRT4
sirtuin 4
chr11_+_55617328 0.000 NM_001003750
OR8I2
olfactory receptor, family 8, subfamily I, member 2

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Nothing significant found in function category.