Motif ID: LMO2.p2

Z-value: 1.483


Transcription factors associated with LMO2.p2:

Gene SymbolEntrez IDGene Name
LMO2 4005 LIM domain only 2 (rhombotin-like 1)



Activity profile for motif LMO2.p2.

activity profile for motif LMO2.p2


Sorted Z-values histogram for motif LMO2.p2

Sorted Z-values for motif LMO2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of LMO2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_171280944 1.874 SP5
Sp5 transcription factor
chr19_-_6643953 1.625 C3
complement component 3
chr7_+_17304707 1.330 NM_001621
AHR
aryl hydrocarbon receptor
chr10_+_92970302 1.217 NM_032373
PCGF5
polycomb group ring finger 5
chr14_-_105392671 1.194


chr1_+_167342149 1.167 ATP1B1
ATPase, Na+/K+ transporting, beta 1 polypeptide
chr17_-_36587965 1.138 NM_033062
KRTAP4-2
keratin associated protein 4-2
chr17_+_36642240 1.102 NM_031962
KRTAP9-9
KRTAP9-3
keratin associated protein 9-9
keratin associated protein 9-3
chr20_+_48781457 1.096 NM_032521
PARD6B
par-6 partitioning defective 6 homolog beta (C. elegans)
chr20_+_42463279 1.078 NM_000457
NM_178849
NM_178850
HNF4A


hepatocyte nuclear factor 4, alpha


chr19_+_7566698 1.044 NM_001080429
NM_020902
KIAA1543

KIAA1543

chr2_-_6923215 0.952 NM_207315
CMPK2
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr10_+_92970487 0.951 PCGF5
polycomb group ring finger 5
chr18_+_65219114 0.937 NM_152721
DOK6
docking protein 6
chr14_-_22891263 0.916 NM_020372
SLC22A17
solute carrier family 22, member 17
chr17_+_36515166 0.899 NM_001146041
KRTAP4-9
keratin associated protein 4-9
chr1_+_56883333 0.895 NM_006252
PRKAA2
protein kinase, AMP-activated, alpha 2 catalytic subunit
chr2_-_96167900 0.883 NM_001002036
ASTL
astacin-like metallo-endopeptidase (M12 family)
chr1_+_161027115 0.869 NM_016371
HSD17B7
hydroxysteroid (17-beta) dehydrogenase 7
chr20_+_42463419 0.824 HNF4A
hepatocyte nuclear factor 4, alpha
chr20_+_42463350 0.818 HNF4A
hepatocyte nuclear factor 4, alpha
chr2_+_241279934 0.816 NM_198998
AQP12A
AQP12B
aquaporin 12A
aquaporin 12B
chr18_+_75760434 0.801


chr5_+_156625629 0.796 NM_001037333
NM_001037332
CYFIP2

cytoplasmic FMR1 interacting protein 2

chr20_+_42463387 0.794 HNF4A
hepatocyte nuclear factor 4, alpha
chr2_+_79593679 0.792 CTNNA2
catenin (cadherin-associated protein), alpha 2
chr20_+_44070946 0.785 NM_004994
MMP9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
chr2_+_222997529 0.782 NM_152386
SGPP2
sphingosine-1-phosphate phosphatase 2
chr14_-_105851580 0.781 IGHA1
IGHA2
IGHD
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant alpha 2 (A2m marker)
immunoglobulin heavy constant delta
immunoglobulin heavy constant gamma 1 (G1m marker)
chr2_-_75280121 0.773 NM_001058
NM_015727
TACR1

tachykinin receptor 1

chr14_+_23675233 0.761 PSME1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr14_+_23675206 0.754 NM_006263
NM_176783
PSME1

proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)

chrX_+_115481774 0.747 NM_007231
SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chr20_-_3097070 0.743 NM_014731
ProSAPiP1
ProSAPiP1 protein
chr2_+_222997456 0.735 SGPP2
sphingosine-1-phosphate phosphatase 2
chr13_+_77170470 0.728 NM_001040153
SLAIN1
SLAIN motif family, member 1
chr2_+_220015016 0.717 SPEG
SPEG complex locus
chr2_+_79593567 0.697 NM_001164883
NM_004389
CTNNA2

catenin (cadherin-associated protein), alpha 2

chr20_-_42872295 0.696 NM_182970
RIMS4
regulating synaptic membrane exocytosis 4
chr17_-_36594652 0.688 NM_033060
KRTAP4-1
keratin associated protein 4-1
chr17_-_36507900 0.686 NM_031960
KRTAP4-8
keratin associated protein 4-8
chr16_+_12902955 0.675 NM_001145204
NM_001145205
SHISA9

shisa homolog 9 (Xenopus laevis)

chr17_+_14145051 0.665 NM_006041
HS3ST3B1
heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1
chr20_+_61796731 0.664 NM_032945
TNFRSF6B
tumor necrosis factor receptor superfamily, member 6b, decoy
chrX_+_152562013 0.663 DUSP9
dual specificity phosphatase 9
chr6_+_36103431 0.661 NM_001315
NM_139012
NM_139013
NM_139014
MAPK14



mitogen-activated protein kinase 14



chr10_+_38685299 0.654 HSD17B7P2
hydroxysteroid (17-beta) dehydrogenase 7 pseudogene 2
chr20_+_13924263 0.653 MACROD2
MACRO domain containing 2
chr17_+_58908152 0.647 NM_000789
ACE
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
chrX_+_115481848 0.644 SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chr3_+_30623376 0.640 TGFBR2
transforming growth factor, beta receptor II (70/80kDa)
chr8_-_81155564 0.622 NM_001025252
TPD52
tumor protein D52
chr6_+_118335381 0.615 NM_001029858
SLC35F1
solute carrier family 35, member F1
chr16_+_86194075 0.614 JPH3
junctophilin 3
chr2_-_215956429 0.611 FN1
fibronectin 1
chr20_+_60744268 0.594 SLCO4A1
solute carrier organic anion transporter family, member 4A1
chr8_+_22280942 0.590 NM_001135153
SLC39A14
solute carrier family 39 (zinc transporter), member 14
chr16_+_56616782 0.589 NM_002428
MMP15
matrix metallopeptidase 15 (membrane-inserted)
chr6_-_132764257 0.585 NM_015529
MOXD1
monooxygenase, DBH-like 1
chr11_+_817584 0.581 NM_173584
EFCAB4A
EF-hand calcium binding domain 4A
chr13_+_112681626 0.572 NM_024979
MCF2L
MCF.2 cell line derived transforming sequence-like
chr20_+_60744231 0.569 NM_016354
SLCO4A1
solute carrier organic anion transporter family, member 4A1
chr1_+_167342493 0.567 NM_001677
ATP1B1
ATPase, Na+/K+ transporting, beta 1 polypeptide
chr4_+_129951877 0.566 PHF17
PHD finger protein 17
chr17_+_35147738 0.566 GRB7
growth factor receptor-bound protein 7
chr16_+_76690664 0.564 NM_016373
NM_130791
NM_130844
WWOX


WW domain containing oxidoreductase


chr2_-_241408296 0.558 NM_004321
KIF1A
kinesin family member 1A
chr16_+_87232501 0.558 NM_013278
IL17C
interleukin 17C
chr19_-_6621078 0.557 TNFSF14
tumor necrosis factor (ligand) superfamily, member 14
chr15_-_42274529 0.554 NM_032892
FRMD5
FERM domain containing 5
chr18_+_75724655 0.552 NM_012283
KCNG2
potassium voltage-gated channel, subfamily G, member 2
chr3_-_52694554 0.546 NM_018313
PBRM1
polybromo 1
chr14_-_105163301 0.543 IGHG4
immunoglobulin heavy constant gamma 4 (G4m marker)
chr14_-_105279740 0.536


chr17_-_77635703 0.534 FASN
fatty acid synthase
chr1_+_27192719 0.526 NM_001013642
TRNP1
TMF1-regulated nuclear protein 1
chr16_+_86193993 0.521 NM_020655
JPH3
junctophilin 3
chr14_-_106105805 0.521 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr2_+_137239583 0.517 THSD7B
thrombospondin, type I, domain containing 7B
chr20_+_254205 0.512 NM_006943
SOX12
SRY (sex determining region Y)-box 12
chr14_-_106154332 0.507 LOC100126583
IGHG1
hypothetical LOC100126583
immunoglobulin heavy constant gamma 1 (G1m marker)
chr8_+_120289735 0.507 NM_052886
MAL2
mal, T-cell differentiation protein 2 (gene/pseudogene)
chr2_-_101134146 0.505 NM_001102426
TBC1D8
TBC1 domain family, member 8 (with GRAM domain)
chr14_-_22891865 0.503 NM_016609
SLC22A17
solute carrier family 22, member 17
chr6_-_48144344 0.500 NM_001013732
NM_207499
C6orf138

chromosome 6 open reading frame 138

chr6_+_36103491 0.500 MAPK14
mitogen-activated protein kinase 14
chr11_+_63864263 0.497 NM_032251
CCDC88B
coiled-coil domain containing 88B
chr2_-_109728693 0.495 SEPT10
septin 10
chr2_+_118562499 0.494 NM_016133
INSIG2
insulin induced gene 2
chrX_+_105856531 0.493 NM_194463
RNF128
ring finger protein 128
chr4_+_6962438 0.493 TBC1D14
TBC1 domain family, member 14
chr3_-_188936941 0.492 NM_001130845
BCL6
B-cell CLL/lymphoma 6
chr20_-_14266200 0.491 NM_013281
NM_198391
FLRT3

fibronectin leucine rich transmembrane protein 3

chr2_+_233270286 0.490 GIGYF2
GRB10 interacting GYF protein 2
chr2_-_109728958 0.490 NM_144710
NM_178584
SEPT10

septin 10

chr6_+_37245860 0.489 NM_002648
PIM1
pim-1 oncogene
chr17_+_72827185 0.487 NM_006640
SEPT9
septin 9
chr22_-_49240594 0.485 SBF1
SET binding factor 1
chr8_+_22281118 0.481 SLC39A14
solute carrier family 39 (zinc transporter), member 14
chr2_-_73350103 0.481 NM_001080410
FBXO41
F-box protein 41
chr2_+_219532590 0.480 NM_003936
CDK5R2
cyclin-dependent kinase 5, regulatory subunit 2 (p39)
chr2_-_121759237 0.478 NM_014553
TFCP2L1
transcription factor CP2-like 1
chr4_+_2390469 0.472 NM_001193282
LOC402160
hypothetical protein LOC402160
chr16_+_84202515 0.471 NM_001134473
KIAA0182
KIAA0182
chr6_+_7486862 0.469 NM_001008844
NM_004415
DSP

desmoplakin

chr20_-_61356247 0.468 NM_152864
NKAIN4
Na+/K+ transporting ATPase interacting 4
chr2_+_14690290 0.467 FAM84A
family with sequence similarity 84, member A
chr14_-_26136799 0.463 NM_002515
NM_006489
NM_006491
NOVA1


neuro-oncological ventral antigen 1


chr6_+_7486836 0.463 DSP
desmoplakin
chr10_+_124124196 0.462 PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr16_-_88613287 0.461 NM_001042610
DBNDD1
dysbindin (dystrobrevin binding protein 1) domain containing 1
chr6_+_36103561 0.459 MAPK14
mitogen-activated protein kinase 14
chr20_-_23014828 0.459 NM_012072
CD93
CD93 molecule
chr16_+_56616970 0.458 MMP15
matrix metallopeptidase 15 (membrane-inserted)
chr6_+_138524717 0.454 NM_020340
KIAA1244
KIAA1244
chr20_-_844856 0.453 NM_015985
ANGPT4
angiopoietin 4
chr2_-_219633481 0.451 NM_002181
IHH
Indian hedgehog
chr17_+_4683280 0.448 NM_001024937
NM_015716
NM_153827
NM_170663
MINK1



misshapen-like kinase 1



chr15_-_42274760 0.447 FRMD5
FERM domain containing 5
chr2_+_233099113 0.447 NM_000751
CHRND
cholinergic receptor, nicotinic, delta
chr20_+_61655934 0.446


chr16_+_86194170 0.442 JPH3
junctophilin 3
chr22_-_41353575 0.441 CYB5R3
cytochrome b5 reductase 3
chr18_+_11679135 0.439 NM_182978
GNAL
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
chr2_-_217267742 0.438 IGFBP5
insulin-like growth factor binding protein 5
chr5_+_168996816 0.438 NM_004946
DOCK2
dedicator of cytokinesis 2
chr17_+_72827227 0.438 SEPT9
septin 9
chr19_+_40223249 0.436 NM_002151
NM_182983
HPN

hepsin

chr8_-_17315171 0.436 MTMR7
myotubularin related protein 7
chr3_+_54131731 0.436 NM_018398
CACNA2D3
calcium channel, voltage-dependent, alpha 2/delta subunit 3
chr2_-_198359182 0.436 NM_197970
BOLL
bol, boule-like (Drosophila)
chr6_+_7486891 0.434 DSP
desmoplakin
chr2_-_224410444 0.432 AP1S3
adaptor-related protein complex 1, sigma 3 subunit
chr3_+_52694975 0.432 NM_014366
NM_206825
NM_206826
GNL3


guanine nucleotide binding protein-like 3 (nucleolar)


chr2_-_133144094 0.431 LYPD1
LY6/PLAUR domain containing 1
chr13_+_110164047 0.423 ING1
inhibitor of growth family, member 1
chr20_-_32354736 0.416 NM_000687
AHCY
adenosylhomocysteinase
chr20_-_61649259 0.413 NM_080823
SRMS
src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites
chr14_-_88328848 0.412 NM_183387
EML5
echinoderm microtubule associated protein like 5
chr5_+_168996852 0.411 DOCK2
dedicator of cytokinesis 2
chr8_+_346933 0.410 FBXO25
F-box protein 25
chr6_-_32659958 0.410 HLA-DRB1
HLA-DRB5
major histocompatibility complex, class II, DR beta 1
major histocompatibility complex, class II, DR beta 5
chr3_-_50311666 0.408 NM_012191
NM_003549
NAT6
HYAL3
N-acetyltransferase 6 (GCN5-related)
hyaluronoglucosaminidase 3
chr8_-_145609737 0.404 SLC39A4
solute carrier family 39 (zinc transporter), member 4
chr13_+_97426713 0.404 IPO5
importin 5
chr2_+_219354948 0.404 CYP27A1
cytochrome P450, family 27, subfamily A, polypeptide 1
chr2_-_166358951 0.403 GALNT3
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)
chr17_-_36570508 0.402 NM_032524
KRTAP4-4
keratin associated protein 4-4
chr20_-_60484420 0.401 NM_080473
GATA5
GATA binding protein 5
chr4_-_8211335 0.399 NM_001130083
NM_001130084
NM_001130085
NM_001130086
NM_001130087
NM_001130088
NM_032432
ABLIM2






actin binding LIM protein family, member 2






chr8_+_22280731 0.398 SLC39A14
solute carrier family 39 (zinc transporter), member 14
chr3_+_54131613 0.397 CACNA2D3
calcium channel, voltage-dependent, alpha 2/delta subunit 3
chr2_-_21081694 0.396 APOB
apolipoprotein B (including Ag(x) antigen)
chr16_-_49205063 0.395


chr10_+_99175967 0.394 PGAM1
phosphoglycerate mutase 1 (brain)
chr14_-_105308531 0.394


chr20_+_18217120 0.393 NM_001083330
NM_003434
ZNF133

zinc finger protein 133

chr16_+_51690564 0.393 CHD9
chromodomain helicase DNA binding protein 9
chr5_+_126140949 0.390 LMNB1
lamin B1
chr6_+_160068135 0.388 NM_004906
NM_152858
WTAP

Wilms tumor 1 associated protein

chr2_-_37752731 0.386 NM_006449
CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chr2_+_28971007 0.385 NM_015131
WDR43
WD repeat domain 43
chr6_+_143423656 0.383 NM_016108
AIG1
androgen-induced 1
chr14_+_54104099 0.381 SAMD4A
sterile alpha motif domain containing 4A
chr5_+_76284435 0.380 NM_001882
CRHBP
corticotropin releasing hormone binding protein
chr2_-_166358792 0.380 GALNT3
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)
chr2_-_210888010 0.377 NM_079420
MYL1
myosin, light chain 1, alkali; skeletal, fast
chr8_+_17058170 0.376 NM_016353
ZDHHC2
zinc finger, DHHC-type containing 2
chr2_+_162908869 0.376 GCA
grancalcin, EF-hand calcium binding protein
chr2_+_220017617 0.375 SPEG
SPEG complex locus
chr5_+_67547357 0.375 PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr17_+_71292275 0.373 NM_001080419
UNK
unkempt homolog (Drosophila)
chr20_+_17628592 0.373 NM_001014977
NM_178477
BANF2

barrier to autointegration factor 2

chr5_+_78567604 0.373 NM_152405
JMY
junction mediating and regulatory protein, p53 cofactor
chrX_-_153428621 0.372 G6PD
glucose-6-phosphate dehydrogenase
chr10_-_18988172 0.372


chr4_+_152417774 0.370 NM_183375
PRSS48
protease, serine, 48
chr6_+_143423723 0.369 AIG1
androgen-induced 1
chr17_-_8643163 0.368 NM_152599
MFSD6L
major facilitator superfamily domain containing 6-like
chr3_+_187813538 0.368 NM_001622
AHSG
alpha-2-HS-glycoprotein
chr16_+_84204424 0.368 NM_014615
KIAA0182
KIAA0182
chr3_+_187813553 0.368 AHSG
alpha-2-HS-glycoprotein
chr14_+_23855291 0.368 LTB4R
leukotriene B4 receptor
chr6_+_36103563 0.367 MAPK14
mitogen-activated protein kinase 14
chr2_+_205118801 0.366 PARD3B
par-3 partitioning defective 3 homolog B (C. elegans)
chr10_+_94598204 0.366 NM_019053
EXOC6
exocyst complex component 6
chr1_+_90060131 0.365 LRRC8D
leucine rich repeat containing 8 family, member D
chr16_+_631828 0.364 NM_138418
FAM195A
family with sequence similarity 195, member A
chr2_+_205118710 0.363 NM_057177
NM_152526
NM_205863
PARD3B


par-3 partitioning defective 3 homolog B (C. elegans)


chr7_-_97719372 0.363 NM_015395
TECPR1
tectonin beta-propeller repeat containing 1
chr20_+_2621193 0.363 NM_001110514
EBF4
early B-cell factor 4
chr17_+_36647795 0.360 NM_031963
KRTAP9-8
keratin associated protein 9-8
chr14_-_105308720 0.359 IGHM
immunoglobulin heavy constant mu
chr17_-_43288137 0.359 NM_199262
SP6
Sp6 transcription factor
chr8_+_22280703 0.358 NM_001128431
NM_001135154
NM_015359
SLC39A14


solute carrier family 39 (zinc transporter), member 14


chr12_+_439803 0.358 NM_173593
B4GALNT3
beta-1,4-N-acetyl-galactosaminyl transferase 3
chr3_+_38182251 0.356 OXSR1
oxidative-stress responsive 1
chr16_+_631902 0.354 FAM195A
family with sequence similarity 195, member A
chr2_+_238432925 0.353 NM_005855
RAMP1
receptor (G protein-coupled) activity modifying protein 1
chr14_-_105308639 0.353



Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.24 4.97e-06 GO:0048856 anatomical structure development
1.25 5.41e-06 GO:0048731 system development
1.22 1.02e-05 GO:0007275 multicellular organismal development
1.20 3.93e-05 GO:0032502 developmental process
1.26 5.71e-04 GO:0030154 cell differentiation
1.25 1.37e-03 GO:0048869 cellular developmental process
1.27 2.18e-02 GO:0007399 nervous system development
1.23 2.79e-02 GO:0048513 organ development

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.38 4.17e-04 GO:0045095 keratin filament
1.69 4.67e-03 GO:0016323 basolateral plasma membrane
1.41 7.04e-03 GO:0030054 cell junction
1.20 7.07e-03 GO:0044459 plasma membrane part
1.30 1.05e-02 GO:0044430 cytoskeletal part
1.07 4.16e-02 GO:0005737 cytoplasm

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.09 9.02e-03 GO:0005515 protein binding
1.31 3.35e-02 GO:0030234 enzyme regulator activity